29,487 results match your criteria outcomes breast


Red and processed meat consumption and cancer outcomes: Umbrella review.

Food Chem 2021 Mar 27;356:129697. Epub 2021 Mar 27.

Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

The purpose of this umbrella review was to evaluate the quality of evidence, validity and biases of the associations between red and processed meat consumption and multiple cancer outcomes according to existing systematic reviews and meta-analyses. The umbrella review identified 72 meta-analyses with 20 unique outcomes for red meat and 19 unique outcomes for processed meat. Red meat consumption was associated with increased risk of overall cancer mortality, non-Hodgkin lymphoma (NHL), bladder, breast, colorectal, endometrial, esophageal, gastric, lung and nasopharyngeal cancer. Read More

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Lobular neoplasia detected at MRI-guided biopsy: imaging findings and outcomes.

Clin Imaging 2021 Mar 31;78:171-178. Epub 2021 Mar 31.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States of America; Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, United States of America.

Objective: To review MRI findings of pure lobular neoplasia (LN) on MRI guided biopsy, evaluate surgical and clinical outcomes, and assess imaging findings predictive of upgrade to malignancy.

Methods: HIPAA compliant, IRB-approved retrospective review of our MRI-guided breast biopsy database from October 2008-January 2015. Biopsies yielding atypical lobular hyperplasia or lobular carcinoma in situ were included in the analysis; all biopsy slides were reviewed by a dedicated breast pathologist. Read More

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Comparisons of postoperative outcomes after breast cancer surgery in patients with and without renal replacement therapy: a matched-pair cohort study using a Japanese nationwide inpatient database.

Breast Cancer 2021 Apr 10. Epub 2021 Apr 10.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Although patients receiving renal replacement therapy (RRT) have more comorbidities and higher mortality and morbidity risks than the general population, surgery during breast cancer treatment is crucial because of limitations in anticancer agents for patients with renal insufficiency. We aimed to compare the short-term postoperative outcomes between patients with and without RRT.

Methods: Patients who underwent surgery for stages 0-III breast cancer between July 2010 and March 2017 were retrospectively identified in a Japanese nationwide inpatient database and divided into those with RRT (RRT group, n = 1547) and those without RRT (control group, n = 364,047). Read More

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Clinical effects of assessing electronic patient-reported outcomes monitoring symptomatic toxicities during breast cancer therapy: a nationwide and population-based study.

Breast Cancer 2021 Apr 9. Epub 2021 Apr 9.

Department of Oncology, Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen, Denmark.

The involvement of cancer patients in symptom reporting talks into our cultural narrative of empowerment and participation in decisions in health of both patients and professionals. Electronic patient-reported outcome (ePRO) is a tool applied for use in such interaction. Based on limited evidence and few empirical studies, health systems are rapidly implementing this instrument in managing patients in active treatment and in follow-up. Read More

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Determinants of short birth interval among women in South Gondar, Ethiopia: community-based unmatched case-control study.

Arch Public Health 2021 Apr 9;79(1):47. Epub 2021 Apr 9.

Department of Pediatric Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor Town, Ethiopia.

Background: The effect of short birth interval on socio-economic, negative maternal and child health outcomes remains common in developing countries. This study aimed to assess determinants of short birth interval among reproductive age women, who gave birth in health institution for last six-month in South Gondar, Ethiopia 2019.

Methods: Community-based unmatched case control study design was conducted from February 1 to March 30, 2019. Read More

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Breast cancer in women under age 40: A decade of trend analysis at a single institution.

Clin Imaging 2021 Mar 31;78:165-170. Epub 2021 Mar 31.

Department of Radiology, Weill Cornell Medicine, 525 E 68(th) street, New York, NY 10065, USA.

Background: Women should be evaluated for breast cancer risk by age 30 to assess for screening need. Recent trends in breast cancer in this population may further inform recommendations.

