123,342 results match your criteria ovarian cancer

Development and validation of a RPLC-MS/MS method for the quantification of ceramides in human serum.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 3;1175:122734. Epub 2021 May 3.

Biomic_AUTh, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, B1.4, 10th Km Thessaloniki-Thermi Rd, P.O. Box 8318, 57001 Thessaloniki, Greece; Laboratory of Forensic Medicine & Toxicology, School of Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece. Electronic address:

Ceramides are key-role lipids involved in numerous central cellular processes. A plethora of studies have demonstrated that the levels of ceramides in blood circulation are related to different disease states, such as type 2 diabetes, cardiovascular diseases, ovarian cancer, multiple sclerosis and others. Herein, a RPLC-MS/MS method for the rapid quantification of ceramides Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1) in human blood serum was developed and validated. Read More

View Article and Full-Text PDF

Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.

Lancet 2021 May 12. Epub 2021 May 12.

MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.

Background: Ovarian cancer continues to have a poor prognosis with the majority of women diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) to determine if population screening can reduce deaths due to the disease. We report on ovarian cancer mortality after long-term follow-up in UKCTOCS. Read More

View Article and Full-Text PDF

General population screening for ovarian cancer.

Lancet 2021 May 12. Epub 2021 May 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.

View Article and Full-Text PDF

Population-based cancer staging for oesophageal, gastric, and pancreatic cancer 2012-2014: International Cancer Benchmarking Partnership SurvMark-2.

Int J Cancer 2021 May 14. Epub 2021 May 14.

Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.

Cancer stage at diagnosis is important information for management and treatment of individual patients as well as in epidemiological studies to evaluate effectiveness of health care system in managing cancer patients. Population-based studies to examine international disparities on cancer survival by stage, however, has been challenging due to the lack of international standardization on recording stage information and variation in stage completeness across regions and countries. The International Cancer Benchmarking Partnership (ICBP) previously assessed the availability and comparability of staging information for colorectal, lung, female breast, and ovarian cancers. Read More

View Article and Full-Text PDF

Cigarette Smoking and Estrogen-Related Cancer.

Cancer Epidemiol Biomarkers Prev 2021 May 14. Epub 2021 May 14.

Department of Veterinary Physiology and Pharmacology, Texas A & M University.

Cigarette smoking is a known cause of many cancers, yet epidemiological studies have found protective associations with the risk of four "estrogen-related" malignancies: endometrial cancer, endometrioid and clear cell ovarian cancers, and thyroid cancer. This review considers epidemiological and biological aspects of these associations, focusing particularly on estrogen signaling, and contrasts them with those for breast cancer, another estrogen-related malignancy. The observational findings regarding the inverse associations are consistent and remain after adjustment for possible confounding factors. Read More

View Article and Full-Text PDF

Mechanisms driving neutrophil-induced T-cell immunoparalysis in ovarian cancer.

Cancer Immunol Res 2021 May 14. Epub 2021 May 14.

Medicine and Immunology, Roswell Park Cancer Institute

T-cell activation and expansion in the tumor microenvironment (TME) are critical for antitumor immunity. Neutrophils in the TME acquire a complement-dependent T-cell suppressor phenotype that is characterized by inhibition of T-cell proliferation and activation through mechanisms distinct from those of myeloid-derived suppressor cells. In this study, we used ascites fluid supernatants (ASC) from patients with ovarian cancer as an authentic component of the TME to evaluate the effects of ASC on neutrophil function and mechanisms for neutrophil-driven immune suppression. Read More

View Article and Full-Text PDF

Should we or should we not? Risk reduction bilateral salpingectomy for BRCA mutation carriers.

Int J Gynecol Cancer 2021 May 14. Epub 2021 May 14.

Instituto de Medicina Integral Prof Fernando Figueira, Recife, Brazil.

View Article and Full-Text PDF

Cytoreductive surgery followed by chemotherapy and olaparib maintenance in BRCA 1/2 mutated recurrent ovarian cancer: a retrospective MITO group study.

Int J Gynecol Cancer 2021 May 14. Epub 2021 May 14.

Department of Urology and Gynecology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy

Introduction: The role of cytoreductive surgery in the poly-ADP ribose polymerase inhibitors era is not fully investigated. We evaluated the impact of surgery performed prior to platinum-based chemotherapy followed by olaparib maintenance in platinum-sensitive BRCA-mutated recurrent ovarian cancer.

