4,082,590 results match your criteria p = 0001 p = 0005


Estimating Bleeding Risk in Patients with Cancer-Associated Thrombosis: Evaluation of Existing Risk Scores and Development of a New Risk Score.

Thromb Haemost 2021 Sep 20. Epub 2021 Sep 20.

Department of Acute Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Background:  Bleeding risk is highly relevant for treatment decisions in cancer-associated thrombosis (CAT). Several risk scores exist, but have never been validated in patients with CAT and are not recommended for practice.

Objectives:  To compare methods of estimating clinically relevant (major and clinically relevant nonmajor) bleeding risk in patients with CAT: (1) existing risk scores for bleeding in venous thromboembolism, (2) pragmatic classification based on cancer type, and (3) new prediction model. Read More

View Article and Full-Text PDF
September 2021

Whole-genome sequencing of multiple isolates of Puccinia triticina reveals asexual lineages evolving by recurrent mutations.

G3 (Bethesda) 2021 Sep;11(9)

USDA-ARS, Cereal Disease Laboratory, St. Paul, MN 55108, USA.

The wheat leaf rust fungus, Puccinia triticina Erikss., is a worldwide pathogen of tetraploid durum and hexaploid wheat. Many races of P. Read More

View Article and Full-Text PDF
September 2021

A passive and objective measure of recognition memory in Alzheimer's disease using Fastball memory assessment.

Brain 2021 Sep 20. Epub 2021 Sep 20.

Bristol Medical School, University of Bristol, Bristol, UK.

Earlier diagnosis of Alzheimer's disease requires biomarkers sensitive to associated structural and functional changes. While considerable progress has been made in the development of structural biomarkers, functional biomarkers of early cognitive change, unconfounded by effort, practice and level of education, are still needed. We present Fastball, a new EEG method for the passive and objective measurement of recognition memory, that requires no behavioural memory response or comprehension of the task . Read More

View Article and Full-Text PDF
September 2021

Allergy to Mammalian Meat Linked to Alpha-Gal Syndrome Potentially After Tick Bite in the Amazon: A Case Series.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Tenon Hospital, Dermatology-Allergology Department, Sorbonne University, Paris, France.

The past decade has seen the emergence of a new type of food allergy occurring after ingestion of mammalian meat. This allergy is related to immunoglobulin (Ig)E specific for galactose-alpha-1,3 galactose (α-Gal). Originally described in the United States in 2009, other cases have subsequently been described in Australia and in Europe, but still very few in Latin America. Read More

View Article and Full-Text PDF
September 2021

Increased Detection of Mycobacterium tuberculosis Disease Using a Tissue-Based Laboratory-Developed Polymerase Chain Reaction Assay Compared to Standard Diagnostics.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut.

Standard diagnostics for Mycobacterium tuberculosis (MTB) including acid-fast bacilli (AFB) smear and culture, and Xpert™ MTB/RIF real-time Polymerase Chain Reaction (RT-PCR; Xpert) have variable sensitivity and/or long turnaround times. We describe the clinical performance of a laboratory-developed tissue-based MTB PCR compared with AFB culture and Xpert using a composite reference standard (CRS). Over an 8-year period, MTB PCR was performed on pulmonary, pleural, or lymph node specimens for 36 patients. Read More

View Article and Full-Text PDF
September 2021

Case Report: A Human Case of Onchocerca lupi Mimicking Nodular Scleritis.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.

We report a case of human ocular onchocerciasis by zoonotic Onchocerca lupi presenting as nodular scleritis. Molecular analyses were used to confirm diagnosis at species level. In addition to few existing reports of human infection by O. Read More

View Article and Full-Text PDF
September 2021

Case Report: HTLV-1-Induced Adult T-Cell Leukemia and Tropical Spastic Paresis.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas.

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus endemic in many areas around the world. HTLV-1 can induce the development of adult T-cell leukemia (ATL) or myelopathy/tropical spastic paraparesis (HAM/TSP). We report a patient who presented to our outpatient clinic with massive splenomegaly, weight loss, urinary retention, and lower extremity weakness for the previous 3 years. Read More

View Article and Full-Text PDF
September 2021

Sun-dried Azolla leaf meal at 10% dietary inclusion improved growth, meat quality, and increased skeletal muscle Ribosomal protein S6 kinase β1 abundance in growing rabbit.

