3,861 results match your criteria oxidative thermal

Maturation of bovine oocytes under low culture temperature decreased glutathione peroxidase activity of both oocytes and blastocysts.

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Pol J Vet Sci 2021 Mar;24(1):93-99

Ondokuz Mayis University, Faculty of Agriculture, Department of Agricultural Biotechnology, 55139, Samsun, Turkey.

It is known that the basic variable in the cellular environment is temperature and low temperature decreases cellular metabolism rate. Also, low cellular metabolic activity reduces oxidative stress, resulting in low ROS production. The aim of this study was therefore to investigate the effect of 36. Read More

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Photobiomodulation Therapy on Myocardial Infarction in Rats: Transcriptional and Posttranscriptional Implications to Cardiac Remodeling.

Lasers Surg Med 2021 Apr 13. Epub 2021 Apr 13.

Universidade Nove de Julho, Rua Vergueiro 249, Liberdade, São Paulo, SP, 01504-001, Brazil.

Background And Objectives: Induction of myocardial infarction (MI) in rats by occlusion of the left anterior descending coronary artery is an experimental model used in research to elucidate functional, structural, and molecular modifications associated with ischemic heart disease. Photobiomodulation therapy (PBMT) has become a therapeutic alternative by modulating various biological processes eliciting several effects, including anti-inflammatory and pro-proliferative actions. The main objective of this work was to evaluate the effect of PBMT in the modulation of transcriptional and post-transcriptional changes that occurred in myocardium signal transduction pathways after MI. Read More

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Elucidation of DNA binding interaction of new Cu(II)/Zn(II) complexes derived from Schiff base and L-tryptophan amino acid: a multispectroscopic and molecular docking approach.

Environ Sci Pollut Res Int 2021 Apr 12. Epub 2021 Apr 12.

Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Herein, we describe the synthesis, structural elucidation, and DNA interaction of newly synthesized Cu(II) and Zn(II) complexes, i.e., [Cu(SB)(L-trp)(HO)]NO (1) and [Zn(SB)(L-trp)(HO)]NO (2) (SB = Schiff base obtained from the reaction between o-vanillin and 2-amino-2-methylpropane-1,3-diol; L-trp = L-tryptophan). Read More

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Clavulanic Acid Attenuating Effect on the Diabetic Neuropathic Pain in Rats.

Neurochem Res 2021 Apr 12. Epub 2021 Apr 12.

Cellular and Molecular Research Center, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Diabetic neuropathy is one of the most common complications of diabetes mellitus. Excess glutamate release and oxidative stress are hypothesized to be involved in the pathophysiology of diabetes-induced neuropathy. This study was designed to investigate the effect of clavulanic acid (CLAV), a competitive beta-lactamase inhibitor, on the streptozocin (STZ)-induced neuropathic pain and possible mechanisms in the spinal cord of rats. Read More

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Characterisation of a copper/zinc superoxide dismutase from Pieris rapae and its role in protecting against oxidative stress induced by chlorantraniliprole.

Pestic Biochem Physiol 2021 May 10;174:104825. Epub 2021 Mar 10.

Anhui Provincial Key Laboratory of Integrated Pest Management on Crops, Key Laboratory of Biology and Sustainable Management of Plant Diseases and Pests of Anhui Higher Education Institutes, School of Plant Protection, Anhui Agricultural University, Hefei 230036, China. Electronic address:

Insecticide exposure typically leads to abnormally high levels of reactive oxygen species (ROS) and oxidative damage in insects. Superoxide dismutases (SODs) are potent antioxidant enzymes for ROS scavenging that are essential to protect insects against insecticide-induced oxidative injury. The small white butterfly, Pieris rapae, is an economically important lepidopteran pest of cruciferous crops, and the anthranilic diamide insecticide chlorantraniliprole is widely used to control this organism. Read More

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Thermal stability of arsenic complexes in soils.

J Hazard Mater 2021 Mar 25;416:125715. Epub 2021 Mar 25.

Czech Geological Survey, Geologicka 6, 152 00 Prague 5, Czech Republic.

