365,948 results match your criteria oxidative

Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells.

Redox Biol 2021 Apr 19;43:101970. Epub 2021 Apr 19.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL-33136, USA; Department of Veterans Affairs, Miami Healthcare System, Miami, FL, 33136, USA. Electronic address:

Background: Chronic gastroesophageal reflux disease (GERD) is a major risk factor for the development of metaplastic Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). Uncontrolled accumulation of reactive oxygen species (ROS) in response to acidic bile salts (ABS) in reflux conditions can be lethal to cells. In this study, we investigated the role of APE1/REF1 in regulating nuclear erythroid factor-like 2 (NRF2), the master antioxidant transcription factor, in response to reflux conditions. Read More

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Commodity plastic burning as a source of inhaled toxic aerosols.

J Hazard Mater 2021 Apr 8;416:125820. Epub 2021 Apr 8.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China.

Commodity plastic is ubiquitous in daily life and commonly disposed of via unregulated burning, particularly in developing regions. We report here the much higher emission factors (13.1 ± 7. Read More

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Quassinoids: Phytochemistry and antitumor prospect.

Phytochemistry 2021 Apr 19;187:112769. Epub 2021 Apr 19.

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Quassinoids, originating from the oxidative degradation of tetracyclic tirucallane triterpene, are a diverse class of secondary metabolites identifying from nature mostly in Simaroubaceae family. The crucial pharmacological activities and structural complexity of quassinoids have long fascinated scientists due to their medicinal uses, infamous toxicity, and unique biosynthesis. In the past few decades, 482 quassinoids, assigned to 6 skeletons, have been isolated and identified from plants. Read More

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Potentiation of lethal and sub-lethal effects of benzophenone and oxybenzone by UV light in zebrafish embryos.

Aquat Toxicol 2021 Apr 19;235:105835. Epub 2021 Apr 19.

Department of Biological Sciences, University of Alberta, 11455 Saskatchewan Drive, Edmonton, Alberta, T6G 2E9, Canada; National Institute for Nanotechnology, 11421 Saskatchewan Drive, Edmonton, Alberta, T6G 2M9, Canada; Director of Office of Environmental Nanosafety, University of Alberta, Canada. Electronic address:

Benzophenones are widely used as organic UV filters in many personal care products, especially sunscreen, to protect humans from UV radiation. The increasing use of benzophenone class UV filters has raised concerns about the potential effects on the aquatic environment. These organic UV filters are designed to absorb UV light. Read More

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Protective effects of glutamine against soy saponins-induced enteritis, tight junction disruption, oxidative damage and autophagy in the intestine of Scophthalmus maximus L.

Fish Shellfish Immunol 2021 Apr 19. Epub 2021 Apr 19.

Marine College, Shandong University, Weihai, Shandong, 264209, China. Electronic address:

Soy saponins, as thermo-stable anti-nutrients in soybean meal (SBM), are the primary causal agents of SBM-induced enteritis, which represents a well-documented pathologic alternation involving the distal intestines of various farmed fish. Our previous work showed that soy saponins might lead to SBM-induced enteritis, destroy tight junction structure and induce oxidative damage in juvenile turbot. Glutamine, as a conditionally essential amino acid, is an important substrate utilized for the growth of intestinal epithelial cells. Read More

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Bioactivity Profiling of Per- and Polyfluoroalkyl Substances (PFAS) Identifies Potential Toxicity Pathways Related to Molecular Structure.

Toxicology 2021 Apr 19:152789. Epub 2021 Apr 19.

Attagene, Inc., 7030 Kit Creek Rd, Morrisville, NC, 27560, USA.

Per- and polyfluoroalkyl substances (PFAS) are a broad class of hundreds of fluorinated chemicals with environmental health concerns due to their widespread presence and persistence in the environment. Several of these chemicals have been comprehensively studied for experimental toxicity, environmental fate and exposure, and human epidemiology; however, most chemicals have limited or no data available. To inform methods for prioritizing these data-poor chemicals for detailed toxicity studies, we evaluated 142 PFAS using an in vitro screening platform consisting of two multiplexed transactivation assays encompassing 81 diverse transcription factor activities and tested in concentration-response format ranging from 137 nM to 300 μM. Read More

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Biomarkers for Alcohol abuse /withdrawal and their association with clinical scales and temptation to drink. A prospective pilot study during 4-week residential rehabilitation.

Alcohol 2021 Apr 19. Epub 2021 Apr 19.

