682,746 results match your criteria oxygen

Circular RNA circ_0010729 Knockdown Attenuates Oxygen-Glucose Deprivation-Induced Human Cardiac Myocytes Injury by miR-338-3p/CALM2 Axis.

J Cardiovasc Pharmacol 2021 May;77(5):594-602

Department of Cardiovascular III, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Abstract: Circular RNAs have pivotal roles in cardiovascular disease. The injury of cardiac myocytes is associated with occurrence of cardiovascular disease. Circular RNA hsa_circ_0010729 (circ_0010729) is associated with cardiac myocytes injury. Read More

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MiR-129-5p Protects H9c2 Cardiac Myoblasts From Hypoxia/Reoxygenation Injury by Targeting TRPM7 and Inhibiting NLRP3 Inflammasome Activation.

J Cardiovasc Pharmacol 2021 May;77(5):586-593

Department of Cardiology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.

Abstract: As a biomarker for heart failure, miR-129-5p is abnormally expressed during myocardial I/R, but its specific functions and mechanisms remain largely unclear. Thus, this study explored the roles and possible mechanisms of miR-129-5p in hypoxia/reoxygenation (H/R)-insulted H9c2 cardiac myoblasts. After H/R insult, miR-129-5p expression levels were decreased, along with reduced cell viability and enhanced lactate dehydrogenase release in H9c2 cells. Read More

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Influence of Gestational Age and Mode of Delivery on Neonatal Outcomes in Prenatally Diagnosed Isolated Congenital Diaphragmatic Hernia.

Fetal Diagn Ther 2021 May 5:1-9. Epub 2021 May 5.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Aim: The optimal gestational age (GA) at delivery and mode of delivery (MoD) for pregnancies with fetal congenital diaphragmatic hernia (CDH) is undetermined. The impact of early term (37-38 weeks 6 days) versus full term (39-40 weeks 6 days) and MoD on immediate neonatal outcomes in prenatally diagnosed isolated CDH cases was evaluated.

Material And Methods: A retrospective chart review of pregnancies evaluated and delivered with the prenatal diagnosis of CDH between July 1, 2008, and December 31, 2018. Read More

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Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy.

Neuroimmunomodulation 2021 May 5:1-10. Epub 2021 May 5.

Department of Ophthalmology, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Background: The major event in the development of diabetes-related blindness and vision impairment is the onset of retinal cell damage. Overall awareness of insulin-like growth factor-2 (IGF2) mechanisms emphasizes its protective behavior in retinal cells that help to provide new information about the development of treatment for retinal complications.

Objectives: This study analyzes the effect of in vitro changes associated with the cell survival and rescue mechanism in IGF2 inhibition and activation using chromeceptin and IGF2 peptides in ARPE-19 cells cultured in high glucose conditions. Read More

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Exploring the relation between BOLD fMRI and cognitive performance using a computer-based quantitative systems pharmacology model: Applications to the COMTVAL158MET genotype and ketamine.

Eur Neuropsychopharmacol 2021 May 1;50:12-22. Epub 2021 May 1.

In Silico Biosciences, Hugo Geerts, 686 Westwind Dr, Berwyn, PA 19312, United States.

BOLD fMRI is increasingly used mostly in an observational way to probe the effect of genotypes or therapeutic intervention in normal and diseased subjects. We use a mechanism-based quantitative systems pharmacology computer model of a human cortical microcircuit, previously calibrated for the 2-back working memory paradigm, adding established biophysical principles, of glucose metabolism, oxygen consumption, neurovascular effects and the paramagnetic impact on blood oxygen levels to calculate a readout for the voxel-based BOLD fMRI signal. The objective was to study the effect of the Catechol-O-methyl Transferase Val158Met (COMT) genotype on performance and BOLD fMRI. Read More

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Efficient solar light facilitated photo-oxidative detoxification of gaseous 2-chloroethyl ethyl sulfide on ZrO-doped g-CN under dry and humid air.

Chemosphere 2021 Apr 27;280:130685. Epub 2021 Apr 27.

Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 03722, Republic of Korea. Electronic address:

Photo-oxidation of chemical warfare agents is considered a promising strategy to cope with threats from accidental or intentional release. In this study, heterostructure photocatalysts comprising different amounts of zirconium oxide (ZrO) over carbon nitride (CN) were synthesized via simple thermal exfoliation, followed by a precipitation method. The successful photocatalytic detoxification activity of the as-prepared photocatalyst was analyzed against 2-chloroethyl ethyl sulfide (CEES) under simulated solar light and natural sunlight irradiation in dry and humid air. Read More

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Xiaokang Liuwei Dihuang decoction ameliorates the immune infertility of male rats induced by lipopolysaccharide through regulating the levels of sex hormones, reactive oxygen species, pro-apoptotic and immune factors.

Biomed Pharmacother 2021 May 2;139:111514. Epub 2021 May 2.

Department of Urology and Andrology, the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650000, China. Electronic address:

Male immune infertility is a kind of disease that damages family life and happiness. The development of novel methods treating male immune infertility is of great significance. This study aimed to investigate the therapeutic effects of Chinese medicine Xiaokang Liuwei Dihuang decoction on immune infertility of male rats and explored the involved mechanisms. Read More

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The post plasma-catalytic decomposition of toluene over K-modified OMS-2 catalysts at ambient temperature: Effect of K loading amount and reaction mechanism.

J Colloid Interface Sci 2021 May 2;598:519-529. Epub 2021 May 2.

Key Laboratory of Industrial Ecology and Environmental Engineering, MOE, Dalian University of Technology, Dalian 116024, China; Institute of Electrostatics and Special Power, School of Electrical Engineering, Dalian University of Technology, Dalian 116024, China.

The present work is devoted to study the post plasma-catalytic (PPC) degradation of toluene using packed-bed discharge (PBD) plasma over K-modified manganese oxide octahedral molecular sieve (OMS-2) catalysts at ambient temperature. Compared to plasma alone, PPC can significantly improve the toluene degradation and mineralization performance simultaneously, and the generation of discharge byproducts and organic intermediates is suppressed. The catalytic capacity of OMS-2 for toluene degradation is greatly promoted by tuning potassium ions (K) content in OMS-2 tunnel, which might be owing to the formation of more surface active oxygen species derived from weak Mn-O bonds, plenty of oxygen vacancies, as well as more superior low-temperature reducibility. Read More

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In vitro effects of bis(N-[4-(hydroxyphenyl)methyl]-2-pyridinemethamine)zinc perchlorate monohydrate 4 on the physiology and interaction process of Leishmania amazonensis.

Parasitol Int 2021 May 2:102376. Epub 2021 May 2.

Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Programa de Pós-Graduação em Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Leishmaniasis is one of the most relevant neglected tropical diseases in the world, affecting 14 million people. Despite the high morbidity, mortality and socio-economic impact, few therapeutic options are available for this disease. To make matters worse, the available molecules have several limitations such as limited efficacy, high cost, side effects and increased resistance. Read More

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Characterizing the seizure onset zone and epileptic network using EEG-fMRI in a rat seizure model.

Neuroimage 2021 May 2:118133. Epub 2021 May 2.

Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China; Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

Accurate epileptogenic zone (EZ) or seizure onset zone (SOZ) localization is crucial for epilepsy surgery optimization. Previous animal and human studies on epilepsy have reported that changes in blood oxygen level-dependent (BOLD) signals induced by epileptic events could be used as diagnostic markers for EZ or SOZ localization. Simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) recording is gaining interest as a non-invasive tool for preoperative epilepsy evaluation. Read More

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Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury.

Exp Neurol 2021 May 2:113735. Epub 2021 May 2.

Department of Physical Therapy, University of Florida, Gainesville, FL, United States; Brooks Rehabilitation, Jacksonville, FL, United States; Breathing Research and Therapeutics Center, University of Florida, Gainesville, FL, United States. Electronic address:

After spinal cord injury (SCI) respiratory complications are a leading cause of morbidity and mortality. Acute intermittent hypoxia (AIH) triggers spinal respiratory motor plasticity in rodent models, and repetitive AIH may have the potential to restore breathing capacity in those with SCI. As an initial approach to provide proof of principle for such effects, we tested single-session AIH effects on breathing function in adults with chronic SCI. Read More

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Preconditioning of mesenchymal stem cells with ghrelin exerts superior cardioprotection in aged heart through boosting mitochondrial function and autophagy flux.

Eur J Pharmacol 2021 May 2:174142. Epub 2021 May 2.