Animal 2021 Sep 17;15(10):100348. Epub 2021 Sep 17.

Department of Animal and Rangeland Sciences, Oregon State University, OR, USA.

Rapidly growing human populations and the increased need for high nutritive value meat in terms of low fat, high protein, and low sodium content are the driving reasons for the increase in rabbit meat production. However, dietary protein alternatives to sustain rabbit meat production, without competing with humans for strategic crops are needed. Therefore, the current study was conducted to investigate the effect of Azolla leaf meal (ALM) as a dietary protein source on growth performance, meat quality, and abundance and activation of Ribosomal protein S6 kinase β1 (p70S6K1), a downstream target of mammalian target of rapamycin signalling pathway and, thus, a key player in the regulation of protein synthesis and muscle mass. Read More

View Article and Full-Text PDF
September 2021

Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients.

Int Immunopharmacol 2021 Sep 9;100:108125. Epub 2021 Sep 9.

Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil. Electronic address:

Mucosal barrier alterations may play a role in the pathogenesis of several diseases, including COVID-19. In this study we evaluate the association between bacterial translocation markers and systemic inflammation at the earliest time-point after hospitalization and at the last 72 h of hospitalization in survivors and non-survivors COVID-19 patients. Sixty-six SARS-CoV-2 RT-PCR positive patients and nine non-COVID-19 pneumonia controls were admitted in this study. Read More

View Article and Full-Text PDF
September 2021

Multigeneration toxicity of Geunsami® (a glyphosate-based herbicide) to Allonychiurus kimi (Lee) (Collembola) from sub-individual to population levels.

Environ Pollut 2021 Sep 13;291:118172. Epub 2021 Sep 13.

Department of Environmental Science and Ecological Engineering, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

Glyphosate-based herbicide (GBH) is the most widely used herbicide worldwide and has long been considered to have significantly low toxicity to non-target soil invertebrates based on short-term toxicity tests (<56 d). However, long-term GBH toxicity assessment is necessary as GBH is repeatedly applied in the same field annually because of the advent of glyphosate-resistant crops. In this study, a multigeneration test was conducted where Allonychiurus kimi (Collembola) was exposed to GBH for three generations (referred to as F, F, and F) to evaluate the long-term toxic effect. Read More

View Article and Full-Text PDF
September 2021

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: A case report and a review of literature.

Int J Surg Case Rep 2021 Sep 16;87:106420. Epub 2021 Sep 16.

Colorectal Research Center, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction And Importance: Leiomyosarcoma (LMS) of the colon is an extremely rare and highly invasive tumor arising from the muscularis propria of the gastrointestinal tract. After the introduction of oncogenic role of KIT by immunohistochemistry (IHC), the reported cases of gastrointestinal leiomyosarcoma were highly limited. True LMS of the colon is such a rare disorder that there isn't much description of its nature. Read More

View Article and Full-Text PDF
September 2021

A concise review towards defining the exposome of oesophageal cancer in sub-Saharan Africa.

Environ Int 2021 Sep 17;157:106880. Epub 2021 Sep 17.

Department of Bioanalysis, Centre of Excellence in Mycotoxicology and Public Health, Ghent University, Ghent, Belgium; MYTOX-SOUTH, International Thematic Network, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent, Belgium.

Context: Oesophageal cancer (EC) is among the common causes of illness and death among all cancers worldwide. Advanced EC has a poor prognosis, with worse outcomes observed in low-income settings. Oesophageal squamous cell carcinoma (ESCC) is the most common EC histology reported globally, with the highest ESCC incidence rates in the 'Asian Belt' and the African EC corridor. Read More

View Article and Full-Text PDF
September 2021

First-in-child phase I/II study of the dual mTORC1/2 inhibitor vistusertib (AZD2014) as monotherapy and in combination with topotecan-temozolomide in children with advanced malignancies: arms E and F of the AcSé-ESMART trial.

