184 results match your criteria oxymetazoline increased


Epistaxis management on COVID-19-positive patients: Our early case experience and treatment.

Clin Case Rep 2020 Jul 21. Epub 2020 Jul 21.

Department of Otolaryngology - Head and Neck Surgery Detroit Medical Center Detroit MI USA.

Epistaxis management on COVID-19 patients is concerning for otolaryngologists due to the highly virulence and increased concentration within respiratory droplets and nasal secretions. Authors suggest initial management with oxymetazoline nasal drops and local pressure before considering nasal packing with absorbable material to prevent COVID-19 transmission to surrounding healthcare workers. Read More

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Effects of agonists and phorbol esters on α-adrenergic receptor-Rab protein interactions.

Eur J Pharmacol 2020 Oct 1;885:173423. Epub 2020 Aug 1.

Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico. Electronic address:

In a cell line, stably expressing α-adrenoceptors fused to the mCherry red fluorescent protein, noradrenaline, methoxamine, and oxymetazoline induced concentration-dependent increases in intracellular calcium. All of these agents increase α-adrenoceptor phosphorylation and internalization. Transient co-expression of these receptors with Rab proteins tagged with the enhanced Green Fluorescent Protein was employed to estimate α-adrenoceptor-Rab interaction using Förster Resonance Energy Transfer. Read More

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October 2020

Involvement of the Hippocampal Alpha2A-Adrenoceptors in Anxiety-Related Behaviors Elicited by Intermittent REM Sleep Deprivation-Induced Stress in Mice.

Biol Pharm Bull 2020 ;43(8):1226-1234

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University.

Attention deficit/hyperactivity disorder (AD/HD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. In patients with AD/HD, a decrease in the total and rapid eye movement (REM) sleep times has been observed. We have previously reported that mice with REM sleep deprivation-induced stress (REMSD) may show the hyperactivity- and inattention-like symptoms of AD/HD. Read More

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Investigation of cytotoxic effects of oxymetazoline on lung in a rat model of rhinitis medicamentosa.

Curr Mol Pharmacol 2020 Jul 27. Epub 2020 Jul 27.

Department of Medical Biology, Gaziantep University Faculty of Medicine, Gaziantep. Turkey.

Background: Rhinitis medicamentosa, also known as 'rebound congestion,' is inflammation of the nasal mucosa caused by the overuse of topical nasal decongestants. Although local decongestants resolve the initial nasal obstruction, the overuse causes rebound obstruction. However, how the overuse of the decongestant causes rhinitis medicamentosa is not known. Read More

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Glycogen Synthase Kinase-3 modulates α-adrenergic receptor action and regulation.

Eur J Cell Biol 2020 Apr 22;99(2-3):151072. Epub 2020 Feb 22.

Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, Mexico. Electronic address:

The possibility that glycogen synthase kinase 3 (GSK3) could modulate α-adrenergic receptor (α-AR) function and regulation was tested employing LNCaP and HEK293 cells transfected to express the enhanced green fluorescent protein-tagged human α-AR. Receptor phosphorylation and internalization, intracellular free calcium, α-AR-GSK3 colocalization, and coimmunoprecipitation were studied. The effects of the pharmacological GSK3 inhibitor, SB-216763, and the coexpression of a dominant-negative mutant of this kinase, as well as the signaling, desensitization, and internalization of receptors with S229, S258, S352, and S381 substitutions for alanine or aspartate, were also determined. Read More

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Microvascular Effects of Pulsed Dye Laser in Combination With Oxymetazoline.

Lasers Surg Med 2020 01 22;52(1):17-22. Epub 2019 Nov 22.

Beckman Laser Institute and Medical Clinic, University of California, 1002 Health Sciences Rd, Irvine, California, 92617.

Background And Objective: Oxymetazoline, an α-1A agonist, is approved by the United States Food and Drug Administration (FDA) for treatment of persistent facial erythema associated with rosacea and induces vasoconstriction by interacting with α receptors. The objective of our study was to study the microvascular effects of oxymetazoline and pulsed dye laser (PDL).