Objective: The aim of this study was to analyze trends over time in the rate of breast cancer, tumor characteristics and treatment in women under age 40. Read More

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Implants and Breast Pocket Irrigation: Outcomes of Antibiotic, Antiseptic, and Saline Irrigation.

Aesthet Surg J 2021 Apr 9. Epub 2021 Apr 9.

Division of Plastic Surgery, Albany Medical Center, Albany, NY.

Background: Breast implant-associated infection and capsular contracture are challenging complications that can result in poor outcomes following implant-based breast surgery. Antimicrobial irrigation of the breast pocket or implant is a widely accepted strategy to prevent these complications, but the literature lacks an evidence-based consensus on the optimal irrigation solution.

Objectives: The objective of this systematic review is to compare clinical outcomes, specifically capsular contracture, infection, and reoperation rates, associated with the use of antibiotic, antiseptic, and saline irrigation. Read More

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Predictors of the Provision of Mother's Milk Feedings in Newborns Admitted to the Neonatal Intensive Care Unit.

Breastfeed Med 2021 Apr 8. Epub 2021 Apr 8.

Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Breast milk reduces morbidity and mortality in infants admitted to neonatal intensive care unit (NICU). We determined predictors of procuring mother's own milk (MOM) among NICU-admitted newborn-mother dyads: (1) initiation of any milk expression; (2) initiation of milk expression within 6 hours of birth; (3) MOM as the first enteral feeding; (4) colostrum for oral care within 36 hours of birth if not yet orally fed; and (5) provision of MOM at 21 days of life or discharge, whichever occurred first. We performed a retrospective chart review of NICU-admitted newborn-mother dyads at an urban medical center from June 1, 2018-May 31, 2019. Read More

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Factors associated with breast cancer recurrence and survival at Sangre Grande Hospital, Trinidad.

Cancer Causes Control 2021 Apr 9. Epub 2021 Apr 9.

Department of Life Sciences, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Purpose: The aim of this study is to determine the demographic, pathological, and treatment-related factors that predict recurrence and survival in a Trinidadian cohort of breast cancer patients.

Methods: The inclusion criteria for this study were female, over 18 years, and with a primary breast cancer diagnosis confirmed by a biopsy report occurring between 2010 and 2015 at Sangre Grande Hospital, Trinidad. Univariate associations with 5-year recurrence-free survival and 5-year overall survival were calculated using the Kaplan-Meier method for categorical variables and Cox Proportional Hazards for continuous variables. Read More

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Evaluation of clinical outcomes and efficacy of palonosetron and granisetron in combination with dexamethasone in Egyptian patients receiving highly emetogenic chemotherapy.

Cancer Chemother Pharmacol 2021 Apr 9. Epub 2021 Apr 9.

Medical Oncology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: Chemotherapy-induced nausea and vomiting (CINV) is considered one of the most serious adverse events affecting chemotherapy-receiving cancer patients. It dramatically affects their food intake, nutritional status and more importantly their quality of life. We can observe CINV in highly emetogenic chemotherapy (HEC) such as adriamycin-cyclophosphamide combination (AC) in breast cancer patients and cisplatin-based regimens in other cancer types. Read More

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Skin-Reducing Mastectomy with Immediate Prepectoral Reconstruction: Surgical, Aesthetic, and Patient-Reported Outcomes with and without Dermal Matrices.

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From McGill University and the Division of Surgical Oncology, Jewish General Hospital.

Background: Prepectoral breast reconstruction is being increasingly popularized, largely because of technical advances. Patients with ptotic breasts and active cancer require mastectomies through a mastopexy excision pattern to achieve proper pocket control in a prepectoral single-stage operation. This article presents a single-surgeon experience with direct-to-implant, prepectoral reconstruction following skin-reducing mastectomies. Read More

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The Acute and Late Toxicities of MRI-Guided External Beam Partial Breast Irradiation Delivered Using a Once-Per-Day Regimen.

Front Oncol 2021 23;11:649301. Epub 2021 Mar 23.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, South Korea.

