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Anxiety and Depression Impact on Inhospital Complications and Outcomes After Total Knee and Hip Arthroplasty: A Propensity Score-Weighted Retrospective Analysis.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Department of Orthopeadic Surgery and Sports Medicine, Detroit Medical Center, Detorit, MI (Zalikha and El-Othmani), and the Department of Biomedical Sciences, Oakland University William Beaumont School of Medicine, Auburn Hills, MI (Karabon and Hajj Hussein).

Introduction: The purpose of this study was to assess the impact of anxiety and depression on immediate inhospital outcomes and complications after total joint arthroplasty of the hip (total hip arthroplasty [THA]) and knee (total knee arthroplasty [TKA]) using a large national registry.

Methods: Data from the National Inpatient Sample was used to identify all patients undergoing TKA and THA between 2006 and 2015. Patients were divided in four groups based on a concomitant diagnosis of depression, anxiety, depression plus anxiety, and neither depression nor anxiety (control group). Read More

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November 2020

Multiplexed drug-based selection and counterselection genetic manipulations in Drosophila.

Cell Rep 2021 Sep;36(11):109700

Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Integrative Molecular Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA; McNair Medical Institute at The Robert and Janice McNair Foundation, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

The power of Drosophila melanogaster as a model system relies on tractable germline genetic manipulations. Despite Drosophila's expansive genetics toolbox, such manipulations are still accomplished one change at a time and depend predominantly on phenotypic screening. We describe a drug-based genetic platform consisting of four selection and two counterselection markers, eliminating the need to screen for modified progeny. Read More

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September 2021

RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy.

Cell Stem Cell 2021 Sep 14. Epub 2021 Sep 14.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

Doxorubicin is an anthracycline chemotherapy agent effective in treating a wide range of malignancies, but its use is limited by dose-dependent cardiotoxicity. A recent genome-wide association study identified a SNP (rs2229774) in retinoic acid receptor-γ (RARG) as statistically associated with increased risk of anthracycline-induced cardiotoxicity. Here, we show that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from patients with rs2229774 and who suffered doxorubicin-induced cardiotoxicity (DIC) are more sensitive to doxorubicin. Read More

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September 2021

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.

Cell Chem Biol 2021 Sep 8. Epub 2021 Sep 8.

Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address:

Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest clinical outcome. The PIM family of kinases has emerged as a factor that is both overexpressed in TNBC and associated with poor outcomes. Preclinical data suggest that TNBC with an elevated MYC expression is sensitive to PIM inhibition. Read More

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September 2021

Juvenile myelomonocytic leukemia in the molecular era: a clinician's guide to diagnosis, risk-stratification, and treatment.

Blood Adv 2021 Sep 15. Epub 2021 Sep 15.

Benioff Children's Hospital, University of California, San Francisco, San Francisco, California, United States.

Juvenile myelomonocytic leukemia is an overlapping myeloproliferative and myelodysplastic disorder of early childhood. It is associated with a spectrum of diverse outcomes ranging from spontaneous resolution in rare patients to transformation to acute myeloid leukemia in others that is generally fatal. This unpredictable clinical course, along with initially descriptive diagnostic criteria, led to decades of productive international research. Read More

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September 2021

Primary vs. Specialist Care for Obstructive Sleep Apnea: A Systematic Review and Individual Participant Data Level Meta-Analysis.

Ann Am Thorac Soc 2021 Sep 15. Epub 2021 Sep 15.

IRBLLEIDA, 170673, Lleida, Spain.

Rationale: Primary care clinicians may be well placed to play a greater role in obstructive sleep apnea management.

Objectives: To evaluate the outcomes and cost-effectiveness of sleep apnea management in primary versus specialist care, using an individual-participant data meta-analysis to determine whether age, gender, severity of OSA and daytime sleepiness impacted outcomes.

Methods: Data sources were CINAHL, CENTRAL, MEDLINE Ovid SP, Scopus, ProQuest, US NIH Ongoing Trials Register, ISRCTN registry [inception until 09-25-2019]. Read More

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September 2021

Risk Factors and Outcomes for Gastroparesis After Lung Transplantation.

