77,710 results match your criteria oxidized low‑density


Nutritional Status Influences Oxidative Stress and Insulin Resistance in Preschool Children.

Metab Syndr Relat Disord 2021 Jul 27. Epub 2021 Jul 27.

Servicio de Medicina Física y Rehabilitación, Hospital General de Zona No. 197, Texcoco, Mexico.

Child malnutrition represents a major public health problem with physiological, psychological, and social short- and long-term implications. To compare the influence of nutritional status on oxidative stress (OS) markers in children aged 3-6 years. Children were categorized into four groups: underweight, normal weight, overweight, and obesity. Read More

View Article and Full-Text PDF

Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress-induced mitochondrial dysfunction.

Aging Cell 2021 Jul 27:e13444. Epub 2021 Jul 27.

Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.

The nuclear factor-erythroid 2-related factor-2 (Nrf2), a major antioxidant transcription factor, is decreased in several age-related diseases including age-related macular degeneration (AMD), the most common cause of blindness among the elderly in western society. Since Nrf2's mito-protective response is understudied, we investigated its antioxidant response on mitochondria. Control and Nrf2-deficient retinal pigmented epithelial (RPE) cells were compared after treating with cigarette smoke extract (CSE). Read More

View Article and Full-Text PDF

Pyrrole-Embedded Linear and Helical Graphene Nanoribbons.

J Am Chem Soc 2021 Jul 23. Epub 2021 Jul 23.

Département de chimie and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, 1045 Ave de la Médecine, Québec, Canada G1V 0A6.

Linear and helical graphene nanoribbons ( and ) bearing electron-rich pyrrole units have been synthesized by using the photochemical cyclodehydrochlorination (CDHC) reaction. The pyrrole units in the polymer backbone make the polymer electron-rich with moderate bandgap values and relatively high HOMO energy levels. The planarization of the pyrrole unit through cyclization yields a bandgap value almost 0. Read More

View Article and Full-Text PDF

Catalytic sulfate formation mechanism influenced by important constituents of cloud water the reaction of SO oxidized by hypobromic acid in marine areas.

Phys Chem Chem Phys 2021 Jul 23. Epub 2021 Jul 23.

Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.

Comprehensive investigations of the possible formation pathways of sulfate, the main composition of atmospheric aerosol in marine areas, continue to challenge atmospheric chemists. As one of the most important oxidation routes of S(iv) contributing to sulfate formation, the reaction process of S(iv) oxidized by hypobromic acid, which is ubiquitous with the gas-phase mixing ratios of ∼310 ppt and has a well-known oxidative capacity, has attracted wide attention. However, little information is available about the detailed reaction mechanism. Read More

View Article and Full-Text PDF

Chemical modification strategies for viscosity-dependent processing of gellan gum.

Carbohydr Polym 2021 Oct 15;269:118335. Epub 2021 Jun 15.

Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland.

Recently, the hydrogel-forming polysaccharide gellan gum (GG) has gained popularity as a versatile biomaterial for tissue engineering purposes. Here, we examine the modification strategies suitable for GG to overcome processing-related limitations. We emphasize the thorough assessment of the viscoelastic and mechanical properties of both precursor solutions and final hydrogels. Read More

View Article and Full-Text PDF
October 2021

Depolymerization of biorefinery lignin by improved laccases of the white-rot fungus Obba rivulosa.

Microb Biotechnol 2021 Jul 26. Epub 2021 Jul 26.

Fungal Genetics and Biotechnology, Department of Microbiology, University of Helsinki, University of Helsinki, Biocenter 1 PO Box 56 Viikinkaari 9, Helsinki, FI-00014, Finland.

Fungal laccases are attracting enzymes for sustainable valorization of biorefinery lignins. To improve the lignin oxidation capacity of two previously characterized laccase isoenzymes from the white-rot fungus Obba rivulosa, we mutated their substrate-binding site at T1. As a result, the pH optimum of the recombinantly produced laccase variant rOrLcc2-D206N shifted by three units towards neutral pH. Read More

View Article and Full-Text PDF

The Wet-Oxidation of a Cu(111) Foil Coated by Single Crystal Graphene.

Adv Mater 2021 Jul 26:e2102697. Epub 2021 Jul 26.

