8,557 results match your criteria overactive bladder


Efficacy and safety of onabotulinumtoxinA in patients with overactive bladder: subgroup analyses by sex and by serum prostate-specific antigen levels in men from a randomized controlled trial.

Int Urol Nephrol 2021 Jul 22. Epub 2021 Jul 22.

Specialty Medical and Development, GlaxoSmithKline, Tokyo, Japan.

Purpose: We aimed to assess onabotulinumtoxinA treatment outcomes by sex in patients with overactive bladder (OAB) and then explore the impact of serum prostate-specific antigen (PSA) levels in men.

Methods: Patients inadequately managed with OAB medications were randomized to receive single-dose onabotulinumtoxinA (100 U) or placebo intravesical injection in a phase III trial in Japan. We performed subgroup analyses by sex and post-hoc subgroup analyses using male PSA categories. Read More

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Prevalence and associated risk factors among patients with overactive bladder syndrome in Pakistan.

Pak J Med Sci 2021 Jul-Aug;37(4):1185-1189

Dr. Saima Riaz, PhD. Assistant Professor Riphah College of Rehabilitation & Allied Health Sciences, RIU, Lahore, Pakistan.

Objectives: To determine the Prevalence and associated risk factors among patients with overactive bladder syndrome in Pakistan.

Methods: This was a community-based, face to face, cross sectional survey to calculate the prevalence and its associated risk factors. A sample of 1058 patients, women and men aged between 35 to 60 years having symptoms of overactive bladder was selected through convenience sampling from different cities of Pakistan during September to December 2020. Read More

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February 2021

Endocannabinoids in Bladder Sensory Mechanisms in Health and Diseases.

Front Pharmacol 2021 5;12:708989. Epub 2021 Jul 5.

Discipline of Human Physiology, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA, Australia.

The recent surge in research on cannabinoids may have been fueled by changes in legislation in several jurisdictions, and by approval for the use of cannabinoids for treatment of some chronic diseases. Endocannabinoids act largely, but not exclusively on cannabinoid receptors 1 and 2 (CBR1 and CBR2) which are expressed in the bladder mainly by the urothelium and the axons and endings of motor and sensory neurons. A growing body of evidence suggests that endocannabinoid system constitutively downregulates sensory bladder function during urine storage and micturition, under normal physiological conditions. Read More

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Acupuncture in addition to standard conservative treatment for overactive bladder; a feasibility trial for a randomized controlled study.

Neurourol Urodyn 2021 Jul 21. Epub 2021 Jul 21.

Department of Sport, Exercise and Rehabilitation, Programme Lead BSc Physiotherapy, Northumbria University, Newcastle upon Tyne, UK.

Aims: This study aims to assess the feasibility of an randomized controlled trial (RCT) to test treatment efficacy of acupuncture for symptoms of overactive bladder syndrome (OAB), a common long-term condition with physical, psychological, social and sexual consequences.

Methods: A total of 30 participants were recruited and randomized to either standard conservative management for OAB or standard conservative management plus acupuncture. Standard care consisted of individually tailored advice regarding bladder health, pelvic floor exercises and lifestyle adjustments. Read More

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Factors affecting urinary frequency after low-dose-rate brachytherapy for prostate cancer.

Low Urin Tract Symptoms 2021 Jul 20. Epub 2021 Jul 20.

Department of Urology, Nara Medical University, Kashihara, Japan.

Objectives: Lower urinary tract symptoms are transiently exacerbated by low-dose-rate brachytherapy (LDR-BT) for prostate cancer and recover to pretreatment levels 1 year thereafter. Generally, these symptoms are influenced by temperature. We aimed to search for factors affecting the lower urinary tract symptoms after seed implant including seasons. Read More

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Assessment of sacral spinal excitability using stimulus-response curves of the bulbocavernosus reflex.

Clin Neurophysiol 2021 Jun 25;132(9):2123-2129. Epub 2021 Jun 25.

Sorbonne Université, GRC 01, GREEN Groupe de Recherche Clinique en Neuro-Urologie, AP-HP, Hôpital Tenon, 75020 Paris, France; Department of Neuro-urology, Tenon Hospital, AP-HP, 4, rue de la Chine, 75020 Paris, France.