Department of Cardiology, Shandong Provincial Hospital, Huaiyin District, Jinan, Shandong Province, 250021, China. Electronic address:

Application of mesenchymal stem cells (MSCs) is considered as a promising cell-based therapy to induce cardioprotection against ischemia-reperfusion (IR) injury. Preconditioning of MSCs is the key strategy to improve MSCs functions in vitro and their efficacy in vivo, especially in elderly subjects in whom cardioprotection is lost. This study investigated the effects of preconditioning of human umbilical cord-derived MSCs with ghrelin and their combination with nicotinamide-mononucleotide (NMN) on cardioprotection, and the role of autophagy flux and mitochondrial function in aged hearts subjected to IR injury. Read More

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Copper Phosphide Nanoparticles Used for Combined Photothermal and Photodynamic Tumor Therapy.

ACS Biomater Sci Eng 2021 May 5. Epub 2021 May 5.

Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Copper-based nanomaterials are widely used in near-infrared (NIR) light-mediated deep tumor treatment because of their abundant photothermal and photodynamic properties. However, copper phosphide (CuP) nanoparticles (NPs) are rarely investigated. Herein, CuP NPs were prepared to strengthen their local surface plasmon resonance absorption in the NIR region, exhibiting promising photothermal and photodynamic properties. Read More

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Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species-mediated PI3K/AKT pathway.

J Cell Mol Med 2021 May 5. Epub 2021 May 5.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China.

Prostate cancer is a major health concern in males worldwide, owing to its high incidence. Sparstolonin B (SsnB), a component of the Chinese herbal medicine Sparganium stoloniferum, is used to treat many diseases. However, the effects and mechanisms of action of SsnB in prostate cancer have not yet been reported. Read More

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Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway.

CNS Neurosci Ther 2021 May 5. Epub 2021 May 5.

Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Aim: Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been shown to play a critical role in the injury process. We wanted to explore whether zinc can inhibit ferroptosis, reduce inflammation, and then exert a neuroprotective effect. Read More

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Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants.

Int Wound J 2021 May 5. Epub 2021 May 5.

Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Nuevo León, Mexico.

Wound healing is a complex process of communication between growth factors, reactive species of oxygen, cells, signalling pathways, and cytokines in the extracellular matrix, in which growth factors are the key regulators. In humans, the main regulators of the cellular responses in wound healing are five growth factors, namely EGF, bFGF, VEGF, and TGF-β1. On the other hand, antioxidants such as astaxanthin, beta-carotene, epigallocatechin gallate, delphinidin, and curcumin have been demonstrated to stimulate cell proliferation, migration and angiogenesis, and control inflammation, to suggest a practical approach to design new strategies to treat non-healing cutaneous conditions. Read More

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Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer's disease.

Aging Cell 2021 May 5:e13368. Epub 2021 May 5.

Department of Surgery, Columbia University, New York, NY, USA.

Mitochondrial dysfunction is one of the early pathological features of Alzheimer's disease (AD). Accumulation of cerebral and mitochondrial Aβ links to mitochondrial and synaptic toxicity. We have previously demonstrated the mechanism by which presequence peptidase (PITRM1)-mediated clearance of mitochondrial Aβ contributes to mitochondrial and cerebral amyloid pathology and mitochondrial and synaptic stress in adult transgenic AD mice overexpressing Aβ up to 12 months old. Read More

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Frailty is associated with in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands: the COVID-OLD study.

Age Ageing 2021 May;50(3):631-640

Department of Internal Medicine, Haga Teaching Hospital, The Hague, the Netherlands.

Background: During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk of hospitalisation and death. Reports on the association of frailty with poor outcome have been conflicting.

Objective: The aim of the present study was to investigate the independent association between frailty and in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands. Read More

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Sexual health knowledge and needs among young adults with congenital heart disease.

PLoS One 2021 5;16(5):e0251155. Epub 2021 May 5.

Department of Nursing, Dankook University, Chungnam, Korea.

Advances in the treatment of congenital heart disease (CHD) have increased life expectancy, entailing medical surveillance for a considerable number of adolescents and young adults with CHD for issues arising in areas such as sexual health. This study aimed to assess the sexual knowledge and the needs for sexual health education among this group. The participants comprised 53 young adult outpatients (27 males, median age: 23 years) who had undergone surgical interventions (median: 3 times) for CHD. Read More

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Catalysis of the electrochemical oxygen reduction reaction (ORR) by animal and human cells.