Center for Multidimensional Carbon Materials (CMCM), Institute for Basic Science (IBS), Ulsan, 44919, Republic of Korea.

The wet-oxidation of a single crystal Cu(111) foil is studied by growing single crystal graphene islands on it followed by soaking it in water. O-labeled water is also used; the oxygen atoms in the formed copper oxides in both the bare and graphene-coated Cu regions come from water. The oxidation of the graphene-coated Cu regions is enabled by water diffusing from the edges of graphene along the bunched Cu steps, and along some graphene ripples where such are present. Read More

View Article and Full-Text PDF

[Transformation Characteristics of Dissolved Organic Matter During UV/Chlorine Treatment of Municipal Secondary Effluent].

Huan Jing Ke Xue 2021 Aug;42(8):3847-3857

State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China.

As an emerging advanced oxidation technology, UV/chlorine treatment is capable of effectively oxidizing various organic pollutants. Till now, the transformation of dissolved effluent organic matter (dEfOM) in real wastewater during UV/chlorine treatment remains unclear. In this study, ultraviolet and fluorescence spectroscopy were combined with Fourier transform ion cyclotron resonance mass spectrometry to probe the transformation of dEfOM in two municipal secondary effluents during UV/chlorine treatment. Read More

View Article and Full-Text PDF

Iodine Immobilized Metal-Organic Framework for NIR-Triggered Antibacterial Therapy on Orthopedic Implants.

Small 2021 Jul 26:e2102315. Epub 2021 Jul 26.

Orthopedics Research Institute of Zhejiang University, Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, P. R. China.

Iodine has been known as an effective disinfectant with broad-spectrum antimicrobial potency yet without drug resistance risk when used in clinic. However, the exploration of iodine for antibacterial therapy in orthopedics remains sparse due to its volatile nature and poor solubility. Herein, leveraging the superior absorption capability of metal-organic frameworks (MOFs) and their inherent photocatalytic properties, iodine-loaded MOF surface is presented to realize responsive iodine release along with intracellular reactive oxygen species(ROS) oxidation under near-infrared (NIR) exposure to achieve synergistic antibacterial effect. Read More

View Article and Full-Text PDF

Biomolecule Release from Alginate Composite Hydrogels Triggered by Logically Processed Signals.

Chemphyschem 2021 Jul 26. Epub 2021 Jul 26.

Clarkson University, Department of Chemistry and Biomolecule Science, Clarkson University, 13699, United States, 13699, Potsdam, UNITED STATES.

Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin. The alginate pores, particularly located at the periphery, were blocked by semi-interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (semi-IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules. The beads were loaded with insulin and various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB). Read More

View Article and Full-Text PDF

Oxidative stress-responsive apoptosis-inducing protein in patients with heterozygous familial hypercholesterolemia.

Heart Vessels 2021 Jul 26. Epub 2021 Jul 26.

Department of Biofunctional Microbiota, School of Medicine, Juntendo University, Tokyo, Japan.

Oxidative stress, an inducer of apoptosis, plays a critical role in ischemia/reperfusion injury and atherosclerosis. We previously identified an apoptosis-inducing ligand, the post-translationally modified secreted form of eukaryotic translation initiation factor 5A (eIF5A), 'oxidative stress-responsive apoptosis-inducing protein' (ORAIP). In this study, we investigated the role of ORAIP in patients with heterozygous familial hypercholesterolemia (HeFH), a leading cause of premature cardiovascular disease. Read More

View Article and Full-Text PDF

Cross-Linked and Surface-Modified Cellulose Acetate as a Cover Layer for Paper-Based Electrochromic Devices.

ACS Appl Polym Mater 2021 May 16;3(5):2393-2401. Epub 2021 Mar 16.

Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, Vuorimiehentie 1, FI-00076 Espoo, Finland.

We studied the surface and microstructure of cellulose acetate (CA) films to tailor their barrier and mechanical properties for application in electrochromic devices (ECDs). Cross-linking of CA was carried out with pyromellitic dianhydride to enhance the properties relative to unmodified CA: solvent resistance (by 43% in acetone and 37% in DMSO), strength (by 91% for tensile at break), and barrier (by 65% to oxygen and 92% to water vapor). Surface modification via tetraethyl orthosilicate and octyltrichlorosilane endowed the films with hydrophobicity, stiffness, and further enhanced solvent resistance. Read More

View Article and Full-Text PDF

Structural and Biochemical Characterization of the Flavin-Dependent Siderophore-Interacting Protein from .