Eur J Cancer 2021 Sep 17;157:268-277. Epub 2021 Sep 17.

Gustave Roussy Cancer Campus, Department of Paediatric and Adolescent Oncology, Villejuif, France; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. Electronic address:

Aim: Arms E and F of the AcSé-ESMART phase I/II platform trial aimed to define the recommended dose and preliminary activity of the dual mTORC1/2 inhibitor vistusertib as monotherapy and with topotecan-temozolomide in a molecularly enriched population of paediatric patients with relapsed/refractory malignancies. In addition, we evaluated genetic phosphatidylinositol 3-kinase (PI3K)/AKT/ mammalian (or mechanistic) target of rapamycin (mTOR) pathway alterations across the Molecular Profiling for Paediatric and Young Adult Cancer Treatment Stratification (MAPPYACTS) trial (NCT02613962).

Experimental Design And Results: Four patients were treated in arm E and 10 in arm F with a median age of 14. Read More

View Article and Full-Text PDF
September 2021

First Japanese autopsy case showing LRRK2 mutation G2019S and TDP-43 proteinopathy.

Parkinsonism Relat Disord 2021 Sep 15;91:85-87. Epub 2021 Sep 15.

Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Tottori, Japan.

This is the first Japanese autopsy case of Leucine-rich repeat kinase 2 (LRRK2) G2019S mutation with atypical TDP43 proteinopathy. Our case is important that presented clinically dysphagia and pathologically TDP-43 proteinopathy. TDP43 may play an important role of clinical presentation with LRRK2 G2019S mutation carriers. Read More

View Article and Full-Text PDF
September 2021

Entacapone - Another Parkinson's medication associated with lymphocytic colitis.

Parkinsonism Relat Disord 2021 Sep 15;91:83-84. Epub 2021 Sep 15.

St Stephen's Hospital, Hervey Bay, Urraween, QLD, 4655, Australia.

In response to the report of Ong and colleagues of a series of patients with levodopa/dopa decarboxylase inhibitor associated microscopic colitis, we report a case of entacapone associated microscopic colitis. We agree that chronic diarrhoea in patients with Parkinson's disease should prompt consideration of drug-induced microscopic colitis as the cause. Read More

View Article and Full-Text PDF
September 2021

The glycosylation status of MHC class I molecules impacts their interactions with TAPBPR.

Mol Immunol 2021 Sep 17;139:168-176. Epub 2021 Sep 17.

Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK. Electronic address:

Glycosylation plays a crucial role in the folding, structure, quality control and trafficking of glycoproteins. Here, we explored whether the glycosylation status of MHC class I (MHC-I) molecules impacts their affinity for the peptide editor, TAPBPR. We demonstrate that the interaction between TAPBPR and MHC-I is stronger when MHC-I lacks a glycan. Read More

View Article and Full-Text PDF
September 2021

Neutrophil extracellular traps (NETs) in a randomized controlled trial of a combination of antiviral and nonsteroidal anti-inflammatory treatment in a bovine model of respiratory syncytial virus infection.

Vet Immunol Immunopathol 2021 Sep 3;241:110323. Epub 2021 Sep 3.

Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, 1 Shields Ave, Davis, CA, United States.

The function of neutrophils in viral infections has long been established and studies have been done to examine the role of neutrophil extracellular traps (NETs). Further study and analysis of NETs in viral infections may reveal a new therapeutic target. Administration of ibuprofen and GS-561937, a fusion protein inhibitor (FPI), have been experimentally shown to decrease the severity of bovine respiratory syncytial virus (BRSV) infection. Read More

View Article and Full-Text PDF
September 2021

Unexpected death in a young child associated with anomalous aortic origin of the left main coronary artery without physical exertion: A case of an anomalous coronary artery with highly abundant elastic fibers.

Leg Med (Tokyo) 2021 Sep 15;53:101965. Epub 2021 Sep 15.

Tokyo Medical Examiner's Office, Tokyo Metropolitan Government, Tokyo, Japan.