PLoS One 2021 5;16(5):e0251273. Epub 2021 May 5.

Laboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, 31432, Toulouse, France.

Animal cells from the Vero lineage and MRC5 human cells were checked for their capacity to catalyse the electrochemical oxygen reduction reaction (ORR). The Vero cells needed 72 hours' incubation to induce ORR catalysis. The cyclic voltammetry curves were clearly modified by the presence of the cells with a shift of ORR of 50 mV towards positive potentials and the appearance of a limiting current (59 μA. Read More

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Structure and species composition of diatom community during the wet season in three floodplain lakes of Brazilian Pantanal.

PLoS One 2021 5;16(5):e0251063. Epub 2021 May 5.

Centro de Estudos Florestais, CEF, Instituto Superior de Agronomia de Lisboa, Universidade de Lisboa, Lisboa, Portugal.

In order to access environmental conditions, the use of bioindicators that have a close relationship with environmental stressors is a largely common practice, but when evaluating environmental inferences, the individual dominant taxa need to be interpreted. Humid regions such as the marshlands are fragile ecosystems and sustain communities of microalgae, often used as bioindicators, of which diatoms are a good example. Although they provide an excellent response to chemical and physical changes in water, diatom studies in surface sediments in wetlands are scarce worldwide. Read More

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Triple sulfur-oxygen-strontium isotopes probabilistic geographic assignment of archaeological remains using a novel sulfur isoscape of western Europe.

PLoS One 2021 5;16(5):e0250383. Epub 2021 May 5.

CNRS, CAGT, UMR 5288, Université Paul Sabatier, Toulouse, France.

Sulfur isotope composition of organic tissues is a commonly used tool for gathering information about provenance and diet in archaeology and paleoecology. However, the lack of maps predicting sulfur isotope variations on the landscape limits the possibility to use this isotopic system in quantitative geographic assignments. We compiled a database of 2,680 sulfur isotope analyses in the collagen of archaeological human and animal teeth from 221 individual locations across Western Europe. Read More

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Increasing Hemoglobin Concentration With An Artificial Oxygen Carrier Improves Severe Anemia-Induced Degraded Cognitive Function.

J Trauma Acute Care Surg 2021 May 5. Epub 2021 May 5.

Professor Emeritus, University of California, San Francisco; Professor, Department of Pathology, University of Michigan Medical School; Director of Research, U.S. Army Institute of Surgical Research, JBSA-Ft Sam Houston, San Antonio, TX, and Professor of Medicine, Uniformed Services University, Bethesda MD; Wellstar Pulmonary and Critical Care Medicine, Marietta, GA; Professor, Department of Anesthesiology and Perioperative Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, PA; Assistant Professor, Laboratory Medicine Program and Department of Medical Oncology & Hematology, University Health Network, University of Toronto, Ontario, Canada;

Abstract: Prior to death patients commonly experience impaired consciousness for a significant period of time, frequently preventing family and others from final interactions with the patient. Some of these episodes of cognitive impairment may be treatable, with treatment not offered owing to the perception of ultimate futility, or expense, or both. One of the causes of terminal loss of consciousness or decreased lucidity can be inadequate cerebral oxygen delivery. Read More

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Off-label tocilizumab and adjuvant iron chelator effectiveness in a group of severe COVID-19 pneumonia patients: A single center experience.

Medicine (Baltimore) 2021 May;100(18):e25832

Lucian Blaga University of Sibiu, Faculty of Medicine Sibiu, Academic Emergency Hospital Sibiu - Internal Medicine Clinic, Sibiu, Romania.

Abstract: Tocilizumab (TCZ), a monoclonal recombinant antibody against IL-6 receptor, is currently used in managing the cytokine release syndrome (CRS) that occurred in coronavirus disease 2019 (COVID-19) selected cases. The primary objective of our study was to establish the effectiveness of TCZ in patients with severe or critical severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pneumonia.We retrospectively analyzed 25 consecutive patients, admitted in the Academic Emergency Hospital Sibiu, Romania from April 1, 2020 until May 25, 2020, all with confirmed SARS-CoV-2 infection and severe pneumonia. Read More

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Risk factors associated with the need for oxygen therapy in patients with COVID-19.

