90,330 results match your criteria outcome recovery


Clinical Manifestations and Long-Term Outcome of Early Lyme Neuroborreliosis According to EFNS Diagnostic Criteria (Definite versus Possible) in Central Europe. A Retrospective Cohort Study.

Eur J Neurol 2021 Jun 11. Epub 2021 Jun 11.

Institute for Microbiology and Immunology Ljubljana, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1104, Ljubljana, Slovenia.

Background: Characteristics and long-term outcome of Lyme neuroborreliosis (LNB) according to diagnostic certainty (definite versus possible) are incompletely understood.

Methods: In this retrospective cohort study of adults with definite or possible LNB, clinical and microbiologic characteristics and long-term outcome over 12-months were evaluated at a single medical center. Severity of acute disease and long-term outcome were assessed using a composite clinical score encompassing clinical findings and symptoms and by the probability of incomplete recovery. Read More

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A placebo-controlled randomized clinical trial of amantadine hydrochloride for evaluating the functional improvement of patients following severe acute traumatic brain injury.

J Neurosurg Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran -

Background: Considering the known derangements in the dopaminergic neurotransmitter systems following traumatic brain injury (TBI), dopamine agonists are used as a pharmacologic option. In this study, we evaluate the effects of Amantadine Hydrochloride on the functional improvement of severe TBI patients.

Methods: Within a triple-blinded (patients, intervention administrators, and outcome assessors) placebo-controlled randomized clinical trial, we evaluated the effects of Amantadine (100mg BD (twice a day) for 14 days, then 150mg BD for another 7 days, and 200mg BD for another 21 days) on outcome measurements of weekly mean Glasgow Outcome Scale (GOS) and Disability Rating Scale (DRS), through six weeks of trial for 57 patients (29 Amantadine, 28 placeboes) with severe TBI admitted in our hospital. Read More

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Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC Peripartum Cardiomyopathy Registry.

Eur J Heart Fail 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands.

Aims: Hypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive disorders co-exist, and to what extent they impact outcomes, is less clear. We describe differences in phenotype and outcomes in women with PPCM with and without hypertensive disorders during pregnancy. Read More

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The Effects of Transcranial Direct Current Stimulation on Balance and Gait in Stroke Patients: A Systematic Review and Meta-Analysis.

Front Neurol 2021 25;12:650925. Epub 2021 May 25.

Department of Rehabilitation Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.

Balance dysfunction after stroke often results in individuals unable to maintain normal posture, limits the recovery of gait and functional independence. We explore the short-term effects of transcranial direct current stimulation (tDCS) on improving balance function and gait in stroke patients. We systematically searched on PubMed, Web of Science, EMBASE, Cochrane Central Register of Controlled Trials, and Google Scholar for studies that explored the effects of tDCS on balance after stroke until August 2020. Read More

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Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery.

J Cardiothorac Vasc Anesth 2021 May 12. Epub 2021 May 12.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA.

Objectives: The objective of this study was to identify novel serum biomarkers specific to postoperative delirium after major cardiac surgery to provide insight into the pathologic processes involved in delirium and its sequelae.

Design: Nested, case-control study.

Setting: Cardiac surgical intensive care unit in a single-site hospital setting. Read More

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The Association Between Psychological Factors and Outcomes After Distal Radius Fracture.

J Hand Surg Am 2021 Jun 7. Epub 2021 Jun 7.

Department of Orthopaedics, Edinburgh Orthopaedic Trauma Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.

Purpose: The aim of this study was to identify psychological factors associated with pain intensity and disability following distal radius fracture.

Methods: We prospectively followed 216 adult patients with distal radius fracture for 9 months. Demographics, injury and treatment details, and psychological measures (Hospital Anxiety and Depression Score [HADS], Pain Catastrophizing Scale, Posttraumatic Stress Disorder Checklist-Civilian, Tampa Scale for Kinesiophobia, Illness Perception Questionnaire Brief [IPQB], General Self-Efficacy Scale, and Recovery Locus of Control [RLOC]) were collected at enrollment. Read More

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Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART-a UK, multicentre, observational study.

J Cardiovasc Magn Reson 2021 Jun 10;23(1):77. Epub 2021 Jun 10.

Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, LS2 9JT, UK.