Objective: To analyze and quantify sacral spinal excitability through bulbocavernosus reflex (BCR) stimulus-response curves.

Methods: Thirty subjects with upper motor neuron lesions (UMN) and nine controls were included in this prospective, monocentric study. Sacral spinal excitability was assessed using stimulus-response curves of the BCR, modeled at different bladder filling volumes relative to the desire to void (as defined by the International Continence Society) during a cystometry. Read More

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NMDAR in bladder smooth muscle is not a pharmacotherapy target for overactive bladder in mice.

PeerJ 2021 7;9:e11684. Epub 2021 Jul 7.

Public Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.

Overactive bladder (OAB) is a common condition that affects a significant patient population. The N-methyl-D-aspartate receptor (NMDAR) has a role in developing bladder overactivity, pharmacological inhibition of which inhibits bladder overactivity. The common pathogenesis of OAB involves bladder smooth muscle (BSM) overactivity. Read More

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Sacral Neuromodulation for Lower Urinary Tract Symptoms: Effect of Therapy on Saudi Patient Sexual Function.

Sex Med 2021 Jul 15;9(4):100388. Epub 2021 Jul 15.

Resident Urology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Background: Sacral neuromodulation (SNM) is FDA-approved therapy for lower urinary tract and bowel dysfunction. It is newly introduced therapy in Saudi Arabia.

Aim: To evaluate the effect of SNM therapy in both male and female Saudi patient's sexual function. Read More

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Correction of overactive bladder with botulinum toxin type A (BTX-A).

Toxicon 2021 Jul 15;200:96-101. Epub 2021 Jul 15.

I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

One of the most common dysfunction is overactive bladder. The clinical symptoms are associated with an involuntary contraction of the detrusor muscle of the urethra. Drugs are the basis of overactive bladder therapy. Read More

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Youtube videos as an information source about urinary incontinence.

J Gynecol Obstet Hum Reprod 2021 Jul 13:102197. Epub 2021 Jul 13.

Department of Obstetrics and Gynecology, Başkent University, Dr. Turgut Noyan Application and Research Center, Adana, Turkey. Electronic address:

Aim: Youtube is one of the most popular video-sharing websites, and people use Youtube as a source of information. Patients with urinary incontinence may seek information about their condition on Youtube. This study aims to assess the videos on Youtube about urinary incontinence and evaluate the information regarding whether patients can understand and/or act accordingly. Read More

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RE: Parasacral transcutaneous electrical nerve stimulation in children with overactive bladder: comparison between sessions administered two and three times weekly.

Int Braz J Urol 2021 Sep-Oct;47(5):1074-1076

Pós-graduação em Educação Física, Universidade Federal do Vale do São Francisco - UNIVASF, Paulo Afonso, BA, Brasil.

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Association between the Trp64Arg polymorphism of the ADRB3 gene and overactive bladder.

Neurourol Urodyn 2021 Jul 14. Epub 2021 Jul 14.

Department of Medical Pharmacology, Medical Faculty, Istanbul Atlas University, Istanbul, Turkey.

Background: The β -adrenergic receptor (ADRB3) is very important in the regulation of the human detrusor muscle function. The well-known tryptophan64arginine polymorphism of the ADRB3 gene alters the response of the receptor to various stimuli, including adrenalin and noradrenalin, and may increase the susceptibility to develop overactive bladder (OAB). Therefore, this study was performed to determine whether ADRB3 Trp64Arg polymorphism is associated with the pathophysiology of OAB syndrome. Read More

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Intravesical injection of onabotulinumtoxinA in neurogenic overactive bladder patients with human T-cell leukemia virus type 1-associated myelopathy: A single-institution case series.

IJU Case Rep 2021 Jul 5;4(4):251-254. Epub 2021 May 5.

Department of Urology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan.

Introduction: Neurogenic overactive bladder is a main feature of human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis. We successfully performed intravesical onabotulinumtoxinA therapy for refractory neurogenic overactive bladder due to human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis.

