112,381 results match your criteria oxygen levels


Knockdown of circBFAR inhibits proliferation and glycolysis in gastric cancer by sponging miR-513a-3p/hexokinase 2 axis.

Biochem Biophys Res Commun 2021 May 9;560:80-86. Epub 2021 May 9.

Department of Medical Oncology, Chinese PLA General Hospital, Beijing, 100853, China. Electronic address:

The relationship between circular RNAs (circRNAs) and many types of cancer has been of great interest. A novel circRNA, circBFAR, has been identified, but the functions of circBFAR and its underlying mechanism in gastric cancer (GC) have not been reported. This study was designed to investigate the role of circBFAR in GC and its downstream miRNA targets. Read More

View Article and Full-Text PDF

Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2.

Stem Cell Reports 2021 May;16(5):1165-1181

School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, T6G2E1, AB, Canada; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, T6G2E1, AB, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, T6G2E1, AB, Canada; Department of Medical Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, T6G2E1, AB, Canada. Electronic address:

SARS-CoV-2 infection is associated with lower blood oxygen levels, even in patients without hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying explanation as to whether SARS-CoV-2 directly or indirectly affects erythropoiesis. Here, we show significantly enriched CD71 erythroid precursors/progenitors in the blood circulation of COVID-19 patients. Read More

View Article and Full-Text PDF

The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures.

PLoS Biol 2021 May 12;19(5):e3000988. Epub 2021 May 12.

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

Although visceral adipocytes located within the body's central core are maintained at approximately 37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell and generally exist at cooler temperatures. Responses of brown and beige/brite adipocytes to cold stress are well studied; however, comparatively little is known about mechanisms by which white adipocytes adapt to temperatures below 37°C. Here, we report that adaptation of cultured adipocytes to 31°C, the temperature at which distal marrow adipose tissues and subcutaneous adipose tissues often reside, increases anabolic and catabolic lipid metabolism, and elevates oxygen consumption. Read More

View Article and Full-Text PDF

Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial.

J Wound Care 2021 May;30(Sup5):S7-S14

Cardiff University, UK.

Objectives: Perfusion and blood oxygen levels are frequently insufficient in patients with hard-to-heal wounds due to poor circulation, vascular disruption and vasoconstriction, reducing the wound's capacity to heal. This study aimed to investigate the effect of topical oxygen on healing rates in patients with hard-to-heal diabetic foot ulcers (DFUs) (i.e. Read More

View Article and Full-Text PDF

Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway.

J Nat Prod 2021 May 12. Epub 2021 May 12.

School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212100, People's Republic of China.

1-Deoxynojirimycin, an α-glucosidase inhibitor, possesses various biological activities such as antitumor, antidiabetic, and antiviral effects. However, the application of 1-deoxynojirimycin is restricted by its poor lipophilicity and low bioavailability. In this study, three 1-deoxynojirimycin derivatives (-) comprising 1-deoxynojirimycin and kaempferol were designed and synthesized to modify their pharmacokinetics and improve their antitumor efficacy. Read More

View Article and Full-Text PDF

Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP-exposed SH-SY5Y cells pre-treated with rutin.

Metab Brain Dis 2021 May 12. Epub 2021 May 12.

Department of Medical Biosciences, University of the Western Cape, Robert Sobukwe Road, Private Bag X17, Bellville, 7535, South Africa.

Many plant-derived bioactive compounds such as rutin are reportedly effective in attenuating neuronal death in most neurodegenerative disorders. Parkinson's disease (PD) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra of the midbrain, and has previously been modelled in-vitro through the specific neurotoxic activity of 1-methyl-4-phenylpyridinium (MPP) on dopaminergic neurons. Rutin is a bioflavonoid with multiple pharmacological effects, and this study investigated the neuroprotective effects of rutin in the human dopaminergic SH-SY5Y cell line using the neurotoxin MPP. Read More

View Article and Full-Text PDF

Redox-related gene expression and sugar accumulation patterns are altered in the edible inflorescence produced by the cultivated form of pacaya palm (Chamaedorea tepejilote).

Ann Bot 2021 May 12. Epub 2021 May 12.

Institut de Recherche pour le Développement (IRD), UMR DIADE, Université de Montpellier, Montpellier, France.