The release of soil arsenic (As) in an unsaturated zone under oxidative conditions and at two temperatures simulating the seasonal effect (15 °C and 23 °C) was studied in four cultivated soils from the Elbe River catchment (Czech Republic, Central Europe). The soils with a low geogenic As background contained from 10 to 50 µg.g of As, mostly originating from atmospheric deposition in the past. Read More

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Characterization of stress degradation products of nintedanib by UPLC, UHPLC-Q-TOF/MS/MS and NMR: Evidence of a degradation product with a structure alert for mutagenicity.

J Pharm Biomed Anal 2021 Mar 24;199:114037. Epub 2021 Mar 24.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), IDPL R&D Campus, Balanagar, Hyderabad, 500037, Telangana, India. Electronic address:

Nintedanib is an anti-cancer drug used for the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer. The purpose of this study was to explore its degradation chemistry under various stress conditions recommended in ICH guidelines Q1A R(2). The drug was subjected to hydrolytic, photolytic, thermal and oxidative (HO, AIBN, FeCl and FeSO) stress conditions. Read More

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Separation, identification and characterization of stress degradation products of bortezomib using HPLC and LC-MS.

Eur J Mass Spectrom (Chichester) 2021 Apr 7:14690667211006246. Epub 2021 Apr 7.

GVK Biosciences PVT Limited, IDA, Nacharam, Hyderabad, India.

Bortezomib (BT) is a reversible inhibitor of proteasome which is used in the treatment of hematological cancers. To study the degradation behavior, BT was subjected to acidic, basic, neutral, photolytic, oxidative and thermal degradation conditions as per ICH guideline Q1A (R2). A gradient HPLC method has been developed for separating all the degradation products formed under various degradation conditions on Waters XBridge C column (150 mm × 4. Read More

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Dicyanotriphenylamine-Based Polyimides as High-Performance Electrodes for Next Generation Organic Lithium-Ion Batteries.

ACS Appl Mater Interfaces 2021 Apr 7. Epub 2021 Apr 7.

Institute of Chemistry, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan.

Aromatic polyimide (PI) derivatives have recently been investigated as redox-active electrode materials for Li-ion batteries because of their high thermal stability and thermo-oxidative stability complemented by excellent solvent resistance, good electrical and mechanical properties, and chemical resistance. In this work, we report two PI derivatives from a newly synthesized 4,4'-diamino-3″,4″-dicyanotriphenylamine (DiCN-TPA) monomer and two dianhydrides, pyromellitic dianhydride (PMDA) and 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTCDA); designated as TPA-PMPI and TPA-NTCPI, respectively, as electrode materials for Li-ion batteries. Characterizations of the PIs reveal excellent thermal stability and bipolar property. Read More

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Establishment of validated stability indicating purity method based on the stress degradation behavior of gonadotropin-releasing hormone antagonist (ganirelix) in an injectable formulation using HPLC and LC-MS-QTOF.

Eur J Mass Spectrom (Chichester) 2021 Apr 7:14690667211005335. Epub 2021 Apr 7.

Department of Chemistry, 207673Koneru Lakshmaiah Education Foundation, Guntur, India.

Stress study of a drug substance or pharmaceutical drug product provides a vision into degradation pathways and degradation products of the active pharmaceutical ingredient and helps in interpretation of the chemical structure of the degradation impurities. In the current study, Ganirelix active ingredient presented in the Orgalutran® was stressed with acidic and alkali hydrolysis, photolysis, thermal and oxidation conditions as per the guidelines of International Conference on Harmonization (ICH) Q1A (R2). Ganirelix was found to be labile under thermal and alkali hydrolytic stress conditions, while it was stable to acid hydrolytic, oxidative and photolytic stress. Read More

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Synthesis and Chemistry of Benzo[][1,2,6]thiadiazino[3,4-][1,4]diazepin-10(11)-ones and Related Ring Transformations.

J Org Chem 2021 Apr 5. Epub 2021 Apr 5.

Department of Chemistry, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus.

2-[(3,5-Dichloro-4-1,2,6-thiadiazin-4-ylidene)amino]benzamides are cyclized to benzo[][1,2,6]thiadiazino[3,4-][1,4]diazepin-10(11)-ones via (i) treatment with NaH and via (ii) Pd-catalyzed C-N coupling. The behavior of the latter toward nucleophiles and thermal, oxidative, and reductive conditions revealed unexpected transformations to 3,5-dioxo-4,5-dihydro-3-benzo[][1,4]diazepine-2-carbonitrile and 2-(4-substituted-1,2,5-thiadiazol-3-yl)quinazolin-4(3)-ones. Read More

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The Characteristics of Natural Rubber Composites with Klason Lignin as a Green Reinforcing Filler: Thermal Stability, Mechanical and Dynamical Properties.

