87,486 results match your criteria p = 0005 month

Association Between Hyperoxemia and Increased Cell-Free Plasma Hemoglobin During Cardiopulmonary Bypass in Infants and Children.

Pediatr Crit Care Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA. Department of Pediatrics, Division of Critical Care Medicine, Ochsner Hospital for Children, New Orleans, LA. Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA. UPMC Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA.

Objectives: To determine potential risk factors for severe hemolysis during pediatric cardiopulmonary bypass and examine whether supraphysiologic levels of oxygen and cardiopulmonary bypass duration are associated with hemolysis.

Design: Prospective observational study.

Setting: Cardiac ICU in a university-affiliated children's hospital. Read More

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September 2021

Pre-game drinking among young adults and its association with positive and negative alcohol consequences.

Addict Behav 2021 Sep 15;124:107120. Epub 2021 Sep 15.

Pennsylvania State University, Edna Bennett Pierce Prevention Research Center, 320E Biobehavioral Health Building, University Park, PA 16802, United States.

Background: Pre-gaming, or drinking before going out, is common among young adults and associated with heavier drinking and negative consequences. However, findings have been mixed as to whether a unique, day-level association between pre-gaming and negative consequences exists independent of alcohol intake. It is also unknown whether young adults experience more positive consequences of alcohol use on days they engage in pre-gaming. Read More

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September 2021

Dynamic associations between anxiety, stress, physical activity, and eating regulation over the course of a behavioral weight loss intervention.

Appetite 2021 Sep 21:105706. Epub 2021 Sep 21.

Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University/The Miriam Hospital, Weight Control and Diabetes Research Center, Providence, RI, USA.

Negative emotional experiences are associated with dysregulated eating behaviors that impede weight management. While weight loss interventions promote physical activity and self-regulation of eating, no studies have examined how physical activity may directly influence eating by attenuating associations between negative emotions and eating.

Objective: The current study examined how momentary negative emotions (stress and anxiety), moderate-to-vigorous intensity physical activity (MVPA), and their interactions predict eating dysregulation (i. Read More

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September 2021

Persistent Opioid Use After Spine Surgery: A Prospective Cohort Study.

Spine (Phila Pa 1976) 2021 Oct;46(20):1428-1435

Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.

Study Design: Single-center, investigator-initiated, prospective cohort study.

Objective: This study aimed to determine patient-reported reasons for persistent opioid use following elective spine surgery, assess the frequency of withdrawal symptoms, and characterize pain-related care sought after discharge.

Summary Of Background Data: Patients are often prescribed opioids at discharge from hospital following surgery. Read More

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October 2021

Magnetically Controlled Growing Rods Graduation: Deformity Control with High Complication Rate.

Spine (Phila Pa 1976) 2021 Oct;46(20):E1105-E1112

Tel Aviv Sourasky Medical Center, Dana-Dwek Childrens Hospital, Pediatric Orthopedic Surgery, Tel Aviv, Israel.

Study Design: A multicenter retrospective review of consecutive series of patients.

Objective: Long-term experience with using the magnetically controlled growing rods (MCGR) to treat patients with deformity in the growing spine to the conclusion of treatment with posterior spine fusion.

Summary Of Background Data: MCGR treatment for growing spine gained popularity with paucity of long-term follow up data. Read More

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October 2021

Daily Physical Activity, Sedentary Behavior and Alcohol Use in At-Risk College Students.

Ann Behav Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA.

Background: The college years present an opportunity to establish health behavior patterns that can track across adulthood. Health behaviors tend to cluster synergistically however, physical activity and alcohol have shown a positive association.

Purpose: This study applied a multi-method approach to estimate between- and within-person associations between daily physical activity, sedentary behavior and alcohol use among polysubstance-using college students. Read More

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September 2021

Treatment of tibial plateau fractures involving the posterolateral column using the extended anterolateral approach.

Medicine (Baltimore) 2021 Sep;100(38):e27316

Yangzhou Jiangdu People's Hospital, 9 Dongfanghong Road, Jiangdu District, Yangzhou City, Jiangsu Province, China.