ACS Omega 2021 Jul 6;6(28):18537-18547. Epub 2021 Jul 6.

Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.

is an opportunistic pathogen with a high mortality rate due to multi-drug-resistant strains. The synthesis and uptake of the iron-chelating siderophores acinetobactin (Acb) and preacinetobactin (pre-Acb) have been shown to be essential for virulence. Here, we report the kinetic and structural characterization of BauF, a flavin-dependent siderophore-interacting protein (SIP) required for the reduction of Fe(III) bound to Acb/pre-Acb and release of Fe(II). Read More

View Article and Full-Text PDF

Two-Dimensional Bis(dithiolene)iron(II) Self-Powered UV Photodetectors with Ultrahigh Air Stability.

Adv Sci (Weinh) 2021 Jul 19;8(14):2100564. Epub 2021 May 19.

Department of Chemistry School of Science The University of Tokyo Tokyo 113-0033 Japan.

Organometallic two-dimensional (2D) nanosheets with tailorable components have recently fascinated the optoelectronic communities due to their solution-processable nature. However, the poor stability of organic molecules may hinder their practical application in photovoltaic devices. Instead of conventional organometallic 2D nanosheets with low weatherability, an air-stable -conjugated 2D bis(dithiolene)iron(II) (FeBHT) coordination nanosheet (CONASH) is synthesized via bottom-up liquid/liquid interfacial polymerization using benzenehexathiol (BHT) and iron(II) ammonium sulfate [Fe(NH)(SO)] as precursors. Read More

View Article and Full-Text PDF

A Simple Onlay Sellar Reconstruction Does Not Increase the Risk of Postoperative Cerebrospinal Fluid Leak in Well-Selected Patients.

J Neurol Surg B Skull Base 2021 Jul 8;82(Suppl 3):e231-e235. Epub 2020 Jan 8.

Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

 A variety of endonasal sellar repair techniques have been described; many of which are complex, expensive, and carry potential morbidity but are felt to be necessary to prevent postoperative cerebrospinal fluid (CSF) leaks. We propose an effective, technically simple repair for select sellar defects utilizing an onlay of regenerated oxidized cellulose.  Retrospective review of patients from a single neurosurgeon who underwent endoscopic transsphenoidal surgery for pituitary adenoma and sellar reconstruction with only an onlay of regenerated oxidized cellulose. Read More

View Article and Full-Text PDF

Elucidating the Mechanism of Ambient-Temperature Aldol Condensation of Acetaldehyde on Ceria.

ACS Catal 2021 Jul 30;11(14):8621-8634. Epub 2021 Jun 30.

Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, United States.

Using in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and density functional theory (DFT) calculations, we conclusively demonstrate that acetaldehyde (AcH) undergoes aldol condensation when flown over ceria octahedral nanoparticles, and the reaction is desorption-limited at ambient temperature. -Crotonaldehyde (CrH) is the predominant product whose coverage builds up on the catalyst with time on stream. The proposed mechanism on CeO(111) proceeds via AcH enolization (i. Read More

View Article and Full-Text PDF

Investigation of Charge Performance in Anatase TiO Powder for Methane Conversion by Vis-NIR Spectroscopy.

ACS Catal 2021 Jul 20;11(13):8226-8238. Epub 2021 Jun 20.

Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.

The intrinsic behavior of photogenerated charges and reactions with chemicals are key for a photocatalytic process. To observe these basic steps is of great importance. Here we present a reliable and robust system to monitor these basic steps in powder photocatalysts, and more importantly to elucidate the key issue in photocatalytic methane conversion over the benchmark catalyst TiO. Read More

View Article and Full-Text PDF

Auto-Antibody Production During Experimental Atherosclerosis in Mice.

Front Immunol 2021 9;12:695220. Epub 2021 Jul 9.

Laboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, United States.