Background: Although coronavirus disease 2019 (COVID-19) is primarily a respiratory illness, myocardial injury is increasingly reported and associated with adverse outcomes. However, the pathophysiology, extent of myocardial injury and clinical significance remains unclear.

Methods: COVID-HEART is a UK, multicentre, prospective, observational, longitudinal cohort study of patients with confirmed COVID-19 and elevated troponin (sex-specific > 99th centile). Read More

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Development of a practically usable prediction model for quality of life of ICU survivors: A sub-analysis of the MONITOR-IC prospective cohort study.

J Crit Care 2021 May 26;65:76-83. Epub 2021 May 26.

Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Intensive Care Medicine, Nijmegen, the Netherlands. Electronic address:

Purpose: As the goal of ICU treatment is survival in good health, we aimed to develop a prediction model for ICU survivors' change in quality of life (QoL) one year after ICU admission.

Materials & Methods: This is a sub-study of the prospective cohort MONITOR-IC study. Adults admitted ≥12 h to the ICU of a university hospital between July 2016-January 2019 were included. Read More

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Early recovery of frontal EEG slow wave activity during propofol sedation predicts outcome after cardiac arrest.

Resuscitation 2021 Jun 7. Epub 2021 Jun 7.

Department of Anaesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Aim Of The Study: EEG slow wave activity (SWA) has shown prognostic potential in post-resuscitation care. In this prospective study, we investigated the accuracy of continuously measured early SWA for prediction of the outcome in comatose cardiac arrest (CA) survivors.

Methods: We recorded EEG with a disposable self-adhesive frontal electrode and wireless device continuously starting from ICU admission until 48 hours from return of spontaneous circulation (ROSC) in comatose CA survivors sedated with propofol. Read More

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Continuous-Flow Left Ventricular Assist Device Explantation After More Than 5 Years of Circulatory Support and Ventricular Reconditioning.

Tex Heart Inst J 2021 Jun;48(2)

Center for Cardiac Support, Texas Heart Institute, Houston, Texas.

Continuous-flow left ventricular assist devices have proved to be effective, durable, life-saving tools in patients with end-stage heart failure. However, because of the risks associated with mechanical circulatory support (including stroke, infection, gastrointestinal bleeding, and device malfunction), the optimal goal of device therapy is myocardial recovery and device removal. Ventricular reconditioning and pump explantation after continuous-flow support have been reported; however, little is known about variables that govern the pace and degree of myocardial response in patients who experience such recovery. Read More

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Sleep disturbance as a therapeutic target to improve opioid use disorder treatment.

Exp Clin Psychopharmacol 2021 Jun 10. Epub 2021 Jun 10.

Department of Psychiatry and Behavioral Sciences.

Sleep health is an important factor across several physical and mental health disorders, and a growing scientific consensus has identified sleep as a critical component of opioid use disorder (OUD), both in the active disease state and during OUD recovery. The goal of this narrative review is to collate the literature on sleep, opioid use, and OUD as a means of identifying therapeutic targets to improve OUD treatment outcomes. Sleep disturbance is common and often severe in persons with OUD, especially during opioid withdrawal, but also in persons on opioid maintenance therapies. Read More

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Rapid blood cell recovery with immunosuppressive therapy combined with romiplostim in a patient with very severe hepatitis-associated aplastic anemia who underwent liver transplantation.

Int J Hematol 2021 Jun 10. Epub 2021 Jun 10.

Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Patients with hepatitis-associated aplastic anemia (HAA) who undergo living-donor liver transplantation (LDLT) have a poor prognosis with infections and bleeding complications. Rapid recovery of blood cells is critical for preventing these complications and improving the outcome. Immunosuppressive therapy (IST) combined with thrombopoietin receptor agonists is considered effective for aplastic anemia. Read More

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Comparison of Percutaneous Transforaminal Endoscopic Discectomy and Microscope-Assisted Tubular Discectomy for Lumbar Disc Herniation.

Orthop Surg 2021 Jun 10. Epub 2021 Jun 10.

Department of Spinal Surgery, Qingdao Chest Hospital, Qingdao, China.

Objective: The aim of the present study was to compare the clinical outcomes and quality of life following percutaneous transforaminal endoscopic discectomy (PTED) and microscope-assisted tubular discectomy (MTD) for lumbar disc herniation (LDH).