Polymers (Basel) 2021 Mar 31;13(7). Epub 2021 Mar 31.

Natural Resource Ecology and Management, Oklahoma State University, Stillwater, OH 74078, USA.

The objective of this work was to investigate the influences of Klason lignin as a filler on the thermal stability and properties of natural rubber composites. The modulus and tensile strength of stabilized vulcanizates were measured before and after thermo-oxidative aging. It was determined that lignin filled natural rubber had significantly enhanced thermo-oxidative aging and mechanical properties compared to those of controlled samples. Read More

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Comprehensive Thermal Characteristics of Different Cultivars of Flaxseed Oil ( L.).

Molecules 2021 Mar 31;26(7). Epub 2021 Mar 31.

Department of Pathophysiology, Faculty of Medicine, Medical University of Lublin, ul. Jaczewskiego 8b, 20-090 Lublin, Poland.

The aim of this study was to describe the thermal properties of selected cultivars of flaxseed oil by the use of the differential scanning calorimetry (DSC) technique. The crystallization and melting profiles were analyzed depending on different scanning rates (1, 2, 5 °C/min) as well as oxidative induction time (OIT) isothermally at 120 °C and 140 °C, and oxidation onset temperatures (Ton) at 2 and 5 °C/min were measured. The crystallization was manifested as a single peak, differing for a cooling rate of 1 and 2 °C/min. Read More

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The Archaeal Small Heat Shock Protein Hsp17.6 Protects Proteins from Oxidative Inactivation.

Int J Mol Sci 2021 Mar 4;22(5). Epub 2021 Mar 4.

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Small heat shock proteins (sHsps) are widely distributed among various types of organisms and function in preventing the irreversible aggregation of thermal denaturing proteins. Here, we report that Hsp17.6 from exhibited protection of proteins from oxidation inactivation. Read More

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Effect of Cooking Methods on the Antioxidant Capacity of Foods of Animal Origin Submitted to In Vitro Digestion-Fermentation.

Antioxidants (Basel) 2021 Mar 13;10(3). Epub 2021 Mar 13.

Departamento de Nutrición y Bromatología, Instituto de Nutrición y Tecnología de Alimentos, Centro de Investigación Biomédica, Universidad de Granada, 18071 Granada, Spain.

The human body is exposed to oxidative damage to cells and though it has some endogenous antioxidant systems, we still need to take antioxidants from our diet. The main dietary source of antioxidants is vegetables due to their content of different bioactive molecules. However, there are usually other components of the diet, such as foods of animal origin, that are not often linked to antioxidant capacity. Read More

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Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs.

Cancers (Basel) 2021 Mar 29;13(7). Epub 2021 Mar 29.

Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.

Purpose: This study aimed to assess the potential of flavonoids in combating CIPN.

Methods: PubMed and Google Scholar were used, and studies that investigated flavonoids in models of CIPN and models of neuropathic pain similar to CIPN were included. Only studies investigating peripheral mechanisms of CIPN were used. Read More

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Thermal Decomposition Behavior of Prussian Blue in Various Conditions.

Materials (Basel) 2021 Mar 1;14(5). Epub 2021 Mar 1.

Nanomaterials Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba 305-8565, Japan.

Prussian blue analogs (PBA) are widely studied for radioactive cesium decontamination. However, there are fewer works related to their post use storage. Considering the oxidative stabilization of the material after the selective uptake of Cs, the thermogravimetric properties in powder and bead form, with various Cs and other alkali metal ions adsorbed, and various heating rates were studied. Read More

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Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74.

Viruses 2021 Mar 15;13(3). Epub 2021 Mar 15.

Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

Small molecules targeting the PF74 binding site of the HIV-1 capsid protein (CA) confer potent and mechanistically unique antiviral activities. Structural modifications of PF74 could further the understanding of ligand binding modes, diversify ligand chemical classes, and allow identification of new variants with balanced antiviral activity and metabolic stability. In the current work, we designed and synthesized three series of PF74-like analogs featuring conformational constraints at the aniline terminus or the phenylalanine carboxamide moiety, and characterized them using a biophysical thermal shift assay (TSA), cell-based antiviral and cytotoxicity assays, and in vitro metabolic stability assays in human and mouse liver microsomes. Read More

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Combining Patulin with Cadmium Induces Enhanced Hepatotoxicity and Nephrotoxicity In Vitro and In Vivo.

