885 results match your criteria outcomes booster


Acceptance and commitment therapy for high frequency episodic migraine without aura: Findings from a randomized pilot investigation.

Headache 2021 Jun 11. Epub 2021 Jun 11.

UO Neurologia Salute Pubblica e Disabilità, Fondazione IRRCS Istituto Neurologico Carlo Besta, Milano, Italy.

Objective: We compared the incremental effects of adding acceptance and commitment therapy (ACT) to pharmacological treatment as usual (TAU) in a sample of patients with high frequency episodic migraine without aura (HFEM), assessing impact on a spectrum of measures across multiple domains.

Background: Patients with HFEM are at risk of developing chronic migraine and medication overuse headache. ACT has been shown to be effective for the treatment of various chronic pain conditions, but little attention has been given to its therapeutic value in the management of recurring headaches. Read More

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Feasibility of a 6-Month Home-Based Fall Prevention Exercise Program in Older Adults with COPD.

Int J Chron Obstruct Pulmon Dis 2021 3;16:1569-1579. Epub 2021 Jun 3.

Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, ON, Canada.

Purpose: Older adults with chronic obstructive pulmonary disease (COPD) have a high risk and rate of falls. Home-based fall prevention exercise programs reduce falls in older adults and may be an alternative approach for people with COPD without access to hospital-based rehabilitation. Therefore, we aimed to determine the feasibility of a home-based fall prevention exercise program in older adults with COPD and to examine the effect of the program on fall-related outcomes at baseline, 3 and 6 months. Read More

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Motivational interviewing with community-dwelling older adults after hip fracture (MIHip): protocol for a randomised controlled trial.

BMJ Open 2021 Jun 9;11(6):e047970. Epub 2021 Jun 9.

La Trobe University College of Science Health and Engineering, Bundoora, Victoria, Australia.

Introduction: Community-dwelling people recovering from hip fracture have the physical capacity to walk in their community but lack the confidence to do so. The primary aim of this trial is to determine whether motivational interviewing increases time spent walking at 12 months in community-dwelling people after hip fracture compared with an attention placebo control group. Secondary aims are to evaluate cost effectiveness, patient and health service outcomes and to complete a process evaluation. Read More

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Building family caregiver skills using a simulation-based intervention for care of patients with cancer: protocol for a randomized controlled trial.

BMC Nurs 2021 Jun 9;20(1):93. Epub 2021 Jun 9.

Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA.

Background: Family caregivers of patients with cancer undergoing radiation therapy experience significant distress and challenges related to high symptom burden and complex care demands. This is particularly true for caregivers of patients with head and neck, esophageal, anal, rectal, and lung cancers, who are often receiving combined-modality treatment and may have tracheostomy tubes, gastrostomy tubes, or colostomies/ileostomies. This study aims to evaluate a simulation-based nursing intervention to provide information, support, and training to caregivers during radiation therapy. Read More

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Health inequities related to vaccination: An evidence map of potentially influential factors and systematic review of interventions.

Vaccine 2021 Jun 3. Epub 2021 Jun 3.

Alberta Research Centre for Health Evidence (ARCHE), Department of Pediatrics, University of Alberta, Edmonton, Canada.

Introduction: The National Advisory Committee on Immunization (NACI) makes recommendations for vaccines in Canada. To inform considerations for equity when making recommendations, the NACI Secretariat developed a matrix of factors that may influence vaccine equity. To inform the matrix we mapped the evidence for PROGRESS And Other factors potentially associated with unequal levels of illness or death from vaccine-preventable diseases (VPDs) and systematically reviewed the evidence for interventions aimed at reducing inequities. Read More

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Immunogenicity and safety of an investigational quadrivalent meningococcal conjugate vaccine administered as a booster dose in children vaccinated against meningococcal disease 3 years earlier as toddlers: A Phase III, open-label, multi-center study.

Hum Vaccin Immunother 2021 Jun 4:1-10. Epub 2021 Jun 4.

Global Clinical Development, Sanofi Pasteur, Swiftwater, PA, USA.

