1,744 results match your criteria outcomes crs

Antidepressants for people with epilepsy and depression.

Cochrane Database Syst Rev 2021 Apr 16;4:CD010682. Epub 2021 Apr 16.

Department of Health Data Science, University of Liverpool, Liverpool, UK.

Background: Depressive disorders are the most common psychiatric comorbidity in people with epilepsy, affecting around one-third, with a significant negative impact on quality of life. There is concern that people may not be receiving appropriate treatment for their depression because of uncertainty regarding which antidepressant or class works best, and the perceived risk of exacerbating seizures. This review aimed to address these issues, and inform clinical practice and future research. Read More

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Treatment options for advanced gastric cancer with peritoneal metastasis: experience from a single institution in Korea.

Ann Surg Treat Res 2021 Apr 30;100(4):209-217. Epub 2021 Mar 30.

Department of Surgery, Dankook University College of Medicine, Cheonan, Korea.

Purpose: This study aimed to compare treatment options and outcomes based on peritoneal cancer index (PCI) among patients with peritoneal metastasis (PM) of advanced gastric cancer (AGC).

Methods: Between January 2016 and July 2019, clinicopathological data of patients with AGC diagnosed with PM were reviewed. Different treatment methods were performed according to the PCI score: (1) group A (PCI ≤ 13) received cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with postoperative intraperitoneal (IP) and systemic chemotherapy (n = 29), while (2) group B (PCI > 13) received IP chemotherapy with systemic chemotherapy (n = 22). Read More

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Safe Anastomoses without Ostomies in Cytoreductive Surgery with Heated Intraperitoneal Chemotherapy: Technical Considerations and Modifications.

Ann Surg Oncol 2021 Apr 14. Epub 2021 Apr 14.

Peritoneal Malignancies Unit, Department of Surgery, Hospital Moisés Broggi, Consorci Sanitari Integral, Barcelona, Spain.

Background: Gastrointestinal complications, predominantly anastomotic leak (AL), are the most frequent source of severe morbidity after cytoreductive surgery (CRS).

Objective: The aim of this study was to present the technical standards for colorectal anastomoses developed and systematically applied to all patients undergoing CRS in a high-volume tertiary center, and the associated AL rates.

Methods: This was a descriptive study reporting the technical characteristics of a standardized protocol for three types of colorectal anastomoses (colorectal, ileorectal, and ileocolic) in CRS with heated intraperitoneal chemotherapy (HIPEC), and a retrospective analysis of prospectively collected data on anastomotic outcomes. Read More

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Comparison of Intranasal Steroid Application Using Nasal Saline Irrigation and a Mucosal Atomization Device to Treat Chronic Rhinosinusitis.

J Aerosol Med Pulm Drug Deliv 2021 Apr 13. Epub 2021 Apr 13.

Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Warsaw, Poland.

Chronic rhinosinusitis (CRS) is a disease that can significantly reduce patients' quality of life (QoL). Intranasal steroid therapy is the most commonly used treatment for CRS. There are many evaluation tools dedicated to assessing CRS patients' QoL, but none of them evaluates QoL during local steroid therapy. Read More

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Treatment modification after second-line failure among people living with HIV in the Asia-Pacific.

Antivir Ther 2021 Apr 12. Epub 2021 Apr 12.

The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.

Background: The World Health Organisation recommends continuation with the failing second-line regimen if third-line option is not available. We investigated treatment outcomes among people living with HIV in Asia who continued with failing second-line regimens compared to those who had treatment modifications after failure.

Methods: Treatment modification was defined as a change of two antiretrovirals, a drug class change, or treatment interruption (TI), all for >14 days. Read More

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Outcomes following synchronous liver resection, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal liver and peritoneal metastases: A bi-institutional study.

Surg Oncol 2021 Apr 2;37:101553. Epub 2021 Apr 2.

Peter MacCallum Cancer Centre, Department of Surgical Oncology, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia.

Purpose: Synchronous liver resection, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal liver (CRLM) and peritoneal metastases (CRPM) has traditionally been contraindicated. However, latest practice promotes specialist, multidisciplinary-led consideration for select patients. This study aimed to evaluate the perioperative and oncological outcomes of synchronous resection in the management of CRLM and CRPM from two tertiary referral centres. Read More

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A Near-Zero Anastomotic Leak Rate in Cytoreductive Surgery with Heated Intraperitoneal Chemotherapy is Achievable.

Ann Surg Oncol 2021 Apr 9. Epub 2021 Apr 9.

