265,545 results match your criteria oxidative injury

Oxidative stress and DNA damage induced by trifloxystrobin on earthworms (Eisenia fetida) in two soils.

Sci Total Environ 2021 Jul 17;797:149004. Epub 2021 Jul 17.

College of Resources and Environment, Shandong Agricultural University, Key Laboratory of Agricultural Environment in Universities of Shandong, 61 Daizong Road, Taian 271018, China. Electronic address:

Trifloxystrobin is a new type of fungicide, which is extensively used due to its excellent antifungal activity. In this study, oxidative stress and DNA damage induced by trifloxystrobin exposure was evaluated using Eisenia fetida at subchronic toxicity concentrations in artificial soil and brown soil (0.1-2. Read More

View Article and Full-Text PDF

Oxidative stress and endoplasmic reticulum stress contributed to hepatotoxicity of decabromodiphenyl ethane (DBDPE) in L-02 cells.

Chemosphere 2021 Jul 13;286(Pt 1):131550. Epub 2021 Jul 13.

School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Electronic address:

Decabromodiphenyl ethane (DBDPE) is one of the most commonly used novel brominated flame retardants (NBFRs), and its mass production and widespread application have caused health threats to the human being. Existing studies have shown that DBDPE has hepatotoxicity. And we have found that DBDPE could change cytochrome P450 3A (CYP3A) expression levels in rat livers, whereas the mechanism is unclear. Read More

View Article and Full-Text PDF

Ecotoxicity of chlorpyrifos on earthworm Eisenia fetida (Savigny, 1826): Modifications in oxidative biomarkers.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jul 19:109145. Epub 2021 Jul 19.

Department of Basic Sciences, Faculty of Veterinary, Shahrekord University, Iran.

Chlorpyrifos (CPF; O, O'-diethyl-3, 5, 6-trichloro-2-pyridyl phosphorothionate) as an organophosphate compound with moderate toxicity that entered the soil in 1965, is widely used as an active substance of many insecticides. CPF may affect some biochemical mechanisms, particularly through disrupting pro- and anti-oxidant balance and inducing free radical-induced oxidative stress. Expired pesticides, if present in ecosystem, may pose new issues of toxicological concern. Read More

View Article and Full-Text PDF

New Determination Methods, Toxic Mechanisms, and Control Strategies (Preface to the special issue of Food and Chemical Toxicology on the Outcomes of Mycotoxins in Food).

Food Chem Toxicol 2021 Jul 19;155:112436. Epub 2021 Jul 19.

Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003, Hradec Králové, Czech Republic. Electronic address:

The special issue "Mycotoxins in Food: New Determination Methods, Toxic Mechanisms, and Control Strategies" in Food and Chemical Toxicology contains 28 articles on current hot topics in mycotoxins, including deoxynivalenol, T-2 toxin, and fumonisins. Intestinal toxicity, immune toxicity, and oxidative stress are especially concerned by researchers in this special issue; moreover, mycotoxin detoxification and exposure and assessments in humans are reported in this context. All the new results in this special issue will help to further understand the toxic mechanisms of mycotoxins and cast new light for the control of mycotoxin contamination. Read More

View Article and Full-Text PDF

Experimental respiratory exposure to putative Gulf War toxins promotes persistent alveolar macrophage recruitment and pulmonary inflammation.

Life Sci 2021 Jul 19:119839. Epub 2021 Jul 19.

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Aims: Respiratory disorders are a prominent component of Gulf War Illness. Although much of the underlying mechanisms of Gulf War Illness remain undefined, chronic immune dysfunction is a consistent feature of this multi-symptomatic, multi-organ disorder. Alveolar macrophages represent the predominant mononuclear phagocytes of the pulmonary mucosa, orchestrating the host response to pathogens and environmental stimuli. Read More

View Article and Full-Text PDF

Echinacea purpurea polysaccharide prepared by fractional precipitation prevents alcoholic liver injury in mice by protecting the intestinal barrier and regulating liver-related pathways.

Int J Biol Macromol 2021 Jul 19. Epub 2021 Jul 19.