Case Presentation: We retrospectively reviewed four neurogenic overactive bladder patients with human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis who underwent bladder wall injections of onabotulinumtoxinA from April to October 2020. Read More

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The Costs and Healthcare Resource Utilization Associated with Anticholinergic Burden in Long-Stay Nursing Home Residents with Overactive Bladder in the US.

Pharmacoecon Open 2021 Jul 13. Epub 2021 Jul 13.

Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of Houston, Health and Biomedical Sciences Building 2, Office 4052, 4849 Calhoun Road, Houston, TX, 77204-5047, USA.

Background: Overactive bladder (OAB) is a prevalent condition commonly treated with anticholinergic medications. The extent to which anticholinergic burden is associated with costs and healthcare resource use (HCRU) in the long-stay nursing home (LSNH) setting is currently unknown.

Objectives: This research evaluated the impact of anticholinergic burden on HCRU and related costs among LSNH residents with OAB. Read More

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The characteristics and risk factors of healthcare-seeking men with lower urinary tract symptoms in China: Initial report from the POInT group.

Neurourol Urodyn 2021 Jul 12. Epub 2021 Jul 12.

Bristol Urological Institute, Southmead Hospital, Bristol, UK.

Aims: To investigate the clinical characteristics of health care-seeking men presenting with lower urinary tract symptoms (LUTS) in China and to reveal risk factors for symptom severity.

Methods: This multicenter, hospital-based, cross-sectional study recruited 1477 eligible male subjects, who were at least 45 years, seeking health care at 9 participating hospitals across the mainland China. The general medical information and subjective symptoms were recorded, followed by the measurement of prostate volume, urodynamic indices, and laboratory tests for kidney function, plus glucose/lipid metabolism. Read More

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[Overactive bladder: urodynamic characteristics of detrusor overactivity due to the etiology of low urinary tract dysfun- ction].

Urologiia 2021 Jun(3):39-44

Ural State Medical University, Ekaterinburg, Russia.

The aim of the study was to detect features of detrusor overactivity as an urodynamic phenomenon in patients with different etiology of low urinary tract dysfunction.

Materials And Methods: The study included 283 patients (61% females and 39% males) aged 18-82 years (49.2+/-13. Read More

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Concentration-dependent alpha-Adrenoceptor Antagonism and Inhibition of Neurogenic Smooth Muscle Contraction by Mirabegron in the Human Prostate.

Front Pharmacol 2021 24;12:666047. Epub 2021 Jun 24.

Department of Urology, University Hospital, LMU Munich, Munich, Germany.

Mirabegron is available for treatment of storage symptoms in overactive bladder, which may be improved by β-adrenoceptor-induced bladder smooth muscle relaxation. In addition to storage symptoms, lower urinary tract symptoms in men include obstructive symptoms attributed to benign prostatic hyperplasia, caused by increased prostate smooth muscle tone and prostate enlargement. In contrast to the bladder and storage symptoms, effects of mirabegron on prostate smooth muscle contraction and obstructive symptoms are poorly understood. Read More

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Urogynecological survey in a group of Italian women treated for overactive bladder: Symptoms and quality of life analysis during the Covid-19 period.

Taiwan J Obstet Gynecol 2021 Jul;60(4):674-678

Department of Gynecological and Obstetric Sandro Pertini Hospital, Rome, Italy.

Objectives: The aim of this study is to assess the impact of life change and social distancing measures, during the Covid-19 outbreak, on the OAB symptoms and quality of life in women underwent different types of treatment.

Materials And Methods: Observational survey analysis in OAB treated patients was performed. The women showed a greater than 50% improvement during specific therapy for OAB. Read More

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Pelvic organ prolapse surgery and overactive bladder symptoms-a population-based cohort (FINPOP).

Int Urogynecol J 2021 Jul 10. Epub 2021 Jul 10.

Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.

Introduction And Hypothesis: It is unclear how compartment of pelvic organ prolapse (POP) impacts overactive bladder (OAB) symptom severity or improvement after POP surgery. We hypothesized that anterior and apical prolapse are more strongly associated with OAB symptoms than posterior compartment prolapse.