Background And Aims: The pacaya palm is a dioecious neotropical palm species that is exploited in Latin America for its male inflorescence which is edible when immature. It is cultivated, in a non-intensive manner, in Guatemala, where a morphotype occurs that produces much larger, more highly branched inflorescences compared to wild palms. We sought to identify molecular factors underlying this phenotypic divergence, which is likely to be a product of domestication. Read More

View Article and Full-Text PDF

Vitamin E regulates bovine granulosa cell apoptosis via NRF2-mediated defense mechanism by activating PI3K/AKT and ERK1/2 signaling pathways.

Reprod Domest Anim 2021 May 12. Epub 2021 May 12.

College of Animal Science and Technology, Hebei Agricultural University, Baoding, Hebei, 071000, People's Republic of China.

High-yield dairy cows are usually subject to high-intensive cell metabolism and produce excessive reactive oxygen species (ROS). Once ROS is beyond the threshold of scavenging ability, it can induce oxidative stress, imperiling the reproductive performance of cows. The study was to investigate the effects of vitamin E (VE) on H O -induced proliferation and apoptosis of bovine granulosa cells and the underlying molecular mechanism. Read More

View Article and Full-Text PDF

The effect of mild hypothermia plus rutin on the treatment of spinal cord injury and inflammatory factors by repressing TGF-β/smad pathway.

Acta Cir Bras 2021 7;36(3):e360307. Epub 2021 May 7.

PhD. Department of Spine Surgery - Guizhou Orthopedic Hospital - Guizhou Province, China.

Purpose: To probe the mechanism of mild hypothermia combined with rutin in the treatment of spinal cord injury (SCI).

Methods: Thirty rats were randomized into the following groups: control, sham, model, mild hypothermia (MH), and mild hypothermia plus rutin (MH+Rutin). We used modified Allen's method to injure the spinal cord (T10) in rats, and then treated it with MH or/and rutin immediately. Read More

View Article and Full-Text PDF

Hesperetin ameliorates hepatic oxidative stress and inflammation the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD.

Food Funct 2021 May;12(9):3898-3918

Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, China.

Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease. Dietary supplementation has become a promising strategy for managing NAFLD. Hesperetin, a citrus flavonoid, is mainly found in citrus fruits (oranges, grapefruit, and lemons) and possesses multiple pharmacological properties, including anti-cancer, anti-Alzheimer and anti-diabetic effects. Read More

View Article and Full-Text PDF

Apelin-13 protects human neuroblastoma SH-SY5Y cells against amyloid-beta induced neurotoxicity: Involvement of anti oxidant and anti apoptotic properties.

J Basic Clin Physiol Pharmacol 2021 May 10. Epub 2021 May 10.

Golestan Neuroscience Research Center (GNRC), Department of Anatomy, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Objectives: We investigated the effect of apelin-13 on the cellular model of AD, amyloid-β (Aβ) treated SH-SY5Y cells in rats.

Methods: The SH-SY5Y cells were pretreated with different doses of apelin-13 (1, 2.5, 5, and 10 μg/mL), half an hour before adding 50% Aβ treatment. Read More

View Article and Full-Text PDF

Zafirlukast promotes mitochondrial respiration by stimulating mitochondrial biogenesis in human bronchial epithelial cells.

J Mol Histol 2021 May 11. Epub 2021 May 11.

Department of Thoracic Surgery, The First Hospital of Jilin University, No. 71 Xinmin Street, Chaoyang District, Changchun, Jilin Province, 130021, China.

Lung diseases, including asthma, pose a serious global health issue. Loss of mitochondrial function and decreased mitochondrial biogenesis play pivotal roles in the initiation and progression of chronic lung diseases. Thus, maintaining mitochondrial function and homeostasis is an important treatment goal. Read More

View Article and Full-Text PDF

microRNA-9-5p protects liver sinusoidal endothelial cell against oxygen glucose deprivation/reperfusion injury.

Open Life Sci 2021 19;16(1):375-383. Epub 2021 Apr 19.

Department of Anesthesiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 Litang Road, Beijing 102218, China.

Background: Maintenance of the function and survival of liver sinusoidal endothelial cells (LSECs) play a crucial role in hepatic ischemia/reperfusion (I/R) injury, a major cause of liver impairment during the surgical treatment. Emerging evidence indicates a critical role of microRNAs in I/R injury. This study aims to investigate whether miR-9-5p exerts a protective effect on LSECs. Read More

View Article and Full-Text PDF

Dual Size/Charge-Switchable Nanocatalytic Medicine for Deep Tumor Therapy.

