1,394,172 results match your criteria outcome measures

The psychological readiness to return to sports of patients with anterior cruciate ligament reconstruction preoperatively and 6 months postoperatively.

Phys Ther Sport 2021 Apr 30;50:114-120. Epub 2021 Apr 30.

Clinical Center for Sports Medicine and Sports Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

Objective: To determine the association of psychological readiness to return to sports preoperative and 6 months post-reconstruction in athletes with anterior cruciate ligament (ACL) injury.

Design: Retrospective cohort study.

Setting: Clinical center of sports medicine. Read More

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Non-parameningeal head and neck rhabdomyosarcoma in children, adolescents, and young adults: Experience of the European paediatric Soft tissue sarcoma Study Group (EpSSG) - RMS2005 study.

Eur J Cancer 2021 May 7;151:84-93. Epub 2021 May 7.

SIREDO Oncology Center, Institute Curie, PSL University, Paris, France.

Background/objectives: The primary aim of this study was to analyse and evaluate the impact of different local treatments on the pattern of relapse in children with primary head and neck non-parameningeal (HNnPM) rhabdomyosarcoma (RMS), treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 study. The secondary aim was to assess whether current risk stratification is valid for this specific site.

Design/methods: This study includes all patients with localised HNnPM RMS enrolled in the RMS2005 study between 2005 and 2016. Read More

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Clinical Characteristics and Outcomes of Eyes with Intraocular Inflammation after Brolucizumab: Post Hoc Analysis of HAWK and HARRIER.

Ophthalmol Retina 2021 May 7. Epub 2021 May 7.

Ophthalmology, Sorbonne University, APHP, Paris, France.

Purpose: This analysis of the pivotal phase III HAWK and HARRIER trials aimed to provide insights on the timing of presentation, management, and outcomes of intraocular inflammation (IOI)-related adverse events (AEs), as reported by investigators in these trials.

Design: Post hoc analysis of investigator-reported IOI-related AEs in HAWK and HARRIER.

Participants: Of 1088 brolucizumab-treated eyes (3 mg or 6 mg), 49 eyes experienced at least 1 IOI-related AE and were included in this analysis. Read More

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Machine learning can predict anti-VEGF treatment demand in a Treat-and-Extend regimen for patients with nAMD, DME and RVO associated ME.

Ophthalmol Retina 2021 May 7. Epub 2021 May 7.

AIMI, ARTORG Center, University of Bern, Bern, Switzerland.

Purpose: To assess the potential of machine learning to predict low and high treatment demand in real life in patients with nAMD, RVO and DME treated according to a TER.

Design: Retrospective cohort study.

Participants: 377 eyes (340 patients) with nAMD, 333 eyes (285 patients) with RVO or DME, treated with anti-VEGF according to a predefined TER protocol during 2014-2018. Read More

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Survival Analysis and Risk Factors of New Vertebral Fracture after Vertebroplasty for Osteoporotic Vertebral Compression Fracture.

Spine J 2021 May 7. Epub 2021 May 7.

Department of Orthopedic Surgery, Guri Hospital, Hanyang University College of Medicine, 153 Gyeongchun-ro, Guri-si, Gyeonggi-do 11923, South Korea. Electronic address:

Background Context: Although risk factors of new adjacent vertebral fracture (AVF) and remote vertebral fracture (RVF) after vertebroplasty may differ, research on this topic is lacking.

Purpose: To determine the natural course of new vertebral fractures after vertebroplasty for osteoporotic vertebral compression fracture (OVCF) and to analyze each risk factor for understanding the incidence of AVF and RVF.

Study Design: Retrospective cohort study. Read More

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Predictors of Serious, Preventable, and Costly Medical Complications in a Population of Adult Spinal Deformity Patients.

Spine J 2021 May 7. Epub 2021 May 7.

Department of Orthopaedic Surgery, University of California Davis, Davis, CA.

Background Context: In 2008, the Centers for Medicare and Medicaid Services (CMS) established a list of hospital-acquired conditions (HACs) with significant deleterious effects on both patients and providers. Adult spinal deformity (ASD) surgery is complex and highly invasive, and as such may result in significant morbidity including these HACs.

Purpose: Identify predictors for developing the most common HACs among adult spinal deformity(ASD) patients undergoing corrective surgery. Read More

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Longer Operative Time Associated with Prolonged Length of Stay, Non-Home Discharge and Transfusion Requirement after Anterior Cervical Discectomy and Fusion: an Analysis of 24,593 Cases.

Spine J 2021 May 7. Epub 2021 May 7.

Department of Orthopaedic Surgery, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA; Center for Spine Health, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA.

Background: Prolonged operative time of single-level ACDF has been associated with adverse postoperative outcomes. The current literature does not contain a comprehensive quantitative description of these associations PURPOSE: This study characterized the associations between single-level anterior cervical discectomy and fusion(ACDF) operative time and 1)30-day postoperative healthcare utilization, and 2)the incidence of local wound complications, need for transfusion and mechanical ventilation.