Materials And Methods: A dorsal window chamber was surgically installed on 20 mice. Read More

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January 2020

Should Excess Topical Decongestant Use Raise a Red Flag? Rhinitis Medicamentosa and Opioid Use Disorder.

Ann Otol Rhinol Laryngol 2020 Feb 4;129(2):164-169. Epub 2019 Oct 4.

Boston University School of Medicine, Boston, MA, USA.

Objective: The objective of this study was to determine whether patients with rhinitis medicamentosa (RM) have an increased odds of having an opioid use disorder (OUD) and which characteristics may predict this association.

Methods: The authors conducted a retrospective case control study of patients 18 years and older who presented to the otolaryngology clinic at an academic medical center from January 2013 through December 2017. Cases, defined as patients who presented with excessive decongestant nasal spray usage based on history, were matched to control patients who presented with chronic rhinitis and did not report regular nasal decongestant usage. Read More

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February 2020

Underwater nasal decongestant use: a novel approach to middle ear equalization.

Undersea Hyperb Med 2018 Nov-Dec;45(6):679-682

Department of Anesthesiology, University of Florida, Gainesville, Florida U.S.

Middle ear barotrauma is the most common diving-related injury. It is estimated to occur in more than 50% of experienced divers. Although divers learn how to effectively equalize their ears with various maneuvers, airway congestion may impede the ability to equalize the middle ear space via the Eustachian tube. Read More

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October 2019

Hemodynamic and pharmacokinetic analysis of oxymetazoline use during nasal surgery in children.

Laryngoscope 2019 12 20;129(12):2775-2781. Epub 2019 Feb 20.

Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

Objectives/hypothesis: Oxymetazoline is an α-adrenergic agonist that is commonly used as a topical hemostatic agent in the operating room during ear, nose, and throat surgery. There are limited data on oxymetazoline pharmacokinetics in children who undergo general anesthesia. We assessed the hemodynamic effects and systemic absorption of topically applied oxymetazoline in children undergoing various nasal procedures. Read More

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December 2019

Topical Oxymetazoline for Fecal Incontinence in Patients with Spinal Cord Injury: A Double-Blind Randomized Controlled Crossover Study.

Dis Colon Rectum 2019 02;62(2):234-240

Semmelweis University, 1st Department of Internal Medicine, Budapest, Hungary.

Background: Topical α-agonists contract the internal anal sphincter muscle; therefore, they may serve as treatment for fecal incontinence.

Objectives: The aim of this study was to investigate the effect of the α-agonist oxymetazoline 1.0% on fecal incontinence in patients with spinal cord injury. Read More

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February 2019

The effects of nasal decongestion on obstructive sleep apnoea.

Am J Otolaryngol 2019 Jan - Feb;40(1):52-56. Epub 2018 Aug 23.

Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China; Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China. Electronic address:

Background: Many studies have indicated associations between impaired nasal breathing and sleep disorders. However, the precise nature of the relationship between nasal patency and sleep remains unclear.

Purpose: We analysed the effects of nasal patency on sleep architecture and breath in nasal obstruction-predominant obstructive sleep apnoea (NO-OSA) patients by applying nasal decongestant. Read More

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Clinical Pharmacokinetics of Oxymetazoline Cream Following Topical Facial Administration for the Treatment of Erythema Associated With Rosacea.

J Drugs Dermatol 2018 Feb;17(2):213-220

Background: Oxymetazoline cream 1.0% is FDA-approved for the topical treatment of persistent facial erythema associated with rosacea in adults. This phase 2, multicenter, randomized, double-blind, parallel-group study assessed the pharmacokinetics, safety, and tolerability of oxymetazoline in patients with moderate to severe erythema associated with rosacea. Read More

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February 2018

α-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes.

Biochem Pharmacol 2018 02 24;148:27-40. Epub 2017 Nov 24.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden. Electronic address:

The capacity of G protein-coupled receptors to modulate mechanistic target of rapamycin (mTOR) activity is a newly emerging paradigm with the potential to link cell surface receptors with cell survival. Cardiomyocyte viability is linked to signalling pathways involving Akt and mTOR, as well as increased glucose uptake and utilization. Our aim was to determine whether the α-adrenoceptor (AR) couples to these protective pathways, and increased glucose uptake. Read More

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February 2018

Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of α-adrenergic receptors.

