27,809 results match your criteria oxidative processes


Lipid overload impairs hepatic VLDL secretion via oxidative stress-mediated PKCδ-HNF4α-MTP pathway in large yellow croaker (Larimichthys crocea).

Free Radic Biol Med 2021 Jun 8. Epub 2021 Jun 8.

Key Laboratory of Aquaculture Nutrition and Feed (Ministry of Agriculture and Rural Affairs) and Key Laboratory of Mariculture (Ministry of Education), Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong, People's Republic of China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, 1 Wenhai Road, 266237, Qingdao, Shandong, People's Republic of China. Electronic address:

Lipid overload-induced hepatic steatosis is a major public health problem worldwide. However, the potential molecular mechanism is not completely understood. Herein, we found that high-fat diet (HFD) or oleic acid (OA) treatment induced oxidative stress which prevented the entry of hepatocyte nuclear factor 4 alpha (HNF4α) into the nucleus by activating protein kinase C delta (PKCδ) in vivo and in vitro in large yellow croaker (Larimichthys crocea) This reduced the level of microsomal triglyceride transfer protein (MTP) transcription, resulting in the impaired secretion of very-low-density lipoprotein (VLDL) and the abnormal accumulation of triglyceride (TG) in hepatocytes. Read More

View Article and Full-Text PDF

Pathophysiological Aspects of the Development of Abdominal Aortic Aneurysm with a Special Focus on Mitochondrial Dysfunction and Genetic Associations.

Biomol Concepts 2021 Jun 11;12(1):55-67. Epub 2021 Jun 11.

Department of Basic Research, Institute for Atherosclerosis Research, Moscow121609, Russia.

Abdominal aortic aneurysm (AAA) is a complex degenerative vascular disease, with considerable morbidity and mortality rates among the elderly population. The mortality of AAA is related to aneurysm expansion (the enlargement of the aortic diameter up to 30 mm and above) and the subsequent rupture. The pathogenesis of AAA involves several biological processes, including aortic mural inflammation, oxidative stress, vascular smooth muscle cell apoptosis, elastin depletion, and degradation of the extracellular matrix. Read More

View Article and Full-Text PDF

Impact of the apelin/APJ axis in the pathogenesis of Parkinson's disease with therapeutic potential.

J Neurosci Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

The pathogenesis of Parkinson's disease (PD) remains elusive. There is still no available disease-modifying strategy against PD, whose management is mainly symptomatic. A growing amount of preclinical evidence shows that a complex interplay between autophagy dysregulation, mitochondrial impairment, endoplasmic reticulum stress, oxidative stress, and excessive neuroinflammation underlies PD pathogenesis. Read More

View Article and Full-Text PDF

Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis.

Shock 2021 Jun 10. Epub 2021 Jun 10.

Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de Sao Paulo - Sao Paulo - Brazil Laboratory of Medical Research - Faculty of Medicine of the University of São Paulo-USP, São Paulo, Brazil Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Abstract: Sepsis' pathogenesis involves multiple mechanisms that lead to a dysregulation of the host's response. Significant efforts have been made in search of interventions that can reverse this situation and increase patient survival. Poly (ADP-polymerase) (PARP) is a constitutive nuclear and mitochondrial enzyme, which functions as a co-activator and co-repressor of gene transcription, thus regulating the production of inflammatory mediators. Read More

View Article and Full-Text PDF

Mitochondrial function in development and disease.

Dis Model Mech 2021 Jun 11;14(6). Epub 2021 Jun 11.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often described as the cellular 'powerhouses' due to their essential role in aerobic oxidative phosphorylation, mitochondria perform many other essential functions beyond energy production. As signaling organelles, mitochondria communicate with the nucleus and other organelles to help maintain cellular homeostasis, allow cellular adaptation to diverse stresses, and help steer cell fate decisions during development. Read More

View Article and Full-Text PDF

Apoptotic mechanism of premature ovarian failure and rescue effect of Traditional Chinese Medicine: a review.

