10,487 results match your criteria overactive

Evaluation of the Clinical Efficacy and Complications of Duloxetine in Comparison to Solifenacin in the Treatment of Overactive Bladder Disease in Women: A Randomized Clinical Trial.

Urol J 2021 Aug 3. Epub 2021 Aug 3.

Department of Urology, Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran.

Purpose: SNRIs (serotonin and norepinephrine reuptake inhibitors) like duloxetine are known to have role in the treatment of anxiety disorder and stress urinary incontinence. According to the correlation of anxiety disorder and overactive bladder, this study aimed to evaluate the clinical efficacy and complications of duloxetine (SNRI) as a medication in the treatment of overactive bladder in the female patients. We were interested to know the probable therapeutic effect and side effects of duloxetine in overactive bladder. Read More

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Long-term outcomes of Altis® single-incision sling procedure for stress urinary incontinence.

Int Urogynecol J 2021 Aug 2. Epub 2021 Aug 2.

Urology Department, Centro Hospitalar Vila Nova de Gaia/Espinho EPE, Vila Nova de Gaia, Portugal.

Introduction And Hypothesis: In women with predominant stress urinary incontinence (SUI), recent data are still controversial regarding the short-term outcomes of mini-slings and there is a lack of evidence about the outcomes in the long term. Our aim was to evaluate the long-term effectiveness and complication rates of Altis® (Coloplast).

Methods: A total of 145 women with clinical SUI were implanted with an Altis® sling between April 2012 and December 2015. Read More

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Efficacy of Yun-Type Optimized Pelvic Floor Training Therapy for Middle-Aged Women With Severe Overactive Bladder: A Randomized Clinical Trial.

Front Surg 2021 14;8:670123. Epub 2021 Jul 14.

Department of Urology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.

This study aimed to evaluate the clinical efficacy of Yun-type optimized pelvic floor training therapy for middle-aged women with severe overactive bladder (OAB). This randomized, observer-blinded, parallel-group controlled clinical trial included 108 middle-age women with severe OAB and assigned them to the intervention group (treated with combination of Yun-type optimized pelvic floor training with solifenacin for 12 weeks) and control group (treated with solifenacin for 6 weeks and, after 2 weeks of elution, received the combination of Yun-type optimized pelvic floor training and solifenacin for 6 weeks). The outcomes associated with OAB, pelvic floor muscle (PFM) function, and sexual function were compared after 6 and 12/14 weeks of treatment. Read More

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Sacral Neuromodulation with the InterStim System for Overactive Bladder: 3-Year Results from the French Prospective, Multicenter, Observational SOUNDS Study.

Eur Urol Focus 2021 Jul 29. Epub 2021 Jul 29.

CHU de Rouen, Hôpital Charles Nicolle, Rouen, France.

Background: SOUNDS strengthens the evidence basis of sacral neuromodulation (SNM) for overactive bladder (OAB) through real-world data.

Objective: To analyze diary-based effectiveness, quality of life (QoL), disease severity, symptom bother, and safety data for SNM with the InterStim system up to 3 yr after implantation.

Design, Setting, And Participants: Twenty-five representative French sites enrolled 291 patients with OAB followed according to the local standard of care. Read More

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Is there concordance between overactive bladder and detrusor overactivity in men with predominant storage urinary symptoms referred to Functional Urology and Urodynamics Units?

Actas Urol Esp 2021 Jul 28. Epub 2021 Jul 28.

Hospital Germans Trias i Pujol y Universidad Autónoma de Barcelona, Badalona, Barcelona, España.

Objective: To assess the diagnostic concordance of overactive bladder (OAB) and detrusor overactivity (DO) in male patients with predominant storage lower urinary tract symptoms (LUTS) and evaluate their clinical and urodynamic profile according to DO presence and degree of obstruction.