Biochim Biophys Acta Mol Cell Res 2017 Dec 6;1864(12):2378-2388. Epub 2017 Sep 6.

Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, Ciudad Universitaria, Ciudad de México 04510, Mexico. Electronic address:

In LNCaP cells that stably express α-adrenergic receptors, oxymetazoline increased intracellular calcium and receptor phosphorylation, however, this agonist was a weak partial agonist, as compared to noradrenaline, for calcium signaling. Interestingly, oxymetazoline-induced receptor internalization and desensitization displayed greater effects than those induced by noradrenaline. Phorbol myristate acetate induced modest receptor internalization and minimal desensitization. Read More

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December 2017

Factors influencing biased agonism in recombinant cells expressing the human α -adrenoceptor.

Br J Pharmacol 2017 Jul 10;174(14):2318-2333. Epub 2017 Jun 10.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.

Background And Purpose: Agonists acting at GPCRs promote biased signalling via Gα or Gβγ subunits, GPCR kinases and β-arrestins. Since the demonstration of biased agonism has implications for drug discovery, it is essential to consider confounding factors contributing to bias. We have examined bias at human α -adrenoceptors stably expressed at low levels in CHO-K1 cells, identifying off-target effects at endogenous receptors that contribute to ERK1/2 phosphorylation in response to the agonist oxymetazoline. Read More

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Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial.

Sci Rep 2017 01 18;7:40425. Epub 2017 Jan 18.

Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

In the clinic, approximately 30% of children with adenoid hypertrophy (AH) concomitant with allergic rhinitis (AR) report poor responses to intranasal steroids. To determine whether the combination of mometasone furoate (MF) and oxymetazoline (OXY) is more effective than either agent alone, we performed a two-stage, parallel, randomized, double-blind, double-dummy, clinical trial with 240 AH children with concomitant perennial AR. During the first stage, all children were randomly assigned to the MF or control group for six weeks of treatment. Read More

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January 2017

Closing the Research-Practice Gap: Increasing Evidence-Based Practice for Nasogastric Tube Insertion Using Education and an Electronic Order Set.

J Emerg Nurs 2017 Mar 20;43(2):133-137. Epub 2016 Oct 20.

Akron, OH.

Patients and practitioners rate the insertion of a nasogastric tube as one of the most painful and distressing procedures performed. Research supports using lidocaine and a nasal vasoconstrictor to significantly decrease patient discomfort. The recommended medications were not being used routinely in a large urban emergency department. Read More

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Mechanistic insight into the norepinephrine-induced fibrosis in systemic sclerosis.

Sci Rep 2016 09 21;6:34012. Epub 2016 Sep 21.

Department of Dermatology, Gunma University Graduate School of Medicine, Japan.

Raynaud's phenomenon is frequently observed in systemic sclerosis (SSc) patients, and cold- or stress-induced norepinephrine (NE) has been speculated to be associated with vasoconstriction. Objective was to elucidate the role of NE in fibrosis in SSc. IL-6 is a potent stimulator of collagen production in fibroblasts. Read More

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September 2016

Oxymetazoline Metered Dose Spray: Factors Affecting Delivery Volume.

J Pediatr Pharmacol Ther 2016 May-Jun;21(3):247-51

Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio ; Department of Anesthesiology & Pain Medicine, The Ohio State University, Columbus, Ohio.

Objectives: The current study compared the amount of oxymetazoline delivered by various anesthesia providers when holding the bottle in the upright and inverted position. Additionally, the amount delivered from a full bottle and a half-full bottle was also investigated.

Methods: Using an analytical balance that was calibrated to zero, we evaluated the impact the position of the bottle and the volume of oxymetazoline in the bottle had on the amount being delivered by both anesthesia staff and trainees. Read More

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Effects of benzalkonium chloride on histamine H1 receptor mRNA expression in nasal epithelial cells.