Methods: This study had a retrospective design. From June 2017 to June 2018, the clinical data of 120 patients with LDH treated with PTED (60 cases, PTED group) and MTD (60 cases, MTD group) were analyzed and followed up for at least 20 months. Read More

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Effect of recovery-based interventions on recovery knowledge and attitudes of mental health professionals, regarding recovery-oriented practice: A quantitative narrative review.

Int J Ment Health Nurs 2021 Jun 9. Epub 2021 Jun 9.

Federation University, Berwick, Victoria, Australia.

Mental health recovery is an enabling process encouraging consumers to live a productive life, notwithstanding the presence of debilitating symptoms of illness. The recovery model has been integrated into all areas of mental health. However, literature shows that mental health professionals are not equipped to provide recovery-oriented care to consumers. Read More

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Hyperimmune anti-COVID-19 IVIG (C-IVIG) treatment in severe and critical COVID-19 patients: A phase I/II randomized control trial.

EClinicalMedicine 2021 Jun 4:100926. Epub 2021 Jun 4.

Dow University of Health Sciences - Ojha Campus, Karachi, Pakistan.

Background: Hyperimmune anti-COVID-19 Intravenous Immunoglobulin (C-IVIG) is an unexplored therapy amidst the rapidly evolving spectrum of medical therapies for COVID-19 and is expected to counter the three most life-threatening consequences of COVID-19 including lung injury by the virus, cytokine storm and sepsis.

Methods: A single center, phase I/II, randomized controlled, single-blinded trial was conducted at Dow University of Health Sciences, Karachi, Pakistan. Participants were COVID-19 infected individuals, classified as either severely or critically ill with Acute Respiratory Distress Syndrome (ARDS). Read More

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Very-Short-Term Sleep Deprivation Slows Early Recovery of Lymphocytes in Septic Patients.

Front Med (Lausanne) 2021 24;8:656615. Epub 2021 May 24.

Department of Critical Care Medicine, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.

Sleep plays an important role in immune function. However, the effects of very-short-term sleep deprivation on the early recovery of immune function after sepsis remain unclear. This study was conducted in the intensive care unit to investigate the effects of 2 consecutive days of sleep deprivation (SD) on lymphocyte recovery over the following few days in septic patients who were recovering from a critical illness. Read More

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Pregabalin versus placebo to prevent chronic pain after whiplash injury in at-risk individuals: results of a feasibility study for a large randomised controlled trial.

Pain 2021 Jun 8. Epub 2021 Jun 8.

Recover Injury Research Centre, NHMRC Centre of Research Excellence in Recovery Following Road Traffic Injuries, The University of Queensland, Herston, Australia. Department of Emergency Medicine, Gold Coast Hospital and Health Service, Gold Coast, Queensland, Australia. Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, Australia. School of Medicine, Griffith University, Gold Coast, QLD, Australia. Faculty of Medicine, The University of Queensland, Herston, Australia. Department of Emergency Medicine, Logan Hospital, Brisbane, Australia. Medical School, The University of Western Australia, Perth, Australia. Menzies Health Institute Queensland, Griffith University, Brisbane, Australia. Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina School of Medicine, Chapel Hill, USA. Centre for the Business and Economics of Health, University of Queensland, Brisbane, Australia. Dipartimento di Sociologia e Diritto dell'Economia, University of Bologna, Bologna, Italy.

Abstract: There are few effective treatments for acute whiplash-associated disorders (WAD). Early features of central sensitisation predict poor recovery. The effect of pregabalin on central sensitisation might prevent chronic pain after acute whiplash injury. Read More

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Perceived Social Support is Strongly Associated with Recovery after Injury.

J Trauma Acute Care Surg 2021 Apr 8. Epub 2021 Apr 8.

Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA Division of Trauma, Burn, and Surgical Critical Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA Division of Trauma, Acute Care Surgery & Surgical Critical Care, Boston Medical Center, Boston University School of Medicine, Boston, MA Division of Trauma, Burn & Critical Care Surgery, Harborview Medical Center, University of Washington, Seattle, WA.

Background: The strength of one's social support network is a potentially modifiable factor that may have a significant impact on recovery after injury. We sought to assess the association between one's perceived social support (PSS) and physical and mental health outcomes 6-12 months post-injury.