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Synergetic Innovation Center for Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China. Electronic address:

Oxidative damage and intestinal dysbiosis are regarded as crucial culprits in alcoholic liver disease (ALD). This study aimed to examine the protective effects of Echinacea purpurea polysaccharides (EPPs) against ALD and explore the underlying mechanisms based on hepatic oxidative stress, inflammation, and intestinal barrier function. Three polysaccharide fractions, namely, EPP40, EPP60, and EPP80, were obtained by stepwise ethanol precipitation, and their antioxidant activity in vitro was investigated. Read More

View Article and Full-Text PDF

Using Transcriptomics and Metabolomics to Understand Species Differences in Sensitivity to Chlorpyrifos in Japanese Quail and Double-Crested Cormorant Embryos.

Environ Toxicol Chem 2021 Jul 22. Epub 2021 Jul 22.

Ecotoxicology and Wildlife Health Division, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON, Canada, K1A 0H3.

Modern 21 century toxicity testing makes use of omics technologies to address critical questions in toxicology and chemical management. Of interest are questions relating to chemical mechanisms of toxicity, differences in species sensitivity, and translation of molecular effects to observable apical endpoints. Our study addressed these questions by comparing apical outcomes and multiple omics responses in early-life stage exposure studies with Japanese quail (JQ; Coturnix japonica) and double-crested cormorant (DCCO; Phalacrocorax auritus), representing a model and ecological species, respectively. Read More

View Article and Full-Text PDF

MG53 suppresses NFκB activation to mitigate age-related heart failure.

JCI Insight 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgery, The Ohio State University, Columbus, United States of America.

Aging is associated with chronic oxidative stress and inflammation that impact the tissue repair and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell membrane injury in a redox-dependent manner. Here we demonstrate that the expression of MG53 is reduced in failing human heart and aging mouse heart, concomitant with elevated NFκB activation. Read More

View Article and Full-Text PDF

Ferroptosis-Strengthened Metabolic and Inflammatory Regulation of Tumor-Associated Macrophages Provokes Potent Tumoricidal Activities.

Nano Lett 2021 Jul 22. Epub 2021 Jul 22.

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, People's Republic of China.

Modulation of tumor-associated macrophages (TAMs) holds promise for cancer treatment, mainly relying on M1 signaling activation and pro-inflammatory promotion. Nevertheless, the antitumor activity is often limited by the anti-inflammatory factors in the tumor microenvironment. Moreover, the metabolic function of TAMs is also critical to tumor progression. Read More

View Article and Full-Text PDF

Cyclic, Hydrophobic Hexapeptide Fusahexin Is the Product of a Nonribosomal Peptide Synthetase in .

J Nat Prod 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry and Bioscience, Aalborg University, Frederik Bajers Vej 7H, DK-9220 Aalborg, Denmark.

The plant pathogenic fungus is known to produce a wide array of secondary metabolites during plant infection. This includes several nonribosomal peptides. Recently, the fusaoctaxin (/9) and gramilin () gene clusters were shown to be induced by host interactions. Read More

View Article and Full-Text PDF

Оxidative stress and endogenous intoxication in cancer patients.

Klin Lab Diagn 2021 Jul;66(7):401-406

Federal State Budgetary Institution "National Medical Research Center of Oncology N.N. Blokhin", under the Ministry of Health of the Russian Federation.

In the blood serum of 93 patients with various localities of the malignant process, the content of nitric oxide (NO), indicators of lipid peroxidation (POL): superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione in red blood cells were determined. 9 patients with ovarian cancer were examined during chemotherapy (6 courses), 40 patients with colon cancer, previously operated, were with malignant liver damage. In 39 patients with anemia, NO indicators were compared with the level of interleukin 6 (IL-6) and hepcidin-25 (GP-25). Read More

View Article and Full-Text PDF

Molecular Biology and Genetic Tools to Investigate Functional Redundancy Among Fe-S Cluster Carriers in E. coli.

Methods Mol Biol 2021 ;2353:3-36

Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, CNRS UMR 7283, Aix-Marseille University, Marseille, France.

