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Progression-Free Survival at 24 Months as A Landmark After Autologous Stem Cell Transplant in Relapsed or Refractory Diffuse Large B-cell Lymphoma.

Transplant Cell Ther 2022 Jun 22. Epub 2022 Jun 22.

Division of Hematology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) who achieve progression-free survival (PFS) at 24 months (PFS24) following immunochemotherapy (IC) have excellent overall survival (OS) comparable to that of the age- and sex-matched general population. However, a similar landmark has not been established for patients with relapsed or refractory (RR) DLBCL following frontline IC who are subsequently treated with salvage therapy followed by autologous stem cell transplant (ASCT).

Objective: To evaluate the role of PFS24 as a landmark after ASCT in patients with RR DLBCL. Read More

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SARS-Cov-2 infection in severe asthma patients treated with biologics.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

1st Department of Pulmonary Medicine and Intensive Care Unit, National and Kapodistrian University of Athens, Medical School, 115 27 Athens, Greece.

Background: At the beginning of the pandemic, there have been considerable concerns regarding COVID-19 severity and outcomes in severe asthma patients treated with biologics.

Objective: To prospectively observe a cohort of severe asthmatics treated with biologics for the risk of SARS-CoV-2 infection and disease severity during COVID-19 pandemic.

Methods: Physicians from centers treating severe asthma patients all over Greece provided demographic and medical data regarding their patients treated with biologics. Read More

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Effectiveness of Maintenance and Reliever Therapy using inhaled corticosteroid-formoterol in asthmatics.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.

Background: Real-world evidence on the effectiveness of Maintenance and Reliever Therapy (MART) using inhaled corticosteroids plus long-acting beta 2-agonist (ICS-LABA) is sparse.

Objective: This study aimed to evaluate the clinical effectiveness of MART (ICS-formoterol) by comparing its effectiveness to that of ICS-LABA plus as-needed short-acting beta 2-agonist (SABA) in adult asthmatics.

Methods: We retrospectively retrieved data from the medical records of the Ajou University Medical Cente r, Korea, to compare clinical outcomes between patients treated with MART (the MART group) and those treated with ICS-LABA plus SABA (the non-MART group). Read More

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SARS-CoV-2 omicron: Light at the end of the long pandemic tunnel or another false dawn for immunodeficient patients?

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Department of Clinical immunology, Auckland Hospital, Park Rd, Grafton 1010, Auckland New Zealand; Department of Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland.

COVID-19 has had a disastrous impact on the world. Apart from at least 6 million deaths, countless COVID-19 survivors are suffering long-term physical and psychiatric morbidity. Hundreds of millions have been plunged into poverty caused by economic misery, particularly in developing nations. Read More

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Food-dependent Exercise-induced Wheals, Angioedema, and Anaphylaxis: A Systematic Review.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany.

Background: Food-dependent exercise-induced wheals, angioedema, and anaphylaxis remain insufficiently characterized.

Objective: We systematically reviewed the literature on clinical manifestations, laboratory investigations, culprit foods, triggering exercise, comorbidities, and treatment outcomes.

Methods: Using predefined search terms and Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) recommendations, we searched three electronic databases to identify relevant literature published before July 2021. Read More

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Application of Molecular Imaging in Immune Checkpoints Therapy: From Response Assessment to Prognosis Prediction.

Crit Rev Oncol Hematol 2022 Jun 22:103746. Epub 2022 Jun 22.

Department of Breast-Thyroid-Surgery and Cancer Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, 2000 East Xiang'an Road, Xiamen, China; Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer (Xiang'an Hospital of Xiamen University), 2000 East Xiang'an Road, Xiamen, China; Xiamen Key Laboratory for Endocrine Related Cancer Precision Medicine, Xiang'an Hospital of Xiamen University, 2000 East Xiang'an Road, Xiamen, China; Xiamen Research Center of Clinical Medicine in Breast & Thyroid Cancers, 2000 East Xiang'an Road, Xiamen, China; Cancer Research Center, School of Medicine, Xiamen University, 4221 South Xiang'an Road, Xiamen, China. Electronic address:

Recently, immune checkpoint therapy (ICT) represented by programmed cell death1 (PD-1) and its major ligands, programmed death ligand 1 (PD-L1), has achieved significant success. Detection of PD-L1 by immunohistochemistry (IHC) is a classic method to guide the treatment of ICT patients. However, PD-L1 expression in the tumor microenvironment is highly complex. Read More

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Supplementary Motor Area Syndrome after Brain Tumor Surgery: A Systematic Review.