J Tradit Chin Med 2021 Jun;41(3):492-498

Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Social and environmental factors render premature ovarian failure (POF) as a major cause of decline or loss of female fertility. The natural pregnancy rate of patients with POF is only 5%-10%. Follicular atresia is the main factor in the pathogenesis of POF. Read More

View Article and Full-Text PDF

Tandem Mass Tag-Based Quantitative Proteomic Analysis of Chicken Bursa of Fabricius Infected With Reticuloendotheliosis Virus.

Front Vet Sci 2021 25;8:666512. Epub 2021 May 25.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.

Reticuloendotheliosis virus (REV) is a type C avian retrovirus that causes immunosuppression, dwarf syndrome, and lymphoma in infected hosts. In this study, we used tandem mass tag (TMT) labeling and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to characterize protein alterations in chicken bursa of Fabricius, before and after REV infection at 7, 14, 21, and 28 days. Our data showed that 1,127, 999, 910, and 1,138 differentially expressed proteins were significantly altered at 7, 14, 21, and 28 days after REV infection, respectively. Read More

View Article and Full-Text PDF

Kynurenines and Neurofilament Light Chain in Multiple Sclerosis.

Front Neurosci 2021 25;15:658202. Epub 2021 May 25.

Department of Neurology, Faculty of Medicine, University of Szeged, Szeged, Hungary.

Multiple sclerosis is an autoimmune, demyelinating, and neurodegenerative disease of the central nervous system. In recent years, it has been proven that the kynurenine system plays a significant role in the development of several nervous system disorders, including multiple sclerosis. Kynurenine pathway metabolites have both neurotoxic and neuroprotective effects. Read More

View Article and Full-Text PDF

Effects of purslane supplementation on C-reactive protein levels and biomarkers of oxidative stress as marks for metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials.

Phytother Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Endocrinology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.

The antioxidant and antiinflammatory properties of purslane (Portulaca oleracea L.) are known in preclinical studies but further examination is needed to expand their potential into the clinical scenario. A systematic review and meta-analysis of randomized controlled trials were performed to elucidate the effects of purslane supplementation on C-reactive protein (CRP) levels and biomarkers of oxidative stress in metabolic syndrome, its related complications, and other diseases. Read More

View Article and Full-Text PDF

Entangled radicals may explain lithium effects on hyperactivity.

Sci Rep 2021 Jun 9;11(1):12121. Epub 2021 Jun 9.

Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4, Canada.

It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium's effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dynamics of a naturally occurring radical pair involving oxygen. Read More

View Article and Full-Text PDF

Biogenic metallic elements in the human brain?

Sci Adv 2021 Jun 9;7(24). Epub 2021 Jun 9.

School of Pharmacy and Bioengineering, Guy Hilton Research Centre, Thornburrow Drive, Keele University, Staffordshire ST4 7QB, UK.

The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing positively charged Cu, Cu, Fe, and Fe control key processes, catalyzing oxidative metabolism and neurotransmitter and neuropeptide production. Here, we report the discovery of elemental (zero-oxidation state) metallic Cu accompanying ferromagnetic elemental Fe in the human brain. Read More

View Article and Full-Text PDF

The derepression of transposable elements in lung cells is associated with the inflammatory response and gene activation in idiopathic pulmonary fibrosis.

Mob DNA 2021 Jun 9;12(1):14. Epub 2021 Jun 9.

Department of Genetic Medicine, Weill Cornell Medical College, 1300 York Avenue, Box 164, New York, NY, 10065, USA.

Background: Transposable elements (TEs) are repetitive sequences of viral origin that compose almost half of the human genome. These elements are tightly controlled within cells, and if activated, they can cause changes in both gene regulation and immune viral responses that have been associated with several chronic inflammatory diseases in humans. As oxidants are potent activators of TEs, and because oxidative injury is a major risk factor in relation to idiopathic pulmonary fibrosis (IPF), we hypothesized that TEs might be involved in the regulation of gene expression and so contribute to inflammation in cases of IPF. Read More

View Article and Full-Text PDF

The clinical impact of maternal weight on offspring health: lights and shadows in breast milk metabolome.

Expert Rev Proteomics 2021 Jun 9. Epub 2021 Jun 9.

Neonatal Intensive Care Unit, Department of Surgical Sciences, AOU and University of Cagliari. SS 554 km 4,500, 09042 Monserrato. Italy.

