61,747 results match your criteria p53 gene


Bioinformatics and Studies Reveal the Importance of p53, PPARG and Notch Signaling Pathway in Inhibition of Breast Cancer Stem Cells by Hesperetin.

Adv Pharm Bull 2021 Feb 19;11(2):351-360. Epub 2020 Apr 19.

Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara II, 55281 Yogyakarta, Indonesia.

The failure of chemotherapy in breast cancer is caused by breast cancer stem cells (BCSCs), a minor population of cells in bulk mammary tumors. Previously, hesperetin, a citrus flavonoid, showed cytotoxicity in several cancer cells and increased cytotoxicity of doxorubicin and cisplatin. Hesperetin also inhibited osteogenic and adipocyte differentiation, however, a study of the effect of hesperetin on BCSCs has not yet been performed. Read More

View Article and Full-Text PDF
February 2021

MicroRNA-302s Might Regulate ARL4C-Mediated Gastric Cancer Progression via p53 Signaling: Bioinformatics Analysis and Experiments Validation.

Onco Targets Ther 2021 13;14:2541-2553. Epub 2021 Apr 13.

Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

Background: Our previous studies demonstrate that ARL4C is the most critical clinical biomarker for gastric cancer (GC) patients among ARL family members (ARLs) and functions as an oncogene in GC. However, its underlying mechanisms in GC need to be further illustrated. In this study, we aim to explore the upstream and downstream molecular mechanisms of ARL4C in GC cells. Read More

View Article and Full-Text PDF

NEIL3 may act as a potential prognostic biomarker for lung adenocarcinoma.

Cancer Cell Int 2021 Apr 20;21(1):228. Epub 2021 Apr 20.

Department of Pathology, Affiliated Hospital of Nantong University, Nantong, 226001, China.

Background: Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death. This study aimed to develop and validate reliable prognostic biomarkers and signature.

Methods: Differentially expressed genes were identified based on three Gene Expression Omnibus (GEO) datasets. Read More

View Article and Full-Text PDF

The effect of miR-539 regulating TRIAP1 on the apoptosis, proliferation, migration and invasion of osteosarcoma cells.

Cancer Cell Int 2021 Apr 20;21(1):227. Epub 2021 Apr 20.

Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

Objective: The purpose of this study is to explore the effect of miRNA-539 on osteosarcoma (OS) and the underlying mechanism, so as to find a new method for early diagnosis and treatment of osteosarcoma.

Method: miRNA-539 mimics was transfected into osteosarcoma cells 143b and MG-63 and upregulated the expression of miR-539. QT-PCR was used to detect transfection efficacy. Read More

View Article and Full-Text PDF

BACH1 is transcriptionally inhibited by TET1 in hepatocellular carcinoma in a microRNA-34a-depedent manner to regulate autophagy and inflammation.

Pharmacol Res 2021 Apr 17:105611. Epub 2021 Apr 17.

Department of Emergency Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230031, Anhui, P.R. China. Electronic address:

Hepatocellular carcinoma (HCC), one of the main contributors to cancer-associated deaths globally, is characterized by high invasiveness. Herein, we studied the molecular mechanisms underlying ten-eleven translocation 1 (TET1)-mediated autophagy in HCC. Following data mining using GSE101728, GSE14520 and GSE138178, TET1 was screened out, and the differential expression of TET1 was verified by bioinformatics analysis. Read More

View Article and Full-Text PDF

Impact of human rhinoviruses on gene expression in pediatric patients with severe acute respiratory infection.

Virus Res 2021 Apr 17:198408. Epub 2021 Apr 17.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Human rhinovirus (HRV) is one of the most common viruses, causing mild to severe respiratory tract infections in children and adults. Moreover, it can lead to patients' hospitalization. Nowadays, evaluation of gene expression alterations in host cells due to viral respiratory infections considered essential to understand the viral effects on cells. Read More

View Article and Full-Text PDF

Chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.

Blood 2021 Apr 19. Epub 2021 Apr 19.

Children's Hospital Research Foundation, Cincinnati, Ohio, United States.

The Chd8 gene encodes a member of chromodomain helicase DNA-binding (CHD) family of SNF2H-like ATP-dependent chromatin remodeler, mutations of which define a subtype of Autism spectrum disorders. Increasing evidence from recent studies indicates that ATP-dependent chromatin-remodeling genes are involved in the control of crucial gene-expression programs in hematopoietic stem/progenitor cell (HSPC) regulation. Here we identify CHD8 as a specific and essential regulator of normal hematopoiesis. Read More

View Article and Full-Text PDF

Role of p53-miRNAs circuitry in immune surveillance and cancer development: A potential avenue for therapeutic intervention.

Semin Cell Dev Biol 2021 Apr 16. Epub 2021 Apr 16.

Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002, India. Electronic address:

The genome's guardian, p53, is a master regulatory transcription factor that occupies sequence-specific response elements in many genes and modulates their expression. The target genes transcribe both coding RNA and non-coding RNA involved in regulating several biological processes such as cell division, differentiation, and cell death. Besides, p53 also regulates tumor immunology via regulating the molecules related to the immune response either directly or via regulating other molecules, including microRNAs (miRNAs). Read More

View Article and Full-Text PDF

Effects of Copper Nanoparticles on mRNA and Small RNA Expression in Human Hepatocellular Carcinoma (HepG2) Cells.

J Nanosci Nanotechnol 2021 Oct;21(10):5083-5098

Retired from EPA, Durham NC 27709, USA.

With the advancement of nanotechnology, nanoparticles are widely used in many different industrial processes and consumer products. Copper nanoparticles (Cu NPs) are among the most toxic nanomaterials. We investigated Cu NPs toxicity in Human Hepatocellular carcinoma (HepG2) cells by examining signaling pathways, and microRNA/mRNA interactions. Read More

View Article and Full-Text PDF
October 2021

The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis.

PLoS Genet 2021 Apr 19;17(4):e1009512. Epub 2021 Apr 19.

Department of Molecular and Cell Biology, Institute for Systems Genomics, University of Connecticut, Storrs, Connecticut, United States of America.

The actin cytoskeleton is a well-known player in most vital cellular processes, but comparably little is understood about how the actin assembly machinery impacts programmed cell death pathways. In the current study, we explored roles for the human Wiskott-Aldrich Syndrome Protein (WASP) family of actin nucleation factors in DNA damage-induced apoptosis. Inactivation of each WASP-family gene revealed that two of them, JMY and WHAMM, are necessary for rapid apoptotic responses. Read More

View Article and Full-Text PDF

Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response.

Front Oncol 2021 31;11:659049. Epub 2021 Mar 31.

Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA, United States.

Cellular homeostasis is governed by the precise expression of genes that control the translation, localization, and termination of proteins. Oftentimes, environmental and biological factors can introduce mutations into the genetic framework of cells during their growth and division, and these genetic abnormalities can result in malignant transformations caused by protein malfunction. For example, p53 is a prominent tumor suppressor protein that is capable of undergoing more than 300 posttranslational modifications (PTMs) and is involved with controlling apoptotic signaling, transcription, and the DNA damage response (DDR). Read More

View Article and Full-Text PDF

Nkx2.5 Functions as a Conditional Tumor Suppressor Gene in Colorectal Cancer Cells Acting as a Transcriptional Coactivator in p53-Mediated p21 Expression.

Front Oncol 2021 1;11:648045. Epub 2021 Apr 1.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

NK2 homeobox 5 (Nkx2.5), a homeobox-containing transcription factor, is associated with a spectrum of congenital heart diseases. Recently, Nkx2. Read More

View Article and Full-Text PDF

Algorithm-Based Meta-Analysis Reveals the Mechanistic Interaction of the Tumor Suppressor LIMD1 With Non-Small-Cell Lung Carcinoma.

Front Oncol 2021 31;11:632638. Epub 2021 Mar 31.

Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.

Non-small-cell lung carcinoma (NSCLC) is the major type of lung cancer, which is among the leading causes of cancer-related deaths worldwide. LIMD1 was previously identified as a tumor suppressor in lung cancer, but their detailed interaction in this setting remains unclear. In this study, we have carried out multiple genome-wide bioinformatic analyses for a comprehensive understanding of LIMD1 in NSCLC, using various online algorithm platforms that have been built for mega databases derived from both clinical and cell line samples. Read More

View Article and Full-Text PDF

Identification of Ten Core Hub Genes as Potential Biomarkers and Treatment Target for Hepatoblastoma.

Front Oncol 2021 1;11:591507. Epub 2021 Apr 1.

Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, China.

Background: This study aimed to systematically investigate gene signatures for hepatoblastoma (HB) and identify potential biomarkers for its diagnosis and treatment.

Materials And Methods: GSE131329 and GSE81928 were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between hepatoblastoma and normal samples were identified using the Limma package in R. Read More

View Article and Full-Text PDF

Ring finger 20/ring finger 40/WW domain-containing adaptor with coiled-coil complex interacts with p53 to regulate gene transcription in DNA damage response.

Oncol Lett 2021 Jun 1;21(6):436. Epub 2021 Apr 1.