Methods: This retrospective study included platinum-sensitive recurrent ovarian cancer BRCA-mutated patients from 13 Multicenter Italian Trials in Ovarian cancer and gynecological malignancies centers treated between September 2015 and May 2019. Read More

View Article and Full-Text PDF

Recommendations for Postoperative Surveillance of Pediatric Benign Ovarian Neoplasms.

J Pediatr Adolesc Gynecol 2021 May 11. Epub 2021 May 11.

Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH. Electronic address:

Study Objective: Assess postoperative management of pediatric patients with benign ovarian neoplasms to develop recommendations for postoperative care.

Design: A retrospective cohort study.

Setting: Eight pediatric hospitals in the Midwest. Read More

View Article and Full-Text PDF

Local application of low level laser therapy in mice ameliorates ovarian damage induced by cyclophosphamide.

Mol Cell Endocrinol 2021 May 11:111318. Epub 2021 May 11.

Instituto de Biología y Medicina Experimental (IByME) - CONICET, Buenos Aires, Argentina. Electronic address:

The aim of the present study is to assess whether low level laser therapy (LLLT) can protect ovaries from chemotherapy-induced gonadotoxicity using a mice model of premature ovarian failure induced by cyclophosphamide (CTX). LLLT (64 J/cm) increased the number of antral follicles whilst decreasing the number of atretic follicles compared to CTX alone. LLLT increased the number of primordial follicles compared with those in the CTX group but they did not differ from those in the control group. Read More

View Article and Full-Text PDF

Challenges in Adjuvant Therapy for Premenopausal Women Diagnosed With Luminal Breast Cancers.

Am Soc Clin Oncol Educ Book 2021 Mar;41:1-15

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.

More than 90% of women with newly diagnosed breast cancer present with stage I to III disease and, with optimal multidisciplinary therapy, are likely to survive their disease. Of these patients, 70% are hormone receptor-positive and candidates for adjuvant endocrine therapy. The adoption of cumulatively better adjuvant treatments contributed to improved outcomes in patients with hormone receptor-positive, early-stage breast cancer. Read More

View Article and Full-Text PDF

Conversion of RNA Aptamer into Modified DNA Aptamers Provides for Prolonged Stability and Enhanced Antitumor Activity.

J Am Chem Soc 2021 May 14. Epub 2021 May 14.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.

Aptamers, synthetic single-strand oligonucleotides that are similar in function to antibodies, are promising as therapeutics because of their minimal side effects. However, the stability and bioavailability of the aptamers pose a challenge. We developed aptamers converted from RNA aptamer to modified DNA aptamers that target phospho-AXL with improved stability and bioavailability. Read More

View Article and Full-Text PDF

Laboratory Verification of a and Massively Parallel Sequencing Assay from Wet Bench to Bioinformatics for Germline DNA Analysis.

Glob Med Genet 2021 Jun 16;8(2):62-68. Epub 2021 Mar 16.

Department of Laboratory Medicine, National University Hospital Singapore, Singapore.

 A robust genetic test for and genes is necessary for the diagnosis, prognosis, and treatment of patients with hereditary breast and ovarian cancer. We evaluated a commercial amplicon-based massively parallel sequencing (MPS) assay, BRCA MASTR Plus on the MiSeq platform, for germline genetic testing.  This study was performed on 31 DNA from cell lines and proficiency testing samples to establish the accuracy of the assay. Read More

View Article and Full-Text PDF

Therapeutic Mechanism and Effect of Camptothecin on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.

J Immunol Res 2021 24;2021:5556659. Epub 2021 Apr 24.

Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.

Camptothecin (CPT) is a cytotoxic quinoline alkaloid isolated from the bark and branches of the Chinese tree . CPT inhibits topoisomerase I. It possesses various antitumor activities and is mainly used in the treatment of colon, ovarian, liver, and bone cancers as well as leukemia. Read More

View Article and Full-Text PDF

Exploring the concepts and practices of advanced breast cancer treatment: a narrative review.

Ann Transl Med 2021 Apr;9(8):721

Department of Medical Oncology (Breast Cancer), Cancer Hospital of the University of Chinese Academy of Sciences/Zhejiang Cancer Hospital, Hangzhou, China.

Objective: To explore the concepts and practices of advanced breast cancer treatment.