Iron-sulfur (Fe-S) clusters are among the oldest protein cofactors, and Fe-S cluster-based chemistry has shaped the cellular metabolism of all living organisms. Over the last 30 years, thanks to molecular biology and genetic approaches, numerous actors for Fe-S cluster assembly and delivery to apotargets have been uncovered. In prokaryotes, Escherichia coli is the best-studied for its convenience of growth and its genetic amenability. Read More

View Article and Full-Text PDF
January 2021

A chronic low-dose magnesium L-lactate administration has a beneficial effect on the myocardium and the skeletal muscles.

J Physiol Biochem 2021 Jul 22. Epub 2021 Jul 22.

INRAE, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Université Clermont Auvergne, 28 Place Henri Dunant, 63000, Clermont-Ferrand, France.

The purpose of this study was to determine whether magnesium L-lactate is responsible for having a beneficial effect on the myocardium and the skeletal muscles and how this substrate acts at the molecular level. Twenty seven young male Wistar rats were supplied with a magnesium L-lactate (L) solution, a magnesium chloride (M) solution and/or water (W) as a vehicle for 10 weeks. The treated animals absorbed the L and M solutions as they wished since they also had free access to water. Read More

View Article and Full-Text PDF

A review on interplay between small RNAs and oxidative stress in cancer progression.

Mol Cell Biochem 2021 Jul 22. Epub 2021 Jul 22.

Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Chennai, 603 103, India.

Oxidative stress has been known to be the underlying cause in many instances of cancer development. The new aspect of cancer genesis that has caught the attention of many researchers worldwide is its connection to non-coding RNAs (ncRNAs). ncRNAs may not be protein coding, but in light of the more recent discovery of their wide range of functions, the term 'dark matter of the genome' has been rendered inapplicable. Read More

View Article and Full-Text PDF

Bone mineral density and oxidative stress in adolescent girls with anorexia nervosa.

Eur J Pediatr 2021 Jul 22. Epub 2021 Jul 22.

Department of Pediatrics, Faculty of Medicine, National Institute of Children's Diseases, Comenius University, Limbová 1, 833 40, Bratislava, Slovakia.

Oxidative stress appears to be involved in the pathogenesis of osteoporosis-a serious complication of anorexia nervosa (AN). We evaluated the oxidative status in adolescent girls with AN and its potential relationship with bone mineral density (BMD). Girls with AN (n = 43) and age-matched healthy controls (n = 20) underwent anthropometric and BMD examination. Read More

View Article and Full-Text PDF

Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats.

J Asian Nat Prod Res 2021 Jul 22:1-12. Epub 2021 Jul 22.

Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

The purpose of the present study was to examine the protective action and mechanisms of quercetin on the blood-brain barrier (BBB) in rats subjected to transient middle cerebral artery occlusion (tMCAO) and reperfusion. Quercetin (10, 30, 50 mg/kg) was intraperitoneally administered at the onset of reperfusion. The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway. Read More

View Article and Full-Text PDF

A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation .

J Asian Nat Prod Res 2021 Jul 22:1-12. Epub 2021 Jul 22.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Dimethyl itaconate (DMI) is an analog of dimethyl fumarate (DMF), an approved NF-E2-related Factor 2 (Nrf2) activator for multiple sclerosis. This study evaluated the potential of DMI as an anti-inflammatory agent by comparing DMI with DMF in electrophilicity, Nrf2 activation, and anti-inflammation . The results showed that DMI was less electrophilic but better at inducing a durable activation of Nrf2 when compared with DMF. Read More

View Article and Full-Text PDF

Aqueous-alcoholic Ferulla extract reduces memory impairments in rats exposed to cadmium chloride.

Brain Behav 2021 Jul 21. Epub 2021 Jul 21.

Neuroscience, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

Introduction: Cadmium (Cd) is the most dangerous heavy metal that is becoming more widespread in nature as a result of industrial activities. One of the toxic effects of Cd on the body is its neurological effect. The mechanism of these effects has been attributed to the induction of oxidative stress. Read More

View Article and Full-Text PDF

Early triggers of moderately high-fat diet-induced kidney damage.