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurological Surgery, Northwell Health, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine at Hofstra, New York, NY, USA.

Background: Supplementary motor area syndrome (SMAS) may occur after frontal tumor surgery, with variable presentation and outcomes. We reviewed the literature on postoperative SMAS following brain tumor resection.

Methods: PubMed, Web-of-Science, Scopus, and Cochrane were searched following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to include studies reporting SMAS after brain tumor resection. Read More

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Postoperative Complication Rates after One-Level Cervical Spine Surgery in Patients with Parkinson's Disease: A Database Study.

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurosurgery, University of Southern California, Keck School of Medicine, Los Angeles, California; Department of Orthopedic Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California.

Objective: Parkinson's Disease (PD) is a risk factor for worse surgical outcomes. The degree to which Parkinson's affects outcomes in cervical spine surgery is not well understood. Therefore, we characterize rates of postoperative complications among patients with PD who undergo cervical spine surgery. Read More

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Impact of operability and total metastatic ablation on outcomes after stereotactic ablative radiotherapy (SABR) for oligometastases.

Int J Radiat Oncol Biol Phys 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Victoria, Australia.

Purpose: Medical operability is prognostic for survival after SABR in primary malignancies. This study investigates the prognostic significance of medical operability and total versus subtotal ablation of all oligometastatic disease sites.

Material/methods: Consecutive patients with 1-5 sites of active extracranial oligometastases had medical operability status and presence of subtotal versus total metastatic ablation recorded prospectively on an institutional database. Read More

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Drivers of Inpatient Hospitalization Costs, Joint-Specific Patient-Reported Outcomes, and Health-Related Quality of Life in Shoulder Arthroplasty for Cuff Tear Arthropathy.

J Shoulder Elbow Surg 2022 Jun 22. Epub 2022 Jun 22.

Department of Orthopaedics and Sports Medicine, University of Washington Medical Center, Seattle, WA, USA. Electronic address:

Background: Cuff tear arthropathy (CTA) can be successfully treated with various types of shoulder arthroplasty. While reverse total shoulder arthroplasty (RSA) is commonly used to treat CTA, CTA hemiarthroplasty (CTA-H, hemiarthroplasty with an extended humeral articular surface) can also be effective in patients with preserved glenohumeral elevation and an intact coracoacromial arch. As the value of arthroplasty is being increasingly scrutinized, cost containment has become a priority. Read More

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Symptom control and survival for people severely ill with COVID: a multicentre cohort study (CovPall-Symptom).

J Pain Symptom Manage 2022 Jun 22. Epub 2022 Jun 22.

International Observatory on End of Life Care, Division of Health Research, Lancaster University, Lancaster, UK.

Context: Evidence of symptom control outcomes in severe COVID is scant.

Objective: To determine changes in symptoms among people severely ill or dying with COVID supported by palliative care, and associations with treatments and survival.

Methods: Multicentre cohort study of people with COVID across England and Wales supported by palliative care services, during the pandemic in 2020 and 2021. Read More

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Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges.

Semin Cancer Biol 2022 Jun 22. Epub 2022 Jun 22.