Booster doses of meningococcal conjugate vaccines induce long-term protection against invasive meningococcal disease. We evaluated the immunogenicity and safety of a booster dose of MenACYW-TT in pre-school children who were primed 3 years earlier with MenACYW-TT or MCV4-TT (Nimenrix®). In this Phase III, open-label, multi-center study (NCT03476135), children (4-5 years old), who received a primary dose of MenACYW-TT or MCV4-TT as toddlers in a previous study, received a booster dose of MenACYW-TT. Read More

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Developing a children's health risk behaviour prevention program targeting grade 4-7 learners in the western cape, South Africa: a study protocol.

BMC Public Health 2021 05 30;21(1):1021. Epub 2021 May 30.

Department of Physiotherapy, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, University Drive, Durban, 4001, South Africa.

Background: Health risk behaviour among South African youth is a significant public health concern. Despite a societal mind shift to educating the public on the prevention of health risk behaviour, behavioural change is not progressing at the rate needed to influence health risk behaviour positively. The project aims to explore behavioural trends and willingness to engage in risky behaviour among senior primary school children. Read More

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Systematic review of child passenger safety laws and their associations with child restraint system use, injuries and deaths.

Inj Prev 2021 May 19. Epub 2021 May 19.

Department of Clinical and Health Psychology, Centre for Applied Developmental Psychology, School of Health in Social Science, The University of Edinburgh, Edinburgh, Edinburgh, UK.

Background And Objective: Many countries and all US states have legislation that mandates how children of certain ages and/or sizes should be restrained in vehicles. The objective of the current systematic review was to describe the associations between legislation and three outcomes: child restraint system use, correct child restraint system use and child passenger injuries/deaths.

Methods: Included studies were published between 2004 and 2020 and evaluated associations between child passenger safety laws and the outcomes described above. Read More

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An Open-Label Randomized Controlled Parallel-Group Pilot Study Comparing the Immunogenicity of a Standard-, Double- And Booster-Dose Regimens of the 2014 Seasonal Trivalent Inactivated Influenza Vaccine In Kidney Transplant Recipients.

Transplantation 2021 Feb 22. Epub 2021 Feb 22.

1. Departamento de Moléstias Infecciosas, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brasil. 2. Instituto Butantan, Divisão de Ensaios Clínicos, São Paulo, Brasil. 3. Serviço de Biologia Molecular da Divisão de Laboratório Central, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brasil. 4. Instituto Adolfo Lutz, Centro de Virologia, São Paulo, Brasil. 5. Serviço de Transplante Renal, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brasil.

Background: Immunogenicity of influenza vaccine in transplant recipients is suboptimal and alternative vaccination regimens are necessary.

Methods: We compared the immunogenicity of a standard-dose trivalent inactivated influenza vaccination (SDTIIV), double-dose trivalent inactivated influenza vaccination (DDTIIV) and booster-dose trivalent inactivated influenza vaccination (BDTIIV) of the 2014 seasonal trivalent inactivated influenza vaccine in kidney transplant recipients. We randomized 176 participants to SDTIIV (59), DDTIIV (59) and BDTIIV regimens (58). Read More

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February 2021

Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease.

Sci Rep 2021 05 11;11(1):9927. Epub 2021 May 11.

Bahrain Defence Force Hospital, Riffa, Bahrain.

Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Read More

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Sustained resiliency building and burnout reduction for healthcare professionals via organizational sponsored mindfulness programming.

Explore (NY) 2021 Apr 16. Epub 2021 Apr 16.

Division of Health Behavior and Health Promotion, College of Public Health, The Ohio State University, Columbus, OH, United States.

Purpose: To measure healthcare professional (HCP) result sustainability following implementation of an organizationally sponsored Mindfulness Based Intervention (MBI), Mindfulness in Motion (MIM), in areas of burnout, perceived stress, resilience, and work engagement.

Methods: A follow-up survey was sent via email to healthcare professionals (n = 220) who previously participated in the 8-week MIM intervention. Survey assessed burnout, perceived stress, resilience, work engagement, and included open-ended questions pertaining to barriers, facilitators, and sustained impact of practicing mindfulness after program end. Read More

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"Less stress": a pilot study on a cognitive behavioral treatment program for anxiety in children with autism spectrum disorders.

Scand J Child Adolesc Psychiatr Psychol 2021 25;9:30-40. Epub 2021 Apr 25.

Stavanger University Hospital, Division of Psychiatry, Stavanger, Norway.