Adv Sci (Weinh) 2021 05 1;8(9):2002816. Epub 2021 Mar 1.

State Key Lab of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China.

Elevating intratumoral levels of highly toxic reactive oxygen species (ROS) by nanocatalytic medicine for tumor-specific therapy without using conventional toxic chemodrugs is recently of considerable interest, which, however, still suffers from less satisfactory therapeutic efficacy due to the relatively poor accumulation at the tumor site and largely blocked intratumoral infiltration of nanomedicines. Herein, an ultrasound (US)-triggered dual size/charge-switchable nanocatalytic medicine, designated as Cu-LDH/HMME@Lips, is constructed for deep solid tumor therapy via catalytic ROS generations. The negatively charged liposome outer-layer of the nanomedicine enables much-prolonged blood circulation for significantly enhanced tumoral accumulation, while the positively charged Fenton-like catalyst Cu-LDH released from the liposome under the US stimulation demonstrates much enhanced intratumoral penetration via transcytosis. Read More

View Article and Full-Text PDF

Variations in Physiological, Psychomotor, and Analgesic Parameters during Titration of Nitrous Oxide in 3-12 Years Old Children Managed with Inhalation Sedation.

Int J Clin Pediatr Dent 2020 Nov-Dec;13(6):650-655

Children Dental Centre, Gurugram, Haryana, India.

Background: The present study was designed to assess variations in physiological, psychomotor parameters, and analgesic effects at various levels of nitrous oxide-oxygen analgesia in 3-12 years old children.

Design: One hundred children aged 3-12 years were assessed for physiological, psychomotor, and analgesic parameters at various concentrations of NO, i.e. Read More

View Article and Full-Text PDF

Long-Term Domiciliary Noninvasive Ventilation for COPD.

Authors:
Robert L Owens

Respir Care 2021 May 11. Epub 2021 May 11.

Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.

COPD can lead to abnormalities in oxygenation as well as ventilation. Thanks to pioneering work by Dr Thomas Petty, supplemental oxygen therapy has been shown to improve morbidity and mortality for individuals with COPD and severe daytime hypoxemia. However, efforts to augment ventilation have been less uniformly successful. Read More

View Article and Full-Text PDF

Efficient Nitrification and Low-Level NO Emission in a Weakly Acidic Bioreactor at Low Dissolved-Oxygen Levels Are Due to Comammox.

Appl Environ Microbiol 2021 May 11;87(11). Epub 2021 May 11.

School of the Environment, Guangdong Engineering Research Center of Water Treatment Processes and Materials, Jinan University, Guangzhou, China

Nitrification is an essential process for nutrient removal from wastewater and an important emission source of nitrous oxide (NO), which is a powerful greenhouse gas and a dominant ozone-depleting substance. In this study, nitrification and NO emissions were tested in two weakly acidic (pH 6.3 to 6. Read More

View Article and Full-Text PDF

Flow increases tolerance of heat and hypoxia of an aquatic insect.

Biol Lett 2021 May 12;17(5):20210004. Epub 2021 May 12.

Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.

Recent experiments support the idea that upper thermal limits of aquatic insects arise, at least in part, from a lack of sufficient oxygen: rising temperatures typically stimulate metabolic demand for oxygen more than they increase rates of oxygen supply from the environment. Consequently, factors influencing oxygen supply, like water flow, should also affect thermal and hypoxia tolerance. We tested this hypothesis by measuring the effects of experimentally manipulated flows on the heat and hypoxia tolerance of aquatic nymphs of the giant salmonfly (Plecoptera: ), a common stonefly in western North America. Read More

View Article and Full-Text PDF

Developmental neurotoxicity of antimony (Sb) in the early life stages of zebrafish.

Ecotoxicol Environ Saf 2021 May 8;218:112308. Epub 2021 May 8.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

Accumulating studies have revealed the toxicity of antimony (Sb) to soil-dwelling and aquatic organisms at the individual level. However, little is known about the neurotoxic effects of antimony and its underlying mechanisms. To assess this issue, we investigated the neurotoxicity of antimony (0, 200, 400, 600 and 800 mg/L) in zebrafish embryos. Read More

View Article and Full-Text PDF

Assessment of the effect of long-term exposure to microplastics and depuration period in Sparus aurata Linnaeus, 1758: Liver and blood biomarkers.