Sudden death due to anomalous aortic origin of a coronary artery is far less common among young children in the absence of exercise stress. This report describes the case of a 2-year-old boy with a lower respiratory tract infection who suffered sudden cardiac arrest in his bed at home. The autopsy revealed that the left coronary artery (LCA) originated from the right sinus of Valsalva with an acute angle takeoff and traveled between the aorta and the pulmonary trunk (an interarterial course). Read More

View Article and Full-Text PDF
September 2021

Splenic peliosis associated with spontaneous rupture and massive bleeding.

Leg Med (Tokyo) 2021 Sep 15;53:101966. Epub 2021 Sep 15.

Department of Legal Medicine, International University of Health and Welfare, Japan.

We report findings from an autopsy case who died from massive bleeding because of splenic peliosis. The case subject was an 80-year-old man who had diabetes mellitus and who was receiving hemodialysis and anticoagulant therapy. Postmortem computed tomography demonstrated massive intra-abdominal hemorrhage especially seen around the spleen. Read More

View Article and Full-Text PDF
September 2021

Comparison of different chemical treatments of brush and flat carbon electrodes to improve performance of microbial fuel cells.

Bioresour Technol 2021 Sep 13;342:125932. Epub 2021 Sep 13.

Department of Civil and Environmental Engineering, The Pennsylvania State University, 231Q Sackett Building, University Park, PA 16802, United States. Electronic address:

Anodes in microbial fuel cells (MFCs) can be chemically treated to improve performance but the impact of treatment on power generation has not been examined for different electrode base materials. Brush or flat anodes were chemically treated and then compared in identical two-chambered MFCs using the electrode potential slope (EPS) analysis to quantify the anode resistances. Flat carbon cloth anodes modified with carbon nanotubes (CNTs) produced 1. Read More

View Article and Full-Text PDF
September 2021

Age-related viral load and severity of systemic pathological lesions in acute naturally occurring African swine fever virus genotype II infections.

Comp Immunol Microbiol Infect Dis 2021 Sep 13;79:101709. Epub 2021 Sep 13.

Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address:

African swine fever (ASF) causes a contagious hemorrhagic disease in all ages of pigs without sex predilections. The objective of this study was to determine the age-related viral loads and severity of systemic pathological lesions among three different swine group ages (weaned pigs, fattening pigs, and sows) during a recent outbreak of acute ASF in Vietnam. Age-related viral loads were determined in 5 major organs (lung, liver, spleen, kidney, and lymph node) by immunohistochemistry as well as in the blood by real-time polymerase chain reaction (PCR). Read More

View Article and Full-Text PDF
September 2021

Responses of root phenology in ecotypes of Eriophorum vaginatum to transplantation and warming in the Arctic.

Sci Total Environ 2021 Aug 31;805:149926. Epub 2021 Aug 31.

The Ecosystems Center, Marine Biological Laboratory, 7 MBL St., Woods Hole, MA 02543, USA. Electronic address:

The effect of climate change on phenology and growth is less understood for belowground plant tissues than for aboveground plant tissues, particularly in high-latitude regions. Ecotypes within a species adapted to a locality may display different responses to climate change. We established two common garden plots in the Arctic tundra north of the Brooks Range in northern Alaska. Read More

View Article and Full-Text PDF

Vulvar squamous cell carcinoma associated with Equus caballus papillomavirus type 2 infection in a Japanese mare.

Tumour Virus Res 2021 Sep 17:200226. Epub 2021 Sep 17.

Division of Infection Control and Disease Prevention, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. Electronic address:

Equus caballus papillomavirus type 2 (EcPV2) infection has been associated with genital squamous cell carcinoma (SCC) development in horses. However, very few reports on EcPV2-associated disease in Asia exist. Our study characterizes pathological and virological features of an EcPV2-associated vulvar SCC from a Japanese mare. Read More

View Article and Full-Text PDF
September 2021

Neural dynamics underlying the acquisition of distinct auditory category structures.

Neuroimage 2021 Sep 17:118565. Epub 2021 Sep 17.