Department of Physical and Rehabilitation Medicine, ICS Maugeri Spa - SB, Institute of G Nervi, Genoa, Italy. Electronic address:

A bulk of evidences in the field of translational medicine applied to clinical toxicology and rehabilitation have highlighted the possibility of using biomarkers as a support in the diagnosis of alcohol-related diseases and in monitoring of withdrawal. In a cohort of 55 subjects admitted to a 4-week residential rehabilitation period for alcohol detoxification. we applied a complementary approach correlating novel and conventional peripheral blood and urine parameters in combination with clinical and functional evaluation, contextually considered with patient's history. Read More

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Safety aspects of kraft lignin fractions: Discussions on the in chemico antioxidant activity and the induction of oxidative stress on a cell-based in vitro model.

Int J Biol Macromol 2021 Apr 19. Epub 2021 Apr 19.

Graduate Program in Genetics, Department of Genetics - Federal University of Paraná (UFPR), Curitiba, PR, Brazil. Electronic address:

Lignin is a complex phenolic biopolymer present in plant cell walls and a by-product of the cellulose pulping industry. Lignin has functional properties, such as antioxidant activity, that make it a potential natural active ingredient for health-care products. However, not all safety aspects of lignin fractions have been adequately investigated. Read More

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Oxidative Stress in Vascular Calcification.

Clin Chim Acta 2021 Apr 19. Epub 2021 Apr 19.

Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan province, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China. Electronic address:

Vascular calcification (VC), which is closely associated with significant mortality in cardiovascular disease, chronic kidney disease (CKD), and/or diabetes mellitus, is characterized by abnormal deposits of hydroxyapatite minerals in the arterial wall. The impact of oxidative stress (OS) on the onset and progression of VC has not been well described. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, xanthine oxidases, myeloperoxidase (MPO), nitric oxide synthases (NOSs), superoxide dismutase (SOD) and paraoxonases (PONs) are relevant factors that influence the production of reactive oxygen species (ROS). Read More

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Oxidative Phosphorylation KADP In Vitro Depends on Substrate Oxidative Capacity: Insights from a Luciferase-Based Assay to Evaluate ADP Kinetic Parameters.

Biochim Biophys Acta Bioenerg 2021 Apr 19:148430. Epub 2021 Apr 19.

Department of Medicine, Division of Endocrinology; Center for Disparities in Diabetes, Obesity, and Metabolism, University of Arizona, Tucson, Arizona, (United States).

The KADP of oxidative phosphorylation (OxPhos) identifies the cytosolic ADP concentration which elicits one-half the maximum OxPhos rate. This kinetic parameter is commonly measured to assess mitochondrial metabolic control sensitivity. Here we describe a luciferase-based assay to evaluate the ADP kinetic parameters of mitochondrial ATP production from OxPhos, adenylate kinase (AK), and creatine kinase (CK). Read More

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Protective Effects of Selenium in Tacrolimus-induced Lung Toxicity: Potential Role of Hemeoxygenase-1.

Can J Physiol Pharmacol 2021 Apr 22. Epub 2021 Apr 22.

Minia University Faculty of Medicine, 68877, Pharmacology, El Minia, Egypt;

The present study aimed to evaluate the protective effects of selenium administration against tacrolimus (Tac) induced lung toxicity and to assess the relation between heme oxygenase 1 (HO-1) and these effects. The study was conducted on 36 Wistar male albino rats equally divided into 4 groups: (1) normal control, (2) Selenium (Sel 0.1mg/kg/day p. Read More

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Inducible nitric oxide synthase (iNOS) mediates ethanol-induced redox imbalance and up-regulation of inflammatory cytokines in the kidney.

Can J Physiol Pharmacol 2021 Apr 22. Epub 2021 Apr 22.

Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, Brazil, 14040120;

Overexpression of the inducible isoform of the enzyme nitric oxide synthase (iNOS) has been associated to pathological processes in the kidney. Ethanol consumption induces the renal expression of iNOS. However, the contribution of this enzyme to the deleterious effects of ethanol in the kidney remains elusive. Read More

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Iron(III) Complex-Functionalized Gold Nanocomposite as a Strategic Tool for Targeted Photochemotherapy in Red Light.

Inorg Chem 2021 Apr 22. Epub 2021 Apr 22.

Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal West 795004, India.

Iron(III)-phenolate/carboxylate complexes exhibiting photoredox chemistry and photoactivated reactive oxygen species (ROS) generation at their ligand-to-metal charge-transfer (LMCT) bands have emerged as potential strategic tools for photoactivated chemotherapy. Herein, the synthesis, in-depth characterization, photochemical assays, and remarkable red light-induced photocytotoxicities in adenocarcinomic human immortalized human keratinocytes (HaCaT) and alveolar basal epithelial (A549) cells of iron(III)-phenolate/carboxylate complex of molecular formula, [Fe(L)(L)] (), where L is bis(3,5 di--butyl-2-hydroxybenzyl)glycine and L is 5-(1,2-dithiolan-3-yl)--(1,10-phenanthroline-5-yl)pentanamide, and the gold nanocomposite functionalized with complex (-AuNPs) are reported. There was a significant red shift in the UV-visible absorption band on functionalization of complex to the gold nanoparticles (λ: 573 nm, ; λ: 660 nm, -AuNPs), rendering the nanocomposite an ideal candidate for photochemotherapeutic applications. Read More

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Synthesis of Spirocycles via Ni-Catalyzed Intramolecular Coupling of Thioesters and Olefins.