Background: Comorbid anxiety disorders are prevalent in children with autism spectrum disorders (ASD), but only a minority receives adequate treatment for anxiety. Cognitive behavioral therapy (CBT) has been shown to be effective in treating anxiety disorders. The objectives of the present pilot study were to test the feasibility of the CBT program "Less stress" for comorbid anxiety disorders in children with ASD and explore whether an improvement in diagnostic outcomes for anxiety disorders and symptoms of anxiety was found after treatment. Read More

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Cognitive reappraisal and self-compassion as emotion regulation strategies for parents during COVID-19: An online randomized controlled trial.

Internet Interv 2021 Apr 6;24:100388. Epub 2021 Apr 6.

Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.

Objective: Parenting during pandemic restrictions places extreme demands on everyday family life, leading to increased stress levels for parents and distressed parent-child interactions. This RCT aimed to investigate whether cognitive reappraisal and self-compassion are helpful emotion regulation (ER) strategies to reduce individual and parental stress during the COVID-19 pandemic.

Method: An online intervention for parents was developed focusing on the application of ER strategies to pandemic requirements of families. Read More

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The Association of School Nurse Workload With Student Health and Academic Outcomes: A Cross-Sectional Study.

J Sch Nurs 2021 Apr 28:10598405211012957. Epub 2021 Apr 28.

5939New York City Department of Health and Mental Hygiene, Office of School Health, Long Island City, NY, USA.

This study assessed associations between school nurse workload and student health and academic outcomes. We hypothesized that lower school nurse workload would be associated with better student outcomes, with associations being greater for members of groups who experience health disparities. Our methods entailed secondary analysis of data for New York City school students in kindergarten through 12th grade during 2015-2016 ( = 1,080,923), using multilevel multivariate regression as the analytic approach. Read More

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Outcomes in Octogenarians and the Effect of Comorbidities After Intact Abdominal Aortic Aneurysm Repair in the Netherlands: A Nationwide Cohort Study.

Eur J Vasc Endovasc Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Vascular Surgery, Erasmus University Medical Centre, Rotterdam, the Netherlands.

Objective: Age is an independent risk factor for mortality after both elective open surgical repair (OSR) and endovascular aneurysm repair (EVAR). As a result of an ageing population, and the less invasive nature of EVAR, the number of patients over 80 years (octogenarians) being treated is increasing. The mortality and morbidity following aneurysm surgery are increased for octogenarians. Read More

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Primary Disease Prevention for Southwest American Indian Families During the COVID-19 Pandemic: Camp in a Box.

Front Sociol 2021 9;6:611972. Epub 2021 Mar 9.

Department of Family and Community Medicine, College of Medicine, University of Arizona, Tucson, AZ, United States.

The goal of the American Indian Youth Wellness Camp in a Box was to engage, educate and empower families to improve their health and overall well-being during the COVID-19 pandemic. Camp in a Box was a 9-week program, inclusive of a 1-week intensive camp component followed by an 8-week booster component with content focused on nutrition, mental health and physical activity education. The Camp in a Box is a Tribal/Urban Indian-University partnership, and materials were developed to replace an existing weeklong residential camp and to comply with social distancing guidelines. Read More

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The effects of booster sessions on self-management interventions for chronic musculoskeletal pain: a systematic review and meta-analysis of randomised controlled trials.

Pain 2021 Apr 9. Epub 2021 Apr 9.

University College London London North West University Healthcare NHS Trust University College London, Royal National Orthopaedic Hospital.

Abstract: Our objective was to investigate the effectiveness of booster sessions after self-management interventions as a means of maintaining self-management behaviours in the treatment of chronic musculoskeletal pain. We searched MEDLINE, EMBASE, Science Citation Index, Cochrane Central Register of Controlled Trials and PsycINFO. Two authors independently identified eligible trials and collected data. Read More

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ABCC4 single-nucleotide polymorphisms as markers of tenofovir disoproxil fumarate-induced kidney impairment.

Pharmacogenomics J 2021 Apr 13. Epub 2021 Apr 13.

Unit of Clinical Pharmacology, Department of Laboratory Medicine, ASST Fatebenefratelli Sacco, Milan, Italy.

