280,886 results match your criteria oxidative stress

Comprehensive evolutionary analysis and nomenclature of plant G3BPs.

Life Sci Alliance 2022 Sep 26;5(9). Epub 2022 May 26.

Center for Desert Agriculture (CDA), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia

Stress induces extensive reprogramming of mRNA metabolism, which includes the transcription and translation of stress-related genes and the formation of stress granules. RasGAP SH3 domain-binding proteins (G3BPs, also called Rasputins) form a highly conserved family of proteins found throughout eukaryotic evolution, which coordinate signal transduction and posttranscriptional gene regulation and play a key role in the formation of stress granules. G3BPs play a role in osmotic, oxidative, and biotic stress in mammals, and recent results revealed that they play similar functions in higher plants. Read More

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September 2022

Evaluation of mitochondrial oxidative toxicity in mammalian cardiomyocytes by determining the highly reproducible and reliable increase in mitochondrial superoxides after exposure to therapeutic drugs.

Toxicol In Vitro 2022 May 23:105393. Epub 2022 May 23.

Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea. Electronic address:

Mitochondria are important cytoplasmic elements present in eukaryotic cells, and are involved in converting energy to ATP through oxidative phosphorylation. Mitochondria are vulnerable to reactive oxygen species (ROS), thereby making it imperative to evaluate the toxicity. However, existing methods that evaluate mitochondrial toxicity in cardiomyocytes are limited. Read More

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Quantitative proteomics reveals the antibiotics adaptation mechanism of Aeromonas hydrophila under kanamycin stress.

J Proteomics 2022 May 23:104621. Epub 2022 May 23.

National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address:

Aeromonas hydrophila is a widespread opportunistic pathogen of aquatic fishes in freshwater habitats. The current emergence of antimicrobial-resistant A. hydrophila has been reported in the world while the bacterial antibiotics adaptive mechanism remains poorly explored. Read More

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Fluorinated diselenide nanoparticles for radiosensitizing therapy of cancer.

Free Radic Biol Med 2022 May 23. Epub 2022 May 23.

Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovsky Sq.2, 162 06, Prague 6, Czech Republic.

Radiation resistance of cancer cells represents one of the major challenges in cancer treatment. The novel self-assembled fluoralkylated diselenide nanoparticles (fluorosomes) based on seleno-l-cystine (17FSe) possess redox-active properties that autocatalytically decompose hydrogen peroxide (HO) and oxidize the intracellular glutathione (GSH) that results in regulation of cellular oxidative stress. Alkylfluorinated diselenide nanoparticles showed a significant cytotoxic and radiosensitizing effect on cancer cells. Read More

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Cholesterol accumulation induced by acetylated LDL exposure modifies the enzymatic activities of the TCA cycle without impairing the respiratory chain functionality in macrophages.

Biochimie 2022 May 23. Epub 2022 May 23.

Université Paris-Saclay, EA 7357, Lipides: systèmes analytiques et biologiques, Châtenay-Malabry, 92296, France; Hôpital Bicêtre, AP-HP, Laboratoire de Biochimie, Le Kremlin Bicêtre, 94270, France.

The unregulated uptake of modified low-density lipoproteins (LDL) by macrophages leads to foam cell formation, promoting atherosclerotic plaque progression. The cholesterol efflux capacity of macrophages by the ATP-Binding Cassette transporters depends on the ATP mitochondrial production. Therefore, the mitochondrial function maintenance is crucial in limiting foam cell formation. Read More

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Sexual Dimorphism in Renal Heme Oxygenase-1 and Arachidonic Acid Metabolizing Enzymes in Spontaneously Hypertensive Rats versus Normotensive Wistar Kyoto Rats.

Prostaglandins Other Lipid Mediat 2022 May 23:106650. Epub 2022 May 23.

Department of Oral Biology & Diagnostic Sciences, Augusta University, Augusta, GA. 30912; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Mansoura University, Egypt. Electronic address:

Numerous studies have demonstrated a sexual dimorphism in blood pressure (BP) control in spontaneously hypertensive rats (SHR), however the mechanisms remain to be further elucidated. Based on the established role of arachidonic acid metabolites and heme oxygenase (HO) in BP control, we hypothesize that higher BP in male SHR is associated with differential expression in renal HO and arachidonic acid metabolizing enzymes vs. female SHR. Read More

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Determination of cytotoxicity following oxidative treatment of pharmaceutical residues in wastewater.