Material And Methods: Epidemiological, cross-sectional multicenter study. A 3-day bladder diary (3dBD), International Prostate Symptom Score (IPSS) and Bladder Control Self-Assessment Questionnaire (B-SAQ) questionnaires were analyzed. Read More

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Testing sensation of gently squeezing the testes has diagnostic value in spinal cord injury men.

Spinal Cord Ser Cases 2021 Jul 30;7(1):67. Epub 2021 Jul 30.

Neurology, Internal Medicine, Sakura Medical Center, Toho University, Tokyo, Japan.

Study Design: Retrospective cohort study.

Objectives: Determine the diagnostic value of testing the sensation of squeezing the testes.

Setting: Research group run by the University of Antwerp. Read More

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Effect of systemic atherosclerosis on overactive bladder symptoms in men with benign prostatic hyperplasia.

Low Urin Tract Symptoms 2021 Jul 28. Epub 2021 Jul 28.

Department of Urology, Yonsei University College of Medicine, Seoul, South Korea.

Objective: Symptoms of male overactive bladder (OAB) may be caused by several systemic pathophysiological factors rather than a single-source etiology. We investigated the clinical factors associated with the severity of OAB symptoms in treatment-naïve men with coexisting benign prostatic hyperplasia.

Methods: We obtained records from a health promotion center database of male patients who visited between March 2019 and February 2020. Read More

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Sepsis and multiple sclerosis: Causative links and outcomes.

Immunol Lett 2021 Jul 25;238:40-46. Epub 2021 Jul 25.

Department of Pathology, Department of Microbiology and Immunology, Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.

Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. Read More

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Lower urinary tract dysfunction in Parkinsonian syndromes.

Neurol Sci 2021 Jul 28. Epub 2021 Jul 28.

Department of Uro‑Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Purpose Of Review: The aim of this review is to outline the clinical presentation, pathophysiology and evaluation of lower urinary tract (LUT) dysfunction in Parkinson's disease and other parkinsonian syndromes including multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration.

Recent Findings: LUT dysfunction commonly occurs in neurological disorders, including patients with parkinsonian syndromes. The pattern of LUT dysfunction and its severity are variable, depending upon the site of lesion within the neural pathways. Read More

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Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity.

Mol Cell 2021 Jul 21. Epub 2021 Jul 21.

Department of Biological Sciences, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

The β-adrenergic receptor (βAR) is predominantly expressed in adipose tissue and urinary bladder and has emerged as an attractive drug target for the treatment of type 2 diabetes, obesity, and overactive bladder (OAB). Here, we report the cryogenic electron microscopy structure of the βAR-G signaling complex with the selective agonist mirabegron, a first-in-class drug for OAB. Comparison of this structure with the previously reported βAR and βAR structures reveals a receptor activation mechanism upon mirabegron binding to the orthosteric site. Read More

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Adverse events associated with mirabegron 50mg versus placebo: A systematic review and meta-analysis.

J Hou F Xu H Du N Li

Prog Urol 2021 Jul 23. Epub 2021 Jul 23.

Department of Urology, Fourth Affiliated Hospital, China Medical University, 4 Chong Shan East Road, Shenyang, Liaoning, China. Electronic address:

Purpose: The safety of mirabegron 50mg monotherapy was comprehensively assessed versus placebo for overactive bladder.

Methods: A systematic literature search was conducted up to June, 2020 using PUBMED, EMBASE and Cochrane Library. Randomized controlled trials evaluating safety of mirabegron in overactive bladder were collected, and safety was assessed according to 15 adverse events. Read More

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Pelvic floor muscle training, the risk of falls and urgency urinary incontinence in older women.

Z Gerontol Geriatr 2021 Jul 26. Epub 2021 Jul 26.

Department of Urology, Jessenius Faculty of Medicine, Martin, Comenius University Bratislava, Bratislava, Slovakia.

Purpose: The primary aim of the work was to evaluate the effect of physical training and pelvic floor muscle training combined with dual tasks (PFMT-DT) in older women on urgency urinary incontinence (UUI). The secondary aim of the work was to evaluate the impact of interventions on static and dynamic balance, risk of falls and fear of falls.

