6 results match your criteria overexpressing mir-129-5p

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Exosomes derived from miR-129-5p modified bone marrow mesenchymal stem cells represses ventricular remolding of mice with myocardial infarction.

J Tissue Eng Regen Med 2021 Nov 23. Epub 2021 Nov 23.

Department of cardiology, Shijiazhuang People's Hospital, 5 Fangbei Road, Shijiazhuang, Hebei, 050011, China.

Background: Myocardial infraction (MI) is a severe disease with great mortality. Mesenchymal stem cells (MSCs)-derived exosomes display protection against MI. MicroRNA-129-5p was reported to exert anti-inflammation activity by targeting high mobility group box 1 (HMGB1). Read More

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November 2021

Circular RNA THBS1 promotes proliferation and apoptosis of non-small cell lung cancer cells by sponging miR-129-5p and regulating SOX4 expression.

J BUON 2020 Jul-Aug;25(4):1721-1727

Department of Respiration, the PLA Navy Anqing Hospital, Anqing, China.

Purpose: To investigate the influence of circular ribonucleic acid thrombospondin-1 (circTHBS1) on the proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells by sponging miR-129-5p and regulating the expression of SRY-box transcription factor 4 (SOX4).

Methods: Carcinoma and para-carcinoma specimens were collected from 40 NSCLC patients, and 25 pairs of specimens were obtained from patients with metastatic and non-metastatic NSCLC. After NSCLC cells were cultured, the proliferation was detected via cell counting kit-8 (CCK-8) and 5-Ethynyl-2'- deoxyuridine (EdU) assays, and the cell cycle and apoptosis rate were analyzed through flow cytometry. Read More

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LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2.

Authors:
Xin Jiang Dong Chen

Aging (Albany NY) 2020 10 20;12(20):20069-20084. Epub 2020 Oct 20.

Department of Orthopedics, China-Japan Friendship Hospital, Beijing, China.

In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) in human gliomas. TCGA, GTEx and CGGA database analyses showed that high expression correlates with advanced tumor stage and poor survival of glioma patients. expression is higher in glioma cell lines compared to normal human astrocytes (NHA). Read More

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October 2020

HMGB1 regulates SNAI1 during NSCLC metastasis, both directly, through transcriptional activation, and indirectly, in a RSF1-IT2-dependent manner.

Mol Oncol 2020 06 6;14(6):1348-1364. Epub 2020 May 6.

Department of Pathology, Xuzhou Medical University, China.

High-mobility group protein B1 (HMGB1) has important functions in cancer cell proliferation and metastasis. However, the mechanisms of HMGB1 function in non-small-cell lung cancer (NSCLC) remain unclear. This study aimed to investigate the underlying mechanism of HMGB1-dependent tumor cell proliferation and NSCLC metastasis. Read More

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LncRNA NEAT1 affects inflammatory response by targeting miR-129-5p and regulating Notch signaling pathway in epilepsy.

Cell Cycle 2020 02 17;19(4):419-431. Epub 2020 Jan 17.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

It is crucial to understand the molecular mechanisms involved in epileptogenesis. This study aims to investigate the role of lncRNA NEAT1, miR-129-5p and Notch signaling pathway in epilepsy. In this research, temporal lobe tissues were collected from patients with epilepsy and healthy controls. Read More

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February 2020

The relationship between lncRNA PCGEM1 and STAT3 during the occurrence and development of endometrial carcinoma.

Biomed Pharmacother 2018 Nov 22;107:918-928. Epub 2018 Aug 22.

Department of Breast Surgery, Cancer Hospital of China Medical University, Shenyang, Liaoning Province, 110042, People's Republic of China; Liaoning Cancer Hospital & Institute, Shenyang, Liaoning Province, 110042, People's Republic of China. Electronic address:

We investigated the effects of lncRNA PCGEM1 on the tumorigenesis and development of endometrial carcinoma (EC) and its possible molecular mechanism. We found that PCGEM1 expression was significantly higher in EC tissues than in normal endometrial tissues via quantitative reverse transcription (qRT)-PCR. The upregulation of PCGEM1 promoted the proliferation, migration, and invasive ability of EC cells while inhibiting apoptosis. Read More

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November 2018
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