Methods: Moderate-to-severely injured patients admitted to one of three Level I trauma centers were asked to complete a phone-based survey assessing physical and mental health outcomes in addition to return to work and chronic pain 6-12 months post-injury. Read More

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Comparison of direct costs of percutaneous full-endoscopic interlaminar lumbar discectomy and microdiscectomy: Results from Turkey.

Ideggyogy Sz 2021 May;74(5-6):197-205

Department of Neurosurgery, Memorial Bahcelievler Hospital, Istanbul, Turkey.

Background And Purpose: Microdiscectomy (MD) is a stan-dard technique for the surgical treatment of lumbar disc herniation (LDH). Uniportal percutaneous full-endoscopic in-terlaminar lumbar discectomy (PELD) is another surgical op-tion that has become popular owing to reports of shorter hos-pitalization and earlier functional recovery. There are very few articles analyzing the total costs of these two techniques. Read More

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[Thrombolysis with Tenecteplase in a stroke with a long time window after onset of symptoms. Report of one case].

Rev Med Chil 2021 Jan;149(1):128-131

Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.

We report a 78-year-old man with a basal Rankin score of 2 points, last seen 10 hours before in good conditions, who arrived at the emergency department with left hemiparesis, hypoesthesia, and spacial neglect. Neuroimaging was compatible with stroke in the territory of the right middle cerebral artery. Due to the evolution time of the stroke, usual thrombolysis was contraindicated. Read More

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January 2021

Management of mixed acute rejection driven by a donor-specific complement-binding anti-DQB1*03:01 antibody and intraepithelial CD8 T cells in a kidney recipient: A case report.

Br J Biomed Sci 2021 Jun 9. Epub 2021 Jun 9.

Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC, and Cancer Research Institute of Salamanca-IBMCC (CSIC-USAL University), 37007 Salamanca, Spain.

Mixed acute rejection is a clinicopathological entity that is difficult to accurately diagnose, and so may be under-reported. Allografts are lost more often than in either humoral or cellular rejection. The diagnosis requires both histological and immunological studies on renal biopsy and blood specimens from the transplant recipient to provide the required rescue therapy to abolish the allogeneic response against the graft. Read More

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Enhanced Recovery After Surgery Protocol in Emergency Laparotomy: A Randomized Control Study.

Surg J (N Y) 2021 Apr 3;7(2):e92-e99. Epub 2021 Jun 3.

Department of Anesthesiology, All India Institute of Medical, Sciences, Rishikesh, Uttarakhand, India.

 There is established evidence on the role of enhanced recovery after surgery (ERAS) protocols in elective surgeries but its effectiveness in emergency surgeries has been nominally studied. We aimed at studying the feasibility and effectiveness of ERAS protocols in patients undergoing emergency abdominal surgery for intestinal perforation and small bowel obstruction and compare their surgical outcomes with conventional care.  This prospective randomized study was performed for a period of 16 months. Read More

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A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia.

J Inflamm Res 2021 1;14:2363-2376. Epub 2021 Jun 1.

School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.

Introduction: Cerebral ischemia is a leading cause of disability and death worldwide. However, an effective therapeutic approach for the condition remains undiscovered. The previously proposed growth factor-based therapy has been inefficient due to its inability to pass through the blood-brain barrier. Read More

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Outcomes and Nephrotoxicity Associated with Vancomycin Treatment in Patients 80 Years and Older.

Clin Interv Aging 2021 1;16:1023-1035. Epub 2021 Jun 1.

Department of Internal Medicine and Geriatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

Purpose: This retrospective observational study investigated the efficacy and safety of vancomycin to treat patients aged 80 years and older. In particular, the associations between vancomycin trough concentration (VTC) and treatment outcomes or nephrotoxicity were explored.

Patients And Methods: Patients aged ≥80 years had received ≥3 vancomycin treatments and ≥1 detection of VTC. Read More

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The impact of transition from conventional robot-assisted radical prostatectomy to retzius sparing robot-assisted radical prostatectomy: A retrospective multivariate analysis.

Indian J Urol 2021 Apr-Jun;37(2):140-146. Epub 2021 Apr 1.

Department of Urology, Aster Medcity, Cochin, Kerala, India.