Sample: The research sample consisted of 88 older women with UUI, with a mean age of 75 ± 4. Read More

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Hemophagocytic lymphohistiocytosis presenting as acute coronary syndrome.

Autops Case Rep 2021 6;11:e2021285. Epub 2021 May 6.

St. Joseph's University Medical Center, Hematology and Oncology Department, Paterson, NJ, USA.

Acquired Hemophagocytic Lymphohistiocytosis is a rare and deadly syndrome resulting from an overactive immune system, with uncontrolled activation of macrophages and lymphocytes, hypercytokinemia, and systemic inflammatory response. A 75-year-old male presented with typical anginal pain and was diagnosed with the acute coronary syndrome, which required a percutaneous transluminal coronary angioplasty. Instead of resolving the symptoms, the patient began to exhibit pyrexia and worsening altered sensorium with progressing renal failure, anemia, thrombocytopenia and respiratory failure. Read More

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Protein Kinase CK2 Regulates B Cell Development and Differentiation.

J Immunol 2021 08 23;207(3):799-808. Epub 2021 Jul 23.

Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294; and.

Protein kinase CK2 (also known as Casein Kinase 2) is a serine/threonine kinase composed of two catalytic subunits (CK2α and/or CK2α') and two regulatory CK2β subunits. CK2 is overexpressed and overactive in B cell acute lymphoblastic leukemia and diffuse large B cell lymphomas, leading to inappropriate activation of the NF-κB, JAK/STAT, and PI3K/AKT/mTOR signaling pathways and tumor growth. However, whether CK2 regulates normal B cell development and differentiation is not known. Read More

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An Examination of the Relationship between Urinary Neurotrophin Concentrations and Transcutaneous Electrical Nerve Stimulation (TENS) Used in Pediatric Overactive Bladder Therapy.

J Clin Med 2021 Jul 17;10(14). Epub 2021 Jul 17.

Department of Pediatrics and Nephrology, Medical University of Białystok, 17 Waszyngtona Str., 15-274 Białystok, Poland.

This article aims to explore changes in urinary concentrations of selected neurotrophins in the course of TENS therapy in children with overactive bladder (OAB). A two-group open-label prospective study was conducted. The intervention group comprised 30 children aged between 5 and 12 years old with OAB refractory to conservative therapy. Read More

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Efficacy and safety of onabotulinumtoxinA in patients with overactive bladder: subgroup analyses by sex and by serum prostate-specific antigen levels in men from a randomized controlled trial.

Int Urol Nephrol 2021 Jul 22. Epub 2021 Jul 22.

Specialty Medical and Development, GlaxoSmithKline, Tokyo, Japan.

Purpose: We aimed to assess onabotulinumtoxinA treatment outcomes by sex in patients with overactive bladder (OAB) and then explore the impact of serum prostate-specific antigen (PSA) levels in men.

Methods: Patients inadequately managed with OAB medications were randomized to receive single-dose onabotulinumtoxinA (100 U) or placebo intravesical injection in a phase III trial in Japan. We performed subgroup analyses by sex and post-hoc subgroup analyses using male PSA categories. Read More

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Prevalence and associated risk factors among patients with overactive bladder syndrome in Pakistan.

Pak J Med Sci 2021 Jul-Aug;37(4):1185-1189

Dr. Saima Riaz, PhD. Assistant Professor Riphah College of Rehabilitation & Allied Health Sciences, RIU, Lahore, Pakistan.

Objectives: To determine the Prevalence and associated risk factors among patients with overactive bladder syndrome in Pakistan.

Methods: This was a community-based, face to face, cross sectional survey to calculate the prevalence and its associated risk factors. A sample of 1058 patients, women and men aged between 35 to 60 years having symptoms of overactive bladder was selected through convenience sampling from different cities of Pakistan during September to December 2020. Read More

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February 2021

Endocannabinoids in Bladder Sensory Mechanisms in Health and Diseases.