University of Perugia, Department of Surgery and Medicine, Unit of Medical Oncology, Perugia, Italy. Electronic address:

Immune checkpoint inhibitors (ICIs) have demonstrated impressive antitumor activity in patients with advanced and early stage melanoma, thus improving long-term survival outcomes. However, most patients derive limited benefit from immunotherapy, due to the development of primary, adaptive, or acquired resistance mechanisms. Immunotherapy resistance is a complex phenomenon that depends on genetic and epigenetic mechanisms which, in turn, drive the interplay between cancer cells and the tumor microenvironment (TME). Read More

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Impact of Interfacility Transfer of Ruptured Abdominal Aortic Aneurysm Patients.

J Vasc Surg 2022 Jun 22. Epub 2022 Jun 22.

Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Case Western Reserve University School of Medicine/University Hospitals, Cleveland Medical Center, Cleveland, OH. Electronic address:

Objectives: Interfacility transfer (IT) of patients with ruptured (r) abdominal aortic aneurysm (AAA) occurs not infrequently for a higher level of care. This study evaluates using contemporary administrative database the impact of IT on mortality after rAAA repair.

Methods: Healthcare Cost and Utilization Project Database for NY (2016) and NJ/MD/FL (2016-2017) were queried using ICD-10 edition to identify patients who underwent open and endovascular repair of AAA. Read More

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Efficacy of teicoplanin in bloodstream infections caused by Enterococcus faecium: post-hoc analysis of a nationwide surveillance.

Int J Infect Dis 2022 Jun 22. Epub 2022 Jun 22.

Asia-Pacific Foundation for Infectious Diseases, Suite 1712, Rosedale Officetel 280, Gwangpyeong-ro, Gangnam-gu, Seoul 06367, Republic of Korea.

Objectives: Vancomycin and teicoplanin are glycopeptides with activity against Enterococcus faecium. However, studies on the clinical efficacy of teicoplanin are limited. The present study was aimed to compare the therapeutic efficacy of teicoplanin and vancomycin in E. Read More

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The development and application of a chairside oral health risk and need stratification tool in general dental services.

J Dent 2022 Jun 22:104206. Epub 2022 Jun 22.

Dental Public Health, Cardiff University School of Dentistry. Electronic address:

Objective: To describe the development and application of the Assessment of Clinical Oral Risks and Needs (ACORN) stratification tool based on a traffic light system in National Health Service (NHS) general dental services (GDS) Wales, UK.

Materials And Methods: This was a secondary analysis of routinely-collected dental care data. All courses of treatment provided in dental practices participating in NHS GDS Reform Programme between July 2018 - September 2019, in which an ACORN assessment and age were recorded were included in the analysis. Read More

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Results from a national-wide retrospective cohort measure the impact of C3 and soluble C5b-9 levels on kidney outcomes in C3 glomerulopathy.

Kidney Int 2022 Jun 22. Epub 2022 Jun 22.

INSERM UMRS1138, Centre de Recherche des Cordeliers, Team "Inflammation, Complement and cancer", Paris, France; Assistance Publique-Hôpitaux de Paris, Hopital Européen Georges Pompidou, Department of Immunology, Paris, France.

C3 glomerulopathy (C3G) is a rare complement-mediated disease. Specific treatments are not yet available and factors predictive of kidney survival such as age, kidney function and proteinuria are not specific to C3G. The prognostic value of biomarkers of complement activation, which are pathognomonic of the diseases, remain unknown. Read More

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Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA.

Int J Cardiol 2022 Jun 22. Epub 2022 Jun 22.

Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, UK; Department of Cardiology, Thomas Jefferson University Philadelphia, PA, USA; Institute of Population Health, University of Manchester, UK. Electronic address:

Background: there is limited data on Emergency department (ED) cardiovascular disease (CVD) presentations and outcomes amongst cancer patients.

Objectives: The present study aimed to describe the clinical characteristics, prevalence, and clinical outcomes of the most common cardiovascular ED admissions in patients with cancer.

Methods: All ED encounters with a primary CVD diagnosis from the US Nationwide Emergency Department Sample between January 2016 to December 2018 were stratified by cancer type as well as metastatic status. Read More

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Management of thyroid nodules.