Background And Purpose: The use of external beam accelerated partial breast irradiation (APBI) using a twice-per-day regimen has raised concerns about increase rates of late toxicities. We compared toxicity outcomes of external beam APBI using a once-per-day regimen and accelerated hypofractionated whole breast irradiation (AWBI) in patients with early-stage breast cancer.

Materials And Methods: This was a single-institution, retrospective cohort study. Read More

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What Does CATS Have to Do With Cancer? The Cognitive Activation Theory of Stress (CATS) Forms the SURGE Model of Chronic Post-surgical Pain in Women With Breast Cancer.

Front Psychol 2021 23;12:630422. Epub 2021 Mar 23.

The Mind-Body Lab, Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway.

Chronic post-surgical pain (CPSP) represents a highly prevalent and significant clinical problem. Both major and minor surgeries entail risks of developing CPSP, and cancer-related surgery is no exception. As an example, more than 40% of women undergoing breast cancer surgery struggle with CPSP years after surgery. Read More

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The Impact of Premastectomy Versus Postmastectomy Radiation Therapy on Outcomes in Prepectoral Implant-Based Breast Reconstruction.

Ann Plast Surg 2021 Mar 18. Epub 2021 Mar 18.

From the Long Island Plastic Surgical Group, Garden City, NY Temple University School of Medicine, Philadelphia, PA Keck School of Medicine of University of Southern California, Los Angeles Stanford University School of Medicine, Stanford, CA Yale New Haven Health/Bridgeport Hospital, Bridgeport, CT.

Purpose: Prepectoral implant-based breast reconstruction is being increasingly performed over subpectoral reconstruction because of the reduced invasiveness of the procedure, postoperative pain, and risk of animation deformity. Radiation therapy is a well-known risk factor for complications in implant-based breast reconstruction. The effect of premastectomy versus postmastectomy radiation therapy on outcomes after prepectoral breast reconstruction has not been well-defined. Read More

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Routine Postoperative Antibiotics After Tissue Expander Placement Postmastectomy Does Not Improve Outcome.

Ann Plast Surg 2021 Mar 31. Epub 2021 Mar 31.

From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Stony Brook University Hospital, Health Sciences Center T19-060, Stony Brook Medicine, Stony Brook, NY.

Purpose: In an attempt to reduce the incidence of infectious complications after tissue expander-based breast reconstruction, the routine administration of postoperative antibiotics regimen is common in many practices. In recent years, there has been a plethora of reports scrutinizing the prophylactic use of postoperative antibiotics in this setting. The aim of this study was to determine the efficacy of prolonged administration of postoperative antibiotics compared with perioperative-only antibiotic administration for prophylaxis after tissue expander placement for immediate mastectomy reconstruction. Read More

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ECMO (extra corporeal membrane oxygenation) in major trauma: A 10 year single centre experience.

Injury 2021 Apr 2. Epub 2021 Apr 2.

National Trauma Research Institute, Australia; Trauma Services, The Alfred, Australia.

Aim To review the indications, complications and outcomes of extracorporeal membrane oxygenation (ECMO) in major trauma patients. Methods Single centre, retrospective, cohort study. Results Over a ten year period, from 13,420 major trauma patients, 11 were identified from our institutional trauma registry as having received ECMO. Read More

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Long-term survival in an acute promyelocytic leukemia patient with recurrent granulocytic sarcomas: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25257

Department of Pathology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Rationale: Granulocytic sarcoma (GS) is an extramedullary myeloid tumor composed of immature cells of the granulocytic series. It rarely occurs in acute promyelocytic leukemia (APL). No case of long-term survival in an APL patient with recurrent GS has been reported. Read More

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Palbociclib with letrozole as second-line neo-systemic therapy after failure of neo-adjuvant chemotherapy for luminal type breast cancer: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25175

Division of Breast Surgery, Department of Surgery.