Introduction: Pre-pregnancy overweight and obesity, depending on maternal nutrition and metabolic state, can influence fetal, neonatal and long-term offspring health, regarding cardio-metabolic, respiratory, immunological and cognitive outcomes. Thus, maternal weight can act, through mechanisms that are not full understood, on the physiology and metabolism of some fetal organs and tissues, to adapt themselves to the intrauterine environment and nutritional reserves. These effects could occur by modulating gene expression, neonatal microbiome, and through breastfeeding. Read More

View Article and Full-Text PDF

Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial.

Arterioscler Thromb Vasc Biol 2021 Jun 10:ATVBAHA121316388. Epub 2021 Jun 10.

Periodontology Unit, UCL Eastman Dental Institute and Hospital, University College London, United Kingdom. (M.O., Y.L., F.D.).

Objective: Inflammation, oxidative stress, and endothelial dysfunction are known to contribute to ischemia-reperfusion injury. Remote ischemic preconditioning (RIPC) protects from endothelial dysfunction and the damage induced by ischemia-reperfusion. Using intensive periodontal treatment (IPT), an established human model of acute systemic inflammation, we investigated whether RIPC prevents endothelial dysfunction and modulates systemic levels of inflammation and oxidative stress. Read More

View Article and Full-Text PDF

β-Adrenoceptor regulation of metabolism in U937 derived macrophages.

Mol Omics 2021 Jun 8. Epub 2021 Jun 8.

Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Science, Monash University, Parkville, Victoria 3052, Australia.

Macrophages have important roles in the immune system including clearing pathogens and wound healing. Metabolic phenotypes in macrophages have been associated with functional phenotypes, where pro-inflammatory macrophages have an increased rate of glycolysis and anti-inflammatory macrophages primarily use oxidative phosphorylation. β-adrenoceptor (βAR) signalling in macrophages has been implicated in disease states such as cancer, atherosclerosis and rheumatoid arthritis. Read More

View Article and Full-Text PDF

Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature.

Int J Womens Health 2021 1;13:525-537. Epub 2021 Jun 1.

Laboratory of Clinical Morphology, Research Institute of Human Morphology, Moscow, Russia.

Objective: To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress.

Methods: A systematic literature review regarding current aspects of endometriosis etiology, genesis and development was performed using the PubMed, Google Scholar, and eLibrary databases. Keywords included endometriosis, etiology, development, genesis, associations and mechanisms. Read More

View Article and Full-Text PDF

Gene expression in human umbilical vein endothelial cells exposed to fine particulate matter: RNA sequencing analysis.

Int J Environ Health Res 2021 Jun 9:1-13. Epub 2021 Jun 9.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Beijing University of Technology, Beijing, China.

Exposure to airborne particulate matter (PM2.5) is associated with cardiovascular diseases. In order to investigate the molecular mechanisms of air pollution-induced CVDs toxicity, human umbilical vein endothelial cells (HUVECs) were exposed to PM2. Read More

View Article and Full-Text PDF

Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury.

J Cereb Blood Flow Metab 2021 Jun 8:271678X211020629. Epub 2021 Jun 8.

Division of Internal Medicine, Universitätsspital and University of Zurich; Zurich, Switzerland.

Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) contributes to poor outcomes in patients after rupture of an intracranial aneurysm. The lack of diagnostic biomarkers and novel drug targets represent an unmet need. The aim of this study was to investigate the clinical and pathophysiological association between cerebrospinal fluid hemoglobin (CSF-Hb) and SAH-SBI. Read More

View Article and Full-Text PDF

Role of Iron in the Molecular Pathogenesis of Diseases and Therapeutic Opportunities.

ACS Chem Biol 2021 Jun 9. Epub 2021 Jun 9.

Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

Iron is an essential mineral that serves as a prosthetic group for a variety of proteins involved in vital cellular processes. The iron economy within humans is highly conserved in that there is no proper iron excretion pathway. Therefore, iron homeostasis is highly evolved to coordinate iron acquisition, storage, transport, and recycling efficiently. Read More

View Article and Full-Text PDF

Comparative transcriptomics analysis reveals differential Cd response processes in roots of two turnip landraces with different Cd accumulation capacities.