Physiol Rep 2021 Jul;9(14):e14937

Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Most of the obesity murine models inducing renal injury use calorie-enriched foods, where fat represents 60% of the total caloric supply, however, this strategy doubles the standard proportion of fat ingestion in obese patients. Therefore, it is crucial to study the impact of a high-fat intake on kidney physiology that resembles common obesity in humans to understand the trigger mechanisms of the long-term consequences of overweight and obesity. In this study, we analyzed whether chronic feeding with a moderately high fat diet (MHFD) representing 45% of total calories, may induce kidney function and structural injury compared to C57BL/6 mice fed a control diet. Read More

View Article and Full-Text PDF

Vitamin D improves oxidative stress and histopathological damage in rat ovaries caused by hyperthyroidism.

J Obstet Gynaecol Res 2021 Jul 21. Epub 2021 Jul 21.

Department of Gynecology and Obstetrics, Adıyaman University School of Medicine, Adıyaman, Turkey.

Objective: The aim of this study is to investigate the histopathological and biochemical efficacy of vitamin D on oxidative damage and fibrosis in rat ovaries induced by experimental hyperthyroidism.

Methods: This study is a comparative, prospective experimental rat study. Sprague-Dawley female rats were divided into four groups. Read More

View Article and Full-Text PDF

Fish oil-based lipid emulsion alleviates parenteral nutrition-associated liver diseases and intestinal injury in piglets.

JPEN J Parenter Enteral Nutr 2021 Jul 21. Epub 2021 Jul 21.

Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background And Aims: This study aimed to investigate the impact of fish oil-based lipid emulsion (FO) on enterohepatic injuries and intestinal microbiota in piglets of total parenteral nutrition (TPN).

Methods: Newborn piglets were divided into three groups, including enteral diet (the controls), TPN with 100% FO and TPN with MCT/LCT-based lipid emulsion (MCT/LCT) for 14 days. Serum biochemical indicators, hepatic and intestinal histology, and expression of genes associated with inflammation, oxidative stress, and lipid metabolism were measured. Read More

View Article and Full-Text PDF

The place of vericiguat in the landscape of treatment for heart failure with reduced ejection fraction.

Heart Fail Rev 2021 Jul 21. Epub 2021 Jul 21.

Institute of Life Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, Pisa, Italy.

The significant morbidity and mortality associated with heart failure with reduced (HFrEF) or preserved ejection fraction (HFpEF) justify the search for novel therapeutic agents. The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway plays an important role in the regulation of cardiovascular function. This pathway is disrupted in HF resulting in decreased protection against myocardial injury. Read More

View Article and Full-Text PDF

Dynamic evaluation of the protective effect of Dendrobium officinale polysaccharide on acute alcoholic liver injury mice in vitro and in vivo by NIR fluorescence imaging.

Anal Bioanal Chem 2021 Jul 22. Epub 2021 Jul 22.

Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China.

Acute alcoholic liver injury (AALI) is a threat to human health. Dendrobium officinale polysaccharide (DOP) has the potential to protect the liver by enhancing the anti-oxidative system to maintain the relative balance of ROS (active oxygen species) and antioxidants in AALI mice. However, the dynamic improvement effect of DOP on AALI is still not clear and accurate medication guidance is not available, which limits the clinical application of DOP. Read More

View Article and Full-Text PDF

microRNAs involved in psoriasis and cardiovascular diseases.

Vasc Biol 2021 3;3(1):R49-R68. Epub 2021 Jun 3.

Institute of Translational Pharmacology (IFT), National Research Council of Italy (CNR), Via Fosso del Cavaliere, Rome, Italy.

Psoriasis is a chronic inflammatory disease involving the skin. Both genetic and environmental factors play a pathogenic role in psoriasis and contribute to the severity of the disease. Psoriasis, in fact, has been associated with different comorbidities such as diabetes, metabolic syndrome, gastrointestinal or kidney diseases, cardiovascular disease (CVD), and cerebrovascular diseases (CeVD). Read More

View Article and Full-Text PDF

Mitochondrial dysfunction: A hidden trigger of autism?