College of Life Sciences, Shanghai Normal University, Shanghai 200234, P.R. China.

p53 is one of the most important tumor suppressor genes, and its primary function is to act as a transcriptional activator to control cell cycle arrest, DNA repair and cellular metabolism by recognizing and binding to specific DNA sequences. Defects in the ring finger (RNF)20/RNF40/WW domain-containing adaptor with coiled-coil (WAC) complex, one of the histone H2B ubiquitination E3 ligases, have been reported to be a key factor in oncogenesis, cancer cell migration and invasion. Histone H2B mono-ubiquitination has been demonstrated to be essential for maintaining the functionality of the p53 tumor suppressor protein. Read More

View Article and Full-Text PDF

Therapeutic strategies of different HPV status in Head and Neck Squamous Cell Carcinoma.

Int J Biol Sci 2021 10;17(4):1104-1118. Epub 2021 Mar 10.

Department of Medical Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, P. R. China.

Head and neck squamous cell carcinoma (HNSCC) is the 9 most common malignant tumor in the world. Based on the etiology, HNSCC has two main subtypes: human papillomavirus (HPV) -related and HPV-unrelated. HPV-positive HNSCC is more sensitive to treatment with favorable survival. Read More

View Article and Full-Text PDF

Amelioration of Combination of Paclitaxel and Di Allyl Sulfide on the Alterations of Bcl2, P53 and Apoptosis Changes Against 7,12 Di Methyl Benz (A) Anthracene Induced Skin Cancer in Experimental Animals.

Authors:
N Muninathan

Indian J Clin Biochem 2021 Apr 15;36(2):143-150. Epub 2019 Mar 15.

Department of Research, Meenakshi Medical College and Research Institute, Meenakshi Academy of Higher Education and Research, Enathur, Kanchipuram, 631552 Tamil Nadu India.

The purpose of this study was to investigate the Bcl2, P and apoptosis changes against skin cancer in experimental animals. Skin cancer is the most common form of human cancer. It is estimated that over 1 million new cases occur annually. Read More

View Article and Full-Text PDF

Mode of action assessment of the genotoxic properties of antimony and its compounds evaluated in the ToxTracker assay.

Mutat Res 2021 May 15;865:503333. Epub 2021 Feb 15.

NYU Grossman School of Medicine, New York, USA.

Antimony (Sb) and its compounds are negative in gene mutation assays in bacteria and cultured mammalian cells but positive in some assays for clastogenicity and/or DNA damage. In order to better understand the modes of action for antimony genotoxicity, we assessed reporter gene activation by antimony and antimony compounds in the new expanded ToxTracker assay. ToxTracker evaluates the activation of biomarkers for different cellular defense mechanisms using a series of green fluorescent protein reporters inserted into mouse embryonic stem cell lines. Read More

View Article and Full-Text PDF

Exposures to 2,4-Dichlorophenoxyacetic acid with or without endotoxin upregulate small cell lung cancer pathway.

J Occup Med Toxicol 2021 Apr 17;16(1):14. Epub 2021 Apr 17.

Department of Animal Biotechnology, College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, 141004, India.

Background: Pesticide residues in food and environment along with airborne contaminants such as endotoxins pose health risk. Although herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) has been associated with increased risk of lung cancers such as small cell lung cancer (SCLC) among agricultural workers, there are no data on the SCLC signaling pathway upon 2,4-D exposure without LPS or in combination with endotoxin.

Methods: We exposed Swiss albino mice (N = 48) orally to high (9. Read More

View Article and Full-Text PDF

Assessment spermatogenic cell apoptosis and the transcript levels of metallothionein and p53 in Meretrix meretrix induced by cadmium.

Ecotoxicol Environ Saf 2021 Apr 14;217:112230. Epub 2021 Apr 14.

College of Life and Environmental Science, Wenzhou University, 325035 Wenzhou, China. Electronic address:

Cadmium (Cd) has been widely used in industry and can accumulate in the water, soil, and food. Meretrix meretrix is one of the marine shellfishes cultivated for economic purpose in China. The increasing Cd levels in coastal marine water could adversely affect the economic benefits of shellfish cultivation. Read More

View Article and Full-Text PDF

LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway.

Gastric Cancer 2021 Apr 16. Epub 2021 Apr 16.

Department of Surgery, Division of Digestive Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: Leucin-rich repeat containing protein A (LRRC8A), a component of the volume-regulated anion channel (VRAC), is activated by cell swelling and mediates regulatory volume decrease. We previously reported the expression of and important roles for several ion transporters in various gastrointestinal cancers, which have potential as novel targets for cancer treatment; however, the significance of LRRC8A in gastric cancer (GC) remains unclear.

Materials And Methods: Knockdown experiments were performed by transfecting human GC cell lines with LRRC8A siRNA. Read More

View Article and Full-Text PDF

CHK2 inhibition provides a strategy to suppress hematological toxicity from PARP inhibitors.

Mol Cancer Res 2021 Apr 16. Epub 2021 Apr 16.