Background: Metastatic breast cancer (MBC) has become a chronic disease, with a median overall survival (OS) of around 3 years and a 5-year survival rate of about 25%. OS are strongly associated with the best available care, which consists of not only application of guidelines, but also multidisciplinary specialized care, the most efficacious medicines, and so on. Read More

View Article and Full-Text PDF

The G199X and V157fs mutations in the gene promote malignancy in serous ovarian cancer: an analysis using whole-exome sequencing.

Ann Transl Med 2021 Apr;9(8):710

Department of Gynecology and Obstetrics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.

Background: The carcinogenic mechanisms underlying serous ovarian cancer are not fully understood.

Methods: Whole-exome sequencing and targeted sequencing were performed in ovarian cancer samples to identify novel molecular markers involved in the process of cell malignancy in ovarian cancer. experiments, the oncogenic roles such as cell proliferation, migration and invasion of G199X and V157fs mutations were investigated deeply. Read More

View Article and Full-Text PDF

is involved in the formation of polyploid cancer cells and the response to paclitaxel.

Ann Transl Med 2021 Apr;9(8):693

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.

Background: Most human solid tumors are aneuploid; at the same time, polyploid cancer cells are found to be resistant to radiotherapy and chemotherapy and have a poor prognosis. The transforming growth factor beta induction () protein plays important roles in the development of tumors, depending on the cancer of origin.

Methods: In this study, we established polyploid clones of breast cancer treated with nocodazole. Read More

View Article and Full-Text PDF

Inhibition of sphingosine kinase 2 down-regulates ERK/c-Myc pathway and reduces cell proliferation in human epithelial ovarian cancer.

Ann Transl Med 2021 Apr;9(8):645

Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Epithelial ovarian cancer (EOC) is the leading cause of death from female cancers. In our previous study, sphingosine kinase 2 (SphK2) inhibitor was shown to display anti-EOC activities. The purpose of this study was to evaluate further the expression characteristics and clinical significance of SphK2 in EOC and to explore the roles and underlying mechanisms of SphK2 in EOC cell survival. Read More

View Article and Full-Text PDF

A prognostic nomogram for women with primary ovarian signet-ring cell carcinoma.

Ann Transl Med 2021 Apr;9(7):525

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.

Background: Primary ovarian signet-ring cell carcinoma (POSRCC) is a rare subtype of ovarian carcinoma that is characterized by abundant mucin accumulation. POSRCC is aggressive, and the prognostic factors associated with its clinical outcome remain poorly defined. This study aimed to elucidate the clinical characteristics and survival of patients with POSRCC, and to establish an effective prognostic nomogram and risk stratification model to predict the risks associated with patient outcomes. Read More

View Article and Full-Text PDF

Mining TCGA database for gene expression in ovarian serous cystadenocarcinoma microenvironment.

PeerJ 2021 4;9:e11375. Epub 2021 May 4.

Department of Gynecology, Qingdao Municipal Hospital, Qingdao, China.

Background: Ovarian cancer is one of the leading causes of female deaths worldwide. Ovarian serous cystadenocarcinoma occupies about 90% of it. Effective and accurate biomarkers for diagnosis, outcome prediction and personalized treatment are needed urgently. Read More

View Article and Full-Text PDF

MicroRNA-383-5p predicts favorable prognosis and inhibits the progression of diffuse large B-cell lymphoma.

Oncol Lett 2021 Jul 6;22(1):515. Epub 2021 May 6.

Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

The roles of microRNA (miRNA/miR)-383-5p have been reported in several malignancies, including breast cancer, gastric cancer, ovarian cancer and lung adenocarcinoma. However, its function in diffuse large B-cell lymphoma (DLBCL) remains unclear. Thus, the present study aimed to investigate the role of miR-383-5p in DLCBL. Read More

View Article and Full-Text PDF

Role of the IL-33/ST2 receptor axis in ovarian cancer progression.

Oncol Lett 2021 Jul 29;22(1):504. Epub 2021 Apr 29.

Department of Gynecological Oncology, The First Hospital of Jilin University, Changchun, Jilin 130061, P.R. China.