Chemosphere 2022 May 23:135022. Epub 2022 May 23.

Department for Health Evidence, Radboud Institute for Health Sciences, Radboudumc, Nijmegen, the Netherlands.

Pharmaceutical residues are released in the aquatic environment due to incomplete removal from wastewater. With the presence of multiple chemicals in sewage waters, contaminants may adversely affect the effectiveness of a wastewater treatment plant (WWTP). In certain cases, discharged metabolites are transformed back into their pristine structure and become bioactive again. Read More

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Inflammation resolution in environmental pulmonary health and morbidity.

Toxicol Appl Pharmacol 2022 May 23:116070. Epub 2022 May 23.

National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address:

Inflammation and resolution are dynamic processes comprised of inflammatory activation and neutrophil influx, followed by mediator catabolism and efferocytosis. These critical pathways ensure a return to homeostasis and promote repair. Over the past decade research has shown that diverse mediators play a role in the active process of resolution. Read More

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Estrogen Dampens Central Cannabinoid Receptor 1-mediated Neuroexcitation and Pressor Response in Conscious Female Rats.

Biochem Pharmacol 2022 May 23:115102. Epub 2022 May 23.

Department of Pharmacology & Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.

Activation of the rostral ventrolateral medulla (RVLM) cannabinoid receptor-1 (CBR) causes nNOS-dependent increases in sympathetic activity, blood pressure (BP) and heart rate (HR) in male rats. However, it remains unknown if the CBR-mediated neurochemical and cardiovascular responses are influenced by the ovarian sex hormones, particularly estrogen (E). Therefore, we studied the effects of intra-RVLM CBR activation (WIN 55,212-2) on BP and HR in conscious female rats under the following hormonal states: (1) highest E level (proestrus sham-operated, SO); (2) E-deprivation (ovariectomized, OVX); (3) OVX with E replacement (OVXE2). Read More

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Plppr5 gene inactivation causes a more severe neurological phenotype and abnormal mitochondrial homeostasis in a mouse model of juvenile seizure.

Epilepsy Res 2022 May 20;183:106944. Epub 2022 May 20.

Division of Brain Science, Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China. Electronic address:

Mice with inactivation of the Plppr5 gene (Plppr5-/-) had aggravated hypoxic-ischemic damage and partially weakened neuroprotection of melatonin (a mitochondrial targeted antioxidant), suggesting that abnormal mitochondrial homeostasis contributes to neurological abnormalities in these mice. We examined the hypothesis that Plppr5 inactivation disturbs mitochondrial homeostasis, which may cause long-term adverse consequences on behavior and cognition. We studied the long-term effects of Plppr5 knockout (KO) in both wild-type (WT) and Plppr5-null mice using a combination of neurobehavior, cognition, and standard cellular glutamate-induced excitotoxicity techniques. Read More

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Low level of mancozeb exposure affects ovary in mice.

Ecotoxicol Environ Saf 2022 May 23;239:113670. Epub 2022 May 23.

College of Traditional Chinese Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China. Electronic address:

Mancozeb (MCZ) is widely used as a protective fungicide. This study aimed to explore the effects of low level MCZ exposure on ovary in mice. Twenty Kunming mice were randomly divided into control and MCZ groups (10 mice each). Read More

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Association of DNA methylation in circulating CD4T cells with short-term PM pollution waves: A quasi-experimental study of healthy young adults.

Ecotoxicol Environ Saf 2022 May 23;239:113634. Epub 2022 May 23.

Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health, Xi'an, Shaanxi, China; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, Shaanxi, China. Electronic address:

Background: Fine particulate matter (PM) is a modifiable environmental risk factor with established adverse effects on human health. However, associations between acute PM fluctuation and DNA methylation remain unknown.