Front Pharmacol 2021 5;12:708989. Epub 2021 Jul 5.

Discipline of Human Physiology, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA, Australia.

The recent surge in research on cannabinoids may have been fueled by changes in legislation in several jurisdictions, and by approval for the use of cannabinoids for treatment of some chronic diseases. Endocannabinoids act largely, but not exclusively on cannabinoid receptors 1 and 2 (CBR1 and CBR2) which are expressed in the bladder mainly by the urothelium and the axons and endings of motor and sensory neurons. A growing body of evidence suggests that endocannabinoid system constitutively downregulates sensory bladder function during urine storage and micturition, under normal physiological conditions. Read More

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Acupuncture in addition to standard conservative treatment for overactive bladder; a feasibility trial for a randomized controlled study.

Neurourol Urodyn 2021 Jul 21. Epub 2021 Jul 21.

Department of Sport, Exercise and Rehabilitation, Programme Lead BSc Physiotherapy, Northumbria University, Newcastle upon Tyne, UK.

Aims: This study aims to assess the feasibility of an randomized controlled trial (RCT) to test treatment efficacy of acupuncture for symptoms of overactive bladder syndrome (OAB), a common long-term condition with physical, psychological, social and sexual consequences.

Methods: A total of 30 participants were recruited and randomized to either standard conservative management for OAB or standard conservative management plus acupuncture. Standard care consisted of individually tailored advice regarding bladder health, pelvic floor exercises and lifestyle adjustments. Read More

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Factors affecting urinary frequency after low-dose-rate brachytherapy for prostate cancer.

Low Urin Tract Symptoms 2021 Jul 20. Epub 2021 Jul 20.

Department of Urology, Nara Medical University, Kashihara, Japan.

Objectives: Lower urinary tract symptoms are transiently exacerbated by low-dose-rate brachytherapy (LDR-BT) for prostate cancer and recover to pretreatment levels 1 year thereafter. Generally, these symptoms are influenced by temperature. We aimed to search for factors affecting the lower urinary tract symptoms after seed implant including seasons. Read More

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Assessment of sacral spinal excitability using stimulus-response curves of the bulbocavernosus reflex.

Clin Neurophysiol 2021 Jun 25;132(9):2123-2129. Epub 2021 Jun 25.

Sorbonne Université, GRC 01, GREEN Groupe de Recherche Clinique en Neuro-Urologie, AP-HP, Hôpital Tenon, 75020 Paris, France; Department of Neuro-urology, Tenon Hospital, AP-HP, 4, rue de la Chine, 75020 Paris, France.

Objective: To analyze and quantify sacral spinal excitability through bulbocavernosus reflex (BCR) stimulus-response curves.

Methods: Thirty subjects with upper motor neuron lesions (UMN) and nine controls were included in this prospective, monocentric study. Sacral spinal excitability was assessed using stimulus-response curves of the BCR, modeled at different bladder filling volumes relative to the desire to void (as defined by the International Continence Society) during a cystometry. Read More

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NMDAR in bladder smooth muscle is not a pharmacotherapy target for overactive bladder in mice.

PeerJ 2021 7;9:e11684. Epub 2021 Jul 7.

Public Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.

Overactive bladder (OAB) is a common condition that affects a significant patient population. The N-methyl-D-aspartate receptor (NMDAR) has a role in developing bladder overactivity, pharmacological inhibition of which inhibits bladder overactivity. The common pathogenesis of OAB involves bladder smooth muscle (BSM) overactivity. Read More

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Toll-like Receptor 2 in Autoimmune Inflammation.

Immune Netw 2021 Jun 25;21(3):e18. Epub 2021 Jun 25.

Center for Cancer Cell Biology, Immunology, and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.