Ecotoxicol Environ Saf 2021 Jun 5;220:112392. Epub 2021 Jun 5.

Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Xishuangbanna 666303, China. Electronic address:

Understanding the molecular mechanisms of cadmium (Cd) tolerance and accumulation in plants is important to address Cd pollution. In the present study, we performed comparative transcriptome analysis to identify the Cd response processes in the roots of two turnip landraces, KTRG-B14 (high-Cd accumulation) and KTRG-B36 (low-Cd accumulation). Two common enhanced processes, glutathione metabolism and antioxidant system, were identified in both landraces. Read More

View Article and Full-Text PDF

Co-pyrolysis of spent radioactive ion exchange resin and manganese dioxide: Decrease the decomposition temperatures of functional groups.

J Hazard Mater 2021 Jun 1;418:126275. Epub 2021 Jun 1.

Department of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, China. Electronic address:

With the development of the nuclear industry and clean energy, spent radioactive ion exchange resin has become a major concern that needs to be solved urgently. In this study, the mixed resin (sulfonic aid and quaternary ammonium polystyrene beads, 1:2, v/v) is co-pyrolyzed with manganese dioxide in a tube furnace, selecting argon as the reaction atmosphere. Manganese dioxide exhibits unique catalytic and oxidative activity, and a low mass remaining efficiency of 34. Read More

View Article and Full-Text PDF

GCN5 enables HSP12 induction promoting chromatin remodeling not histone acetylation.

Biochem Cell Biol 2021 Jun 8. Epub 2021 Jun 8.

Università degli Studi di Roma La Sapienza, 9311, Dipartimento di Biologia e Biotecnologie, Piazzale A. Moro 5, Roma, Italy, 00185;

Regulation of stress responsive genes represents one of the best examples of gene induction and the relevance and involvement of different regulators may change for a given gene depending on the challenging stimulus. HSP12 gene is induced by very different stimuli, however the molecular response to the stress has been characterized in detail only for heat shock treatments. In this work we want to verify whether, the regulation of transcription induced by oxidative stress, utilizes the same epigenetic solutions relative to those employed in heat shock response. Read More

View Article and Full-Text PDF

The pleiotropic effects of Prunus avium L. extract against oxidative stress on human fibroblasts. An in vitro approach.

Mol Biol Rep 2021 Jun 7. Epub 2021 Jun 7.

Institute of Plant Breeding and Genetic Resources, ELGO-Dimitra (ex NAGREF), 57001, Thessaloniki, Greece.

There is a persistent interest in innovative and multifunctional ingredients in biology research. With regards to this, natural sources have an important role due to their multiple benefits. Thus, this study aims to present the pleiotropic activity of Prunus avium L. Read More

View Article and Full-Text PDF

Comprehensive transcriptome mining identified the gene expression signature and differentially regulated pathways of the late-onset preeclampsia.

Pregnancy Hypertens 2021 May 28;25:91-102. Epub 2021 May 28.

Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Preeclampsia (PE) is categorized as a pregnancy-related hypertensive disorder and is a serious concern in pregnancies. Several factors, including genetic factors (placenta gene expression, and imprinting), oxidative stress, the inaccurate immune response of the mother, and the environmental factors are responsible for PE development, but still, the exact mechanism of the pathogenesis has remained unknown. The main aim of the present study is to identify the gene expression signature in placenta tissue, to unveil disease etiology mechanisms. Read More

View Article and Full-Text PDF

A comprehensive review of cereal germ and its lipids: Chemical composition, multi-objective process and functional application.

Food Chem 2021 May 12;362:130066. Epub 2021 May 12.

College of Biosystems Engineering and Food Science, National Local Joint Engineering Laboratory for Intelligent Food Processing Technology and Equipment, Zhejiang Key Laboratory of Agricultural Products Processing Technology, Zhejiang Food Processing Technology and Equipment Engineering Laboratory, Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, China; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China. Electronic address:

Cereal germ (CG), a by-product of grain milling, has drawn much attention in the food industry because of its nutritional and functional advantages. Nowadays, the utilization of cereal germ from animal feeds to foodstuff is a popular trend. CGs have high content of polyunsaturated fatty acids in their lipids (43. Read More

View Article and Full-Text PDF

Cellular stress responses and metabolic reprogramming in cancer progression and dormancy.