Abstract: To summarize the surgical technique and clinical effects of the extended anterolateral approach for the treatment of Schatzker type II and Schatzker type V/VI involving the posterolateral column tibial plateau.From January 2015 through December 2018, 28 patients with tibial plateau fractures involving the posterolateral column were included in the study. Among them, 16 patients were Schatzker type II treated using an extended anterolateral approach with lateral tibial locking compression plate fixation. Read More

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September 2021

Home Low Vision Ocular Rehabilitation Telehealth Expansion Due to COVID-19 Pandemic.

Carolyn Ihrig

Telemed J E Health 2021 Sep 24. Epub 2021 Sep 24.

Veterans Affairs Western New York Healthcare System, Buffalo, New York, USA.

In March 2020, the pandemic added a major barrier resulting in the cancelation of all low vision ocular rehabilitation services. To prevent delay of beginning low vision ocular rehabilitation services, all low vision care was switched to telerehabilitation to home. Case managers began to cancel all in-person services and offer Veterans Affairs (VA) video connect services to their home. Read More

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September 2021

WNT7B Regulates Cholangiocyte Proliferation and Function During Murine Cholestasis.

Hepatol Commun 2021 Aug 25. Epub 2021 Aug 25.

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

We previously identified an up-regulation of specific Wnt proteins in the cholangiocyte compartment during cholestatic liver injury and found that mice lacking Wnt secretion from hepatocytes and cholangiocytes showed fewer proliferating cholangiocytes and high mortality in response to a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet, a murine model of primary sclerosing cholangitis. In vitro studies demonstrated that Wnt7b, one of the Wnts up-regulated during cholestasis, induces proliferation of cholangiocytes in an autocrine manner and increases secretion of proinflammatory cytokines. We hypothesized that loss of Wnt7b may exacerbate some of the complications of cholangiopathies by decreasing the ability of bile ducts to induce repair. Read More

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Selective Glucocorticoid Replacement Following Unilateral Adrenalectomy for Hypercortisolism and Primary Aldosteronism.

J Clin Endocrinol Metab 2021 Sep 24. Epub 2021 Sep 24.

Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Background: An institutional study previously demonstrated that cosyntropin stimulation testing on postoperative day 1 (POD1-CST) identified patients at risk for adrenal insufficiency (AI) following unilateral adrenalectomy (UA) for adrenal-dependent hypercortisolism (HC) and primary aldosteronism (PA), allowing for selective glucocorticoid replacement (GR). This study reevaluates the need for GR following UA for patients with HC and PA in a larger cohort.

Methods: A prospective database identified 108 patients who underwent UA for mild autonomous cortisol excess (MACE) (n=47), overt hypercortisolism (OH) (n=27), PA (n=22), and concurrent PA/HC (n=12) from 9/2014-10/2020; all underwent preoperative evaluation for HC. Read More

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September 2021

Use of office based transnasal oesophagoscopy in management of Head & Neck conditions during the COVID-19 pandemic at the Royal Albert Edward Infirmary, Wigan, United Kingdom.

Med J Malaysia 2021 Aug;76(Suppl 4):14-19

The Royal Albert Edward Infirmary, Department of ENT, Wrightington Wigan and Leigh, NHS Foundation Trust, United Kingdom.

Objectives: To assess the clinical and cost effectiveness of transnasal oesophagoscopy (TNO) in cases of suspected upper aerodigestive tract malignancy and define its role as a safe alternative to panendoscopy. We have also analysed if the implementation of TNO during the COVID-19 pandemic was beneficial in order to provide uninterrupted care to the patients with the limited resources available in these challenging times.

Methods: All patients who underwent TNO guided biopsies or dilatation attempted over a 7 month period during COVID- 19 pandemic were included by searching the hospital and department database at The Royal Albert Edward Infirmary. Read More

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Results of Serosurveillance and Forecasting the Third Wave of COVID-19 in an Industrial District in India.

Cureus 2021 Sep 19;13(9):e18097. Epub 2021 Sep 19.

Microbiology, Tata Main Hospital, Jamshedpur, IND.

