269,616 results match your criteria outcomes included


The outcome of intra-cytoplasmic sperm injection (ICSI): do the sperm concentration and motility matter?

Horm Mol Biol Clin Investig 2021 Jun 14. Epub 2021 Jun 14.

Advanced Reproductive Centre (ARC), Hospital Canselor Tuanku Muhriz (HCTM), Kuala Lumpur, Malaysia.

Objectives: The male-factor subfertility was reported to be 30% globally; thus, the intracytoplasmic sperm injection (ICSI) procedure was implemented to improve the overall fertilization (IVF) rates. Nevertheless, at least 10% of fertilization failure still occurs. Concerning this issue, we explored the association of sperm concentration and motility with the quality of embryo development and pregnancy outcome in IVF-ICSI cycles. Read More

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Clinical predictors of poor 30-day headache outcomes after an emergency department visit for acute post-traumatic headache.

Am J Emerg Med 2021 Jun 9;49:158-162. Epub 2021 Jun 9.

Department of Emergency Medicine, Albert Einstein College of Medicine, Montefiore, 111 East 210th Street, Bronx, NY 10467, USA. Electronic address:

Purpose: We investigated clinical risk factors that predict poor 30-day headache outcomes among patients evaluated in the emergency department (ED) for post-traumatic headache (PTH).

Methods: This was an analysis of data from a randomized, placebo-controlled study of IV metoclopramide + diphenhydramine for acute PTH. Patients were enrolled during an ED visit and received telephone follow-up with a structured questionnaire 30 days later. Read More

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Infections and patterns of antibiotic utilization in support and comfort care patients: A tertiary care center experience.

J Infect Public Health 2021 May 26;14(7):839-844. Epub 2021 May 26.

Department of Health Informatics, CPHHI, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Data and Business Intelligence Management Department, ISID, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Purpose: Little is known regarding the burden of infections and clinical practice towards hospitalized patients with limits on life-sustaining measures. We aim to describe the infectious syndromes, clinical care, the emergence of multi-drug resistant organisms and outcomes in this population.

Patients And Methods: Retrospective cohort of patients labeled as support or comfort care in a tertiary care center between 2016-2019. Read More

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Feasibility and early experience of a novel multidisciplinary alcohol-associated liver disease clinic.

J Subst Abuse Treat 2021 Apr 9;130:108396. Epub 2021 Apr 9.

Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, United States of America.

Background: Alcohol cessation improves mortality in alcohol-associated liver disease (ALD), but access to treatment is limited. To address this gap, implementation and early feasibility and outcomes of a multidisciplinary ALD clinic are described.

Methods: The clinic comprised a hepatologist, psychiatrist, psychologist, nurse, and social worker. Read More

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Bridge clinic buprenorphine program decreases emergency department visits.

J Subst Abuse Treat 2021 Apr 17;130:108410. Epub 2021 Apr 17.

Department of Emergency Medicine, Upstate Medical University, Syracuse, NY, USA.

Introduction: Opioid withdrawal due to opioid use disorder (OUD) is an increasing health emergency and complaint in emergency departments (EDs) across the United States. As a response to the increased need for OUD treatment, a low threshold buprenorphine program, or Bridge Clinic, was established within our hospital system. Patients are primarily connected to the Bridge Clinic through the ED, and are able to complete their consultation appointment reliably within 1-3 days of referral. Read More

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A retrospective cohort study of medication dispensing at pharmacies: Administration matters!

Drug Alcohol Depend 2021 May 29;225:108792. Epub 2021 May 29.

Norwegian Centre for Addiction Research (SERAF), University of Oslo, Bygg 45, Ullevål sykehus, Kirkeveien 166, 0450, Oslo, Norway. Electronic address:

Background: Opioid agonist treatment (OAT) for opioid use disorders may be delivered at treatment clinics or dispensed from pharmacies, however the type of delivery may be associated with different risks and benefits. The aim of the study was to investigate whether dispensing of methadone or buprenorphine at pharmacies during treatment for opioid use disorders was associated with adverse outcomes.

Methods: Retrospective cohort study using a national, linked, population-level data set from Denmark. Read More

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Comparison of fixed dose versus train-of-four titration of cisatracurium in acute respiratory distress syndrome.

J Crit Care 2021 May 25;65:86-90. Epub 2021 May 25.