Rationale: Neo-adjuvant systemic therapy includes endocrine therapy and chemotherapy, which is widely used. Luminal breast cancer is resistant to chemotherapy and is more likely to not respond to chemotherapy before surgery. Palbociclib is a cyclin-dependent kinase 4 and 6 inhibitor. Read More

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Frequency and outcomes of benign breast biopsies in trans women: A nationwide cohort study.

Breast 2021 Mar 25;57:118-122. Epub 2021 Mar 25.

Center of Expertise on Gender Dysphoria, Amsterdam UMC, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands; Department of Endocrinology, Amsterdam UMC, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands. Electronic address:

No literature is available on the benign versus malignant breast lesion ratio in trans women (male sex assigned at birth, female gender identity). As hormone treatment in trans women results in breast tissue histologically comparable with cis (non-trans) women, breast pathology may be expected. Previously, an increased breast cancer risk compared with cis men have been observed. Read More

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Adapting a 2-week-wait colorectal service in the pandemic using the quantitative faecal immunochemical test.

Br J Nurs 2021 Apr;30(7):404-408

Colorectal Consultant Surgeon, Royal Cornwall Hospital, Royal Cornwall Hospitals NHS Trust, Truro.

The coronavirus pandemic has brought about an economic and healthcare crisis. This has resulted in delays in virtually all areas of patient care and has forced clinicians to review and adapt their processes, in order to ensure patients continue to have access to timely and effective services. In the author's local Trust, this manifested in altered protocols, developed in order to maintain patient and staff safety while conducting invasive and potentially virus-spreading investigations. Read More

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Synchronous bilateral breast cancer treated with a 3-week hypofractionated radiotherapy schedule: clinical and dosimetric outcomes.

Clin Transl Oncol 2021 Apr 8. Epub 2021 Apr 8.

Hospital Universitari Son Espases, Radiation Oncology Department, Carretera de Valldemossa, 79, 07020, Palma de Mallorca (Islas Baleares), Spain.

Background And Purpose: Synchronous bilateral breast cancer (SBBC) accounts for 1-3.5% of breast cancer patients. The aim of this study was to evaluate dosimetric issues, clinical outcomes, and acute toxicities for SBBC patients receiving synchronous bilateral hypofractionated radiotherapy (SBHRT) and to compare them with patients treated with synchronous bilateral normofractionated RT schedule (SBNRT). Read More

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Management and outcomes of men diagnosed with primary breast cancer.

Breast Cancer Res Treat 2021 Apr 8. Epub 2021 Apr 8.

Department of Radiation Oncology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.

Background: Fewer than 1% of all breast cancers occur in men. As a result, a distinct lack of data exists regarding the management and outcomes in this cohort.

Methods: Any male patient with pathologically confirmed breast cancer diagnosed between August 2000 and October 2017 at either Massachusetts General Hospital or Brigham and Women's Hospital/Dana-Farber Cancer Institute and their affiliate satellite locations were included. Read More

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Quality of Preventive and Chronic Illness Care for Insured Adults With Opioid Use Disorder.

JAMA Netw Open 2021 Apr 1;4(4):e214925. Epub 2021 Apr 1.

Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Nearly all initiatives to improve care for individuals with opioid use disorder (OUD) have focused on improving OUD identification and treatment. Whether individuals with OUD have lower quality of care than individuals without OUD remains unclear.

Objective: To measure quality of non-OUD preventive and chronic illness care and care coordination for individuals with OUD compared with individuals without OUD. Read More

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Patient-reported function, health-related quality of life, and symptoms in APHINITY: pertuzumab plus trastuzumab and chemotherapy in HER2-positive early breast cancer.

Br J Cancer 2021 Apr 7. Epub 2021 Apr 7.

Patient-Centered Outcomes Research, Genentech, Inc., South San Francisco, CA, USA.

Background: We assessed health-related quality of life (symptoms of therapy/patient functioning/global health status), in APHINITY (pertuzumab/placebo, trastuzumab, and chemotherapy as adjuvant HER2-positive early breast cancer therapy).

