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Neuroimage 2022 Jun 22:119397. Epub 2022 Jun 22.

School of Human and Behavioural Sciences, Bangor University, Bangor, UK; The Bangor Imaging Unit, Bangor University, Bangor, United Kingdom; Institute for Applied Human Physiology, Bangor University, Bangor, United Kingdom. Electronic address:

Environmental hypoxia (fraction of inspired oxygen (FO) ∼ 0.120) is known to trigger a global increase in cerebral blood flow (CBF). However, regionally, a heterogeneous response is reported, particularly within the posterior cingulate cortex (PCC) where decreased CBF is found after two hours of hypoxic exposure. Read More

J Biol Chem 2022 Jun 22:102180. Epub 2022 Jun 22.

Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada. Electronic address:

The Integrated Stress Response (ISR) is a network of highly-orchestrated pathways activated when cells are exposed to various types of environmental stressors. While global repression of translation is a well-recognized hallmark of the ISR, less is known about the regulation of mRNA stability during stress. DEAD box proteins are a family of RNA unwinding/remodeling enzymes involved in every aspect of RNA metabolism. Read More

Pharmacol Res 2022 Jun 22:106326. Epub 2022 Jun 22.

Department of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India. Electronic address:

Diabetes is a major public health disease that is globally approaching epidemic proportions. One of the major causes of type 2 diabetes is either a defect in insulin secretion or insulin action which is usually caused by a combination of genetic and environmental factors. Not only these factors but others such as deregulation of various pathways, and oxidative stress are also known to trigger the redox imbalance in diabetics. Read More

Eur J Pharmacol 2022 Jun 22:175117. Epub 2022 Jun 22.

Department of Biochemistry, German University in Cairo, Cairo, Egypt.

Diabetic nephropathy (DN) is one of the most serious consequences of diabetes and the most common reason for end-stage renal disease. The current study was set out to investigate the ability of olmesartan medoxomil (OM) to treat DN by evaluating the reno-protective effects of this drug on fat/fructose/streptozotocin (F/Fr/STZ)-induced diabetic rat model. This model was induced by feeding rats high F/Fr diet for 7 weeks followed by injection of a single sub-diabetogenic dose of STZ (35mg/kg; i. Read More

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Roles of an abundant human urinary protein, uromodulin (UMOD), in kidney stone disease were previously controversial. Recently, we have demonstrated that oxidative modification reverses overall modulatory activity of whole urinary proteins, from inhibition to promotion of calcium oxalate (CaOx) stone-forming processes. We thus hypothesized that oxidation is one of the factors causing those previously controversial UMOD data on stone modulation. Read More

Chemosphere 2022 Jun 22:135453. Epub 2022 Jun 22.

Translational Research Institute of Brain and Brain-like Intelligence, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Department of Pediatrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. Electronic address:

Zeolite imidazolate framework-8 (ZIF-8) is a nanomaterial of metal-organic frameworks (MOFs), which have various applications in drug delivery and water pollution remediation. However, little is known about its developmental neurotoxicity in aquatic organisms, especially on the low-level exposure. In the present study, we investigated the toxic effects of ZIF-8 NPs on the neuron development, behavioral traits, oxidative stress and gene expression in zebrafish embryos. Read More

Genomics Proteomics Bioinformatics 2022 Jun 22. Epub 2022 Jun 22.

Henan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, China; Branch of National Clinical Research Center for Ocular Disease, Henan Provincial People's Hospital, Zhengzhou 450003, China; Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Retinal pigmented epithelium (RPE) has essential functions, such as nourishing and supporting the neural retina, and is of vital importance in the pathogenesis of age-related retinal degeneration. However, the exact molecular changes of RPE in aging remain poorly understood. Here, we isolated human primary RPE (hRPE) cells from 18 eye donors distributed over a wide age range (10-67 years). Read More

J Control Release 2022 Jun 22. Epub 2022 Jun 22.