Lancet Diabetes Endocrinol 2022 Jul;10(7):540-548

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

In the past 30 years, there has been a substantial rise in the detection of thyroid nodules. Largely asymptomatic, thyroid nodules are most often incidental findings that typically pose minimal risk. Data supporting these findings show a rapid rise in the incidental detection of thyroid nodules and cancer, but minimal effect on mortality rates, despite treatment. Read More

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.

Mol Cell 2022 Jun 18. Epub 2022 Jun 18.

Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:

Cancer mortality is primarily a consequence of its metastatic spread. Here, we report that methionine sulfoxide reductase A (MSRA), which can reduce oxidized methionine residues, acts as a suppressor of pancreatic ductal adenocarcinoma (PDA) metastasis. MSRA expression is decreased in the metastatic tumors of PDA patients, whereas MSRA loss in primary PDA cells promotes migration and invasion. Read More

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The Optimal Cesarean Skin Incision in Patients with Super Obesity.

Am J Perinatol 2022 Jun 25. Epub 2022 Jun 25.

Department of Obstetrics and Gynecology and Reproductive Sciences, University of Maryland Medical Center, Baltimore, United States.

Objective To evaluate if supraumbilical midline vertical incision performed in patients with a hanging pannus (umbilicus at the level of the pubic bone) is a reasonable alternative to Pfannenstiel in patients with Body Mass Index (BMI) ≥ 50 kg/m2 undergoing cesarean delivery. Methods Retrospective cohort study in patients with BMI ≥50 kg/m2 undergoing cesarean delivery at a single center from 2016 to 2020. Study groups were Pfannenstiel VS supraumbilical vertical skin incision. Read More

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Applying automated machine learning to predict mode of delivery using ongoing intrapartum data in laboring patients.

Am J Perinatol 2022 Jun 25. Epub 2022 Jun 25.

OB-GYN, Cedars-Sinai Medical Center Department of Obstetrics and Gynecology, Los Angeles, United States.

OBJECTIVE To develop and validate a machine learning model to predict the probability of a vaginal delivery (Partometer) using data iteratively obtained during labor from the electronic health record. STUDY DESIGN A retrospective cohort study of deliveries at an academic, tertiary care, hospital from 2013-2019 who had at least 2 cervical exams. The population was divided into those delivered by physicians with nulliparous term singleton vertex (NTSV) cesarean delivery rates < 23. Read More

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Leaving the Placenta In Situ in Placenta Accreta Spectrum Disorders: A Single Center Case Series.

Am J Perinatol 2022 Jun 25. Epub 2022 Jun 25.

Obstetrics & Gynecology, University of Texas Health Sciences Center at Houston, Houston, United States.

The most common treatment for placenta accreta spectrum disorders (PAS) is planned primary cesarean-hysterectomy. However, other management strategies may improve outcomes and/or allow fertility preservation. This is a series of 11 patients with PAS managed by leaving the placenta in situ at a single academic center in the U. Read More

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Flap to Mastectomy Mass: Are Higher Ratios Associated with Greater Breast Reconstruction Satisfaction?

J Reconstr Microsurg 2022 Jun 25. Epub 2022 Jun 25.

Yale University School of Medicine, New Haven, United States.

Background: Autologous breast reconstruction is associated with superior patient-reported outcomes compared to prosthetic techniques, but little is known about the relationship between autologous flap mass and patient satisfaction. We hypothesized that a higher differential mass (ratio of flap mass to mastectomy mass) would be associated with greater satisfaction with reconstruction.

Methods: In this retrospective study, patients who underwent autologous breast reconstruction between 2015 and 2020 with a deep inferior epigastric perforator (DIEP) flap completed the BREAST-Q survey. Read More

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The Association between Glycosylated Hemoglobin Level and Platelets Reactivity in Patients with Diabetes Mellitus Undergoing Elective Coronary Artery Bypass Grafting.

Thorac Cardiovasc Surg 2022 Jun 25. Epub 2022 Jun 25.

Department of Cardiac Surgery, University Clinical Hospital Center Zagreb, University of Zagreb, Zagreb, Croatia.