Methods: A total of 2933 POP surgeries from a prospective population-based cohort were divided into two groups: (1) anterior and/or apical compartment surgery (± posterior repair), N = 2091; (2) posterior repair only, N = 478. Read More

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Evaluation of the Effect of a Novel β3-Adrenergic Agonist on Choroidal Vascularity.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):17

Alaaddin Keykubat University Education and Research Hospital, Department of Ophthalmology, Antalya, Turkey.

Purpose: To determine the effect of the new β3-agonist (mirabegron), which is used for overactive bladder (OAB) treatment, on central retinal thickness (CRT) and choroidal vascularity.

Material And Methods: The 26 eyes of 26 cases using 50 mg tablet mirabegron once per day for OAB were included in this prospective case control study. The CRT, choroidal thickness (ChT), and choroidal vascularity were measured at baseline, week 1 (W1), month 1 (M1), month 2 (M2), and month 3 (M3). Read More

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Characteristics Associated With Treatment Failure 1 Year After Midurethral Sling in Women With Mixed Urinary Incontinence.

Obstet Gynecol 2021 Aug;138(2):199-207

Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Alpert Medical School of Brown University, Providence, Rhode Island; the Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama; the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; the Division of Urogynecology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina; the Division of Female Pelvic Medicine & Reconstructive Surgery, Department of Obstetrics & Gynecology, Kaiser Permanente, Downey, California; the Division of Urology, Department of Surgery, Perelman School of Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania; the Division of Urogynecology, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, New Mexico; the Center for Urogynecology and Reconstructive Pelvic Surgery, Obstetrics, Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio; the Department of Physical Therapy, Rangos School of Health Sciences, Duquesne University, Pittsburgh, Pennsylvania; the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; and Social, Statistical, & Environmental Sciences, RTI International, Research Triangle Park, North Carolina.

Objective: To evaluate characteristics associated with treatment failure 1 year after midurethral sling in women with mixed urinary incontinence.

Methods: Four-hundred three women who participated in a randomized trial that compared midurethral sling and behavioral and pelvic floor muscle therapy (combined group) compared with midurethral sling alone for mixed incontinence with 1-year follow-up data were eligible for this planned secondary analysis. Overall treatment failure was defined as meeting criteria for subjective or objective failure or both. Read More

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Cardiovascular Risk in Users of Mirabegron Compared with Users of Antimuscarinic Treatments for Overactive Bladder: Findings from a Non-Interventional, Multinational, Cohort Study.

Drug Saf 2021 Aug 8;44(8):899-915. Epub 2021 Jul 8.

Optum, 1325 Boylston Street, Boston, MA, 02215, USA.

Introduction: During clinical trials, mirabegron, a β3-adrenoreceptor agonist, was associated with increased vital signs vs placebo in patients with overactive bladder.

Objective: The purpose of this study was to compare incidence rates of adverse cardiovascular (CV) outcomes following mirabegron or antimuscarinic use.

Methods: We conducted an observational post-marketing safety study utilising real-world data. Read More

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Time until maximum flow rate uroflowmetry: A new parameter for predicting failure of transcutaneous electrical nerve stimulation (TENS) in treating children and adolescents with overactive bladder.

J Pediatr Urol 2021 Jun 11. Epub 2021 Jun 11.

Center for Children's Urinary Disorders (CEDIMI), Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil. Electronic address:

Aim: To analyze uroflowmetry as a predictor of the outcome of treatment with parasacral transcutaneous electrical nerve stimulation (TENS) in patients with pure overactive bladder.

Methods: Thirty-eight patients of 5-16 years of age were included in this prospective cohort study. All the patients had been seen at a referral clinic between 2006 and 2015. Read More

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Is there a Difference in Whole Body Standing Posture in Women with Urinary Incontinence Based on the Presence of Myofascial Dysfunction in the Pelvic Floor Muscles?

Phys Ther 2021 Jul 6. Epub 2021 Jul 6.

