43,224 results match your criteria oxygen supply

Normoxic limitation of maximal oxygen consumption rate, aerobic scope and cardiac performance in exhaustively exercised rainbow trout (Oncorhynchus mykiss).

J Exp Biol 2021 Aug 29;224(15). Epub 2021 Jul 29.

Department of Biological and Environmental Sciences, University of Gothenburg, PO Box 463, 405 30 Gothenburg, Sweden.

In fish, maximum O2 consumption rate (ṀO2,max) and aerobic scope can be expanded following exhaustive exercise in hyperoxia; however, the mechanisms explaining this are yet to be identified. Here, in exhaustively exercised rainbow trout (Oncorhynchus mykiss), we assessed the influence of hyperoxia on ṀO2,max, aerobic scope, cardiac function and blood parameters to address this knowledge gap. Relative to normoxia, ṀO2,max was 33% higher under hyperoxia, and this drove a similar increase in aerobic scope. Read More

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A word on netting of angiotensin-converting enzyme inhibitor therapy in hypoplastic left heart syndrome following stage-I.

Cardiol Young 2021 Jul 28:1-4. Epub 2021 Jul 28.

Department of Pediatric Cardiology, University Clinic Rotterdam, Rotterdam, The Netherland.

NPC-QIC Registry data showed that angiotensin-converting enzyme inhibitors were described in almost 38% for patients with single ventricle physiology after stage-I Norwood palliation. However, mortality and ventricular dysfunction or atrioventricular valve insufficiency seems to be not improved by oral application of angiotensin-converting enzyme inhibitors. The final conclusion was that despite limited evidence of benefit for patients with hypoplastic left heart syndrome, prescription of angiotensin-converting enzyme inhibitors during interstage is still common. Read More

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Fabrics Attached with Highly Efficient Aggregation-Induced Emission Photosensitizer: Toward Self-Antiviral Personal Protective Equipment.

ACS Nano 2021 Jul 27. Epub 2021 Jul 27.

Center for Infection and Immunity, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong, China.

Personal protective equipment (PPE) is vital for the prevention and control of SARS-CoV-2. However, conventional PPEs lack virucidal capabilities and arbitrarily discarding used PPEs may cause a high risk for cross-contamination and environmental pollution. Recently reported photothermal or photodynamic-mediated self-sterilizing masks show bactericidal-virucidal abilities but have some inherent disadvantages, such as generating unbearable heat during the photothermal process or requiring additional ultraviolet light irradiation to inactivate pathogens, which limit their practical applications. Read More

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Ameliorating effect of nitrate on nitrite inhibition for denitrifying P-accumulating organisms.

Sci Total Environ 2021 Jul 20;797:149133. Epub 2021 Jul 20.

Institute of Chemistry, University of Tartu, 14a Ravila St., 50411 Tartu, Estonia.

Lowered air supply and organic carbon need are the key factors to reduce wastewater treatment costs and thereby, avoid eutrophication. Denitrifying PO- removal (DPR) process using nitrate instead of oxygen for PO uptake was started up in the sequencing batch reactor (SBR) at a nitrate dosing rate of 20-25 mg N L d. Operation with a real municipal wastewater supplied with CHCOONa, KHPO and KNO succeeded in the cultivation of biomass containing denitrifying polyphosphate accumulating organisms (DPAOs). Read More

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Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.

PLoS Comput Biol 2021 Jul 26;17(7):e1009206. Epub 2021 Jul 26.

Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America.

Radiologic images provide a way to monitor tumor development and its response to therapies in a longitudinal and minimally invasive fashion. However, they operate on a macroscopic scale (average value per voxel) and are not able to capture microscopic scale (cell-level) phenomena. Nevertheless, to examine the causes of frequent fast fluctuations in tissue oxygenation, models simulating individual cells' behavior are needed. Read More

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[Differentiation of Hydrogen and Oxygen Isotopes in the Water Source Treatment Wetlands of Stream Networks].

