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The liver: Key in regulating appetite and body weight.

Adipocyte 2012 Oct;1(4):259-264

Department of Medicine (Austin Health); University of Melbourne; Heidelberg, VIC Australia.

Liver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat intake. Whether FBPase functions only in glucose metabolism or has other metabolic roles is currently unclear. In our recently published study, we examined the importance of liver FBPase in body weight regulation by performing a series of comprehensive physiological and biochemical assessments of energy balance and specific intervention studies in our transgenic mouse line that overexpresses FBPase specifically in the liver. Read More

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October 2012
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