Dig Dis Sci 2021 Sep 15. Epub 2021 Sep 15.

Division of Digestive and Liver Diseases, Department of Medicine, New York Presbyterian Columbia University Medical Center, 622 West 168th Street, New York, NY, USA.

Background: Gastroparesis is common after lung transplantation and is associated with worse transplant outcomes, including the development of chronic lung allograft dysfunction (CLAD). This study sought to identify the prevalence, risk factors, and outcomes associated with a new diagnosis of gastroparesis after lung transplantation.

Methods: This was a single-center retrospective study of patients who underwent lung transplantation in 2008-2018. Read More

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September 2021

The Association Between Obesity and Key Health or Psychosocial Outcomes Among Autistic Adults: A Systematic Review.

J Autism Dev Disord 2021 Sep 15. Epub 2021 Sep 15.

The Ohio State University, 453 W 10th Ave, 228E Atwell Hall, Columbus, OH, 43210, USA.

Obesity is linked with health and psychosocial outcomes among many populations. However, it is unclear the extent to which obesity is linked with these outcomes among autistic adults. We searched seven research databases for articles examining the association between obesity and autistic adults' health and psychosocial outcomes. Read More

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September 2021

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

J Ophthalmic Inflamm Infect 2021 Nov 1;11(1):31. Epub 2021 Nov 1.

Department of Uveitis, Moorfields Eye Hospital, National Health Service Foundation Trust, 162 City Rd, Old Street, London, EC1V 2PD, UK.

Background: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory eye disease, affecting the inner choroid and the outer retina. Recent advances in multimodal imaging have been important in the understanding of the pathophysiology of the disease, allowing a better characterization of the morphology of this condition.

Methods: Narrative review. Read More

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November 2021

Development of a Programme Theory for Early Intervention Vocational Rehabilitation: A Realist Literature Review.

J Occup Rehabil 2021 Sep 15. Epub 2021 Sep 15.

Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.

Purpose Little is currently known about how early intervention vocational rehabilitation (EIVR) works for people with newly acquired neurological conditions such as traumatic brain injury, acquired brain injury and spinal cord injury. This study aims, from a realist framework, to identify relevant literature and develop an initial programme theory to understand how EIVR might work for people experiencing acquired neurological disability. Realist reviews are ideally placed to address the identified knowledge gap as they assist in gaining a deeper understanding of how the intervention works, for whom it works best, and the contexts that promote the activation of desired outcomes. Read More

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September 2021

Treatment of Primary CNS Lymphoma: Maximizing Clinical Benefit, Minimizing Neurotoxicity.

Curr Oncol Rep 2021 Sep 15;23(11):132. Epub 2021 Sep 15.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA.

Purpose Of Review: The optimal treatment for newly diagnosed and refractory or relapsed primary central nervous system lymphoma (PCNSL) is not fully defined. We review the epidemiology, clinical presentation, and current management strategies for newly diagnosed PCNSL as well as emerging treatments for refractory and relapsed disease.

Recent Findings: In recent decades, the incidence of PCNSL has increased in the elderly population. Read More

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September 2021

Factors Associated With Changes in Pregnancy Intention Among Women Who Were Mothers of Young Children in New York City Following the COVID-19 Outbreak.

JAMA Netw Open 2021 Sep 1;4(9):e2124273. Epub 2021 Sep 1.

Division of Environmental Pediatrics, Department of Pediatrics, NYU Langone Medical Center, New York, New York.

Importance: Early evidence shows a decrease in the number of US births during the COVID-19 pandemic, yet few studies have examined individual-level factors associated with pregnancy intention changes, especially among diverse study populations or in areas highly affected by COVID-19 in the US.

Objective: To study changes in pregnancy intention following the outbreak of the COVID-19 pandemic and identify factors possibly associated with these changes.