Huan Jing Ke Xue 2021 Aug;42(8):3695-3708

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

To explore the isotopic distribution and differentiation of water along the hydraulic flow gradients and plant-bed/ditch systems in constructed root-channel wetlands, surface and subsurface water samples were collected from four ecological wetlands, namely Shijiuyang and Guanjinggang in Jiaxing, as well as Changshuitang and Taishangang in Haining. All samples were collected along water flow pathways during the wet and rainy summer season in August 2019, except for those from Taishangang, which were collected within the plant-bed/ditch system during the dry and cold winter season in January 2020. The abundance of deuterium (D) and O was determined in each functional area of the wetlands to assess the influence of wetlands on water differentiation. Read More

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An Oxygenated Perfluorocarbon Emulsion Improves Liver Graft Preservation Evaluated in DCD livers of Male Sprague Dawley Rats.

Transpl Int 2021 Jul 26. Epub 2021 Jul 26.

Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital, Nanjing University Medical School, Nan-jing, China.

Background: The application of perfluorocarbons, which can carry large quantities of oxygen, in organ preservation was limited by their poor solubility in water. A stable form of perfluorocarbon dispersed in suitable buffers is urgently needed.

Methods: Perfluorocarbon emulsion was designed and characterized with respect to size distribution, rheology, stability and oxygen carrying capacity. Read More

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Effective Adsorption of Methyl Orange on Organo-Silica Nanoparticles Functionalized by a Multi-Hydroxyl-Containing Gemini Surfactant: A Joint Experimental and Theoretical Study.

ACS Omega 2021 Jul 12;6(28):18014-18023. Epub 2021 Jul 12.

Department of Physics, Innovation Center of Materials for Energy and Environment Technologies, College of Science, Tibet University, Lhasa 850000, China.

A novel multi-hydroxyl-containing gemini surfactant (G) is first designed for modifying silica precursors (SiNPs), with the purpose of fabricating organic adsorbents targeted at methyl orange (MO). The purity of G and structural character of the resultant G-SiNPs are unveiled through Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetry-derivative thermogravimetry, scanning electron microscopy, and surface analysis (BET). Compared with SiNPs, G-SiNPs exhibit enhanced hydrophobicity, enlarged interlayer spacing, and increased thermal weight losses with the modifier availability reaching as high as 100%. Read More

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The NEWgenerator non-sewered sanitation system: Long-term field testing at an informal settlement community in eThekwini municipality, South Africa.

J Environ Manage 2021 Jul 21;296:112921. Epub 2021 Jul 21.

Membrane Biotechnology Lab, University of South Florida, Tampa, FL, USA. Electronic address:

Globally, there is a dire need for a new class of advanced non-sewered sanitation systems (NSSS) to provide onsite wastewater treatment that is capable of meeting stringent discharge or reuse criteria. These systems need to be simple to operate and maintain, reliable, and resilient to unreliable electrical service. The NEWgenerator (NG) is a compact, automated, solar-powered wastewater treatment system comprised of three major treatment processes: anaerobic membrane bioreactor (AnMBR), nutrient capture system (NCS) with ion exchange and carbon sorption, and electrochlorination (EC). Read More

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Cardiovascular and Cerebrovascular Implications of Growth Restriction: Mechanisms and Potential Treatments.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, Australia.

Fetal growth restriction (FGR) is a common complication of pregnancy, resulting in a fetus that fails to reach its genetically determined growth potential. Whilst the fetal cardiovascular response to acute hypoxia is well established, the fetal defence to chronic hypoxia is not well understood due to experiment constraints. Growth restriction results primarily from reduced oxygen and nutrient supply to the developing fetus, resulting in chronic hypoxia. Read More

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[Effect of early mechanical ventilation on the expression of inflammatory factors and prognosis in patients with severe traumatic brain injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jun;33(6):727-730

Department of Critical Care Medicine, Xinhua Hospital Chongming Branch, Shanghai 202150, China.

Objective: To observe the effect of early mechanical ventilation on the expression of inflammatory factors and prognosis of patients with severe traumatic brain injury (sTBI).

Methods: From January 2017 to December 2020, 138 patients with sTBI admitted to the department of the emergency of Xinhua Hospital Chongming Branch were enrolled. Although some patients were admitted to hospital without acute respiratory failure, their Glasgow coma score (GCS) were less than 8, they bad risk of hypoxia, so early mechanical ventilation was required. Read More

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Genome-wide analysis of MYB transcription factors of Vaccinium corymbosum and their positive responses to drought stress.

BMC Genomics 2021 Jul 22;22(1):565. Epub 2021 Jul 22.