Methods: Patients received 1 year/18 cycles of pertuzumab/placebo with trastuzumab and chemotherapy and completed EORTC QLQ-C30 and BR23 questionnaires until 36 months post-randomisation/disease recurrence. Changes ≥10 points from baseline were considered clinically meaningful. Read More

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A perspective on adverse health outcomes after breast cancer treatment in women with spinal cord injury.

Spinal Cord 2021 Apr 7. Epub 2021 Apr 7.

Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada.

Aging women face increased risks of both breast cancer and spinal cord injury (SCI). Unique treatment challenges for this population warrant consideration. Despite advances in breast cancer treatments, significant adverse health outcomes continue to occur. Read More

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Diagnostic accuracy of deep learning in medical imaging: a systematic review and meta-analysis.

NPJ Digit Med 2021 Apr 7;4(1):65. Epub 2021 Apr 7.

Institute of Global Health Innovation, Imperial College London, London, UK.

Deep learning (DL) has the potential to transform medical diagnostics. However, the diagnostic accuracy of DL is uncertain. Our aim was to evaluate the diagnostic accuracy of DL algorithms to identify pathology in medical imaging. Read More

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The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients.

Sci Rep 2021 Apr 7;11(1):7657. Epub 2021 Apr 7.

Breast Center, The Fourth Hospital of Hebei Medical University, No.12 Jiankang Road, Shijiazhuang, 050011, Hebei, China.

RecurIndex, a multigene profiling assay, can predict the risk of local recurrence and distant metastasis in female breast cancer (FBC), but its role in male breast cancer (MBC) remains unclear. In this study, the clinicopathological data of 43 consecutive MBC patients undergoing surgeries between 2009 and 2018 were retrospectively analysed. Their paraffin-embedded tissue sections were examined by RecurIndex test which comprised 2 models: recurrence index for local recurrence (RI-LR) and recurrence index for distant recurrence (RI-DR). Read More

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Surgery for fibroadenoma arising from axillary accessory breast.

Authors:
Sung Ryul Lee

BMC Womens Health 2021 Apr 7;21(1):139. Epub 2021 Apr 7.

Department of Surgery, Damsoyu Hospital, 234 Hakdong-ro, Gangnam-gu, Seoul, Republic of Korea.

Background: Patients with fibroadenomas in axillary accessory breasts (AABs) have a palpable mass, cyclic axillary pain, and aesthetic concerns that must be addressed. We compared the baseline patient characteristics, AAB characteristics, and surgical outcomes of patients with AABs with and without fibroadenomas undergoing surgical excision. We also monitored the patients for recurrence of axillary fibroadenomas. Read More

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Predicting cell invasion in breast tumor microenvironment from radiological imaging phenotypes.

BMC Cancer 2021 Apr 7;21(1):370. Epub 2021 Apr 7.

Department of Radiology, University of Pittsburgh School of Medicine, 4200 Fifth Ave, Pittsburgh, PA, 15260, USA.

Background: The abundance of immune and stromal cells in the tumor microenvironment (TME) is informative of levels of inflammation, angiogenesis, and desmoplasia. Radiomics, an approach of extracting quantitative features from radiological imaging to characterize diseases, have been shown to predict molecular classification, cancer recurrence risk, and many other disease outcomes. However, the ability of radiomics methods to predict the abundance of various cell types in the TME remains unclear. Read More

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Downregulated ZNF132 predicts unfavorable outcomes in breast Cancer via Hypermethylation modification.

BMC Cancer 2021 Apr 7;21(1):367. Epub 2021 Apr 7.

Department of Surgical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, 710061, Shaanxi, China.

Background: An important mechanism that promoter methylation-mediated gene silencing for gene inactivation is identified in human tumorigenesis. Methylated genes have been found in breast cancer (BC) and beneficial biomarkers for early diagnosis. Prognostic assessment of breast cancer remain little known. Read More

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