Current models stipulate that B cells and antibodies function during atherosclerosis in two distinct ways based on antibody isotype, where IgM is protective and IgG is inflammatory. To examine this model, we generated mice, which are unable to produce IgG antibodies due to the absence of activation-induced deaminase (AID) but maintain high plasma cholesterol due to the absence of apolipoprotein E (APOE). We saw a dramatic decrease in plaque formation in mice compared to mice. Read More

View Article and Full-Text PDF

Linalool reverses benzene-induced cytotoxicity, oxidative stress and lysosomal/mitochondrial damages in human lymphocytes.

Drug Chem Toxicol 2021 Jul 26:1-9. Epub 2021 Jul 26.

Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Benzene exposure results in bone marrow suppression, leading to a decrease in the number of circulating white blood cells, an increased risk of chronic lymphocytic leukemia, acute myeloid leukemia and aplastic anemia. Since the mechanism of induction of benzene toxicity is due to active metabolites through cytochrome p450 enzymes and production of reactive oxygen species (ROS), we hypothesized that natural compound such linalool with anti-inflammatory/antioxidant properties could be effective in reducing its toxicity. Lymphocytes isolated from healthy individuals were simultaneously cotreated with different concentrations of LIN (10, 25 and 50 µM) and benzene (50 µM) for 4 h at 37 °C. Read More

View Article and Full-Text PDF

The Fermi level as an energy reference in liquid jet X-ray photoelectron spectroscopy studies of aqueous solutions.

Phys Chem Chem Phys 2021 Jul 25. Epub 2021 Jul 25.

Sorbonne Université, CNRS, Laboratoire de Chimie Physique Matière et Rayonnement, UMR 7614, 4 Place Jussieu, 75005 Paris, France.

To advance the understanding of key electrochemical and photocatalytic processes that depend on the electronic structure of aqueous solutions, X-ray photoemission spectroscopy has become an invaluable tool, especially when practiced with liquid microjet setups. Determining vertical ionization energies referenced to the vacuum level, and binding energies referenced to the Fermi level, including the much-coveted reorganization energy of the oxidized species of a redox couple, requires that energy levels be properly defined. The present paper addresses specifically how the vacuum level "just outside the surface" can be known through the energy position of the rising edge of the secondary electrons, and how the Fermi level reference is uniquely determined via the introduction of a redox couple. Read More

View Article and Full-Text PDF

Cooperative Photocatalysis with 4-Amino-TEMPO for Selective Aerobic Oxidation of Amines over TiO2 Nanotubes.

Chem Asian J 2021 Jul 23. Epub 2021 Jul 23.

Wuhan University, College of Chemistry and Molecular Sciences, 299 Bayi Road, 430072, Wuhan, CHINA.

Attaching π-conjugated molecules onto TiO 2 can form surface complexes that could capture visible light. However, to make these TiO 2 surface complexes durable, integrating 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) or its analogues as a redox mediator with photocatalysis is the key to constructing selective chemical transformations. Herein, sodium 6,7-dihydroxynaphthalene-2-sulfonate (DHNS) was obtained by extending the π-conjugated system of catechol by adding a benzene ring and a substituted group sodium sulfonate (-SO 3 - Na + ). Read More

View Article and Full-Text PDF

A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress.

Nat Commun 2021 07 23;12(1):4484. Epub 2021 Jul 23.

University of Geneva, Faculty of Medicine, Department of Pathology and Immunology, Geneva 4, Switzerland.

Reactive oxygen species (ROS) represent a by-product of metabolism and their excess is toxic for hematopoietic stem and progenitor cells (HSPCs). During embryogenesis, a small number of HSPCs are produced from the hemogenic endothelium, before they colonize a transient organ where they expand, for example the fetal liver in mammals. In this study, we use zebrafish to understand the molecular mechanisms that are important in the caudal hematopoietic tissue (equivalent to the mammalian fetal liver) to promote HSPC expansion. Read More

View Article and Full-Text PDF

Multibiomarker responses and bioaccumulation of fipronil in Prochilodus lineatus exposed to spiked sediments: Oxidative stress and antioxidant defenses.

Pestic Biochem Physiol 2021 Aug 21;177:104876. Epub 2021 May 21.