Research & Development Center of Blueberry, Key Laboratory of Forest Silviculture and Conservation of the Ministry of Education, College of Forestry, Beijing Forestry University, 35 QinghuaEast Road, 100083, Beijing, China.

Background: Blueberry (Vaccinium corymbosum L.) is an important species with a high content of flavonoids in fruits. As a perennial shrub, blueberry is characterized by shallow-rooted property and susceptible to drought stress. Read More

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Gas exchange and dive behaviour in the diving beetle Platynectes decempunctatus (Coleoptera: Dytiscidae).

J Insect Physiol 2021 Jul 19:104286. Epub 2021 Jul 19.

Department of Ecology and Evolutionary Biology, School of Biological Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia.

Many aquatic insects use bubbles on the body surface to store and supply O for their dives. There are two types of bubbles: air stores, which store O gained from air at the surface, and gas gills that allow passive extraction of O from water. Many insects using air stores and gas gills return to the surface to replenish their bubbles and, therefore, their requirement for O influences dive behaviour. Read More

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Energy-efficient removal of PFOA and PFOS in water using electrocoagulation with an air-cathode.

Chemosphere 2021 Oct 21;281:130956. Epub 2021 May 21.

Department of Environmental and Sustainable Engineering, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY, 12222, USA. Electronic address:

Electrocoagulation (EC) with a zinc anode demonstrated promising results to remove perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) from an aqueous solution. However, the energy requirement for EC is usually very high due to water electrolysis or aeration. This study aims to reduce energy consumption using an air-cathode in EC (ACEC) to supply oxygen electron acceptor without aeration for attenuating PFOA/PFOS in this new configuration. Read More

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October 2021

Structural changes, increased hypoxia, and oxidative DNA damage in placenta due to maternal smokeless tobacco use.

Birth Defects Res 2021 Jul 20. Epub 2021 Jul 20.

Environmental Toxicology and Electron Microscope Laboratory, ICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.

Background: Smokeless tobacco (SLT) consumption during pregnancy is a well-recognized health risk that causes placental damage including hypoxia and oxidative damage. Although consumption of SLT by women varies from region to region, majority of tea leave pluckers consume SLT for relieving stress and pain. Still, the effects of SLT consumption have not been evaluated in tea garden workers (TGW). Read More

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Pre-shear bioprinting of highly oriented porous hydrogel microfibers to construct anisotropic tissues.

Biomater Sci 2021 Jul 21. Epub 2021 Jul 21.

Research Institute for Medical and Biological Engineering, Ningbo University, Ningbo, 315211, China.

Anisotropic tissues in vivo have special structural characteristics and biological functions. Nowadays, bioprinting is widely used in tissue engineering and an effective way to process cell-laden hydrogels. However, the direct bioprinting of oriented cell-laden hydrogel structures to engineer anisotropic tissues is still difficult. Read More

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Functionalization of Silver/Titanium Dioxide Composites in Chitosan-based Coatings and their Egg Preservation Performances.

J Vis Exp 2021 Jul 2(173). Epub 2021 Jul 2.

Department of Physics, College of Science, Tibet University; Institute of Oxygen Supply, Tibet University;

Eggs are an excellent source of proteins, minerals, and vitamins, which have been popularly consumed in daily diet all over the world. The micro-pores and micro-cracks on the eggshells, however, lead to the loss of moisture and the escape of CO2, resulting in the acceleration of egg deterioration and economic loss. To enhance the stability and sterilizability of the existing chitosan-based coating materials and to develop novel multifunctional nano-composites for anti-bacterial and egg preservation, silver/titanium dioxide (Ag/TiO2) composites are synthesized and applied to modify chitosan for the extension of the egg shelf life. Read More

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Use of Photobioreactors in Regenerative Life Support Systems for Human Space Exploration.

Front Microbiol 2021 29;12:699525. Epub 2021 Jun 29.

Interdisciplinary Biosciences Group, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.

There are still many challenges to overcome for human space exploration beyond low Earth orbit (LEO) (e.g., to the Moon) and for long-term missions (e. Read More

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Molecular Perspectives of Mitophagy in Myocardial Stress: Pathophysiology and Therapeutic Targets.

Front Physiol 2021 30;12:700585. Epub 2021 Jun 30.

Department of Cardiology, The First Medical Center, Chinese People's Liberation Army Hospital, Medical School of Chinese People's Liberation Army, Beijing, China.