University of Kentucky HealthCare, Department of Pharmacy Services, United States of America; University of Kentucky College of Pharmacy, Department of Pharmacy Practice and Science, United States of America. Electronic address:

Purpose: To compare the ventilatory and clinical outcomes associated with a fixed-dose cisatracurium infusion versus a titrated infusion strategy in patients with Acute Respiratory Distress Syndrome (ARDS).

Materials And Methods: Single-center, retrospective, cohort study in a medical ICU of a tertiary care academic medical center. Adult patients ≥18 years old with a continuous infusion of cisatracurium for ≥12 h for treatment of ARDS were included. Read More

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Impact of inappropriate empirical antibiotic treatment on clinical outcomes of urinary tract infections caused by Escherichia coli: a retrospective cohort study.

J Glob Antimicrob Resist 2021 Jun 9. Epub 2021 Jun 9.

Jiangxi Provincial Key Laboratory of Medicine, Clinical Laboratory of the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China. Electronic address:

Objective: We aimed to determine the clinical impact of inappropriate empirical antibiotic treatment (IEAT) compared with appropriate empirical antibiotic treatment (AEAT) in hospitalised patients with urinary tract infections (UTIs) caused by Escherichia coli (E. coli).

Methods: This retrospective cohort study included adult patients with a primary diagnosis of UTI who were treated with empirical antibiotics at a tertiary hospital in southern China over a 2-year period. Read More

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Long-tevrm outcomes of the MICOF keratoprosthesis surgery.

Ocul Surf 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address:

Purpose: To evaluate long-term anatomical and functional outcomes of the MICOF keratoprosthesis to treat end-stage corneal blindness.

Design: Re trospective review of consecutive clinical case series.

Participants: Between October 2000 and October 2015, at the Department of Ophthalmology of Chinese PLA General Hospital (PLAGH), a total of 132 eyes of 131 patients had undergone a MICOF keratoprosthesis implantation. Read More

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Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis.

Clin Microbiol Infect 2021 Jun 9. Epub 2021 Jun 9.

Department of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/University Hospital Virgen del Rocio, 41013 Seville, Spain. Electronic address:

Background: Long-term care facilities (LTCFs) are health care settings with high antimicrobial consumption and hence need to develop effective antimicrobial stewardship programs (ASPs).

Objective: To assess the effects of ASPs on care-related, clinical, and ecological outcomes in LTCFs.

Methods: Data sources were PubMed, EMBASE, CINAHL, and SCOPUS. Read More

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Does Loss of Spondylolisthesis Reduction Impact Clinical and Radiographic Outcomes after Minimally Invasive Transforaminal Lumbar Interbody Fusion.

Spine J 2021 Jun 9. Epub 2021 Jun 9.

Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA; Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA. Electronic address:

Background Context: Minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) is a common operative approach to address degenerative lumbar stenosis and spondylolisthesis which has failed nonoperative care. Compared to open TLIF, MI-TLIF relies to a greater extent on indirect decompression resulting in a heightened awareness of spondylolisthesis reduction among MI surgeons. To what extent intraoperative reduction is achieved as well as the rate and clinical impact of loss or reduction and slip recurrence remain unknown. Read More

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Kinematics after cervical laminoplasty: risk factors for cervical kyphotic deformity after laminoplasty.

Spine J 2021 Jun 9. Epub 2021 Jun 9.

Department of Neurosurgery, Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea. Electronic address:

Background Context: Laminoplasty of the cervical spine is widely used as an effective surgical method to treat compressive myelopathy of the cervical spine; however, there is an adverse effect of kyphosis after surgery. The risk factors or predictors of kyphosis have not been sufficiently evaluated.

Purpose: To assess the risk factors for kyphosis following laminoplasty. Read More

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Cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS.

Clin Immunol 2021 Jun 9:108780. Epub 2021 Jun 9.

Department of Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool L14 5AB, UK; Department of Women's & Children's Health, Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, UK. Electronic address:

Overlapping clinical features promoted the discussion of whether Kawasaki disease (KD) and PIMS-TS share pathophysiological features and disease outcomes. Medical records from English patients with KD (2015-02/20, N = 27) and PIMS-TS (02/2020-21, N = 34) were accessed to extract information. Children with PIMS-TS were older and more frequently of minority ethnicity background. Read More

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Heart rate variability biofeedback in chronic disease management: a systematic review.

Complement Ther Med 2021 Jun 9:102750. Epub 2021 Jun 9.