Blood Cells and Blood Cancer, The Walter and Eliza Hall Institute

Cancer patients treated with poly (ADP-ribose) polymerase inhibitors (PARPi) experience various side effects, with hematological toxicity being most common. Short term treatment of mice with olaparib resulted in depletion of reticulocytes, B cell progenitors and immature thymocytes, whereas longer treatment induced broader myelosuppression. We performed a CRISPR/Cas9 screen that targeted DNA repair genes in Eµ-Myc pre-B lymphoma cell lines as a way to identify strategies to suppress hematological toxicity from PARPi. Read More

View Article and Full-Text PDF

mTOR activation initiates renal cell carcinoma development by coordinating ERK and p38MAPK.

Cancer Res 2021 Apr 16. Epub 2021 Apr 16.

Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University

Renal cell carcinoma (RCC) mainly originates from renal proximal tubules. Intriguingly, disruption of genes frequently mutated in human RCC samples thus far has only generated RCC originated from other renal tubule parts in mouse models. This hampers our understanding of the pathogenesis of RCC. Read More

View Article and Full-Text PDF

Mutant p53 in cell-cell interactions.

Genes Dev 2021 Apr;35(7-8):433-448

The Francis Crick Institute, London NW1 1AT, United Kingdom.

p53 is an important tumor suppressor, and the complexities of p53 function in regulating cancer cell behaviour are well established. Many cancers lose or express mutant forms of p53, with evidence that the type of alteration affecting p53 may differentially impact cancer development and progression. It is also clear that in addition to cell-autonomous functions, p53 status also affects the way cancer cells interact with each other. Read More

View Article and Full-Text PDF

Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited.

Apoptosis 2021 Apr 16. Epub 2021 Apr 16.

Department of Pharmaceutical Biotechnology, University of Pecs, Pecs, Hungary.

Tuberous sclerosis, angiomyolipoma and lymphangioleiomyomatosis are a group of diseases characterized by mutation in tuberous sclerosis genes (TSC 1-2). TSC mutation leads to continuous activation of the mTOR pathway that requires adaptation to increased ATP requirement. With limited treatment options, there is an increasing demand to identify novel therapeutic targets and to understand the correlations between mTOR pathway activation and the lack of cell death in the presence of TSC mutation. Read More

View Article and Full-Text PDF

Polymorphous low-grade neuroepithelial tumor of the young: A detailed patho-molecular analysis and discussion of a case.

Clin Neuropathol 2021 Apr 16. Epub 2021 Apr 16.

Aim: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a rare entity with a diffuse, infiltrative pattern, awaiting to be included in the WHO CNS tumor classification; it occurs in pediatric and young patients with seizures and harbors mutually exclusive BRAFV600E or FGFR mutations. Nonetheless, the presence of these mutations may not be obligatory for diagnosis. The conventional histology of these tumors resembles that of oligodendrogliomas. Read More

View Article and Full-Text PDF

Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer.

ACS Pharmacol Transl Sci 2021 Apr 7;4(2):687-702. Epub 2021 Mar 7.

Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 3210 N. Cramer Street, Milwaukee, Wisconsin 53211, United States.

Triple-negative breast cancer (TNBC) has limited treatment options and the worst prognosis among all types of breast cancer. We describe two prodrugs, namely, CWB-20145 () and its methyl analogue FAN-NM-CH () that reduced the size of TNBC-derived tumors. The DNA cross-linking of nitrogen mustard prodrugs and was superior to that of chlorambucil and melphalan once activated in the presence of HO. Read More

View Article and Full-Text PDF

Preventing tumor progression to the bone by induced tumor-suppressing MSCs.

Theranostics 2021 5;11(11):5143-5159. Epub 2021 Mar 5.

Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081, China.

Advanced breast cancer metastasizes to many organs including bone, but few effective treatments are available. Here we report that induced tumor-suppressing (iTS) MSCs protected bone from metastases while un-induced MSCs did not. iTS MSCs were generated by overexpressing Lrp5, β-catenin, Snail, or Akt. Read More

View Article and Full-Text PDF

[The incidence of high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements in diffuse large B-cell lymphoma].

Zhonghua Xue Ye Xue Za Zhi 2021 Feb;42(2):124-128

Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University, Beijing 100191, China.

To investigate the incidence of high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangement in Chinese diffuse large B-cell lymphoma (DLBCL) . From January 2013 to August 2020, 922 DLBCL cases were collected. C-MYC and BCL2 protein expression levels were analyzed by immunohistochemistry staining. Read More

View Article and Full-Text PDF
February 2021

Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines.

Int J Pharm 2021 Apr 12:120592. Epub 2021 Apr 12.

Department of Animal Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran.

Background: Despite recent advances in therapy, colorectal cancer remains a leading cause of death in affected people. Curcumin is the main bioactive compound of turmeric that has been demonstrated as an effective agent against cancer. However, its poor stability and bioavailability limit therapeutic application. Read More

View Article and Full-Text PDF