Grupo de Estudios de Contaminación Antrópica de Peces (GECAP), Departamento de Ciencias Básicas e INEDES, Universidad Nacional de Luján (UNLu-CONICET), Rutas 5 y 7, Luján 6700, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:

Fipronil is a current use pesticide, widely used in many crops, commonly adsorbed to sediments of aquatic environments. The purpose of this study was to evaluate the biomarker responses and fipronil distribution pattern in different matrixes (fish, sediment and water) after juveniles P. lineatus exposure at two environmental concentrations (5. Read More

View Article and Full-Text PDF

The Use of Ion Milling for Surface Preparation for EBSD Analysis.

Authors:
Wojciech J Nowak

Materials (Basel) 2021 Jul 16;14(14). Epub 2021 Jul 16.

Department of Materials Science, Faculty of Mechanical Engineering and Aeronautics, Rzeszow University of Technology, al. Powstanców Warszawy 12, 35-959 Rzeszow, Poland.

An electron backscattered diffraction (EBSD) method provides information about the crystallographic structure of materials. However, a surface subjected to analysis needs to be well-prepared. This usually requires following a time-consuming procedure of mechanical polishing. Read More

View Article and Full-Text PDF

The Morphology and Microstructure of Oxide Scale Grown on Austenitic Steel during Steam Oxidation at 700 °C for 500 h.

Materials (Basel) 2021 Jul 8;14(14). Epub 2021 Jul 8.

Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Kraków, Poland.

The modern power generation industry needs materials able to withstand severe conditions, such as high temperatures, steam pressure, and an aggressive environment, to create more electric power out of a decreasing amount of fuel. Therefore, new metallic materials are continuously being developed. In order to gain knowledge about modern materials, the investigation of high Cr and Ni austenitic steel oxidized in 100% steam at 700 °C for 500 h was performed. Read More

View Article and Full-Text PDF

Biochemical Methanol Gas Sensor (MeOH Bio-Sniffer) for Non-Invasive Assessment of Intestinal Flora from Breath Methanol.

Sensors (Basel) 2021 Jul 19;21(14). Epub 2021 Jul 19.

Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.

Methanol (MeOH) in exhaled breath has potential for non-invasive assessment of intestinal flora. In this study, we have developed a biochemical gas sensor (bio-sniffer) for MeOH in the gas phase using fluorometry and a cascade reaction with two enzymes, alcohol oxidase (AOD) and formaldehyde dehydrogenase (FALDH). In the cascade reaction, oxidation of MeOH was initially catalyzed by AOD to produce formaldehyde, and then this formaldehyde was successively oxidized via FALDH catalysis together with reduction of oxidized form of β-nicotinamide adenine dinucleotide (NAD). Read More

View Article and Full-Text PDF

Structural and Functional Impairments of Reconstituted High-Density Lipoprotein by Incorporation of Recombinant β-Amyloid42.

Authors:
Kyung-Hyun Cho

Molecules 2021 Jul 16;26(14). Epub 2021 Jul 16.

Korea Research Institute of Lipoproteins, Medical Innovation Complex, Daegu 41061, Korea.

Beta (β)-amyloid (Aβ) is a causative protein of Alzheimer's disease (AD). In the pathogenesis of AD, the apolipoprotein (apo) A-I and high-density lipoprotein (HDL) metabolism is essential for the clearance of Aβ. In this study, recombinant Aβ42 was expressed and purified via the pET-30a expression vector and production system to elucidate the physiological effects of Aβ on HDL metabolism. Read More

View Article and Full-Text PDF

Correlative optical photothermal infrared and X-ray fluorescence for chemical imaging of trace elements and relevant molecular structures directly in neurons.

Light Sci Appl 2021 Jul 22;10(1):151. Epub 2021 Jul 22.

Medical Microspectroscopy, Department of Experimental Medical Science, Lund University, 22180, Lund, Sweden.

Alzheimer's disease (AD) is the most common cause of dementia, costing about 1% of the global economy. Failures of clinical trials targeting amyloid-β protein (Aβ), a key trigger of AD, have been explained by drug inefficiency regardless of the mechanisms of amyloid neurotoxicity, which are very difficult to address by available technologies. Here, we combine two imaging modalities that stand at opposite ends of the electromagnetic spectrum, and therefore, can be used as complementary tools to assess structural and chemical information directly in a single neuron. Read More

View Article and Full-Text PDF