Ovarian cancer remains a significant health problem for women in the world due to its diagnosis at advanced stages of disease and the high mortality rate of patients. To date, ovarian cancer is frequently treated with tumor reduction surgery followed by platinum/paclitaxel-based chemotherapy; however, most patients eventually develop relapsed disease. The mRNA expression levels of interleukin-33 (IL-33) and the suppressor of tumorigenicity 2 (ST2) receptor are significantly upregulated in ovarian cancer tissues and metastatic tumor lesions. Read More

View Article and Full-Text PDF

Paraneoplastic opsoclonus-myoclonus-ataxia syndrome secondary to ovarian cancer.

Pract Neurol 2021 May 13. Epub 2021 May 13.

Department of Neurology, Atkinson Morley Neurosciences Centre, St George's Hospital, Blackshaw Road, Tooting, London, UK.

View Article and Full-Text PDF

Dimeric Her2-specific affibody mediated cisplatin-loaded nanoparticles for tumor enhanced chemo-radiotherapy.

J Nanobiotechnology 2021 May 13;19(1):138. Epub 2021 May 13.

Department of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China.

Background: Solid tumor hypoxic conditions prevent the generation of reactive oxygen species (ROS) and the formation of DNA double-strand breaks (DSBs) induced by ionizing radiation, which ultimately contributes to radiotherapy (RT) resistance. Recently, there have been significant technical advances in nanomedicine to reduce hypoxia by facilitating in situ O production, which in turn serves as a "radiosensitizer" to increase the sensitivity of tumor cells to ionizing radiation. However, off-target damage to the tumor-surrounding healthy tissue by high-energy radiation is often unavoidable, and tumor cells that are further away from the focal point of ionizing radiation may avoid damage. Read More

View Article and Full-Text PDF

Chemotherapy-based gonadotoxicity risk evaluation as a predictor of reproductive outcomes in post-pubertal patients following ovarian tissue cryopreservation.

BMC Womens Health 2021 May 13;21(1):201. Epub 2021 May 13.

Department of Obstetrics and Gynecology, Hadassah Ein-Kerem Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Background: The sterilizing effect of cancer treatment depends mostly on the chemotherapy regimen and extent of radiotherapy. Prediction of long-term reproductive outcomes among cancer survivors according to chemo-radiotherapy regimen may improve pre-treatment fertility preservation counseling and future reproductive outcomes.

Methods: The aim of this study was to evaluate long term reproductive outcomes in cancer survivors according to gonadotoxicity risk estimation of the chemo-radiotherapy regimens utilized. Read More

View Article and Full-Text PDF

Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland.

J Histochem Cytochem 2021 May 14:221554211013715. Epub 2021 May 14.

Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Grainyhead-like 2 (Grhl2) is a transcription factor regulating cell adhesion genes. Grhl2 acts as an epithelial-mesenchymal transition suppressor, and it is a proto-oncogene involved in estrogen-stimulated breast cancer proliferation. However, its expression during ovarian hormone-dependent mammary ductal development remains obscure. Read More

View Article and Full-Text PDF

Postoperative adjuvant dose-dense chemotherapy with bevacizumab and maintenance bevacizumab after neoadjuvant chemotherapy for advanced ovarian cancer: A phase II AGOG/TGOG trial.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 18;262:13-20. Epub 2021 Apr 18.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan; Gynecologic Cancer Research Center, Chang Gung Memorial Hospital, Linkou Branch and Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: The objective of this study is to evaluate the safety and efficacy of adding bevacizumab to dose-dense adjuvant chemotherapy with bevacizumab maintenance after neoadjuvant chemotherapy (NAC) and interval debulking surgery (IDS) for stage III/IV ovarian, tubal, and primary peritoneal cancer.

Study Design: This phase II clinical trial using Simon's minimax two-stage design was conducted. At the first stage, 13 subjects were enrolled, and the trial would proceed to second stage if ≤3 subjects discontinued treatment for study-defined significant adverse events (AEs). Read More

View Article and Full-Text PDF

Role of surgery and hyperthermic intraperitoneal chemotherapy in ovarian cancer.

S I Kim J-W Kim

ESMO Open 2021 May 10;6(3):100149. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Ovarian cancer is one of the deadliest gynaecological malignancies and tends to be diagnosed at an advanced stage. Similar to many malignancies, surgery plays a critical role in many aspects of ovarian cancer management. Hyperthermic intraperitoneal chemotherapy (HIPEC) involves the induction of hyperthermia and delivery of intraperitoneal chemotherapy directly into the peritoneal cavity. Read More

View Article and Full-Text PDF