Former President of Japan Society of Drug Delivery System, 5-3-13, Otsuka, Bunkyo-ku, Tokyo, 112-0012, Japan, Visiting Scientist, Department of Immune Medicine, National Cancer Center Research Institute 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:

In May 2021, 35 years after first announcing the enhanced permeability and retention (EPR) effect, Dr. Maeda passed away. As a theoretical pillar of high molecular weight drug delivery systems (DDS) with high biocompatibility, the EPR effect has been proven worldwide in experimental mouse models. Read More

Sci Total Environ 2022 Jun 22:156885. Epub 2022 Jun 22.

Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China. Electronic address:

2,2,4,4-Tetrabromodiphenyl ether (BDE-47) has received considerable attention because of its high level in biological samples and potential developmental toxicity. Whether BDE-47 ingestion affects ovarian hormone secretion and the detailed underlying mechanism have not been clearly elucidated. The present study aimed to evaluate the toxicity of BDE-47 on ovarian hormone secretion and explored the underlying mechanism. Read More

Toxicology 2022 Jun 22:153242. Epub 2022 Jun 22.

Department of Forensic Medicine and Clinical Toxicology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Modeling of Non-Communicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Lead (Pb) is an environmental neurotoxin that can lead to toxicity. It has shown that tissues can be exposed to oxidative stress in lead poisoning. Since silymarin is a natural agent with antioxidant effects, this study aimed to investigate the antioxidant and chelation effects of silibinin and nano-silibinin on the oxidative stress status in lead-poisoned rats. Read More

Phytomedicine 2022 Jun 19;104:154287. Epub 2022 Jun 19.

Formula-Pattern Research Center, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, Jiangxi 330004, China. Electronic address:

Background: Restoring immune homeostasis by targeting the Th17/Treg response is a potentially valuable therapeutic strategy for ulcerative colitis (UC). Astragaloside IV (AS-Ⅳ) is a phytochemical naturally occurring in Astragalus membranaceus that has good anti-inflammatory, anti-oxidant and anti-stress properties. However, the effects of AS-IV on the homeostasis of Th17/Treg cells in colitis mice remains unknown. Read More

J Inorg Biochem 2022 Jun 2;234:111882. Epub 2022 Jun 2.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Cadmium (Cd) is a widely used heavy metal which is reported to exert extensive harm to the environment and human health. Owing to Cd being an element it is continuously enriched in the environment. The mechanism of splenic toxicity by Cd, however, is not yet clear. Read More

J Hazard Mater 2022 Jun 16;437:129381. Epub 2022 Jun 16.

Department of Neurology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China. Electronic address:

Oxidative stress and mitochondrial dysfunction contribute greatly to fluoride-induced cognitive impairment and behavioural disorders. Honokiol, a natural biphenolic compound, possesses antioxidant and mitochondrial protective properties. The present study investigated the protective actions of honokiol on NaF-elicited cognitive deficits and elucidated the possible mechanism of honokiol-mediated protection. Read More

J Hazard Mater 2022 Jun 9;437:129332. Epub 2022 Jun 9.

College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

Fungal Mn oxidation is a crucial pathway in the biogeochemical cycling of toxic substances. However, few studies have aimed to promote the process of fungal Mn oxidation or systematically establish the mechanism of action. The effects of static magnetic field (SMF) treatment on the growth and Mn(II) oxidation capability of an Mn-oxidizing fungus, Cladosporium sp. Read More

Biomed Pharmacother 2022 Jun 22;153:113308. Epub 2022 Jun 22.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, South Valley University, Qena, Egypt.

Objectives: Dihydromyricetin (DHM), a natural flavonoid isolated from vine tea with anti-inflammatory activity was evaluated for its ability to prevent vascular endothelial dysfunction caused by hyperglycaemia.

Methods: Vasoconstrictor (phenylephrine-PE) and vasodilator (acetylcholine-ACh) responses were monitored for female rat aorta rings maintained in a bioassay organ bath for 3 h at 37 °C in either low (LG: 10 mM) or high (HG: 40 mM, to mimic hyperglycaemia) glucose-Krebs buffer in the absence or presence of 50 µM DHM. Tissues recovered from the organ bath at 3 h were fixed and analyzed for morphological changes and their expression of eNOS, iNOS, HIF-1α, GLUT1, ROR2 tyrosine kinase, NF-κB, TNF-α, Bax, Bcl2, caspase-3, and forindices of increased oxidative stress. Read More

Redox Biol 2022 Jun 14;54:102369. Epub 2022 Jun 14.

Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address:

Background: E-cigarette aerosol containing aldehydes, including acetaldehyde, are metabolized by the enzyme aldehyde dehydrogenase 2 (ALDH2). However, little is known how aldehyde exposure from e-cigarettes, when coupled with an inactivating ALDH2 genetic variant, ALDH2*2 (present in 8% of the world population), affects cardiovascular oxidative stress.

Objectives: The study was to determine how e-cigarette aerosol exposure, coupled with genetics, impacts cardiovascular oxidative stress in wild type ALDH2 and ALDH2*2 knock-in mice. Read More

J Photochem Photobiol B 2022 Jun 17;233:112501. Epub 2022 Jun 17.

Department of Biochemistry and Microbiology, Faculty of Science, Engineering and Agriculture, University of Venda, Private Bag X5050, Thohoyandou 0950, South Africa. Electronic address:

Mistletoe plants that are positioned on the canopy of their hosts are more susceptible to UV radiation exposure. These aerial plants are resistant to damage by UV radiation due the presence of epidermal constituents such as the cuticle, cork layer, trichomes and antioxidant secondary metabolites. In response to the photo-oxidative stress associated with UV exposure, plants generally deploy photo-protective responsive mechanisms that involve the biosynthesis of UV absorbing phenolic compounds such as chlorogenic acids (CGAs). Read More

Environ Int 2022 Jun 15;166:107349. Epub 2022 Jun 15.

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. Electronic address:

Nanoplastics (NPLs) are widespread in our environment. However, their impacts on human health and precise toxicity mechanisms remain poorly understood. Here we studied the internalization, release, and cytotoxicity of polystyrene nanoplastics (PSNPs) using the renal tubular epithelial cell line HKC and human derived liver cell line HL-7702. Read More

Aquat Toxicol 2022 Jun 16;249:106228. Epub 2022 Jun 16.

Basic Experimental Teaching Center, Shaanxi Normal University, Xi'an 710119, China. Electronic address:

Nitrite is a ubiquitous toxic compound in aquatic ecosystems and has negative effects on aquatic organisms. The intestine and the trillions of microbes that inhabit it, play an integral role in maintaining digestive and immune functions. However, the effects of nitrite on intestinal health and microflora have been poorly investigated. Read More

Ecotoxicol Environ Saf 2022 Jun 22;241:113796. Epub 2022 Jun 22.

Weifang Environmental Science Research & Design Institute, Weifang, Shandong 26104, China.

As a flame retardant, triphenyl phosphate (TPHP) is commonly added to various daily products. Due to its easy diffusion, TPHP pollution has become a global concern. Despite the wide focus on environmental risk, the sub-chronic ecotoxicity of TPHP in soil organisms remains unclear. Read More

Ecotoxicol Environ Saf 2022 Jun 22;241:113800. Epub 2022 Jun 22.

Department of Chemistry and Biochemistry Department, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968, United States. Electronic address:

Through the applications of recycling sewage sludge to soils as nutrients, bisphenol A (BPA) and titanium dioxide nanoparticles (TiO-NPs) are commonly found in the agricultural environment. Previous studies have reported that BPA and nanoparticles are harmful to the environment. However, the combined toxicity of both compounds is not yet understood. Read More

Life Sci 2022 Jun 22;304:120725. Epub 2022 Jun 22.

Department of Pharmacy, Lanzhou University, Lanzhou 730000, PR China; State Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Lanzhou 730000, PR China. Electronic address:

Aims: Diabetes mellitus (DM) is a major global health threat characterized by insulin resistance. A new tactic to ameliorate insulin resistance, thereby reversing the exacerbation of DM, is urgently needed. The work is aiming to provide a new strategy for DM treatment as well as to identify new targets. Read More

Metab Brain Dis 2022 Jun 25. Epub 2022 Jun 25.

Department of Pathophysiology, School of Basic Medicine, Jiamusi University, 148-Xuefu Street, Jiamusi, Heilongjiang, 154007, People's Republic of China.