Laboratoire IRISSE EA4075, UFR des Sciences de l'Homme et de l'Environnement, Université de la Réunion, Le Tampon, La Réunion, France. Electronic address:

Background: Heart rate variability biofeedback (HRVB) is a non-pharmacological intervention used in the management of chronic diseases.

Method: A systematic search was performed according to eligibility criteria including adult chronic patients, HRVB as main treatment with or without control conditions, and psychophysiological outcomes as dependent variables.

Results: In total, 29 articles were included. Read More

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Association of kidney function and atrial fibrillation progression to clinical outcomes in patients with cardiac implantable electronic devices.

Am Heart J 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, Stanford University School of Medicine, Stanford, California; Veterans Affairs Palo Alto Health Care System, Palo Alto, California. Electronic address:

Background: Kidney function may promote progression of AF.

Objective: We evaluated the association of kidney function to AF progression and resultant clinical outcomes in patients with cardiac implantable electronic devices (CIED).

Methods: We performed a retrospective cohort study using national clinical data from the Veterans Health Administration linked to CIED data from the Carelink® remote monitoring data warehouse (Medtronic Inc, Mounds View, MN). Read More

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Efficacy of bone-substitute materials use in immediate dental implant placement: A systematic review and meta-analysis.

Clin Implant Dent Relat Res 2021 Jun 12. Epub 2021 Jun 12.

Cochrane Netherlands and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Objective: To assess the efficacy of using a bone substitute material (BSM) in the fixture-socket gap in patients undergoing tooth extraction and immediate implant placement.

Materials And Methods: MEDLINE, EMBASE, and CENTRAL databases were searched for randomized controlled trials (RCTs). RCTs were screened for eligibility, and data were extracted by two authors independently. Read More

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The effectiveness of preoperative stoma site marking on patient outcomes: A systematic review and meta-analysis.

J Adv Nurs 2021 Jun 12. Epub 2021 Jun 12.

Department of Nursing, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea.

Aims: This study systematically reviews the literature regarding preoperative stoma site marking and discusses the effectiveness of the procedure on complication rates, self-care deficits and health-related quality of life (HRQOL).

Design: Systematic review and meta-analysis.

Data Source: Our review was conducted following the PRISMA guidelines. Read More

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Analysis and comparison of autologous platelet-rich plasma preparation systems used in the treatment of enthesopathies: A preliminary study.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Trauma and Hand Surgery, Wroclaw Medical University, Poland.

Background: Autologous platelet-rich plasma (PRP) injection is an alternative but widely accepted method for the treatment of degenerative changes in tendon attachments known as enthesopathies. The PRP is considered a safe source for high concentrations of the growth factors involved in the healing process. Despite initial promising outcomes, many recent studies report conflicting results for this treatment. Read More

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Initial experience of endoscopic ultrasound-guided antegrade covered stent placement with long duodenal extension for malignant distal biliary obstruction (with video).

J Hepatobiliary Pancreat Sci 2021 Jun 12. Epub 2021 Jun 12.

Division of Gastroenterology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Background/purpose: This study aimed to evaluate the feasibility of endoscopic ultrasound (EUS)-guided antegrade covered stent placement with long duodenal extension (EASL) for malignant distal biliary obstruction (MDBO) with duodenal obstruction (DO) or surgically altered anatomy (SAA) after failed endoscopic retrograde cholangiopancreatography (ERCP).

Methods: Outcomes were technical and clinical success, reintervention rate, adverse events, stent patency, and overall survival. Inverse probability of treatment weighting (IPTW) and competing-risk analysis were performed to compare with conventional EUS-BD. Read More

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Utility of preoperative CT-based body metrics in relation to postoperative complications in pediatric liver transplant recipients.

Liver Transpl 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Computed tomography (CT) derived body metrics such as skeletal muscle index (SMI), psoas muscle index (PMI), and subcutaneous fat index (ScFI) are measurable components of sarcopenia, frailty, and nutrition. While these body metrics are advocated in adults for predicting postoperative outcomes after liver transplantation (LT), little is known about the value in pediatric populations. This study assessed the relation between preoperative CT-based body metrics and postoperative short-term outcomes in pediatric LT recipients. Read More

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Perinatal outcome in monochorionic twin pregnancies after selective fetal reduction using radio frequency ablation.

Int J Gynaecol Obstet 2021 Jun 12. Epub 2021 Jun 12.

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

Objective: To study the perinatal outcomes in women with complicated monochorionic twin pregnancy undergoing selective fetal reduction using radiofrequency ablation (RFA).