Design, Setting, And Participants: A cross-sectional, population-based study was conducted among women who were currently pregnant or had delivered a live infant and responded to a survey emailed to 2603 women (n = 1560). Read More

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September 2021

Association of Timing and Duration of Prenatal Analgesic Opioid Exposure With Attention-Deficit/Hyperactivity Disorder in Children.

JAMA Netw Open 2021 Sep 1;4(9):e2124324. Epub 2021 Sep 1.

PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Importance: Prior studies have reported that the use of illicit opioids during pregnancy is associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring; however, evidence regarding the association of analgesic opioids is limited.

Objective: To examine the association of timing and duration of prenatal analgesic opioid exposure with ADHD in children.

Design, Setting, And Participants: This cohort study uses data from the Norwegian Mother, Father and Child Cohort study (1999-2008), a nationwide birth cohort study linked to national health registries, with a mean (SD) follow-up of 10. Read More

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September 2021

Ongoing Outbreak of Extensively Drug-Resistant Campylobacter jejuni Infections Associated With US Pet Store Puppies, 2016-2020.

JAMA Netw Open 2021 Sep 1;4(9):e2125203. Epub 2021 Sep 1.

Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Importance: Extensively drug-resistant Campylobacter jejuni infections cannot be treated with any commonly recommended antibiotics and pose an increasing public health threat.

Objectives: To investigate cases of extensively drug-resistant C jejuni associated with pet store puppies and describe the epidemiologic and laboratory characteristics of these infections.

Design, Setting, And Participants: In August 2017, health officials identified, via survey, patients with C jejuni infections who reported contact with puppies sold by pet stores. Read More

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September 2021

Adolescents' Experiences of Idiopathic Scoliosis in the Presurgical Period: A Qualitative Study.

J Pediatr Psychol 2021 Sep 15. Epub 2021 Sep 15.

School of Psychology, University College Dublin and.

Objective: Adolescent idiopathic scoliosis (AIS) is a sideways curvature of the spine that can progress severely during adolescent development and require surgical intervention. This qualitative study was conducted to explore the psychosocial experiences of adolescents with idiopathic scoliosis during the presurgical stage of treatment.

Methods: Fourteen adolescents with moderate-to-severe AIS aged 12-17 years participated in semistructured interviews and data were analyzed using inductive reflexive thematic analysis. Read More

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September 2021

Cigarette smoking and mammographic breast density among Polish women.

Int J Occup Med Environ Health 2021 Aug 30. Epub 2021 Aug 30.

Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Environmental Epidemiology, Epidemiology Unit).

Objectives: High mammographic breast density (MBD) is one of the strongest breast cancer risk factors. The results of some epidemiological studies suggest that one of the lifestyle factors likely altering breast density is cigarette smoking. The aim of this study was to assess the association between active smoking, considering in detail the duration and intensity of smoking, and MBD among Polish women. Read More

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Outcomes of Primary Total Knee Arthroplasty Following Septic Arthritis of the Native Knee: A Case-Control Study.

J Bone Joint Surg Am 2021 Sep;103(18):1685-1693

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Septic arthritis of the native knee often results in irreversible joint damage leading to the need for total knee arthroplasty (TKA). The purpose of the present study was to examine the intermediate-term risk of periprosthetic joint infection (PJI), aseptic revision, and reoperation following primary TKA in patients with a history of septic arthritis of the native knee as compared with primary TKA performed for the treatment of osteoarthritis.

Methods: We retrospectively identified 215 primary TKAs performed from 1971 to 2016 at a single institution in patients with a history of septic arthritis of the native knee. Read More

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September 2021

Vestibular mapping assessment in idiopathic sudden sensorineural hearing loss.

Ear Hear 2021 Sep 14. Epub 2021 Sep 14.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Objective: The aim of this study was to investigate patterns of semicircular canal (SCC) and otolith organ dysfunction by vestibular mapping, and to determine the clinical implications of treatment outcomes in idiopathic sudden sensorineural hearing loss (ISSNHL).