Background:  Diabetic patients tend to have increased platelet reactivity after coronary artery bypass grafting (CABG). The aim of this study was to determine the association between hemoglobin A1c (HbA1c) values and platelet reactivity and to evaluate the consequent impact on clinical outcomes in patients undergoing CABG.

Methods:  This prospective observational trial consecutively enrolled 225 diabetic patients undergoing CABG, between February 2014 and October 2018. Read More

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Trochleoplasty for severe trochlear dysplasia significantly improves the quality of life of patients with symptomatic patellar instability.

Knee 2022 Jun 22;37:95-102. Epub 2022 Jun 22.

The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry SY10 7AG, United Kingdom. Electronic address:

Background: Trochleoplasty is a recognized surgical technique to address severe trochlear dysplasia. The clinical and radiological outcomes of trochleoplasty surgery in trochlear dysplasia have been well reported. There is a paucity in literature regarding the correlation between trochleoplasty and quality of life (QoL). Read More

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Association between patient age and pediatric cardiac arrest recognition by emergency medical dispatchers.

Am J Emerg Med 2022 Jun 2;58:275-280. Epub 2022 Jun 2.

Department of Emergency Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Republic of Korea; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Republic of Korea.

Background: Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) is an important prognostic factor in pediatric out-of-hospital cardiac arrest (OHCA). The recognition of cardiac arrest by dispatcher is a key factor for successful DA-CPR. In this study, we evaluated the association between pediatric age and dispatcher recognition. Read More

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The association between blood pressure and in-hospital mortality in traumatic brain injury: Evidence from a 10-year analysis in a single-center.

Am J Emerg Med 2022 May 30;58:265-274. Epub 2022 May 30.

Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan.; Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan. Electronic address:

Objective: Blood pressure in patients with traumatic brain injury (TBI) is associated with clinical outcome. However, evidence of blood pressure (BP) range is scarce and the association between BP and clinical outcome is mostly controversial. We aimed to investigate the association between blood pressure and clinical outcome in TBI. Read More

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NUCB2/nesfatin-1 is associated with severity of eating disorder symptoms in female patients with obesity.

Psychoneuroendocrinology 2022 Jun 17;143:105842. Epub 2022 Jun 17.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Charité Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany. Electronic address:

Background: Nesfatin-1 has been described as an anorexigenic peptide. Comprehensive evidence also points towards an involvement of nesfatin-1 in the modulation of emotional pathways with a sex-specific regulation of nesfatin-1 in association with anxiety. Although the implication of nesfatin-1 in the regulation of food intake is well-established in animals, data in humans are lacking. Read More

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A fatal perforation of the distal ileum from an ingested fish bone: A case report.

Int J Surg Case Rep 2022 Jun 21;96:107331. Epub 2022 Jun 21.

Department of Surgery, District General Hospital, Mannar, Sri Lanka.

Introduction And Importance: Foreign body-induced perforations of the ileum are rare consequences among adults.

Presentation Of Case: This is a case report of a delayed presentation of an ileal perforation and concurrent faecal peritonitis presented as an acute abdomen, resultant from an ingested fishbone, which led to fatality despite urgent laparotomy.

Clinical Discussion: Perforations following ingested foreign bodies are frequently unanticipated clinically, and diagnosed during advanced imaging studies or surgical interventions. Read More

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Prediction of 6 months endoscopic third ventriculostomy success rate in patients with hydrocephalus using a multi-layer perceptron network.

Clin Neurol Neurosurg 2022 May 16;219:107295. Epub 2022 May 16.

Department of Neurosurgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: Discrimination between patients most likely to benefit from endoscopic third ventriculostomy (ETV) and those at higher risk of failure is challenging. Compared to other standard models, we have tried to develop a prognostic multi-layer perceptron model based on potentially high-impact new variables for predicting the ETV success score (ETVSS).

Methods: Clinical and radiological data of 128 patients have been collected, and ETV outcomes were evaluated. Read More

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