Methods: A quasi-experimental study utilizing naturally occurring PM pollution waves (PPWs) was conducted on 32 healthy young adults. Read More

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Melatonin enhances the antioxidant capacity to rescue the honey bee Apis mellifera from the ecotoxicological effects caused by environmental imidacloprid.

Ecotoxicol Environ Saf 2022 May 23;239:113622. Epub 2022 May 23.

College of Life Sciences, Chongqing Normal University, Chongqing, China; Chongqing Key Laboratory of Microsporidia Infection and Control, China; The State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.

Imidacloprid severely poisons the nontarget insect honey bee Apis mellifera. Few treatments are available to mitigate the adverse effects of imidacloprid. The primary concern is that the molecular understanding of imidacloprid toxicity is not comprehensive enough. Read More

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Protective effects and mechanisms of lycorine against adriamycin-induced cardiotoxicity.

Phytomedicine 2022 May 17;102:154178. Epub 2022 May 17.

Department of Cardiothoracic Surgery, Central Theater Command General Hospital of Chinese People's Liberation Army, 627 Wuluo Road, Wuhan 430070, China. Electronic address:

Background: Adriamycin (ADR), a high-efficiency, broad-spectrum anthraquinone chemotherapeutic agent, is currently used to treat various malignant tumors and can lead to cumulative, dose-dependent, and irreversible cardiotoxicity. Lycorine (LYC) is a benzyl phenethylamine alkaloid that exerts remarkable therapeutic effects on cancers and sepsis.

Purpose: However, researchers have not yet elucidated whether LYC exerts protective effects against cardiotoxicity induced by ADR and the possible molecular mechanisms. Read More

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A comprehensive system review of pharmacological effects and relative mechanisms of Ginsenoside Re: Recent advances and future perspectives.

Phytomedicine 2022 May 13;102:154119. Epub 2022 May 13.

Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, China; Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, 350122, China; Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou, 350122, China. Electronic address:

Background: Ginsenoside Re (Re) belongs to protopanaxatriol saponins and exists in Panax ginseng, Panax quinquefolium, Panax notoginseng, and other plants in the Araliaceae family. Re has recently become a research focus owing to its pharmacological activities and benefits to human bodies.

Purpose: To summarize recent findings regarding the pharmacological effects and mechanisms of Re and highlight and predict the potential therapeutic effects and systematic mechanism of Re. Read More

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Intergenerational and biological effects of roxithromycin and polystyrene microplastics to Daphnia magna.

Aquat Toxicol 2022 May 7;248:106192. Epub 2022 May 7.

Ningbo Water Supply Co Ltd, Ningbo 315041, China.

The influence of microplastics (MPs) on transgenerational effects of pharmaceuticals are drawing growing attention, however, whether aged process will alter the carrier effects of MPs were unknown. In this study, the intergenerational toxicity of single and combined exposure of polystyrene microplastics (PS-MPs) and roxithromycin (ROX) were investigated at the environmentally related concentrations, using Daphina magna as test organism. In the presence of UV-aged PS-MPs, the survival of D. Read More

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Acute exposure to polystyrene nanoplastics impairs skin cells and ion regulation in zebrafish embryos.

Aquat Toxicol 2022 May 19;248:106203. Epub 2022 May 19.

Department of Life Science, School of Life Science, National Taiwan Normal University, Taipei, Taiwan; Biodiversity Program, Taiwan International Graduate Program, Biodiversity Research Center, Academia Sinica and National Taiwan Normal University, Taipei, Taiwan. Electronic address:

The presence of nanoplastics in aquatic environments is a global problem. Accumulating evidence shows that nanoplastics can accumulate in fish and influence internal organs. However, it is still unknown if nanoplastics can impair skin cells (keratinocytes and ionocytes), which play critical roles in maintaining body fluid homeostasis. Read More

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D-ribose-L-cysteine reduces oxidative stress and inflammatory cytokines to mitigate liver damage, and memory decline induced by copper sulfate in mice.

J Trace Elem Med Biol 2022 May 18;73:127001. Epub 2022 May 18.

Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. Electronic address:

Background: Current evidences have implicated copper in amyloid aggregation that trigger the downstream oxidative stress-mediated neuroinflammation that characterized memory deterioration in patients with Alzheimer's disease (AD). Thus, this study was designed to evaluate the effect of D-Ribose-L-Cysteine (DRLC), a potent antioxidant agent, on copper sulfate (CuSO)-induced memory deterioration and the biochemical mechanisms underpinning its action in mice.

Methods: Male Swiss mice were randomly distributed into 5 groups (n = 10/group). Read More

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Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes.

J Trace Elem Med Biol 2022 May 20;73:127004. Epub 2022 May 20.

Institute for Medical Research and Occupational Health, Zagreb, Croatia. Electronic address:

Background: Silver nanoparticles (AgNP) are one of the most commercialized types of nanomaterials, with a wide range of applications owing to their antimicrobial activity. They are particularly important in hospitals and other healthcare settings, where they are used to maintain sterility of surfaces, textiles, catheters, medical implants, and more. However, AgNP can not only harm bacteria, but also damage mammalian cells and tissue. Read More

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Improvements of autism-like behaviors but limited effects on immune cell metabolism after mitochondrial replacement in BTBR TItpr3/J mice.

J Neuroimmunol 2022 May 19;368:577893. Epub 2022 May 19.

Wadsworth Center, New York State Department of Health, Albany, NY, USA; University at Albany School of Public Health, Rensselaer, NY, USA. Electronic address:

Mitochondria-mediated metabolic impairment and dysfunction are highly related with autism. Herein, the mitochondria-mediated metabolism of BTBR TItpr3/J (BTBR) mice with autistic-like behaviors was investigated. A new BTBR-mt strain generated by deriving BTBR mice with C57BL/6J (B6) mitochondria was used to determine the role of the mitochondrial genome. Read More

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Phytochemical characterisation, antioxidant capacity, and toxicity of gomes crude extracts.

Nat Prod Res 2022 May 26:1-5. Epub 2022 May 26.

Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil.

is a species used in folk medicine and rich in active compounds. In this study, the extracts were submitted to UHPLC-ESI-MS/MS analysis and total polyphenols, tannins, and flavonoids assays. Besides, it was determined its antioxidant capacity, oxidative stress markers and toxicological profile. Read More

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Models predict planned phosphorus load reduction will make Lake Erie more toxic.

Science 2022 May 26;376(6596):1001-1005. Epub 2022 May 26.

Department of Microbiology, University of Tennessee, Knoxville, TN, USA.

Harmful cyanobacteria are a global environmental problem, yet we lack actionable understanding of toxigenic versus nontoxigenic strain ecology and toxin production. We performed a large-scale meta-analysis including 103 papers and used it to develop a mechanistic, agent-based model of growth and microcystin production. Simulations for Lake Erie suggest that the observed toxigenic-to-nontoxigenic strain succession during the 2014 Toledo drinking water crisis was controlled by different cellular oxidative stress mitigation strategies (protection by microcystin versus degradation by enzymes) and the different susceptibility of those mechanisms to nitrogen limitation. Read More

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Utility of Cardiac Troponins in Patients with Chronic Kidney Disease.

Cardiol Rev 2022 May 26. Epub 2022 May 26.

Division of Nephrology/Department of Medicine, Jacobi Medical Center at Albert Einstein College of Medicine.

Cardiovascular disease is a major cause of death worldwide especially in patients with chronic kidney disease (CKD). Troponin T and troponin I are cardiac biomarkers used not only to diagnose acute myocardial infarction (AMI) but also to prognosticate cardiovascular and all-cause mortality. The diagnosis of AMI in the CKD population is challenging because of their elevated troponins at baseline. Read More

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Saprirearine protects H9c2 cardiomyocytes against hypoxia/reoxygenation-induced apoptosis by activating Nrf2.

Acta Biochim Pol 2022 May 26. Epub 2022 May 26.

Department of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, China.

Myocardial infarction is a major cause of mortality and disability worldwide. Ischemia/reperfusion injury is the key factor that results in the increase in infarct size in pathogenesis. To find a novel therapy for myocardial infarction, we have evaluated saprirearine, a natural diterpenoid, using H9c2 cardiomyocytes injured by hypoxia/reoxygenation and explored the possible mechanisms. Read More

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MicroRNA-7a-5p ameliorates diabetic peripheral neuropathy by regulating VDAC1/JNK/c-JUN pathway.