Methods: We retrospectively reviewed 135 consecutive patients diagnosed with ISSNHL from January 2016 to December 2020. Patients underwent video-head impulse tests (vHIT) for each SCC, cervical vestibular-evoked myogenic potential test for the saccules, ocular vestibular-evoked myogenic potential test for the utricles, and hearing tests. Read More

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September 2021

Recent Academic Research on Clinically Relevant Digital Measures: Systematic Review.

J Med Internet Res 2021 Sep 15;23(9):e29875. Epub 2021 Sep 15.

Department of Biomedical Engineering, Duke University, Durham, NC, United States.

Background: Digital clinical measures collected via various digital sensing technologies such as smartphones, smartwatches, wearables, ingestibles, and implantables are increasingly used by individuals and clinicians to capture health outcomes or behavioral and physiological characteristics of individuals. Although academia is taking an active role in evaluating digital sensing products, academic contributions to advancing the safe, effective, ethical, and equitable use of digital clinical measures are poorly characterized.

Objective: We performed a systematic review to characterize the nature of academic research on digital clinical measures and to compare and contrast the types of sensors used and the sources of funding support for specific subareas of this research. Read More

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September 2021

Utility and Outcomes of Pre-Operative Screening Breast MRI for Planned Bilateral Prophylactic Mastectomy in High-Risk Patients.

AJR Am J Roentgenol 2021 Sep 15. Epub 2021 Sep 15.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA.

There is a paucity of data and consensus guidelines on the utility of preoperative MRI for planned bilateral prophylactic mastectomy. To evaluate the utility of breast MRI performed in high-risk patients for the indication of planned bilateral prophylactic mastectomy, with attention to diagnostic performance for breast cancer detection. A secondary aim was to assess the potential impact of breast MRI findings on the decision to perform sentinel lymph node biopsy at the time of prophylactic mastectomy. Read More

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September 2021

Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.

J Cachexia Sarcopenia Muscle 2021 Sep 15. Epub 2021 Sep 15.

College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang-si, Gyeonggi-Do, South Korea.

Background: Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and muscle mass control. Perturbation of the skeletal muscle metabolism elevates the risk of a variety of diseases including metabolic disorders. However, the regulatory pathways and molecules are not completely understood. Read More

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September 2021

Increased risk of second primary malignancies among endometrial cancer survivors receiving surgery alone: A population-based analysis.

Cancer Med 2021 Sep 15. Epub 2021 Sep 15.

Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan.

Background: Women with endometrial cancer (EC) have favorable prognoses, leaving them vulnerable to the development of second primary cancers (SPCs). We investigated the SPC risk and survival outcomes among EC patients treated with surgery alone in order to exclude the impact of adjuvant treatment on the results.

Methods: Data from the Taiwan Cancer Registry from 1995 to 2013 were analyzed. Read More

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September 2021

Roux-en-Y versus Billroth-I reconstruction after distal gastrectomy for gastric cancer.

Cochrane Database Syst Rev 2021 Sep 15;9:CD012998. Epub 2021 Sep 15.

Department of Health Promotion and Human Behavior, Kyoto University School of Public Health, Kyoto, Japan.

Background: Gastric cancer is the fifth most common cancer diagnosed worldwide. Due to improved early detection rates of gastric cancer and technological advances in treatments, a significant improvement in survival rates has been achieved in people with cancer undergoing gastrectomy. Subsequently, there has been increasing emphasis on postgastrectomy syndrome (e. Read More

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September 2021

Pheochromocytoma: An overlooked reversible cause of heart failure with reduced ejection fraction.

Turk Kardiyol Dern Ars 2021 Sep;49(6):501-505

Department of Cardiology, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, Turkey.

Pheochromocytoma is a rare, benign tumor of adrenal medulla, and its clinical symptoms are related to catecholamine production. Clinical presentation may vary in a broad spectrum. Dilated or hypertrophied cardiomyopathies are the possible clinical outcomes of pheochromocytoma. Read More

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September 2021

Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression.