Authors:
Kyle K Payne

Semin Cancer Biol 2021 Jun 4. Epub 2021 Jun 4.

Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA. Electronic address:

Recurrent disease after prolonged cancer dormancy is a major cause of cancer associated mortality, yet many of the mechanisms that are engaged to initiate dormancy as well as later recurrence remain incompletely understood. It is known that cancer cells initiate adaptation mechanisms to adapt tightly regulated cellular processes to non-optimal growth environments; Recent investigations have begun to elucidate the contribution of these mechanisms to malignant progression, with intriguing studies now defining cellular stress as a key contributor to the development and maintenance of cancer dormancy. This review will focus on our current understanding of stress responses facilitating malignant cell adaptation and metabolic reprogramming to establish cancer dormancy. Read More

View Article and Full-Text PDF

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium.

J Vis Exp 2021 May 18(171). Epub 2021 May 18.

Laboratorio de Hígado, Páncreas y Motilidad, Unidad de Medicina Experimental, Facultad de Medicina-UNAM, Hospital General de México "Dr. Eduardo Liceaga";

Metabolic dysfunction-associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease (NAFLD), is the most prevalent liver disease worldwide due to its relationship with obesity, diabetes type 2, and dyslipidemia. Hepatic steatosis, the accumulation of lipid droplets in the liver parenchyma, is a key feature of the disease preceding the inflammation observed in steatohepatitis, fibrosis, and end-stage liver disease. Lipid accumulation in hepatocytes might interfere with proper metabolism of xenobiotics and endogenous molecules, as well as to induce cellular processes leading to the advance of the disease. Read More

View Article and Full-Text PDF

Pharmacological or genetic inhibition of iNOS prevents cachexia-mediated muscle wasting and its associated metabolism defects.

EMBO Mol Med 2021 Jun 7:e13591. Epub 2021 Jun 7.

Department of Biochemistry, McGill University, Montreal, QC, Canada.

Cachexia syndrome develops in patients with diseases such as cancer and sepsis and is characterized by progressive muscle wasting. While iNOS is one of the main effectors of cachexia, its mechanism of action and whether it could be targeted for therapy remains unexplored. Here, we show that iNOS knockout mice and mice treated with the clinically tested iNOS inhibitor GW274150 are protected against muscle wasting in models of both septic and cancer cachexia. Read More

View Article and Full-Text PDF

Preservation of non-Saccharomyces yeasts: Current technologies and challenges.

Compr Rev Food Sci Food Saf 2021 Jun 6. Epub 2021 Jun 6.

Industrial Biotechnology Unit, Center for Research and Assistance in Technology and Design of the State of Jalisco, Zapopan, Mexico.

There is a recent and growing interest in the study and application of non-Saccharomyces yeasts, mainly in fermented foods. Numerous publications and patents show the importance of these yeasts. However, a fundamental issue in studying and applying them is to ensure an appropriate preservation scheme that allows to the non-Saccharomyces yeasts conserve their characteristics and fermentative capabilities by long periods of time. Read More

View Article and Full-Text PDF

Following the Dynamism of the Mitochondrial Network in T Cells.

Methods Mol Biol 2021 ;2310:287-299

Department of Biology, University of Rome Tor Vergata, Rome, Italy.

The dynamism of mitochondria, considered as complex and motile organelles, is brought about by mitochondria ability to undergo cycles of fission and fusion events, whose fine balance determines their morphology in a specific physiological context. A huge body of evidence makes it possible to associate mitochondrial organization to regulation of an increasing number of key cellular processes, such as biosynthetic pathways, oxidative phosphorylation and ATP production, calcium buffering, mtDNA homeostasis, autophagy, and cell death. Here, we review the recently developed imaging methods for studying mitochondrial dynamics, including live-cell imaging, by using mitochondrial-targeted fluorescent proteins. Read More

View Article and Full-Text PDF
January 2021