Peritoneal Malignancies Unit, Department of Surgery, Hospital Moisés Broggi, Consorci Sanitari Integral, Barcelona, Spain.

Gastrointestinal complications are the main source of severe morbidity after cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC), mainly in the form of anastomotic leak. Reducing the rate of anastomotic leaks is of paramount importance and should be approached both through risk factor understanding and reduction, as well as optimization of surgical team performance. We performed a study that describes the details of a technical protocol for the creation of anastomoses after colorectal resections in CRS and HIPEC and the anastomotic outcomes associated with its systematic application in a high-volume peritoneal surface malignancy center. Read More

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Association Between Olfactory Function and Asthma in Adults.

J Asthma Allergy 2021 31;14:309-316. Epub 2021 Mar 31.

Department of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea.

Purpose: Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are common asthma-associated upper airway diseases. Olfactory dysfunction, a common symptom among these patients, is an increasingly recognized condition that is associated with a reduced quality of life and major health outcomes. However, there are few studies on the association between olfactory function and asthma. Read More

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Can Elderly Patients with Peritoneal Metastasis Induced by Appendiceal or Colorectal Tumours Benefit from Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)?

Clin Interv Aging 2021 30;16:559-568. Epub 2021 Mar 30.

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People's Republic of China.

Purpose: Cytoreductive surgery (CRS) added with hyperthermic intraperitoneal chemotherapy (HIPEC) can improve the survival rate of certain patients with peritoneal metastasis (PM). However, the perioperative safety and long-term survival of this intricate and possibly life-threatening procedure in elderly patients (≥65 years) remain controversial.

Methods: Patients with PM due to appendiceal or colorectal tumours who underwent CRS/HIPEC were evaluated systematically at the National Cancer Center of China and the Huanxing Cancer Hospital between June 2017 and June 2019. Read More

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The impact of gastrointestinal anastomotic leaks on survival of patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy.

Am J Surg 2021 Apr 1. Epub 2021 Apr 1.

The Department of General and Oncological Surgery - Surgery C, Sheba Medical Center, Tel Hashomer, Israel; Affiliated with the Sackler School of Medicine, Tel Aviv University, Israel.

Background: Gastrointestinal (GI) leaks after cytoreductive surgery and hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC) is a known life-threatening complication that may alter patients' outcomes. Our aim is to investigate risk factors associated with GI leaks and evaluate the impact of GI leaks on patient's oncological outcomes.

Methods: A retrospective analysis of perioperative and oncological outcomes of patients with and without GI leaks after CRS/HIPEC. Read More

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Antiretroviral Hair Levels, Self-Reported Adherence and Virologic Failure in Second-Line Regimen Patients in Resource-Limited Settings.

AIDS 2021 Apr 6. Epub 2021 Apr 6.

HIV-NAT, TRCARC, Bangkok, Thailand Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil Harvard T.H. Chan School of Public Health, Boston, MA,USA Biostatistics Excellence Centre, Bangkok, Thailand The Kirby Institute, UNSW, Sydney, Australia University of Nebraska Medical Center, Omaha, USA Chulalongkorn University, Bangkok, Thailand Division of AIDS NIAID, NIH, Bethesda, USA University of Pennsylvania, PA,USA Social & Scientific Systems, Silver Spring, USA BARC-SA and Lancet Laboratories, South Africa Clinical HIV Research Unit, Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa Kamuzu Central Hospital, Lilongwe, Malawi Durban International CRS, Durban, South Africa Hospital Nossa Senhora da Conceicao CRS, Rio Grande do Sul, Brazil Emory University, Atlanta, USA Frontier Science & Technology Research Foundation, Inc., Amherst, United States Family Centre for Research with Ubuntu (FAMCRU), Stellenbosch University, Cape Town, South Africa Research Institute for Health Sciences, Chiang Mai, Thailand Kamuzu Central Hospital, Lilongwe, Malawi CART, Clinical Research Site, VHS Infection Disease Medical Centre, Chennai, India Case Western Reserve University, Cleveland, USA University of Washington, Seattle, USA University of California, San Francisco, USA.

Objective: To evaluate associations between hair antiretroviral (ARV) hair concentrations as an objective, cumulative adherence metric, with self-reported adherence and virologic outcomes.

Design: Analysis of cohort A of the ACTG-A5288 study. These patients in resource-limited settings were failing second-line PI-based ART, but were susceptible to ≥1 NRTI and their PI, and continued taking their PI-based regimen. Read More

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Early Time-to-Tocilizumab after B Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy in Myeloma.