Department of Obstetrics and Gynecology, School of Medicine, University of Campinas (UNICAMP), Campinas, Brazil.

Objective: The purpose of this study was to assess the prevalence of postural changes in women who had urinary incontinence (UI) with myofascial dysfunction (MD) and women who had UI without MD in the pelvic floor muscles (PFM).

Methods: A cross-sectional study was performed with 234 women who had UI and were 18 years old or older at the urogynecology outpatient clinic of a tertiary academic hospital. The International Consultation on Incontinence Questionnaire-Short Form and the International Consultation on Incontinence Questionnaire-Overactive Bladder were used to collect urinary data. Read More

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Efficacy of Transcutaneous Electrical Nerve Stimulation in the Management of Neurogenic Overactive Bladder: A Randomized Controlled Trial.

Am J Phys Med Rehabil 2021 Jul 3. Epub 2021 Jul 3.

Department of Rehabilitation Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Objective: To investigate the therapeutic effect of transcutaneous electrical nerve stimulation (TENS) on neurogenic overactive bladder (NOAB) that is refractory to pharmacotherapy.

Methods: This randomized trial recruited 83 participants with NOAB that were non-responsive to 3 months first-line anticholinergic drug treatment. Participants were randomized into treatment and control groups. Read More

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Home-Based SCONE Therapy Improves Symptoms of Neurogenic Bladder.

Neurotrauma Rep 2021 18;2(1):165-168. Epub 2021 Mar 18.

Department of Neurobiology, Keck School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

A wide range of dysfunction can occur after a stroke including symptoms such as urinary urgency, frequency, and urge incontinence. The Spinal Cord Neuromodulator (SCONE) reactivates and retrains spinal neural networks. The present case study introduces initial evidence that home-based, self-administered SCONE therapy may be a safe and effective method of delivering this neuromodulation modality and may have the ability to minimize clinic visits, which is especially salient in today's public health environment. Read More

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Bladder metastasis without hematuria, following radiation therapy for lung adenocarcinoma.

Int Cancer Conf J 2021 Jul 27;10(3):248-253. Epub 2021 May 27.

Department of Pathology, Hokkaido Social Work Association Obihiro Hospital, 2 Higashi 5-jo Minami 9-chome, Obihiro-shi, Hokkaido, Japan.

Bladder metastasis from lung adenocarcinoma is extremely rare. Unlike primary bladder urothelial tumors, the initial symptoms of this disease vary, and include pelvic pain, dysuria, and hematuria. There are few reports on cases without microscopic hematuria. Read More

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Mirabegron improves erectile function in men with overactive bladder and erectile dysfunction: a 12-week pilot study.

Int J Impot Res 2021 Jul 2. Epub 2021 Jul 2.

The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Phosphodiesterase type 5 inhibitors (PDE5i) is the only approved oral treatment for erectile dysfunction (ED) in the US, and alternative management remains necessary when this treatment fails or is contraindicated. Targeting other pathways than the NO-cGMP pathway and/or combining this approach with PDE5i may introduce new treatments for men who are unresponsive to PDE5i. This study aims to evaluate whether Mirabegron improves erectile function in men with concurrent overactive bladder and mild to moderate ED. Read More

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Association between overactive bladder and pelvic organ mobility as evaluated by dynamic magnetic resonance imaging.

Sci Rep 2021 Jul 2;11(1):13726. Epub 2021 Jul 2.

Department of Urology, Yotsuya Medical Cube, 7-7 Nibancho, Chiyoda City, Tokyo, 102-0084, Japan.

Overactive bladder (OAB) is a prevalent condition, which negatively impacts patients' quality of life. Pelvic organ prolapse (POP), also prevalent in women, has been recognized as an important etiology of female OAB, although the pathophysiological mechanisms remain controversial. In this study, we reviewed findings of dynamic magnetic resonance imaging (dMRI) in 118 patients with POP and investigated the association between dMRI findings, including positions and mobilities of pelvic organs as well as parameters of pelvic organ support and bladder outlet obstruction (urethral kinking), and OAB in order to elucidate the pathophysiology of OAB in patients with POP. Read More

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