Chemistry 2021 Apr 22. Epub 2021 Apr 22.

Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710069, P. R. China.

A nickel-catalyzed intramolecular coupling of thioesters and olefins has been developed for the efficient synthesis of spirocycles, a privileged scaffold commonly found in natural products. This transformation is characterized by the simultaneous transfer of both acyl and thiol moieties to the alkene, with the suppression of decarbonylation and β-hydrogen elimination. Initial mechanistic investigations are consistent with an oxidative addition/olefin insertion/reductive elimination mechanism. Read More

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Silicon modulates nitro-oxidative homeostasis along with the antioxidant metabolism to promote drought stress tolerance in lentil plants.

Physiol Plant 2021 Apr 22. Epub 2021 Apr 22.

School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Australia.

Lentil is the fifth most important grain legume growing in arid/semi-arid regions of the world. Drought is one of the major constraints leading up to 50 % of production losses just in lentil. Application of silicon (Si) has been shown to be a promising solution to improve drought tolerance; however, the biochemical mechanisms and interactions involved are not fully understood, especially in legumes. Read More

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Oxidonitrergic and antioxidant effects of a low molecular weight peptide fraction from hardened bean (Phaseolus vulgaris) on endothelium.

Braz J Med Biol Res 2021 19;54(6):e10423. Epub 2021 Apr 19.

Laboratório de Neurobiologia de Sistemas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil.

About 3000 tons of beans are not used in human food due to hardening. Several studies on bean-derived bioactive peptides have shown potential to treat some diseases, including those relying on oxidative dysfunctions. We assessed the effects of peptides extracted from hardened bean Phaseolus vulgaris (PV) on reactive oxygen species (ROS) and nitric oxide (NO) production, cytotoxic and cytoprotective effects in endothelial cells, and oxidonitrergic-dependent vasodilating effects. Read More

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Systemic Inflammation and Oxidative Stress in Adults with Bronchiectasis: Association with Clinical and Functional Features.

Clinics (Sao Paulo) 2021 16;76:e2474. Epub 2021 Apr 16.

Programa de Pos-Graduacao em Ciencias da Reabilitacao, Universidade Nove de Julho (UNINOVE), Sao Paulo, SP, BR.

Objectives: To compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity.

Methods: This study used a cross-sectional design. Seventy-four adults with bronchiectasis (age: 49±15 years, forced expiratory volume in 1 second [FEV1]: 52. Read More

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Rice bran oil emulgel as a pork back fat alternate for semi-dried fish sausage.

PLoS One 2021 22;16(4):e0250512. Epub 2021 Apr 22.

Department of Food Science and Innovation, Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat, Thailand.

The objective of this study was to investigate the effects of rice bran oil emulsion filled gels (EG) substitution for pork back fat on the characteristics of Chinese style semi-dried tilapia sausage (CFS). EG prepared using different gelling agents and processing conditions were used as pork back fat alternate in the CFS. From the results, physical, chemical and microstructural qualities of CFS were governed by the type of EG incorporated. Read More

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Identification of potential metabolic biomarkers of rectal cancer and of the effect of neoadjuvant radiochemotherapy.

PLoS One 2021 22;16(4):e0250453. Epub 2021 Apr 22.

Unitat de Recerca Biomèdica, Institut d'Investigació Sanitària Pere Virgili, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Reus, Spain.

We report a pilot study on the feasibility of determinations of circulating levels of paraoxonase-1 (PON1) and compounds related to energy metabolism as biomarkers for the evaluation of patients with rectal cancer (RC), and the effects produced by neoadjuvant radiochemotherapy (NRCT). We studied 32 patients treated with radiotherapy plus capecitabine concomitant chemotherapy and 48 control subjects. We identified pre-NRCT PON1 and α-ketoglutarate as the parameters that best discriminated between RC patients and the control group. Read More

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Eucalyptus kino: a treasure trove of polyphenols eradicating tumors by elevating caspase-3 level, inhibiting TGF-β and NF-κb gene expression.

Nat Prod Res 2021 Apr 22:1-6. Epub 2021 Apr 22.

Department of Pharmacognosy, College of Pharmacy, Cairo University, Cairo.