Auris Nasus Larynx 2016 Dec 2;43(6):685-8. Epub 2016 Mar 2.

Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Objective: To better understand the causes of the exacerbation of rhinitis medicamentosa (RM) induced by oxymetazoline (OMZ) or benzalkonium chloride (BKC), we examined the impact of pretreatment with OMZ or BKC on cultured human nasal epithelial cells. We also examined the effect of mometasone furoate (MF) on the cultured human nasal epithelial cells treated with OMZ or BKC.

Methods: Cells of the human nasal epithelial cell line HNEpC were treated with OMZ or BKC, and the OMZ- and BKC-induced expression of histamine H1 receptor (H1R) mRNA was assayed using real-time polymerase chain reaction. Read More

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December 2016

Not Just a Drop in the Bucket-Inversion of Oxymetazoline Nasal Decongestant Container Increases Potential for Severe Pediatric Poisoning.

J Pediatr 2016 Jan 30;168:240-241. Epub 2015 Oct 30.

University of California, San Francisco, School of Pharmacy, San Diego, CA.

Oxymetazoline is an over-the-counter nasal decongestant with potent alpha agonist properties. In overdoses as small as 1-2 mL, toxicity can be seen including bradycardia and respiratory depression. We demonstrated that inverting the container increased the volume delivered 20- to 30-fold compared with holding it upright in an in vitro model. Read More

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January 2016

Effect of micronized cellulose powder on the efficacy of topical oxymetazoline in allergic rhinitis.

Allergy Asthma Proc 2015 Nov-Dec;36(6):e134-9. Epub 2015 Jun 29.

Clinic of Allergy and Asthma, Medical University of Sofia, Sofia, Bulgaria.

Background: Defective nasal barrier function is implicated in allergic rhinitis, which results in persistent inflammation and clinical symptoms, among which congestion plays a prominent role. In searching ways to improve the efficacy of nasally applied drugs in this condition, we tested the hypothesis that hydroxypropylmethylcellulose (HPMC), known as a mucoprotective agent, could enhance the efficacy of a decongestant (oxymetazoline nasal spray, 0.05%) by "sealing" it to the mucosa. Read More

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Effects of oxymetazoline on nasal flow and maximum aerobic exercise performance in patients with inferior turbinate hypertrophy.

Laryngoscope 2015 Jun 27;125(6):1301-6. Epub 2014 Dec 27.

Facultad de Ciencias de la Actividad Física y el Deporte de la Universidad de Granada, Granada.

Objectives/hypothesis: To determine the effect of topical intranasal oxymetazoline on nasal resistance and aerobic exercise performance in patients with nasal congestion caused by inferior turbinate hypertrophy.

Study Design: Individual randomized controlled trial.

Methods: Eight patients with inferior turbinate hypertrophy performed a set of exercise tests to exhaustion 1 week apart. Read More

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Intra- and inter-pandemic variations of antiviral, antibiotics and decongestants in wastewater treatment plants and receiving rivers.

PLoS One 2014 25;9(9):e108621. Epub 2014 Sep 25.

Department of Chemistry, Umeå University, Umeå, Sweden.

The concentration of eleven antibiotics (trimethoprim, oxytetracycline, ciprofloxacin, azithromycin, cefotaxime, doxycycline, sulfamethoxazole, erythromycin, clarithromycin, ofloxacin, norfloxacin), three decongestants (naphazoline, oxymetazoline, xylometazoline) and the antiviral drug oseltamivir's active metabolite, oseltamivir carboxylate (OC), were measured weekly at 21 locations within the River Thames catchment in England during the month of November 2009, the autumnal peak of the influenza A[H1N1]pdm09 pandemic. The aim was to quantify the pharmaceutical response to the pandemic and compare this to drug use during the late pandemic (March 2010) and the inter-pandemic periods (May 2011). A large and small wastewater treatment plant (WWTP) were sampled in November 2009 to understand the differential fate of the analytes in the two WWTPs prior to their entry in the receiving river and to estimate drug users using a wastewater epidemiology approach. Read More

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December 2015

Effect of polymer molecular weight and of polymer blends on the properties of rapidly gelling nasal inserts.