Prevalence of immunoglobulin G (IgG) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the industrial district of East Singhbhum (Jharkhand, India) from July, August, November, and December 2020 and January 2021 after the first wave and in July 2021 after the second wave of coronavirus disease 2021 (COVID-19) infections may be utilized to find the possibility of a third wave of COVID-19 infections. Based on the trend of the loss of protective IgG antibodies after the first wave and the seropositivity of 75% in the district in July 2021, simple forecasting and proportional estimates of the seropositivity in the next eight months and the estimated maximum number of the cases was done. We also considered the seropositivity without vaccination in July 2021 (63%). Read More

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September 2021

Assessment of Cerebrospinal Fluid Hydrodynamics Using Magnetic Resonance Imaging in Postcraniospinal Surgery Patients.

Indian J Radiol Imaging 2021 Apr 27;31(2):304-310. Epub 2021 Jul 27.

Department of Radiodiagnosis, Shri Guru Ram Rai Institute of Medical and Health Sciences, Patel Nagar, Dehradun, Uttarakhand, India.

Aim of this study is to evaluate the effect of craniospinal interventions on cerebrospinal fluid (CSF) flow hydrodynamics and study the correlation of postoperative changes in flow alteration with clinical outcome. Fifty patients who underwent various craniospinal procedures were studied using conventional and phase-contrast magnetic resonance imaging (PCMRI) protocol. CSF flow quantification was performed at cerebral aqueduct, foramen magnum, C2-3, and D12-L1 vertebral levels with site showing maximal alteration of CSF flow dynamics considered as the region of interest. Read More

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The effect of caregiver key opinion leaders on increasing caregiver demand for evidence-based practices to treat youth anxiety: protocol for a randomized control trial.

Implement Sci Commun 2021 Sep 23;2(1):107. Epub 2021 Sep 23.

Department of Psychology, Temple University, Weiss Hall, 1701 North 13th Street, Philadelphia, PA, 19122, USA.

Background: Research has identified cognitive behavioral therapy with exposures (CBT) as an effective treatment for youth anxiety. Despite implementation efforts, few anxious youth receive CBT. Direct-to-consumer marketing offers a different approach to address the unmet need for youth receiving effective treatments. Read More

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September 2021

Severe spruelike enteropathy and collagenous colitis caused by olmesartan.

BMC Gastroenterol 2021 Sep 23;21(1):350. Epub 2021 Sep 23.

Department of Pathology, Asahikawa Medical University, 1-1 Midorigaoka Higashi-2 Hokkaido, Asahikawa, Japan.

Background: Olmesartan, which is an angiotensin II receptor blocker, reportedly causes spruelike enteropathy, with intestinal villous atrophy as its typical histopathological finding. Interestingly, collagenous and/or lymphocytic gastritis and colitis occur in some patients. We report the case of a 73-year-old Japanese man with a 2-month clinical history of severe diarrhea and weight loss. Read More

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September 2021

Evaluating the efficacy of mindfulness and acceptance-based treatment components for weight loss: Protocol for a multiphase optimization strategy trial.

Contemp Clin Trials 2021 Sep 20:106573. Epub 2021 Sep 20.

Center for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA.

Behavioral weight loss treatment (BT) for individuals with overweight and obesity is effective but leaves room for improvement. Mindfulness and acceptance-based treatments may bolster weight loss outcomes; yet, little is known about the efficacy of the individual components or the combinations of components that are most effective in producing weight loss above and beyond standard BT strategies for weight loss. This protocol manuscript describes the use of a multiphase optimization strategy to evaluate the independent and combinatory efficacy of three mindfulness and acceptance-based components (mindful awareness, willingness, values). Read More

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September 2021

30-Year Trends in Graft Survival After Heart Transplant: Modeled Analyses of a Transplant Registry.

Ann Thorac Surg 2021 Sep 21. Epub 2021 Sep 21.

Rutgers Robert Wood Johnson Medical School, Department of Medicine, 125 Paterson St, New Brunswick, NJ; Robert Wood Johnson University Hospital, 1 Robert Wood Johnson Place, New Brunswick, NJ; Institute for Health, Health Care Policy and Aging Research, 112 Paterson St, New Brunswick, NJ. Electronic address:

Background: Heart failure is an epidemic in the United States, and transplantation remains the most definitive therapy. We describe multi-decade trends in post-transplant graft survival, adjusted for concurrent changes in the population, over the 30 years antecedent to the most recent heart allocation policy change.