Transplant Cell Ther 2021 Mar 6. Epub 2021 Mar 6.

Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California.

Preemptive administration of tocilizumab (toci) to manage cytokine release syndrome (CRS) after chimeric antigen receptor T cell (CAR-T) therapy may reduce rates of serious CRS but conversely may worsen neurotoxicity or risk of infections. Optimal toci administration strategies for patients with relapsed/refractory multiple myeloma (RRMM) receiving B cell maturation antigen (BCMA)-directed CAR-T therapies have not been evaluated. The objective of this study was to identify whether shorter time-to-toci intervals (hours between first fever attributed to CRS and first dose of toci) have any impact on therapy-related toxicities or clinical outcomes among patients with RRMM receiving BCMA-directed CAR-T therapies. Read More

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Anti-seizure medications for Lennox-Gastaut syndrome.

Cochrane Database Syst Rev 2021 Apr 7;4:CD003277. Epub 2021 Apr 7.

Department of Child Neuropsychiatry, Children's Hospital "G. Salesi", Ospedali Riuniti Ancona, Ancona, Italy.

Background: Lennox-Gastaut syndrome (LGS) is an age-specific epilepsy syndrome characterised by multiple seizure types, including drop seizures. LGS has a characteristic electroencephalogram, an onset before age eight years and an association with drug resistance. This is an updated version of the Cochrane Review published in 2013. Read More

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Peroperative scoring systems for predicting the outcome of cytoreductive surgery in advanced-stage ovarian cancer - A systematic review.

Eur J Surg Oncol 2021 Mar 29. Epub 2021 Mar 29.

Center of Gynecological Oncology Amsterdam, Department of Gynecology, Antoni van Leeuwenhoek- Netherlands Cancer Institute, PO Box 900203, 1006, BE, Amsterdam, the Netherlands. Electronic address:

The extent of peritoneal metastases (PM) largely determines the possibility of complete or optimal cytoreductive surgery in advanced ovarian cancer. An objective scoring system to quantify the extent of PM can help clinicians to decide whether or not to embark on CRS. Therefore several scoring systems have been developed by different research teams and this review summarizes their performance in predicting a complete or optimal cytoreduction in patients with advanced ovarian cancer. Read More

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Impact of age, comorbidity, and treatment characteristics on survival in older women with advanced high grade epithelial ovarian cancer.

Gynecol Oncol 2021 Mar 31. Epub 2021 Mar 31.

Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address:

Objectives: Older women have a worse prognosis with advanced epithelial ovarian cancer (EOC) and comorbidities likely contribute to poor outcomes. We sought to identify comorbid conditions and treatment-related factors in older women.

Methods: A retrospective chart review identified 351 patients who underwent cytoreductive surgery (CRS). Read More

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Cardiotoxicity Associated with Anti-CD19 Chimeric Antigen Receptor T-Cell (CAR-T) Therapy: Recognition, Risk Factors, and Management.

Diseases 2021 Mar 17;9(1). Epub 2021 Mar 17.

Callahan Cancer Center, Great Plains Health, 601 W Leota St, North Platte, NE 69101, USA.

Chimeric antigen receptor T-cells (CAR-T) are improving outcomes in pediatric and adult patients with relapsed or refractory B-cell acute lymphoblastic leukemias and subtypes of non-Hodgkin Lymphoma. As this treatment is being increasingly utilized, a better understanding of the unique toxicities associated with this therapy is warranted. While there is growing knowledge on the diagnosis and treatment of cytokine release syndrome (CRS), relatively little is known about the associated cardiac events that occur with CRS that may result in prolonged length of hospital stay, admission to the intensive care unit for pressor support, or cardiac death. Read More

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Mid-Term Audit of a National Peritoneal Surface Malignancy Program Implementation in a Low Middle Income Country: The Moroccan Experience.

Cancers (Basel) 2021 Mar 3;13(5). Epub 2021 Mar 3.

Department of Surgical Oncology, Gustave Roussy, Cancer Campus, 114 Rue Edouard Vaillant, 94805 Villejuif, France.

Implementing a multimodal management of peritoneal surface malignancies is a steep and complex process, especially as complete cytoreductive surgery (CRS) is the backbone and the major prognostic factor for hyperthermic intraperitoneal chemotherapy (HIPEC) procedures. The implementation of such a program is a challenging process, particularly in low-middle income (LMIC) countries where ressource restrictions may represent a major hurdle to HIPEC appliances acquisition. Herein is the first audit of the implementation of a national peritoneal malignancy program in a north African country. Read More

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Performance of two prognostic scores that incorporate genetic information to predict long-term outcomes following resection of colorectal cancer liver metastases: an external validation of the MD Anderson and JHH-MSK scores.