Department of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for the Neural Basis of Cognition, Pittsburgh, PA, 15232, USA. Electronic address:

Despite the multidimensional and temporally fleeting nature of auditory signals we quickly learn to assign novel sounds to behaviorally relevant categories. The neural systems underlying the learning and representation of novel auditory categories are far from understood. Current models argue for a rigid specialization of hierarchically organized core regions that are fine-tuned to extracting and mapping relevant auditory dimensions to meaningful categories. Read More

View Article and Full-Text PDF
September 2021

Clinical and Pathological Correlations in Chronic Venous Disease.

Ann Vasc Surg 2021 Sep 17. Epub 2021 Sep 17.

Department of Health Sciences, University of Catanzaro, 88100 Catanzaro, Italy.

Background: Chronic Venous Disease (CVD) has a high prevalence in the western world. Varicose veins (VVs) are the main signs of this disease that is characterized by important pathological vessel wall changes. The aim of this study is to correlate the main histopathological abnormalities with related clinical issues of CVD. Read More

View Article and Full-Text PDF
September 2021

Bacterial Urine Profile and Optimal Urine Specimen Collection Timing in Asymptomatic Chronically Catheterized Adults with Spinal Cord Injuries and Disorders.

Am J Infect Control 2021 Sep 17. Epub 2021 Sep 17.

Pathology and Laboratory Medicine Service VA Northeast Ohio Health Care System.

Background: Adults with spinal cord injuries and disorders (SCI/D) require chronic indwelling catheterization which is associated with an increased risk of catheter-associated (CA) adverse events.

Methods: We studied urine samples (culture and urinalysis) from two cohorts of chronically catheterized males with SCI/D. Cohort 1 included 28 participants; three samples per patient were collected (before, after, and seven days after catheter change). Read More

View Article and Full-Text PDF
September 2021

Prediction of Hepatic Drug Clearance with a Human Microfluidic Four-Cell Liver Acinus MicroPhysiology System.

Toxicology 2021 Sep 17:152954. Epub 2021 Sep 17.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA. Electronic address:

Predicting human hepatic clearance remains a fundamental challenge in both pharmaceutical drug development and toxicological assessments of environmental chemicals, with concerns about both accuracy and precision of in vitro-derived estimates. Suggested sources of these issues have included differences in experimental protocols, differences in cell sourcing, and use of a single cell type, liver parenchymal cells (hepatocytes). Here we investigate the ability of human microfluidic four-cell liver acinus microphysiology system (LAMPS) to make predictions as to hepatic clearance for seven representative compounds: Caffeine, Pioglitazone, Rosiglitazone, Terfenadine, Tolcapone, Troglitazone, and Trovafloxacin. Read More

View Article and Full-Text PDF
September 2021

Dysregulation of DPYSL2 expression by mTOR signaling in schizophrenia: multi-level study of postmortem brain.

Neurosci Res 2021 Sep 17. Epub 2021 Sep 17.

Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima, Japan.

The mechanistic target of rapamycin (mTOR)-signaling and dihydropyrimidinase-like 2 (DPYSL2), which are increasingly gaining attention as potential therapeutic targets for schizophrenia, are connected via Cap-dependent translation of the 5'TOP motif. We quantified the expression of molecules constituting the mTOR-signaling and DPYSL2 in the prefrontal cortex (PFC) and superior temporal gyrus (STG) of postmortem brain tissue samples from 24 patients with schizophrenia and 32 control individuals and conducted association analysis to examine abnormal regulation of DPYSL2 expression by the mTOR-signaling in schizophrenia. The average ribosomal protein S6 (S6) levels in the PFC and STG were lower in patients with schizophrenia (p < 0. Read More

View Article and Full-Text PDF
September 2021

Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.

Am J Kidney Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA.

Rationale And Objective: The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in those with and without CKD.

Study Design: Neuroimaging substudy of a randomized trial. Read More

View Article and Full-Text PDF
September 2021

Effects of acute stress on the oscillatory activity of the hippocampus-amygdala-prefrontal cortex network.

Neuroscience 2021 Sep 17. Epub 2021 Sep 17.

Neuronal Circuits Laboratory, Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, 46010, Spain. Electronic address:

Displaying a stress response to threatening stimuli is essential for survival. These reactions must be adjusted to be adaptive. Otherwise, even mental illnesses may develop. Read More

View Article and Full-Text PDF
September 2021