Methods: This retrospective study included 44 patients with monochorionic twins, between 14-28 weeks of gestation, who underwent RFA for selective fetal reduction. Perinatal and maternal outcomes and procedure-related complications were analysed. Read More

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Medication errors during treatment with new oral anticancer agents: consequences for clinical practice based on the AMBORA study.

Clin Pharmacol Ther 2021 Jun 12. Epub 2021 Jun 12.

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich- Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Patients treated with oral anticancer agents (e.g. kinase inhibitors) are a high-risk population for medication errors due to e. Read More

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The effects of vitamin D supplementation on types of falls.

J Am Geriatr Soc 2021 Jun 12. Epub 2021 Jun 12.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Background/objectives: To assess whether vitamin D supplementation prevents specific fall subtypes and sequelae (e.g., fracture). Read More

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Clinical presentation and outcomes of COVID-19 in older hospitalised patients assessed by the record-based multidimensional prognostic index, a cross-sectional study.

Eur Geriatr Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Geriatrics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark.

Purpose: Older people are the most frequently hospital admitted patients with COVID-19. We aimed to describe the clinical presentation of COVID-19 among frail and nonfrail older hospitalised patients and to evaluate the potential association between frailty and clinical course, decision of treatment level with outcomes change in functional capacity and survival.

Methods: We performed a multi-center, retrospective cross-sectional cohort study examining data on clinical presentation and frailty-related domains for hospitalised people aged 75 + years with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test. Read More

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Pertussis in Individuals with Co-morbidities: A Systematic Review.

Infect Dis Ther 2021 Jun 12. Epub 2021 Jun 12.

inScience Communications, Chowley Oak Business Park, Chowley Oak Lane, Tattenhall, Cheshire, UK.

Pertussis is a highly contagious disease of the respiratory tract caused by Bordetella pertussis. Although the burden of pertussis is highest in children, available data suggests that pertussis in the elderly and those with underlying chronic conditions or illnesses can result in significant morbidity, mortality and costs. We undertook a comprehensive review to assess the association between pertussis and chronic conditions/illnesses. Read More

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General population normative data for the EQ-5D-3L in the five largest European economies.

Eur J Health Econ 2021 Jun 12. Epub 2021 Jun 12.

Worldwide Health Economics and Outcomes Research, Bristol-Myers Squibb, Lawrenceville, NJ, USA.

Aim: The EQ-5D is a generic measure of health that is widely applied for health economic and non-economic purposes. Population norms can be used to facilitate the interpretation of EQ-5D data. The objective of this study was to develop a set of pooled normative EQ-5D-3L values for the five largest European economies (EUR5). Read More

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Noninfectious Intermediate, Posterior, or Panuveitis: Results from the Retrospective, Observational, International EyeCOPE Study.

Ophthalmol Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Ophthalmology, Faculty of Medicine, Gazi University, 13th Floor, Besevler, Cankaya, 06500, Ankara, Turkey.

Introduction: The EyeCOPE study characterized noninfectious intermediate posterior, or panuveitis (NIIPPU) before biologic agents were widely available.

Methods: This retrospective, observational study included adults with NIIPPU attending a routine ophthalmological visit. Data were collected from the study visit and medical records. Read More

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Local excision and treatment of early node-negative anal squamous cell carcinomas in a highly HIV prevalent population.

Tech Coloproctol 2021 Jun 12. Epub 2021 Jun 12.

Chelsea and Westminster Hospitals NHS Foundation Trust, London, UK.

Background: Anal squamous cell carcinoma (ASCC) is an uncommon cancer associated with human immunodeficiency virus (HIV) infection. There has been increasing interest in providing organ-sparing treatment in small node-negative ASCC's, however, there is a paucity of evidence about the use of local excision alone in people living with HIV (PLWH). The aim of this study was to evaluate the efficacy of local excision alone in this patient population. Read More

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DSAEK or DMEK for failed penetrating keratoplasty: a systematic review and single-arm meta-analysis.

Int Ophthalmol 2021 Jun 12. Epub 2021 Jun 12.

Department of Ophthalmology, the Third Medical Centre, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China.

Purpose: To review the published literature on indications and outcomes of DSAEK/DSEK and DMEK for the treatment of failed penetrating keratoplasty.

Design: This is a systematic review and single-arm meta-analysis.

Methods: Literature searches were conducted in PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews. Read More

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