J Hepatobiliary Pancreat Sci 2021 Apr 2. Epub 2021 Apr 2.

Department of General, Visceral and Vascular Surgery, Charite Campus Benjamin Franklin, Berlin, Germany.

Introduction: Two novel clinical risk scores (CRS) that incorporate KRAS mutation status (modified CRS (mCRS) and GAME score) were developed. However, they have not been tested in large national and international cohorts. The aim of this study was to validate the prognostic discrimination utility and determine the clinical usefulness of the two novel CRS. Read More

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The Implications of Early Marital Conflict for Children's Development.

J Child Fam Stud 2021 Jan 5;30(1):292-310. Epub 2021 Jan 5.

University of Massachusetts Amherst, Amherst, MA.

Although negative associations between the frequency and intensity of marital conflict and children's adjustment are well documented, less is known about how parents' conflict styles are related to children's developmental outcomes. The present study examines whether exposure to different types of parents' conflict styles, during a child's first year of life, is related to children's behavioral outcomes in the first grade. Parents' conflict resolution styles (CRSs) and child outcomes were examined in a sample of 150 working-class, first-time parents and their children. Read More

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January 2021

Report from the CVOT Summit 2020: new cardiovascular and renal outcomes.

Cardiovasc Diabetol 2021 03 31;20(1):75. Epub 2021 Mar 31.

Forschergruppe Diabetes e. V., Ingolstaedter Landstraße 1, 85764, Neuherberg (Munich), Germany.

The 6th Cardiovascular Outcome Trial (CVOT) Summit "Cardiovascular and Renal Outcomes 2020" was the first to be held virtually on October 29-30, 2020. As in previous years, this summit served as reference meeting for in-depth discussions on the topic of recently completed and presented major outcome trials. This year, focus was placed on the outcomes of VERTIS-CV, EMPEROR-Reduced, DAPA-CKD, and FIDELIO-DKD. Read More

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Remote controlling of CAR-T cells and toxicity management: Molecular switches and next generation CARs.

Transl Oncol 2021 Mar 28;14(6):101070. Epub 2021 Mar 28.

Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran; Breast Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Cell-based immunotherapies have been selected for the front-line cancer treatment approaches. Among them, CAR-T cells have shown extraordinary effects in hematologic diseases including chemotherapy-resistant acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and non-Hodgkin lymphoma (NHL). In this approach, autologous T cells isolated from the patient's body genetically engineered to express a tumor specific synthetic receptor against a tumor antigen, then these cells expanded ex vivo and re-infusion back to the patient body. Read More

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Cytoreductive surgery and mitomycin C hyperthermic intraperitoneal chemotherapy with CO recirculation (HIPEC-CO) for colorectal cancer peritoneal metastases: analysis of short-term outcomes.

Updates Surg 2021 Mar 29. Epub 2021 Mar 29.

Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Peritoneal dissemination from colorectal cancer (CRC) has long been associated with unfavorable prognosis. However, in the last decades, the combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) was able to obtain up to 30% 5-year survival rate in selected centers. Despite the wide diffusion of CRS and HIPEC, until now, there are no clear recommendations on the drug of choice for HIPEC nor its technique, and safety and efficacy data of HIPEC regimens and techniques are lacking. Read More

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Evaluation of the literature surrounding shared decision-making in elective rhinological surgery: A scoping review.

Auris Nasus Larynx 2021 Mar 24. Epub 2021 Mar 24.

Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, United States.

Objective: [1] review all studies utilizing SDM in the treatment of chronic rhinosinusitis (CRS) [2], increase awareness of otolaryngologists to shared decision-making, and [3] provide a framework for its incorporation into research and clinical practice.

Methods: systematic search was performed in November 2019 using PubMed/MEDLINE 1947-, CINAHL Complete 1937-, the Cochrane Library, ClinicalTrials.gov, and Web of Science Core Collection (SCI-EXPANDED, SSCI, A&HCI, ESCI) 1900-. Read More

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Clinicopathological characteristics of primary peritoneal epithelioid mesothelioma of clear cell type: A case report.

Medicine (Baltimore) 2021 Mar;100(12):e25264

Department of Pathology.