Methods: Scientific Registry of Transplant Recipients data were used to identify all primary adult heart recipients 1989 through 2017. Read More

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September 2021

Trends in Post-Acute Care Utilization During the COVID-19 Pandemic.

J Am Med Dir Assoc 2021 Sep 7. Epub 2021 Sep 7.

Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.

Objective: To examine the effect of the COVID-19 pandemic on post-acute care utilization and spending.

Design: We used a large national multipayer claims data set from January 2019 through October 2020 to examine trends in posthospital discharge location and spending.

Setting And Participants: We identified and included 975,179 hospital discharges who were aged ≥65 years. Read More

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September 2021

Facial pyoderma gangrenosum triggered by leishmaniasis in a patient with hidradenitis suppurativa.

Clin Exp Dermatol 2021 Sep 23. Epub 2021 Sep 23.

Department of Dermatology, Mater Dei Hospital, Msida, Malta.

A 58-year-old gentleman, known case of Hurley stage III hidradenitis suppurativa (HS), presented with a 3-month history of a growing, granulomatous plaque involving skin over the right temporal area (Figure 1A). The patient's HS was controlled with adalimumab 40mg weekly, which had been initiated 9 months prior to development of the plaque. Read More

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September 2021

Aging disrupts the temporal organization of antioxidant defenses in the heart of male rats and phase shifts circadian rhythms of systolic blood pressure.

Biogerontology 2021 Sep 23. Epub 2021 Sep 23.

Laboratorio de Cronobiología, Instituto Multidisciplinario de Investigaciones Biológicas-San Luis (IMIBIO-SL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) y Universidad Nacional de San Luis (UNSL), Ejército de los Andes 950, Bloque I, 1° Piso, D5700HHW, San Luis, Argentina.

Aging is one of the main risk factors for cardiovascular diseases, and oxidative stress is a key element responsible for the development of age-related pathologies. In addition, the alteration of circadian rhythms also contributes to cardiovascular pathology, but the underlying mechanisms are not well defined. We investigated the aging consequences on the temporal patterns of antioxidant defenses, the molecular clock machinery, and the blood pressure, in the heart of male rats maintained under constant darkness (free running) conditions. Read More

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September 2021

Recherche sur la fin de vie, la nécessité d’un consensus : premiers résultats.

Sante Publique 2021 March-April;33(2):191-198

During the past 15 years, in France, like in many European countries, the attention paid to patients at the end of their lives has continued to grow. But in the meantime, only a few researchers have managed to collect reliable data on End-of-Life Care and to implement scientific studies describing the reality of these situations. This difficulty is due in particular to the lack of a recognized and operational definition of the end of life. Read More

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September 2021

The effect of estrogen therapy on spermatogenesis in transgender women.

F S Rep 2021 Sep 11;2(3):347-351. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio.

Objective: To describe the histopathologic parameters of orchiectomy specimens obtained after gender-affirming surgery from transgender women who used gender-affirming hormone therapy (GAHT), which included estrogen and spironolactone. Our hypothesis was that an increasing duration of GAHT affects testicular health.

Design: Retrospective cohort study. Read More

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September 2021

Process evaluation of an implementation study in dementia care (EIT-4-BPSD): stakeholder perspectives.

BMC Health Serv Res 2021 Sep 23;21(1):1006. Epub 2021 Sep 23.

Ross and Carol Nese College of Nursing, Pennsylvania State University, University Park, PA, USA.

Background: Behavioral and psychological symptoms of distress in dementia (BPSD) are major drivers of poor quality of life, caregiver burden, institutionalization, and cost of care in nursing homes. The Evidence Integration Triangle (EIT)-4-BPSD in nursing homes was a pragmatic Hybrid III trial of an implementation strategy to help staff use evidence-based non-pharmacological interventions to prevent and manage BPSD. This study aimed to describe and explore the stakeholders' perceptions of the process to implement the EIT-4-BPSD strategy including its utility, and the barriers and facilitators to implementation in real-world settings. Read More

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September 2021

Feasibility of longitudinal monitoring of atherosclerosis with Pulse Wave Imaging in a swine model.

Physiol Meas 2021 Sep 22. Epub 2021 Sep 22.