Medicine (Baltimore) 2021 May;100(18):e25819

Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Abstract: Respiratory failure is the major cause of death in patients with coronavirus disease (COVID-19). Data on factors affecting the need for oxygen therapy in early-stage COVID-19 are limited. This study aimed to evaluate the factors associated with the need for oxygen therapy in patients with COVID-19. Read More

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Predictive Performance of Oximetry to Detect Sleep Apnea in Patients Taking Opioids.

Anesth Analg 2021 May 5. Epub 2021 May 5.

From the Department of Anesthesiology and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Background: Long-term use of opioids for treatment of chronic pain is associated with significant risks including worsening unrecognized or untreated sleep apnea that may increase morbidity and mortality. Overnight oximetry has been validated for predicting sleep apnea in surgical and sleep clinic patients. The objective of the study was to assess the predictive accuracy of oxygen desaturation index (ODI 4%) from home overnight oximetry when compared to apnea hypopnea index (AHI) from polysomnography for predicting sleep apnea in patients taking opioids for chronic pain. Read More

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Evaluation of analgesic interaction between morphine, maropitant and dexmedetomidine in dogs undergoing ovariohysterectomy.

N Z Vet J 2021 May 5:1-27. Epub 2021 May 5.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Aims: To compare the analgesic effect of morphine combined with maropitant and/or dexmedetomidine to morphine alone given at a higher dose, and to evaluate the pharmacokinetics of the drug combinations, in dogs undergoing ovariohysterectomy (OHE).

Methods: Forty client owned-dogs were randomised into four treatment groups (n=10 per group) each to receive a different analgesic protocol. After premedication with I/M acepromazine anaesthesia was induced with propofol to effect and maintained with isoflurane in 100% oxygen delivered via a circle system. Read More

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Anchoring γ-MnO within β-NiCo(OH) as an Interfacial Electrode Material for Boosting Power Density in an Asymmetric Supercapacitor Device and for Oxygen Evolution Catalysis.

Langmuir 2021 May 5. Epub 2021 May 5.

Department of Chemistry, Bharathiar University, Coimbatore 641 046, India.

The great challenge is to improve the high-competence electrochemical supercapacitor (ES) and oxygen evolution reaction (OER) electrocatalyst with earth-abundant transition metals rather than using limited noble metals. Herein, we developed a facile strategy to introduce two different phases such as α-MnO or γ-MnO on porous hexagonal bimetallic β-NiCo(OH)-layered double hydroxide (LDH) nanosheets for an enhanced bifunctionality and to ease out interfacial redox reaction kinetics. Due to the rational intend of LDH morphology and well-retained starlike γ-MnO nanostructures, the bifunctional LDHs exhibit commendable activities toward ESs and in the OER study. Read More

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Curcumin Attenuates Sarcopenia in Chronic Forced Exercise Executed Aged Mice by Regulating Muscle Degradation and Protein Synthesis with Antioxidant and Anti-inflammatory Effects.

J Agric Food Chem 2021 May 5. Epub 2021 May 5.

Department of Food Science and Biotechnology, Sejong University, 209, Neungdong-ro, Gwangjin-gu, Seoul 05006, Republic of Korea.

The aim of the current study is to investigate the effects of spray dry powders of containing 40% curcumin (CM-SD), as a new aqueous curcumin formula, on sarcopenia in chronic forced exercise executed 10 month old ICR mice. CM-SD (80 and 40 mg/kg) increased calf thicknesses and strengths, total body and calf protein amounts, and muscle weights in both gastrocnemius and soleus muscles. mRNA expressions regarding muscle growth and protein synthesis were induced, while those of muscle degradation significantly declined in CM-SD treatment. Read More

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Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/β-catenin pathway.

J Bone Miner Res 2021 May 5. Epub 2021 May 5.

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20025, China.

Lgr4, a G-protein-coupled receptor, is associated with various physiological and pathological processes including oncogenesis, energy metabolism, and bone remodeling. However, whether Lgr4 is involved in osteoblasts' metabolism is not clear. Here we uncover that in preosteoblast cell line, lacking Lgr4 results in decreased osteogenic function along with reduced glucose consumption, glucose uptake, and lactate production in the presence of abundant oxygen, which is referred to as aerobic glycolysis. Read More

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