30 secondary polyphenolic metabolites were characterised in kino methanol extract using HPLC-MS/MS. The antitumor activity of the extract in combination with low level ionising radiation in female mice with solid tumors from inoculated Ehrlich ascites carcinoma cells was investigated. Tumor cell-inoculated mice received daily extract doses (100 mg/kg, 200 mg/kgBW) with or without a single exposure to 0. Read More

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Direct Iodination of Electron-Deficient Benzothiazoles: Rapid Access to Two-Photon Absorbing Fluorophores with Quadrupolar D-π-A-π-D Architecture and Tunable Heteroaromatic Core.

Org Lett 2021 Apr 22. Epub 2021 Apr 22.

Department of Inorganic Chemistry, Faculty of Natural Sciences, Comenius University, SK-84215 Bratislava, Slovakia.

Direct iodination of benzothiazoles under strong oxidative/acidic conditions leads to a mixture of iodinated heteroarenes with 1-2 major components, which are easily separable and which structures depend on the I equivalents used. Among the unexpected but dominant products were identified 4,7-diiodobenzothiazoles with a rare substitution pattern for SAr reactions of this scaffold. These were employed in the synthesis of 4,7-bis(triarylamine-ethynyl)benzothiazoles - a new class of highly efficient quasi-quadrupolar fluorophores displaying large two-photon absorption cross sections (540-1374 GM) in the near-infrared region. Read More

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Asymmetric Total Synthesis and Biosynthetic Implications of Perovskones, Hydrangenone, and Hydrangenone B.

J Am Chem Soc 2021 Apr 22. Epub 2021 Apr 22.

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering East China Normal University, 3663N Zhongshan Road, Shanghai 200062, China.

Perovskones and hydrangenones are a family of structurally complex triterpenoids that were mainly isolated from the genus medicinal plants. These isoprenoids exhibit a broad range of biological activities, such as antitumor and antiplasmodial activities. Here, we report the collective total synthesis of perovskone, perovskones C, D, F, hydrangenone, and hydrangenone B. Read More

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Riboflavin in Neurological Diseases: A Narrative Review.

Clin Drug Investig 2021 Apr 22. Epub 2021 Apr 22.

Neurology Unit, Azienda Sanitaria Locale della Provincia di Bari, Di Venere Teaching Hospital, Via Ospedale Di Venere 1, 70131, Bari, Italy.

Riboflavin is classified as one of the water-soluble B vitamins. It is part of the functional group of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) cofactors and is required for numerous flavoprotein-catalysed reactions. Riboflavin has important antioxidant properties, essential for correct cell functioning. Read More

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The complex combination of COVID-19 and diabetes: pleiotropic changes in glucose metabolism.

Endocrine 2021 Apr 22. Epub 2021 Apr 22.

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Purpose: Angiotensin converting enzyme 2 (ACE2) is the door for SARS-CoV-2, expressed in critical metabolic tissues. So, it is rational that the new virus causes pleiotropic alterations in glucose metabolism, resulting in the complication of pre-existing diabetes's pathophysiology or creating new disease mechanisms. However, it seems that less attention has been paid to this issue. Read More

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The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity in mice.

Environ Sci Pollut Res Int 2021 Apr 22. Epub 2021 Apr 22.

Department of Biochemistry, Veterinary Faculty, Kafkas University, Kars, Turkey.

Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)-treated cancer patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in the pathogenesis of nephrotoxicity caused by 5-FU. In this study, protective effects of two natural compounds, hesperidin and curcumin, on experimentally induced kidney damage in mice with 5-FU were determined. Read More

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Particulate Matter-Induced Cardiovascular Dysfunction: A Mechanistic Insight.

Cardiovasc Toxicol 2021 Apr 22. Epub 2021 Apr 22.

Integrated Genomics, Cellular, Developmental, and Biotechnology Laboratory (IGCDBL), University of Agriculture, Faisalabad, Punjab, 38000, Pakistan.

Air pollution and particulate matter (PM) are significant factors for adverse health effects most prominently cardiovascular disease (CVD). PM is produced from various sources, which include both natural and anthropogenic. It is composed of biological components, organic compounds, minerals, and metals, which are responsible for inducing inflammation and adverse health effects. Read More

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Overexpression of Glyoxalase III gene in transgenic sugarcane confers enhanced performance under salinity stress.

J Plant Res 2021 Apr 22. Epub 2021 Apr 22.

Division of Crop Improvement, ICAR-Sugarcane Breeding Institute, Coimbatore, Tamil Nadu, 641007, India.

The glyoxalase pathway is a check point to monitor the elevation of methylglyoxal (MG) level in plants and is mediated by glyoxalase I (Gly I) and glyoxalase II (Gly II) enzymes in the presence of glutathione. Recent studies established the presence of unique DJ-1/PfpI domain containing protein named glyoxalase III (Gly III) in prokaryotes, involved in the detoxification of MG into D-lactic acid through a single step process. In the present study, eleven transgenic sugarcane events overexpressing EaGly III were assessed for salinity stress (100 mM and 200 mM NaCl) tolerance. Read More

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