Recently, the use of antiretroviral drug tenofovir disoproxil fumarate (TDF) is increased, thanks to the new co-formulation with doravirine, the availability of booster-free regimens, and its advantageous lipid-lowering effect. The aim of our study was to identify genetic markers that contribute to assess the risk of TDF-related renal toxicity. We have retrospectively investigated, in 179 HIV positive patients treated with TDF, the association between the main variants in ABCC2, ABCC4, and ABCC10 genes and four safety endpoints, three clinically relevant as renal outcomes and a higher tenofovir plasma concentration. Read More

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Impact and cost-effectiveness evaluation of a community-based rehabilitation intervention on quality of life among Chinese adults with hearing loss: study protocol for a randomized controlled trial.

Trials 2021 Apr 7;22(1):258. Epub 2021 Apr 7.

China Center for Health Development Studies, Peking University, Beijing, China.

Background: Hearing loss is quite prevalent and can be related to people's quality of life. To our knowledge, there are limited studies assessing the efficacy of hearing interventions on quality of life in adults. Therefore, we aim to conduct a randomized controlled trial (RCT) to determine the impact and cost-effectiveness of community-based hearing rehabilitation on quality of life among Chinese adults with hearing loss. Read More

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The predictive value of left ventricular and left atrial mechanics for atrial fibrillation and heart failure in hypertrophic cardiomyopathy: a prospective cohort study.

Int J Cardiovasc Imaging 2021 Apr 5. Epub 2021 Apr 5.

First Cardiology Department, AHEPA University Hospital, 1, St Kiriakidi str, 54635, Thessaloníki, Greece.

Atrial fibrillation (AF) and heart failure (HF) represent clinical turning points, altering the natural history of HCM and influencing long-term outcome of the disease. The aim of this study was to evaluate the ability of left ventricular (LV) and left atrial (LA) myocardial deformation parameters to predict new-onset AF and HF outcomes in patients with HCM. This was a prospective study that included HCM patients without severe valvular heart disease, prior myocardial infarction or history of AF. Read More

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A Call for a Reform of the Influenza Immunization Program in Mexico: Epidemiologic and Economic Evidence for Decision Making.

Vaccines (Basel) 2021 Mar 19;9(3). Epub 2021 Mar 19.

Vaccinology Section, Sociedad Mexicana de Salud Pública, Mexico City 11590, Mexico.

Limited information is available to determine the effectiveness of Mexico's national influenza vaccination guidelines and inform policy updates. We aim to propose reforms to current influenza vaccination policies based on our analysis of cost-effectiveness studies. This cross-sectional epidemiological study used influenza case, death, discharge and hospitalization data from several influenza seasons and applied a one-year decision-analytic model to assess cost-effectiveness. Read More

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A Cluster Randomized Trial to Reduce Missed Abusive Head Trauma in Pediatric Intensive Care Settings.

J Pediatr 2021 Mar 31. Epub 2021 Mar 31.

Department of Human Development and Family Studies, Penn State University, State College, PA.

Objective: To estimate the impact of the PediBIRN (Pediatric Brain Injury Research Network) 4-variable clinical decision rule (CDR) on abuse evaluations and missed abusive head trauma in pediatric intensive care settings.

Study Design: This was a cluster randomized trial. Participants included 8 pediatric intensive care units (PICUs) in US academic medical centers; PICU and child abuse physicians; and consecutive patients with acute head injures <3 years (n = 183 and n = 237, intervention vs control). Read More

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Significance of a social mobilization intervention for engaging communities in polio vaccination campaigns: Evidence from CORE Group Polio Project, Uttar Pradesh, India.

J Glob Health 2021 Mar 10;11:07011. Epub 2021 Mar 10.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Background: Globally, community engagement is an integral part of most public health programs and the social mobilization (SM) intervention of India's polio eradication program is one such example that contributed to eliminating polio from the country. CORE Group Polio Project (CGPP), a partner of Uttar Pradesh (U.P. Read More

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Determinants of physician attitudes towards the new selective measles vaccine mandate in Germany.

BMC Public Health 2021 03 22;21(1):566. Epub 2021 Mar 22.

Immunization Unit, Robert Koch Institute, Berlin, Germany.

Background: In Germany, a mandatory policy on measles vaccination came into effect in March 2020. Physicians, as the main vaccine providers, have a crucial role in implementing it. Mandatory vaccination changes the preconditions under which patient-provider communication on vaccines occurs. Read More

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Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults.

Trials 2021 Mar 20;22(1):221. Epub 2021 Mar 20.

Department of Pathology, University of Utah, Salt Lake City, USA.