Introduction: To assess the outcomes of Retzius sparing robotic-assisted radical prostatectomy (RS-RARP) in comparison with the conventional RARP.

Materials And Methods: A retrospective analysis of 320 cases of RARP, performed from 2014 April to 2019 April, was performed. The predictor variables included age, body mass index, clinical stage, prostate-specific antigen, Gleason score category in biopsy, D'Amico risk category, presence of the median lobe, prior transurethral resection of the prostate, and the ability to perform the RS-RARP. Read More

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Prospective, Single-Center Comparison of Transcranial Direct Current Stimulation Plus Electroacupuncture and Standard Analgesia in Patients After Total Knee Arthroplasty: Effect on Rehabilitation and Functional Recovery.

Med Sci Monit 2021 Jun 9;27:e930363. Epub 2021 Jun 9.

Department of Rehabilitation Medicine, The Affiliated Huai'an Hospital of Xuzhou Medical University and the Second People's Hospital of Huai'an, Huai'an, Jiangsu, China (mainland).

BACKGROUND The aim of this prospective study was to compare transcranial direct current stimulation (tDCS) plus electroacupuncture with standard analgesia in patients after total knee arthroplasty (TKA) to determine the effects on rehabilitation and functional recovery. MATERIAL AND METHODS Eighty patients with osteoarthritis of the knee who underwent TKA were included in the study. They were divided into experimental (n=40) and control groups (n=40) according to postoperative analgesia method. Read More

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Sofosbuvir with daclatasvir and the outcomes of patients with COVID-19: a systematic review and meta-analysis with GRADE assessment.

Postgrad Med J 2021 Jun 8. Epub 2021 Jun 8.

Faculty of Medicine Universitas Pelita Harapan, Tangerang, Indonesia.

Purpose: This systematic review and meta-analysis aimed to evaluate the effect of sofosbuvir/daclatasvir (SOF/DCV) on mortality, the need for intensive care unit (ICU) admission or invasive mechanical ventilation (IMV) and clinical recovery in patients with COVID-19.

Methods: We performed a systematic literature search through the PubMed, Scopus and Embase from the inception of databases until 6 April 2021. The intervention group was SOF/DCV, and the control group was standard of care. Read More

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Effects of a modified muscle sparing posterior technique in hip hemiarthroplasty for displaced intracapsular fractures on postoperative function compared to a standard lateral approach (HemiSPAIRE): protocol for a randomised controlled trial.

BMJ Open 2021 Jun 8;11(6):e045652. Epub 2021 Jun 8.

Exeter Hip Unit, Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

Introduction: Currently National Institute for Health and Care Excellence clinical guidelines in the UK suggest that surgeons performing partial hip replacements (hemiarthroplasty) should consider using the lateral approach. Alternatively, a newer, modified posterior approach using a muscle sparing technique named 'Save Piriformis and Internus, Repairing Externus' (SPAIRE) can be used leaving the major muscles intact. This randomised controlled trial (RCT) aims to compare the SPAIRE approach to the standard lateral approach, to determine if it allows patients to mobilise better and experience improved function after surgery. Read More

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Effect of intra-arrest trans-nasal evaporative cooling in out-of-hospital cardiac arrest: a pooled individual participant data analysis.

Crit Care 2021 06 8;25(1):198. Epub 2021 Jun 8.

Department of Medicine Center for Resuscitation Science, Karolinska Institute, Solna, Sweden.

Background: Randomized trials have shown that trans-nasal evaporative cooling initiated during CPR (i.e. intra-arrest) effectively lower core body temperature in out-of-hospital cardiac arrest patients. Read More

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[The clinical effect and imaging features of accordion maneuver in promoting bone healing at the docking site after tibial transport under ultrasonic monitoring].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):477-483

Department of Orthopaedics,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China.

To explore the imaging features and clinical effect of accordion maneuver in promoting the bone healing at the docking site after tibial transport under ultrasonic monitoring. Retrospective analysis was conducted on the clinical data of 16 patients with tibial bone transport who were admitted to the Department of Orthopedics, the second Hospital of Shanxi Medical University from May 2018 to October 2019. All the patients were treated with accordion maneuver to promote bone healing at the docking site under ultrasound monitoring. Read More

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