Diabet Med 2022 May 26:e14890. Epub 2022 May 26.

Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin 300052, China.

Aims: The pathogenesis of diabetic peripheral neuropathy (DPN) is complex, and its treatment is extremely challenging. MicroRNA-7a-5p (miR-7a-5p) has been widely reported to alleviate apoptosis and oxidative stress in various diseases. This study aimed to investigate the mechanism of miR-7a-5p in DPN. Read More

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Human Obesity Attenuates Cardioprotection Conferred by Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells.

J Cardiovasc Transl Res 2022 May 26. Epub 2022 May 26.

Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

To explore the impact of obesity on reparative potency of adipose tissue-derived mesenchymal stromal/stem cells (A-MSC) in hypertensive cardiomyopathy, A-MSC were harvested from subcutaneous fat of obese and age-matched non-obese human subjects during bariatric or kidney donation surgeries, and then injected into mice 2 weeks after inducing renovascular hypertension (RVH) or sham surgery. Two weeks later, left ventricular (LV) function and deformation were estimated in vivo by micro-magnetic resonance imaging and myocardial damage ex vivo. Blood pressure and myocardial wall thickening were elevated in RVH + Vehicle and normalized only by lean-A-MSC. Read More

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Albumin therapy for hepatic encephalopathy: current evidence and controversies.

Metab Brain Dis 2022 May 26. Epub 2022 May 26.

Yong Loo Lin School of Medicine, National University of Singapore, Queenstown, Singapore.

Hepatic encephalopathy (HE) is a common complication that occurs in 16-21% of end-stage cirrhosis patients. Emerging evidence suggests that systemic inflammation and oxidative stress may play a role in the development of HE. Recent understanding on the anti-inflammatory properties of human albumin has led to growing interest of using human albumin for the treatment and prevention of HE among decompensated patients. Read More

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Crosstalk between Sirtuins and Nrf2: SIRT1 activators as emerging treatment for diabetic neuropathy.

Metab Brain Dis 2022 May 26. Epub 2022 May 26.

Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai, 400098, India.

About 50% of the diabetic patients worldwide suffer from Diabetic peripheral neuropathy (DPN) which is characterized by chronic pain and loss of sensation, frequent foot ulcerations, and risk for amputation. Numerous factors like hyperglycemia, oxidative stress (OS), impaired glucose signaling, inflammatory responses, neuronal cell death are known to be the various mechanisms underlying DACD and DPN. Development of tolerance, insufficient and inadequate relief and potential toxicity of classical antinociceptives still remains a challenge in the clinical setting. Read More

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Cancer, Phase Angle and Sarcopenia: The Role of Diet in Connection with Lung Cancer Prognosis.

Lung 2022 May 26. Epub 2022 May 26.

Department of Nutritional Sciences and Dietetics, International Hellenic University, Sindos, Thessaloniki, Greece.

Lung cancer is the most common cause of cancer death and is associated with malnutrition and sarcopenia. The detection of sarcopenia and conduction of simple body composition measurements, such as the phase angle (PhA) deriving from bioelectrical impedance analysis (BIA), can help to early identify, monitor, prevent and treat malnutrition. The present review aims to clarify the relationship between PhA and sarcopenia with the pathophysiology, clinical outcomes, and therapeutic aspects of lung cancer. Read More

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Plasma proteomics reveals an improved cardio-metabolic profile in patients with type 2 diabetes post-liraglutide treatment.

Diab Vasc Dis Res 2022 May-Jun;19(3):14791641221094322

Department of Medicine, College of Medicine and King Saud Medical City, King Saud University, Riyadh, Saudi Arabia.

Background: Diabetes mellitus is a chronic multisystem disease with a high global prevalence, including in Saudi Arabia. The Glucagon-like Peptide (GLP-1) receptor agonist liraglutide is known to lower glucose levels, reduce weight and improve cardiovascular outcome. However, mechanisms underlying the benefits of liraglutide treatment in patients with type 2 diabetes mellitus (T2DM) remain unclear. Read More

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