Toxins (Basel) 2021 Mar 18;13(3). Epub 2021 Mar 18.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, Beijing Key Laboratory for Food Non-Thermal Processing, China Agricultural University, No.17 Qinghua East Road, Haidian District, Beijing 100083, China.

Food can be contaminated by various types of contaminants such as mycotoxins and toxic heavy metals. Therefore, it is very likely that simultaneous intake of more than one type of food contaminant by consumers may take place, which provides a strong rationale for investigating the combined toxicities of these food contaminants. Patulin is one of the most common food-borne mycotoxins, whereas cadmium is a representative of toxic heavy metals found in food. Read More

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Influence of Complexation of Thiosemicarbazone Derivatives with Cu (II) Ions on Their Antitumor Activity against Melanoma Cells.

Int J Mol Sci 2021 Mar 18;22(6). Epub 2021 Mar 18.

Faculty of Science, Siedlce University of Natural Sciences and Humanities, 3 Maja 54, 08-110 Siedlce, Poland.

A series of thiosemicarbazone derivatives was prepared and their anti-tumor activity in vitro was tested. The X-ray investigation performed for compounds T2, T3 and T5 confirmed the synthesis pathway and assumed molecular structures of analyzed thiosemicarbazones. The conformational preferences of the thiosemicarbazone system were characterized using theoretical calculations by AM1 method. Read More

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Comparative Study of Thermal-Oxidative Aging and Salt Solution Aging on Bitumen Performance.

Materials (Basel) 2021 Mar 3;14(5). Epub 2021 Mar 3.

Department of Civil and Environmental Engineering, Norwegian University of Science and Technology, Høgskoleringen 7A, 7491 Trondheim, Norway.

The aging of bitumen is detrimental to the durability and service life of asphalt pavement. Previous studies found that bitumen was suspected to be aged by not only thermal oxidation but also solution immersion. This research aims to compare the effect of thermal-oxidative aging and salt solution aging on bitumen performance. Read More

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Caffeic and Dihydrocaffeic Acids Promote Longevity and Increase Stress Resistance in by Modulating Expression of Stress-Related Genes.

Molecules 2021 Mar 10;26(6). Epub 2021 Mar 10.

Grupo de Investigación en Polifenoles (GIP-USAL), Unidad de Nutrición y Bromatología, Facultad de Farmacia, Campus Miguel de Unamuno, Universidad de Salamanca, 37007 Salamanca, Spain.

Caffeic and dihydrocaffeic acid are relevant microbial catabolites, being described as products from the degradation of different phenolic compounds i.e., hydroxycinnamoyl derivatives, anthocyanins or flavonols. Read More

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Antioxidants, Food Processing and Health.

Antioxidants (Basel) 2021 Mar 11;10(3). Epub 2021 Mar 11.

Laboratory of Oxidative Stress Research, Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, SI-1000 Ljubljana, Slovenia.

The loss and/or modification of natural antioxidants during various food processing techniques and storage methods, like heat/thermal, UV, pulsed electric field treatment, drying, blanching and irradiation is well described. Antioxidants in their reduced form are modified mainly by oxidation, and less by pyrolysis and hydrolysis. Thus, they are chemically converted from the reduced to an oxidized form. Read More

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Impact of the Resistance Responses to Stress Conditions Encountered in Food and Food Processing Environments on the Virulence and Growth Fitness of Non-Typhoidal .

Foods 2021 Mar 14;10(3). Epub 2021 Mar 14.

Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Instituto Agroalimentario de Aragón-IA2-(Universidad de Zaragoza-CITA), 50013 Zaragoza, Spain.

The success of as a foodborne pathogen can probably be attributed to two major features: its remarkable genetic diversity and its extraordinary ability to adapt. cells can survive in harsh environments, successfully compete for nutrients, and cause disease once inside the host. Furthermore, they are capable of rapidly reprogramming their metabolism, evolving in a short time from a stress-resistance mode to a growth or virulent mode, or even to express stress resistance and virulence factors at the same time if needed, thanks to a complex and fine-tuned regulatory network. Read More

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