Genes Dis 2021 Sep 16;8(5):629-639. Epub 2020 Jul 16.

Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu 641043, India.

Autism is a heterogeneous neurodevelopmental and neuropsychiatric disorder with no precise etiology. Deficits in cognitive functions uncover at early stages and are known to have an environmental and genetic basis. Since autism is multifaceted and also linked with other comorbidities associated with various organs, there is a possibility that there may be a fundamental cellular process responsible for this. Read More

View Article and Full-Text PDF
September 2021

Liver histopathological alteration and dysfunction after bisphenol A administration in male rats and protective effects of naringin.

Avicenna J Phytomed 2021 Jul-Aug;11(4):394-406

Department of Toxicology, School of Pharmacy, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Bisphenol A (BPA) is an organic synthetic compound, often used in manufacturing polycarbonate plastics. Researches have shown the role of BPA as an endocrine disruptor. The present study intended to evaluate the hepatoprotective properties of naringin, an active flavanone glycoside present in many citrus fruit, against hepatotoxicity induced by BPA. Read More

View Article and Full-Text PDF

A novel mycothiol-dependent thiol-disulfide reductase in involving oxidative stress resistance.

3 Biotech 2021 Aug 14;11(8):372. Epub 2021 Jul 14.

College of Life Science and Agronomy, Zhoukou Normal University, Zhoukou, 466001 Henan China.

gene from encodes a thiol-disulfide oxidoreductase enzyme annotated as dithiol-disulfide isomerase DsbA. It preserves a Cys-Pro-Phe-Cys active-site motif, which is presumed to be an exclusive characteristic of the novel DsbA-mycoredoxin 1 (Mrx1) cluster. However, the real mode of action, the nature of the electron donor pathway and biological functions of NCgl2478 in have remained enigmatic so far. Read More

View Article and Full-Text PDF

Oligodendrocytes in the aging brain.

Neuronal Signal 2021 Sep 6;5(3):NS20210008. Epub 2021 Jul 6.

Blizard Institute, Barts and The London School of Medicine and Dentistry Centre for Neuroscience, Surgery and Trauma, Blizard Institute, 4 Newark Street, Whitechapel E1 2AT, London.

More than half of the human brain volume is made up of white matter: regions where axons are coated in myelin, which primarily functions to increase the conduction speed of axon potentials. White matter volume significantly decreases with age, correlating with cognitive decline. Much research in the field of non-pathological brain aging mechanisms has taken a neuron-centric approach, with relatively little attention paid to other neural cells. Read More

View Article and Full-Text PDF
September 2021

Effect of coenzyme Q10 supplementation on oxidative stress and clinical outcomes in patients with low levels of coenzyme Q10 admitted to the intensive care unit.

J Nutr Sci 2021 12;10:e48. Epub 2021 Jul 12.

Clinical Research Development Unit, Imam Khomeini Hospital, Urmia University of Medical Sciences, Ershad Ave, 5756151818 Urmia, West Azerbaijan Province, Iran.

Today, trauma is known to be the third leading cause of death in most countries. Studies have demonstrated below-normal plasma levels of antioxidants in trauma patients. The present study aimed to assess the efficacy of Coenzyme Q10 (CoQ10) on oxidative stress, clinical outcomes and anthropometrical parameters in traumatic mechanical ventilated patients admitted to the intensive care unit. Read More

View Article and Full-Text PDF

Wogonin Inhibits Cardiac Hypertrophy by Activating Nrf-2-Mediated Antioxidant Responses.

Cardiovasc Ther 2021 1;2021:9995342. Epub 2021 Jul 1.

Department of Cardiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, China.

Background: Cardiac hypertrophy is one of the initial disorders of the cardiovascular system and can induce heart failure. Oxidative stress is an important pathophysiological mechanism of cardiac hypertrophy. Wogonin (Wog), an important flavonoid derived from the root of , is known to possess antioxidant properties. Read More

View Article and Full-Text PDF