Endocr Regul 2021 Sep 13;55(3):163-168. Epub 2021 Sep 13.

Endocrinology Department, Sutherland Hospital, Sydney, NSW, Australia.

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by chronic hypophosphatemia and osteomalacia. We present case of a patient with a protracted clinical course of TIO. TIO profoundly affected every aspect of his life with subsequent profound physical and psychosocial disabilities. Read More

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September 2021

Maternal and fetal outcomes in pregnancies with obstructive sleep apnea.

J Perinat Med 2021 Sep 13. Epub 2021 Sep 13.

Obstetrics & Gynecology, Jewish General Hospital, McGill University, Montreal, QC, Canada.

Objectives: Obstructive sleep apnea (OSA) is linked to many health comorbidities. We aimed to ascertain if OSA correlates with a rise in poor obstetrical outcomes.

Methods: Employing the United States' Healthcare Cost and Utilization Project - National Inpatient Sample, we performed our retrospective cohort study including all women who delivered between 2006 and 2015. Read More

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September 2021

Management of Single Subsegmental Pulmonary Embolism - a Prospective Observational Study at North Shore and Waitakere Hospitals, Auckland.

Intern Med J 2021 Sep 15. Epub 2021 Sep 15.

Consultant Haematologist at Waitemata District Health Board.

Background: Single subsegment pulmonary embolism is increasingly diagnosed but the benefit to anticoagulate in the absence of concurrent deep vein thrombosis is not consistently established.

Aims: To investigate the safety of an observational approach in patients with isolated subsegmental pulmonary embolism and the utility of the second lower limb ultrasound after seven days.

Methods: Prospective observational study of patients diagnosed with isolated subsegmental pulmonary embolism between July 2016 and July 2020 at North Shore and Waitakere Hospitals, Auckland. Read More

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September 2021

Scoping the literature on patient travel abroad for cancer screening, diagnosis and treatment.

Int J Health Plann Manage 2021 Sep 14. Epub 2021 Sep 14.

Department of Social Work, Soochow University, Taipei, Taiwan.

The incidence of cancer is on the rise globally. Under particular circumstances, patients are willing to travel abroad for healthcare treatments. We know relatively little however about patients travelling overseas for cancer-related screening, diagnosis and treatment. Read More

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September 2021

Management of chronic idiopathic pain in patients with dental implant without a clear pathological lesion: A retrospective study.

J Oral Implantol 2021 Sep 14. Epub 2021 Sep 14.

Kyungpook National University School of Dentistry Oral & Maxillofacial Surgery 2177 Dalgubeol Daero KOREA, REPUBLIC OF Daegu Daegu 41940 +82-53-426-5365 Kyungpook National University School of Dentistry.

Non-nociceptive, persistent idiopathic facial pain (PIFP) is a poorly localized, continuous dull pain that occurs even in the absence of apparent pathological lesions or clinical neurologic deficiency. This study aimed to investigate the disease characteristics of PIFP that developed after dental implant treatments. The clinical characteristics of pain as well as treatment method and outcomes were retrospectively analyzed in 20 patients diagnosed with PIFP. Read More

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September 2021

Impact of cirrhosis aetiology on incidence and prognosis of hepatocellular carcinoma diagnosed during surveillance.

JHEP Rep 2021 Jun 26;3(3):100285. Epub 2021 Mar 26.

SBIM, APHP, Hôpital Saint-Louis, Paris, Inserm, UMR-1153, ECSTRA Team, Paris, France.

Background & Aims: In this study we aimed to analyse the impact of the aetiology of cirrhosis on the incidence, characteristics and prognosis of hepatocellular carcinoma (HCC) diagnosed during a surveillance program.

Methods: Individual data from a randomized trial and 2 prospective cohorts of patients with compensated histologically proven cirrhosis recruited between 2000 and 2016 were pooled. The influence of cirrhosis aetiology on survival after HCC detection was assessed using multivariable regression models. Read More

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