Drug Dev Ind Pharm 2012 Jun;38(6):659-69

College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, 12169 Berlin, Germany.

The objective was to investigate the potential of polymer molecular weight (MW) and polymer blends for the control of drug release from in situ gelling nasal inserts prepared by lyophilization of solutions of model drugs (oxymetazoline HCl, diprophyllin) and polymers. Drug release, polymer solution viscosity, water uptake and mass loss, mechanical properties, and bioadhesion potential were measured. Sonication was effective to reduce the viscosity/polymer MW of carrageenan solutions. Read More

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Comparative evaluation of nasal blood flow and airflow in the decongestant response to oxymetazoline.

Ann Allergy Asthma Immunol 2012 Feb;108(2):77-80

Asthma & Allergy Research Group, Centre of Cardiovascular and Lung Biology, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.

Background: Nasal blood flow (NBF) plays a crucial role in many physiological and pathological processes but its regulation and relation to other rhinological outcomes is poorly understood.

Objectives: We measured nasal airway patency, nasal blood flow, and subjective and objective measures of decongestion and assessed their reproducibility and responsiveness.

Methods: 19 healthy adults attended twice. Read More

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February 2012

Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion.

Am J Respir Crit Care Med 2010 Jul 4;182(1):19-24. Epub 2010 Mar 4.

Asthma and Allergy Research Group, Centre for Cardiovascular and Lung Biology, University of Dundee, Dundee DD1 9SY, Scotland, UK.

Rationale: Chronic use of intranasal decongestants, such as oxymetazoline, leads to tachyphylaxis of response and rebound congestion, caused by alpha-adrenoceptor mediated down-regulation and desensitization of response.

Objectives: We evaluated if tachyphylaxis can be reversed by intranasal fluticasone propionate, and the relative alpha(1)- and alpha(2)-adrenoceptor components of tachyphylaxis using the alpha(1)-antagonist prazosin.

Methods: In a randomized, double-blind, placebo-controlled, crossover design, 19 healthy subjects received intranasal oxymetazoline, 200 microg three times a day for 14 days, followed by the addition of fluticasone, 200 microg twice a day for a further 3 days. Read More

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Oxymetazoline inhibits and resolves inflammatory reactions in human neutrophils.

J Pharmacol Sci 2009 Jul;110(3):276-84

Helmholtz-Center Munich, German Research Center for Environmental Health, Institute of Lung Biology and Disease, Germany.

The nasal decongestant oxymetazoline (OMZ) exhibits anti-oxidative and anti-inflammatory properties (I. Beck-Speier et al., J Pharmacol Exp Ther. Read More

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[Effects of oxymetazoline hydrochloride on ex vivo human nasal cilia movement measured with high-speed digital microscopy].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008 Apr;43(4):268-71

Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Beijing Tongren Hospital of Capital Medical University, Beijing 100730, China.

Objective: To investigate the effects of oxymetazoline hydrochloride on ex vivo human nasal cilia movement.

Methods: Ciliary beat frequency (CBF) of cultured human nasal epithelial cells was measured by high-speed digital microscopy in HBSS and oxymetazoline hydrochloride of different concentrations in 20 minutes. RESULTS; CBF of cultured nasal epithelial cells in HBSS and 0. Read More

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Effect of oxymetazoline on healthy human nasal ciliary beat frequency measured with high-speed digital microscopy and mucociliary transport time.

Ann Otol Rhinol Laryngol 2008 Feb;117(2):127-33

Beijing Institute of Otorhinolaryngology, Department of Otolaryngology-Head and Neck Surgery, Affiliated Beijing Tongren Hospital of Capital Medical University, Beijing, China.

Objectives: We investigated the effects of oxymetazoline hydrochloride on the regulation of healthy human nasal ciliary beat frequency (CBF) and its influence on nasal mucociliary transport time (MTT).

Methods: Changes in (cultured) human nasal CBF in response to increasing concentrations of oxymetazoline within 20 minutes were quantified by use of high-speed digital microscopy. Moreover, the MTT before and after application of 0. Read More

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February 2008