Department of Biomedical Engineering, Columbia University, MC 8904, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA, New York, New York, UNITED STATES.

Objective: Atherosclerosis is a vascular disease characterized by compositional and mechanical changes in the arterial walls that lead to a plaque buildup. Depending on its geometry and composition, a plaque can ruptured and cause stroke, ischemia or infarction. Pulse Wave Imaging (PWI) is an ultrasound-based technique developed to locally quantify the stiffness of arteries. Read More

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September 2021

Effects of a Health Promotion Intervention on Physical Activity in African American Men Living with HIV: Randomized Controlled Trial.

AIDS Patient Care STDS 2021 Sep 22. Epub 2021 Sep 22.

Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA.

HIV and its treatment with antiretroviral therapy increase the risk of noncommunicable diseases (NCDs) tied to physical inactivity. Older African American men are also at high risk for NCDs. We tested the efficacy of a theory-based intervention to increase adherence to federal aerobic and muscle-strengthening physical activity (PA) guidelines among African American men aged 40 years and older living with HIV. Read More

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September 2021

The effectiveness and safety profile of netarsudil 0.02% in glaucoma treatment: real-world 6-month outcomes.

Graefes Arch Clin Exp Ophthalmol 2021 Sep 22. Epub 2021 Sep 22.

Sidney Kimmel Medical College, Thomas Jefferson University, 840 Walnut Street, Suite 1100, Philadelphia, PA, 19107, USA.

Purpose: To evaluate the efficacy and safety profile of netarsudil 0.02% ophthalmic solution in a tertiary glaucoma referral center.

Methods: This retrospective cohort study included patients with glaucoma initiated on netarsudil 0. Read More

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September 2021

Corneal structure and endothelial morphological changes after uneventful phacoemulsification in type 2 diabetic and nondiabetic patients.

Arq Bras Oftalmol 2021 20;84(5):454-461. Epub 2021 Sep 20.

Department of Ophthalmology, São João Hospital, Porto, Portugal.

Purpose: The aim of this study was to compare corneal structure and endothelial morphological changes after uneventful phacoemulsification cataract surgery between type 2 diabetic and nondiabetic patients and to determine the preoperative and intraoperative factors that may predict greater endothelial cell density loss.

Methods: Forty-five diabetic pa-tients (45 eyes) and 43 controls (43 eyes) with age-related cataract were enrolled in this prospective observational study. Corneal (thickness and volume) and anterior segment parameters were measured by Scheimpflug tomography; endothelial cell density and morphology (coefficient of variation of cell size, hexagonal cells) were recorded using noncontact specular microscopy. Read More

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September 2021

In vivo efficacy of 3D-printed elastin-gelatin-hyaluronic acid scaffolds for regeneration of nasal septal cartilage defects.

J Biomed Mater Res B Appl Biomater 2021 Sep 22. Epub 2021 Sep 22.

Marquette University, School of Dentistry, Milwaukee, Wisconsin, USA.

Nasal septal cartilage perforations occur due to the different pathologies. Limited healing ability of cartilage results in remaining defects and further complications. This study sought to assess the efficacy of elastin-gelatin-hyaluronic acid (EGH) scaffolds for regeneration of nasal septal cartilage defects in rabbits. Read More

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September 2021

Periosteal Chondroma of the Pelvis: An Uncommon Tumor in an Unusual Location.

Cureus 2021 Aug 13;13(8):e17163. Epub 2021 Aug 13.

Orthopaedic Oncology, UT Health San Antonio, San Antonio, USA.

Periosteal chondromas (PCs) are rare tumors composed of hyaline cartilage that are typically present in long bones and tubular bones of the hand. These lesions are easily mistaken for other, more common tumors. This study reports a case of PC located in the posterior pelvis of a 24-year-old female. Read More

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Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer's disease models.

Cell Death Discov 2021 Sep 21;7(1):256. Epub 2021 Sep 21.

NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, 221004, Xuzhou, Jiangsu, China.

Alzheimer's disease (AD) is characterized by aberrant accumulation of extracellular β-amyloid (Aβ) peptides in the brain. Soluble Aβ oligomers are thought to be the most neurotoxic species and are correlated with cognitive dysfunction in early AD. However, there is still no effective treatment so far. Read More

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September 2021