TLR signaling is critical for broad scale immune recognition of pathogens and/or danger molecules. TLRs are particularly important for the activation and the maturation of cells comprising the innate immune response. In recent years it has become apparent that several different TLRs regulate the function of lymphocytes as well, albeit to a lesser degree compared to innate immunity. Read More

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Sacral Neuromodulation for Lower Urinary Tract Symptoms: Effect of Therapy on Saudi Patient Sexual Function.

Sex Med 2021 Jul 15;9(4):100388. Epub 2021 Jul 15.

Resident Urology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Background: Sacral neuromodulation (SNM) is FDA-approved therapy for lower urinary tract and bowel dysfunction. It is newly introduced therapy in Saudi Arabia.

Aim: To evaluate the effect of SNM therapy in both male and female Saudi patient's sexual function. Read More

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Correction of overactive bladder with botulinum toxin type A (BTX-A).

Toxicon 2021 Jul 15;200:96-101. Epub 2021 Jul 15.

I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

One of the most common dysfunction is overactive bladder. The clinical symptoms are associated with an involuntary contraction of the detrusor muscle of the urethra. Drugs are the basis of overactive bladder therapy. Read More

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Youtube videos as an information source about urinary incontinence.

J Gynecol Obstet Hum Reprod 2021 Jul 13;50(10):102197. Epub 2021 Jul 13.

Department of Obstetrics and Gynecology, Başkent University, Dr. Turgut Noyan Application and Research Center, Adana, Turkey. Electronic address:

Aim: Youtube is one of the most popular video-sharing websites, and people use Youtube as a source of information. Patients with urinary incontinence may seek information about their condition on Youtube. This study aims to assess the videos on Youtube about urinary incontinence and evaluate the information regarding whether patients can understand and/or act accordingly. Read More

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Design and rationale of a clinical trial to increase cardiomyocyte division in infants with tetralogy of Fallot.

Int J Cardiol 2021 Jul 12. Epub 2021 Jul 12.

Division of Cardiology, UPMC Children's Hospital of Pittsburgh and Department of Pediatrics, 4401 Penn Ave, Pittsburgh, PA 15224, USA; Pediatric Institute for Heart Regeneration and Therapeutics (I-HRT), UPMC Children's Hospital of Pittsburgh and Department of Pediatrics, 4401 Penn Ave, Pittsburgh, PA 15224, USA; McGowan Institute of Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address:

Background: Patients with Tetralogy of Fallot with pulmonary stenosis (ToF/PS), the most common form of cyanotic congenital heart disease (CHD), develop adverse right ventricular (RV) remodeling, leading to late heart failure and arrhythmia. We recently demonstrated that overactive β-adrenergic receptor signaling inhibits cardiomyocyte division in ToF/PS infants, providing a conceptual basis for the hypothesis that treatment with the β-adrenergic receptor blocker, propranolol, early in life would increase cardiomyocyte division. No data are available in ToF/PS infants on the efficacy of propranolol as a possible novel therapeutic option to increase cardiomyocyte division and potentially reduce adverse RV remodeling. Read More

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Rhizomelia and Impaired Linear Growth in a Girl with Juvenile Paget Disease: The Natural History of the Condition.

Horm Res Paediatr 2021 Jul 14:1-8. Epub 2021 Jul 14.

Center for Rare Diseases Ruhr CeSER, Ruhr-University Bochum and Witten/Herdecke University, Bochum, Germany.

In ultra-rare bone diseases, information on growth during childhood is sparse. Juvenile Paget disease (JPD) is an ultra-rare disease, characterized by loss of function of osteoprotegerin (OPG). OPG inhibits osteoclast activation via the receptor activator of nuclear factor-κB (RANK) pathway. Read More

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RE: Parasacral transcutaneous electrical nerve stimulation in children with overactive bladder: comparison between sessions administered two and three times weekly.

Int Braz J Urol 2021 Sep-Oct;47(5):1074-1076

Pós-graduação em Educação Física, Universidade Federal do Vale do São Francisco - UNIVASF, Paulo Afonso, BA, Brasil.

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