Long non-coding RNAs (lncRNAs) have been confirmed to be involved in epilepsy development. It has been reported that lncRNA ZFAS1 plays a vital regulatory role in epilepsy progression. Therefore, the role and molecular mechanism of ZFAS1 in epilepsy progression deserve further investigation. Read More

Mol Divers 2022 Jun 25. Epub 2022 Jun 25.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.

A series of dihydrofuran-3-one and 9,10-phenanthrenequinone hybrid compounds were synthetized through a one-pot gold-catalyzed oxidative cyclization and Aldol-type addition cascade reaction of homopropargylic alcohols with 9,10-phenanthrenequinone. The cytotoxicity of newly synthesized compounds was evaluated in CCK8 assay against different human cancer cells, showing significantly antiproliferative activity against tested tumor cell lines with a lowest IC value of 0.92 μM over HCT-116. Read More

Plant Cell Rep 2022 Jun 25. Epub 2022 Jun 25.

Department of Biology, Università degli Studi di Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.

Key Message: Fumonisin B induces rapid programmed cell death in Arabidopsis cells, oxidative and nitrosative bursts, and differentially modulates cell death responsive genes. Glutathione is the main antioxidant involved in the stress response. Fumonisin B (FB) is a fungal toxin produced by Fusarium spp. Read More

J Pathol 2022 Jun 25. Epub 2022 Jun 25.

Department of Medical Surgical Sciences and Biotechnologies, Sapienza University, Latina, Italy.

Cardiac stromal cells (CSCs) are the main players in fibrosis. Dysmetabolic conditions (metabolic syndrome - MetS, and type 2 diabetes - DM2) are strong pathogenetic contributors to cardiac fibrosis. Moreover, modulation of the oxidative state (OxSt) and autophagy is a fundamental function affecting the fibrotic commitment of CSCs, that are adversely modulated in MetS/DM2. Read More

J Appl Microbiol 2022 Jun 25. Epub 2022 Jun 25.

School of Food Science and Engineering, South China University of Technology, Guangzhou, China.

Aims: The aim of the current study was to investigate the effect of plasma-mediated oxidative stress on the post-treatment viability of Listeria monocytogenes at the physiological and molecular levels.

Methods And Results: 10 CFU/mL L. monocytogenes in 10 mL phosphate-buffered saline (PBS) were treated with atmospheric nonthermal plasma for 0, 30, 60, 90 and 120 s, respectively. Read More

Compr Rev Food Sci Food Saf 2022 Jun 24. Epub 2022 Jun 24.

State Key Laboratory of Animal Nutrition, Department of Companion Animal Science, College of Animal Science and Technology, China Agricultural University, Beijing, P. R. China.

Zearalenone (ZEA) is a mycotoxin frequently found in cereal crops and cereal-derived foodstuffs worldwide. It affects plant productivity, and is also a serious hazard to humans and animals if being exposed to food/feed contaminated by ZEA. Studies over the last decade have shown that the toxicity of ZEA in animals is mainly mediated by the various stress responses, such as endoplasmic reticulum (ER) stress, oxidative stress, and others. Read More

Food Chem 2022 Nov 10;393:133458. Epub 2022 Jun 10.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, PR China. Electronic address:

In the present work, the Pickering emulsions with enhanced oxidation stability were fabricated using gliadin (G)/arabinoxylan nanoparticles (GANPs). The influence of different G/AX ratios on the properties of GANPs and corresponding physicochemical characteristics of Pickering emulsions were investigated. Results indicated that the droplet size and ζ-potential of Pickering emulsions declined with the decrease of G/AX ratios. Read More

Food Chem 2022 Nov 11;393:133451. Epub 2022 Jun 11.

Technology Centre, Department of Food Engineering, Federal University of Paraiba, Joao Pessoa 58051-900, Brazil. Electronic address:

The antioxidant capacity of organic coffee husk extract (Coffee arabica L.) added to chicken burgers was evaluated. Two formulations were prepared: with addition of the extract (100 and 200 ppm CAE/kg), in addition to control formulations without the addition of antioxidant, and with the addition of synthetic antioxidant. Read More