A variety of complex risk factors and pathological mechanisms contribute to myocardial stress, which ultimately promotes the development of cardiovascular diseases, including acute cardiac insufficiency, myocardial ischemia, myocardial infarction, high-glycemic myocardial injury, and acute alcoholic cardiotoxicity. Myocardial stress is characterized by abnormal metabolism, excessive reactive oxygen species production, an insufficient energy supply, endoplasmic reticulum stress, mitochondrial damage, and apoptosis. Mitochondria, the main organelles contributing to the energy supply of cardiomyocytes, are key determinants of cell survival and death. Read More

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The lower threshold of hypothermic oxygen delivery to prevent neonatal acute kidney injury.

Pediatr Res 2021 Jul 17. Epub 2021 Jul 17.

Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Oxygen delivery during cardiopulmonary bypass (CPB) is closely related to postoperative acute kidney injury (AKI). The value of critical indexed oxygen delivery (DOi) is a key indicator to reflect oxygen supply in cardiovascular surgery. However, the target DOi value for neonates undergoing hypothermic CPB remains unclear. Read More

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Mitochondria-targeted vitamin E succinate delivery for reversal of multidrug resistance.

J Control Release 2021 Jul 16;337:117-131. Epub 2021 Jul 16.

Ministry of Education (MOE) Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address:

Inducing mitochondrial malfunction is an appealing strategy to overcome tumor multidrug resistance (MDR). Reported here a versatile mitochondrial-damaging molecule, vitamin E succinate (VES), is creatively utilized to assist MDR reversal of doxorubicin hydrochloride (DOX·HCl) via a nanovesicle platform self-assembled from amphiphilic polyphosphazenes containing pH-sensitive 1H-benzo-[d]imidazol-2-yl) methanamine (BIMA) groups. Driven by multiple non-covalent interactions, VES is fully introduced into the hydrophobic membrane of DOX·HCl-loaded nanovesicles with loading content of 23. Read More

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Life cycle sustainability assessment of synthetic fuels from date palm waste.

Sci Total Environ 2021 Jul 9;796:148961. Epub 2021 Jul 9.

Systems Analysis Unit, IMDEA Energy, 28935 Móstoles, Spain.

The use of biowaste feedstock is often suggested for sustainable production of synthetic fuels through gasification followed by the Fischer-Tropsch process. While the technical performance of this type of bioenergy system has significantly been investigated, comprehensive sustainability analyses are still required. The present study evaluates the life cycle sustainability performance of synthetic diesel and gasoline from Tunisian date palm waste, and compares it with that of conventional fossil fuels. Read More

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A NO/ROS/RNS cascaded-releasing nano-platform for gas/PDT/PTT/immunotherapy of tumors.

Biomater Sci 2021 Jul 16. Epub 2021 Jul 16.

School of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China.

Nitric oxide (NO) gas treatment offers a promising strategy for tumor therapy; however, its practical application is still limited due to its poor efficacy and biotoxicity which were caused by gas leakage during blood delivery. Herein, a nano-platform (CMH-OBN) composed of chlorin e6-melanin-hyaluronic acid nanoparticles (Ce6-MNP-HA, CMH) and oxidized bletilla striata polysaccharide microcapsules (Oxi-BSP) carrying NO donors was prepared for responsive and cascaded release of NO, reactive oxygen species (ROS) and its secondary metabolite reactive nitrogen species (RNS) in tumor sites. Melanin not only endowed CMH with good photothermal properties, but also helped Ce6 to produce a large number of ROS under near-infrared (NIR) irradiation. Read More

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High-Dose Buprenorphine Induction in the Emergency Department for Treatment of Opioid Use Disorder.

JAMA Netw Open 2021 Jul 1;4(7):e2117128. Epub 2021 Jul 1.

Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut.

Importance: Emergency departments (EDs) sporadically use a high-dose buprenorphine induction strategy for the treatment of opioid use disorder (OUD) in response to the increasing potency of the illicit opioid drug supply and commonly encountered delays in access to follow-up care.

Objective: To examine the safety and tolerability of high-dose (>12 mg) buprenorphine induction for patients with OUD presenting to an ED.