Sci Total Environ 2021 May 3;786:147479. Epub 2021 May 3.

Instituto Español de Oceanografía, Centro Oceanográfico de Baleares, Muelle de Poniente s/n, E-07015 Palma de Mallorca, Balearic Islands, Spain. Electronic address:

The constant increase in plastic pollution has attracted great attention in recent years due to its potential detrimental effects on organisms and ecosystems. While the consequences of ingestion of large plastic litter are mostly understood, the impacts resulting from a long-term exposure and a recovery period of microplastics (MPs) are still limited. The aims were to monitor oxidative stress, detoxification and inflammatory biomarkers in liver, plasma and erythrocytes of Sparus aurata exposed during 90 days to low-density polyethylene (LDPE)-MPs enriched diet (10% by weight) followed by 30 days of depuration. Read More

View Article and Full-Text PDF

Mothers' voices and white noise on premature infants' physiological reactions in a neonatal intensive care unit: A multi-arm randomized controlled trial.

Int J Nurs Stud 2021 Mar 26;119:103934. Epub 2021 Mar 26.

Associate Professor, Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore. Electronic address:

Background: A few positive effects of mothers' voice on physiological outcomes have been studied and limited studies have focused on the level of cortisol. In addition, white noise has recently been found to be beneficial for human sleep, but studies in premature infants were limited and no study has compared the effects of mothers' voice and white noise on premature infants.

Objective: To examine the effects of mothers' voice and white noise on sleep-wake patterns, salivary cortisol levels, weight gain, heart rate, and oxygen saturation of premature infants in a neonatal intensive care unit (NICU). Read More

View Article and Full-Text PDF

Regulation of plasmodesmata in leaves of Arabidopsis: ATP, NADPH and chlorophyll b levels matter.

J Exp Bot 2021 May 11. Epub 2021 May 11.

Laboratory of Molecular and Ecological Physiology, Komarov Botanical Institute, Russian Academy of Sciences, ul. Professora Popova 2, 197376 St.-Petersburg, Russia.

In mature leaves, cell-to-cell transport via plasmodesmata (PD) between mesophyll cells links assimilate production in photosynthesis with their export to sink organs. This study addresses the question how signals derived from chloroplasts and photosynthesis influence PD permeability. Cell-to-cell transport was analyzed in leaves of Arabidopsis chlorophyll b-less ch1-3 mutant, the same mutant complemented with a cyanobacterial CAO gene (PhCAO) over-accumulating chlorophyll b, the trxm3 mutant lacking plastidial thioredoxin m3, and the ntrc mutant lacking functional NADPH : thioredoxin reductase C. Read More

View Article and Full-Text PDF

Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences.

Disabil Rehabil 2021 May 11:1-8. Epub 2021 May 11.

Division of Sports and Rehabilitation Medicine, Ulm University Hospital, Ulm, Germany.

Purpose: Previously we demonstrated the feasibility of a six-week-long combination of high-intensity interval endurance and strength training (HIT/HIRT) for women with nonmetastatic breast cancer leading to improvements in psychological well-being and performance. Now we report results of a 24-month follow-up.

Methods: Previous intervention (IG,  = 10; 58. Read More

View Article and Full-Text PDF

Triazole-Based Half-Sandwich Ruthenium(II) Compounds: From Antiproliferative Potential to Toxicity Evaluation.

Inorg Chem 2021 May 11. Epub 2021 May 11.

Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal.

A new series of half-sandwich ruthenium(II) compounds [(η-arene)Ru(L)Cl][CFSO] bearing 1,2,3-triazole ligands (arene = -cymene, L = (); arene = -cymene, L = (); arene = benzene, L = (); arene = benzene, (); = 2-[1-(-tolyl)-1-1,2,3-triazol-4-yl]pyridine and = 1,1'-di--tolyl-1,1'-4,4'-bi(1,2,3-triazole) have been synthesized and fully characterized by H and C NMR and IR spectroscopy, mass spectrometry, and elemental analysis. The molecular structures of , , and have been determined by single-crystal X-ray diffraction. The cytotoxic activity of - was evaluated using the MTS assay against human tumor cells, namely ovarian carcinoma (A2780), colorectal carcinoma (HCT116), and colorectal carcinoma resistant to doxorubicin (HCT116dox), and against normal primary fibroblasts. Read More

View Article and Full-Text PDF

Phenolic profile of jujube fruit subjected to gut microbiota fermentation and its antioxidant potential against ethyl carbamate-induced oxidative damage.