Background: Convalescent plasma is being used widely as a treatment for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of COVID-19 convalescent plasma is unclear.

Methods: The Passive Immunity Trial for Our Nation (PassITON) is a multicenter, placebo-controlled, blinded, randomized clinical trial being conducted in the USA to provide high-quality evidence on the efficacy of COVID-19 convalescent plasma as a treatment for adults hospitalized with symptomatic disease. Read More

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Association between live childhood vaccines and COVID-19 outcomes: a national-level analysis.

Epidemiol Infect 2021 03 16;149:e75. Epub 2021 Mar 16.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

We investigated whether countries with higher coverage of childhood live vaccines [BCG or measles-containing-vaccine (MCV)] have reduced risk of coronavirus disease 2019 (COVID-19)-related mortality, while accounting for known systems differences between countries. In this ecological study of 140 countries using publicly available national-level data, higher vaccine coverage, representing estimated proportion of people vaccinated during the last 14 years, was associated with lower COVID-19 deaths. The associations attenuated for both vaccine variables, and MCV coverage became no longer significant once adjusted for published estimates of the Healthcare access and quality index (HAQI), a validated summary score of healthcare quality indicators. Read More

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A preliminary report of a randomized controlled phase 2 trial of the safety and immunogenicity of mRNA-1273 SARS-CoV-2 vaccine.

Vaccine 2021 05 9;39(20):2791-2799. Epub 2021 Feb 9.

Moderna, Inc., 200 Technology Sq, Cambridge, MA 02139, United States. Electronic address:

Background: Vaccines are urgently needed to prevent the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We assessed the safety and immunogenicity of vaccine candidate mRNA-1273, encoding the prefusion-stabilized spike protein of SARS-CoV-2.

Methods: This phase 2, randomized, observer-blind, placebo-controlled trial was conducted at 8 sites in the USA, in healthy adults aged ≥18 years with no known history or risk of SARS-CoV-2 infection, and had not previously received an investigational CoV vaccine or treatment. Read More

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Interchangeability, immunogenicity and safety of a combined 10-valent pneumococcal protein D conjugate vaccine (Synflorix) and 13-valent-PCV (Prevenar13) schedule at 1-2-4-6 months: PREVIX_COMBO, a 3-arm randomised controlled trial.

Vaccine X 2021 Apr 15;7:100086. Epub 2021 Feb 15.

Child Health Division, Menzies School of Heath Research, PO Box 41096, Casuarina, Australia.

Background: Aboriginal children living in remote communities are at high risk of early and persistent otitis media. and non-typeable (NTHi) are primary pathogens. Vaccines with potential to prevent early OM have not been evaluated in this population. Read More

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Public Health and Economic Benefits of Influenza Vaccination of the Population Aged 50 to 59 Years without Risk Factors for Influenza Complications in Mexico: A Cross-Sectional Epidemiological Study.

Vaccines (Basel) 2021 Feb 24;9(3). Epub 2021 Feb 24.

Vaccinology Section, Sociedad Mexicana de Salud Pública, 11590 Mexico City, Mexico.

The Mexican influenza vaccination program does not include a recommendation for people aged 50-59 years without risk factors for influenza complications, and there are limited data regarding the cost-effectiveness of vaccinating this population. To explore the clinical and economic effects of including this population in the vaccination schedule, we performed a cross-sectional epidemiological study using records (2009-2018) from Mexico's Influenza Surveillance System (SISVEFLU), death records (2010-2015) from the National Mortality Epidemiological and Statistical System, and discharge and hospitalization records (2010-2015) from the Automated Hospital Discharge System databases. A 1-year decision-analytic model was used to assess cost-effectiveness through a decision-tree based on data from SISVEFLU. Read More

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February 2021

Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial.

PLoS Med 2021 03 3;18(3):e1003415. Epub 2021 Mar 3.

Department of Public Health, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Convalescent plasma (CP), despite limited evidence on its efficacy, is being widely used as a compassionate therapy for hospitalized patients with COVID-19. We aimed to evaluate the efficacy and safety of early CP therapy in COVID-19 progression.

Methods And Findings: The study was an open-label, single-center randomized clinical trial performed in an academic medical center in Santiago, Chile, from May 10, 2020, to July 18, 2020, with final follow-up until August 17, 2020. Read More

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