AIDS 2021 Apr 6. Epub 2021 Apr 6.
HIV-NAT, TRCARC, Bangkok, Thailand Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil Harvard T.H. Chan School of Public Health, Boston, MA,USA Biostatistics Excellence Centre, Bangkok, Thailand The Kirby Institute, UNSW, Sydney, Australia University of Nebraska Medical Center, Omaha, USA Chulalongkorn University, Bangkok, Thailand Division of AIDS NIAID, NIH, Bethesda, USA University of Pennsylvania, PA,USA Social & Scientific Systems, Silver Spring, USA BARC-SA and Lancet Laboratories, South Africa Clinical HIV Research Unit, Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa Kamuzu Central Hospital, Lilongwe, Malawi Durban International CRS, Durban, South Africa Hospital Nossa Senhora da Conceicao CRS, Rio Grande do Sul, Brazil Emory University, Atlanta, USA Frontier Science & Technology Research Foundation, Inc., Amherst, United States Family Centre for Research with Ubuntu (FAMCRU), Stellenbosch University, Cape Town, South Africa Research Institute for Health Sciences, Chiang Mai, Thailand Kamuzu Central Hospital, Lilongwe, Malawi CART, Clinical Research Site, VHS Infection Disease Medical Centre, Chennai, India Case Western Reserve University, Cleveland, USA University of Washington, Seattle, USA University of California, San Francisco, USA.
Objective: To evaluate associations between hair antiretroviral (ARV) hair concentrations as an objective, cumulative adherence metric, with self-reported adherence and virologic outcomes.
Design: Analysis of cohort A of the ACTG-A5288 study. These patients in resource-limited settings were failing second-line PI-based ART, but were susceptible to ≥1 NRTI and their PI, and continued taking their PI-based regimen. Read More