Rationale: Primary peritoneal epithelioid mesothelioma of clear cell type is an extremely rare entity composed of clear cytoplasm. It is challenging to diagnose because of the morphological resemblance to clear cell tumor.

Patients Concerns: A 69-year-old male patient had swollen lymph nodes in the right inguinal region for 7 months and was constipated for 1 month. Read More

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Optimal oncologic and perioperative outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy are attainable at a community center.

Am J Surg 2021 Mar 18. Epub 2021 Mar 18.

Department of Surgery, Division of Surgical Oncology, Swedish Medical Center, 747 Broadway, Heath 10, Suite 1003, Seattle, WA, 98122, USA. Electronic address:

Background: CRS with HIPEC is a complex operation that has shown survival benefit in patients with a variety of primary and metastatic peritoneal surface malignancies. While optimal oncologic and perioperative outcomes have been defined by expert consensus and demonstrated at university-affiliated, academic centers, similar results have never been presented from a non-university-affiliated, community center in the literature to date.

Methods: All cases of CRS with HIPEC performed at a non-university-affiliated, community center were retrospectively reviewed and analyzed. Read More

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Peripheral eosinophil counts predict efficacy of anti-CD19 CAR-T cell therapy against B-lineage non-Hodgkin lymphoma.

Theranostics 2021 4;11(10):4699-4709. Epub 2021 Mar 4.

Department of Oncology, Xinqiao Hospital, Army Medical University, Chongqing 400037, China.

The onset of cytokine release syndrome (CRS) and persistence of anti-CD19 chimeric antigen receptor T (CAR-T) cells after infusion correlate with clinical responsiveness. However, there are no known baseline biomarkers that can predict the prognosis of patients with B-lineage non-Hodgkin lymphoma (B-NHL). The aim of this study was to identify blood cell populations associated with beneficial outcomes in B-NHL patients administered CAR-T cell immunotherapies. Read More

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Likely clinical depression and HIV-related decline in antiretroviral therapy untreated women who seroconverted during participation in microbicide trials in sub-Saharan Africa.

Int J STD AIDS 2021 Mar 22:956462420975935. Epub 2021 Mar 22.

Division of Gender, Sexuality, and Health, HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Columbia University, New York, NY, USA.

Depression worsens HIV outcomes in populations treated with antiretroviral therapy (ART) medications. Data are limited on the relationship between depression and HIV in untreated populations in sub-Saharan Africa. We aimed to identify associations between likely clinical depression, alcohol use, social support by partners, and HIV viral load (VL) among ART untreated women who recently became HIV positive and enrolled in the Microbicide Trials Network (MTN)-015 study. Read More

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Clinico-metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases.

J Surg Oncol 2021 Mar 22. Epub 2021 Mar 22.

Department of Surgical Oncology, Jules Bordet Institute, Free University of Brussels (ULB), Brussels, Belgium.

Background And Objectives: The histological growth pattern (HGP) represents a strong prognostic factor in patients undergoing surgery for colorectal liver metastases (CRLM). We evaluated whether the combination of HGP with clinico-metabolic parameters could improve its prognostic value.

Methods: In a series of 108 patients undergoing resection of CRLM, the HGP of CRLM was scored according to international guidelines. Read More

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Long Term Olfactory Outcomes Following Frontal Sinus Surgery in Chronic Rhinosinusitis.

Laryngoscope 2021 Mar 22. Epub 2021 Mar 22.

Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York, U.S.A.

Objectives/hypothesis: No studies have evaluated the impact of the types of frontal sinus surgery (FSS) on objective olfaction scores. This study evaluated olfactory function and quality of life (QOL) in chronic rhinosinusitis (CRS) patients before and after total ethmoidectomy with frontal sinusotomy (FS).

Study Design: Prospective cohort study. Read More

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Long-term outcomes after cytoreductive surgery and HIPEC for morcellated uterine leiomyosarcoma; A case series.

Gynecol Oncol Rep 2021 May 4;36:100741. Epub 2021 Mar 4.

Chief of Peritoneal Surface Malignancy Program and Director of the Center for Gastrointestinal Malignancies, MedStar Washington Cancer Institute, Washington, DC, USA.

Uterine leiomyosarcoma (uLMS) is a rare aggressive malignant mesenchymal tumor with high risk of recurrence and poor prognosis regardless of stage. It is often diagnosed postoperatively following myomectomy, hysterectomy or supracervical hysterectomy for presumed benign disease. Primary surgery at the diagnosis of uLMS is considered to affect outcomes. Read More

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