Chemphyschem 2021 Jul 26. Epub 2021 Jul 26.
Clarkson University, Department of Chemistry and Biomolecule Science, Clarkson University, 13699, United States, 13699, Potsdam, UNITED STATES.
Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin. The alginate pores, particularly located at the periphery, were blocked by semi-interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (semi-IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules. The beads were loaded with insulin and various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB). Read More