J Zhejiang Univ Sci B 2021 May;22(5):397-409

Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China.

Objectives: To evaluate the composition of bioactive substances and the antioxidant effects of jujube fruit under gut microbiota fermentation (GMF), and the inhibitory effect on cytotoxicity caused by ethyl carbamate (EC).

Methods: Changes in the contents of flavonoids, polyphenols, total sugars, and reducing sugars of jujube fruit after GMF (0, 2, 6, 12, 24, and 48 h) were determined. The oxidation resistance of fermented jujube fruits (from 0 to 48 h fermentation) was evaluated using in vitro 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) and ferric reducing antioxidant power (FRAP) assays. Read More

View Article and Full-Text PDF

The thermodynamic stability, potential toxicity, and speciation of metals and metalloids in Tehran runoff, Iran.

Environ Geochem Health 2021 May 10. Epub 2021 May 10.

Department of Environmental Engineering, School of Environment, College of Engineering, University of Tehran, P.O. Box 14155-6135, Tehran, Iran.

Surface runoff is the most significant source of water in dry cities like Tehran. The surface runoff is polluted by heavy metals, which their risk level is a function of their speciation. Herein, Tehran runoff quality and the speciation of metals and metalloids were investigated. Read More

View Article and Full-Text PDF

Aqueous TMAO solution under high hydrostatic pressure.

Phys Chem Chem Phys 2021 May 11. Epub 2021 May 11.

Lehrstuhl für Physikalische Chemie II, Ruhr-Universität Bochum, 44780 Bochum, Germany.

Trimethylamine N-oxide (TMAO) is a well known osmolyte in nature, which is used by deep sea fish to stabilize proteins against High Hydrostatic Pressure (HHP). We present a combined ab initio molecular dynamics, force field molecular dynamics, and THz absorption study of TMAO in water up to 12 kbar to decipher its solvation properties upon extreme compression. On the hydrophilic oxygen side of TMAO, AIMD simulations at 1 bar and 10 kbar predict a change of the coordination number from a dominating TMAO·(H2O)3 complex at ambient conditions towards an increased population of a TMAO·(H2O)4 complex at HHP conditions. Read More

View Article and Full-Text PDF

FERONIA restricts Pseudomonas in the rhizosphere microbiome via regulation of reactive oxygen species.

Nat Plants 2021 May 10. Epub 2021 May 10.

Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

Maintaining microbiome structure is critical for the health of both plants and animals. By re-screening a collection of Arabidopsis mutants affecting root immunity and hormone crosstalk, we identified a FERONIA (FER) receptor kinase mutant (fer-8) with a rhizosphere microbiome enriched in Pseudomonas fluorescens without phylum-level dysbiosis. Using microbiome transplant experiments, we found that the fer-8 microbiome was beneficial. Read More

View Article and Full-Text PDF

Effects of cadmium stress on growth and physiological characteristics of sassafras seedlings.

Sci Rep 2021 May 10;11(1):9913. Epub 2021 May 10.

Institute of Ecology and Forestry, College of Forestry, Sichuan Agricultural University, Chengdu, 611130, China.

The effects of cadmium stress on the growth and physiological characteristics of Sassafras tzumu Hemsl. were studied in pot experiments. Five Cd levels were tested [CT(Control Treatment) : 0 mg/kg, Cd5: 5 mg/kg, Cd20: 20 mg/kg, Cd50: 50 mg/kg, and Cd100: 100 mg/kg]. Read More

View Article and Full-Text PDF

Evaluation of mitochondria in mouse oocytes following cisplatin exposure.

J Ovarian Res 2021 May 10;14(1):65. Epub 2021 May 10.

Ovarian Biology Laboratory, Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.

Background: Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common side effect of which is depletion of the primordial follicle reserve, leading to infertility and early menopause. Read More

View Article and Full-Text PDF