Design, Setting, And Participants: In this case series of ED encounters, data were manually abstracted from electronic health records for all ED patients with OUD treated with buprenorphine at a single, urban, safety-net hospital in Oakland, California, for the calendar year 2018. Read More

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Impact of COVID-19 adapted guidelines on resuscitation quality in out-of-hospital-cardiac-arrest: a manikin study.

Minerva Anestesiol 2021 Jul 14. Epub 2021 Jul 14.

Department of Anesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine, and Pain Therapy, Protestant Hospital of the Bethel Foundation, University Hospital of Bielefeld, Bielefeld, Germany.

Background: To evaluate the effects of European Resuscitation Council (ERC) COVID-19-guidelines on resuscitation quality emphasizing advanced airway management in out-of-hospital-cardiacarrest.

Methods: In a manikin study paramedics and emergency physicians performed Advanced-Cardiac-Life-Support in three settings: ERC guidelines 2015 (Control), COVID-19-guidelines as suggested with minimum staff (COVID-19-minimal-personnel); COVID-19-guidelines with paramedics and an emergency physician (COVID-19-advanced-airway-manager). Main outcome measures were no-flow-time, quality metrics as defined by ERC and time intervals to first chest compression, oxygen supply, intubation and first rhythm analysis. Read More

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Development of a Bioartificial Vascular Pancreas.

J Tissue Eng 2021 Jan-Dec;12:20417314211027714. Epub 2021 Jun 28.

Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.

Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient oxygen transfer, leading to islet loss. Furthermore, oxygen diffusion limitations can be magnified when islet numbers are increased dramatically, as in translating from rodent studies to human-scale treatments. Read More

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Portable High-Flow Nasal Oxygen during Walking in Patients with Severe Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial.

Respiration 2021 Jul 14:1-7. Epub 2021 Jul 14.

U.O. Pneumologia Riabilitativa, IRCCS Istituti Clinici Scientifici Maugeri, Istituto di Montescano, Montescano, Italy.

Background: High-flow nasal oxygen (HFNO) improves exercise capacity, oxygen saturation, and symptoms in patients with chronic obstructive pulmonary disease (COPD). Due to the need of electricity supply, HFNO has not been applied during free ambulation.

Objective: We evaluated whether HFNO delivered during walking by a battery-supplied portable device was more effective than usual portable oxygen in improving exercise capacity in patients with COPD and severe exercise limitation. Read More

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Native forest cover safeguards stream water quality under a changing climate.

Ecol Appl 2021 Jul 14:e02414. Epub 2021 Jul 14.

Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, New York, 10027, USA.

Ensuring a sufficient and adequate supply of water for humans and ecosystems is a pressing environmental challenge. The expansion of agricultural and urban lands has jeopardized watershed ecosystem services and a changing climate poses additional risks for regional water supply. We used stream water quality data collected between 2000 and 2014, coupled with detailed precipitation and land cover information, to investigate the effects of landscape composition and short-term precipitation variability on the quality of water resources in the state of São Paulo, Brazil. Read More

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Multimodal imaging of laser speckle contrast imaging combined with mosaic filter-based hyperspectral imaging for precise surgical guidance.

IEEE Trans Biomed Eng 2021 Jul 14;PP. Epub 2021 Jul 14.

Objective: To enable a real-time surgical guidance system that simultaneously monitors blood vessel perfusion, oxygen saturation, thrombosis, and tissue recovery by combining multiple optical imaging techniques into a single system: visible imaging, mosaic filter-based snapshot hyperspectral imaging (HSI), and laser speckle contrast imaging (LSCI).

Methods: The multimodal optical imaging system was demonstrated by clamping blood vessels in the small intestines of rats to create areas of restricted blood flow. Subsequent tissue damage and regeneration were monitored during procedures. Read More

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Uremia and Inadequate Oxygen Supply Induce Eryptosis and Intracellular Hypoxia in Red Blood Cells.

Cell Physiol Biochem 2021 Jul;55(4):449-459

Pontifícia Universidade Católica do Paraná, Curitiba, Brazil,

Background/aims: Chronic kidney disease is frequently accompanied by anemia, hypoxemia, and hypoxia. It has become clear that the impaired erythropoietin production and altered iron homeostasis are not the sole causes of renal anemia. Eryptosis is a process of red blood cells (RBC) death, like apoptosis of nucleated cells, characterized by Ca influx and phosphatidylserine (PS) exposure to the outer RBC membrane leaflet. Read More

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