Design/setting: Retrospective database analysis PATIENT SAMPLE: The American College of Surgeons National Surgical Quality Improvement Program(ACS-NSQIP) database was queried for single-level ACDF cases(2012-2018) using current procedural terminology codes. Read More

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Novel approach for Monte Carlo simulation of the new COVID-19 spread dynamics.

Infect Genet Evol 2021 May 7:104896. Epub 2021 May 7.

National Technical University of Athens, Physics Department, Greece.

A Monte Carlo simulation in a novel approach is used for studying the problem of the outbreak and spread dynamics of the new COVID-19 pandemic in this work. In particular, our goal was to generate epidemiological data based on natural mechanism of transmission of this disease assuming random interactions of a large-finite number of individuals in very short distance ranges. In the simulation we also take into account the stochastic character of the individuals in a finite population and given densities of people. Read More

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Effect of Reducing Sedentary Behavior on Blood Pressure (RESET BP): Rationale, design, and methods.

Contemp Clin Trials 2021 May 7:106428. Epub 2021 May 7.

Department of Health and Human Development, University of Pittsburgh, Pittsburgh, PA, United States of America.

Sedentary behavior (SB) has recently been recognized as a strong risk factor for cardiovascular disease, with new guidelines encouraging adults to 'sit less, move more.' Yet, there are few randomized trials demonstrating that reducing SB improves cardiovascular health. The Effect of Reducing Sedentary Behavior on Blood Pressure (RESET BP) randomized clinical trial addresses this gap by testing the effect of a 3-month SB reduction intervention on resting systolic BP. Read More

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Prevalence and burden of breathlessness in Australian adults: The National Breathlessness Survey-a cross-sectional web-based population survey.

Respirology 2021 May 10. Epub 2021 May 10.

Australian Centre for Airways disease Monitoring (ACAM), the Woolcock Institute of Medical Research, The University of Sydney, Sydney, New South Wales, Australia.

Background And Objective: Chronic respiratory symptoms (in particular, breathlessness and cough) can cause physical, social and emotional distress, and may indicate the presence of an underlying disease that presages future poor health outcomes. Our aim was to investigate the burden of breathlessness in Australian adults, including breathlessness that may be undiagnosed, unlabelled or untreated.

Methods: The National Breathlessness Survey was a cross-sectional, web-based survey conducted in October 2019. Read More

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Are oral health conditions associated with schoolchildren's performance and school attendance in the Kingdom of Bahrain? A life-course perspective.

Int J Paediatr Dent 2021 May 10. Epub 2021 May 10.

Federal University of Minas Gerais, Dental school Av. Antônio Carlos, Belo Horizonte, 312270-901.

Background: The link between oral diseases and school performance and school attendance remains unclear among Middle Eastern children.

Aim: To investigate the relationship of oral conditions with schoolchildren's school performance and attendance using the life course approach.

Design: A cross-sectional study was conducted with 466 schoolchildren aged 7-8 years from Kingdom of Bahrain (KoB) and their parents. Read More

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Predictors for inpatient mortality during the first wave of the SARS-CoV-2 pandemic: A retrospective analysis.

PLoS One 2021 10;16(5):e0251262. Epub 2021 May 10.

White Plains Hospital, White Plains, New York, United States of America.

Background: The coronavirus disease 2019 (COVID-19) pandemic overwhelmed healthcare systems, highlighting the need to better understand predictors of mortality and the impact of medical interventions.

Methods: This retrospective cohort study examined data from every patient who tested positive for COVID-19 and was admitted to White Plains Hospital between March 9, 2020, and June 3, 2020. We used binomial logistic regression to analyze data for all patients, and propensity score matching for those treated with hydroxychloroquine and convalescent plasma (CP). Read More

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Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis.

PLoS Med 2021 May 10;18(5):e1003602. Epub 2021 May 10.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Background: Parents are the primary caregivers of young children. Responsive parent-child relationships and parental support for learning during the earliest years of life are crucial for promoting early child development (ECD). We conducted a global systematic review and meta-analysis to evaluate the effectiveness of parenting interventions on ECD and parenting outcomes. Read More

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Functional Magnetic Resonance Imaging of Language Following Constraint-Induced Aphasia Therapy Primed with Intermittent Theta Burst Stimulation in 13 Patients with Post-Stroke Aphasia.

Med Sci Monit 2021 May 10;27:e930100. Epub 2021 May 10.

Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.

BACKGROUND Aphasia is a debilitating consequence of stroke. This study aimed to investigate the role of functional magnetic resonance imaging (fMRI) activation changes during overt language tasks in promoting language improvements following constraint-induced aphasia therapy (CIAT) primed with intermittent theta burst stimulation (iTBS) in 13 patients with aphasia following ischemic stroke. MATERIAL AND METHODS Participants with post-stroke aphasia participated in CIAT primed with iTBS on 10 consecutive weekdays. Read More

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Training diabetes healthcare practitioners in motivational interviewing: a systematic review.

Health Psychol Rev 2021 May 10:1-27. Epub 2021 May 10.

School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.

Diabetes presents significant self-care challenges that require sustained motivation. Motivational Interviewing (MI) has substantial support in enhancing motivation for behavioral change, but its effective application in routine healthcare requires practitioners to acquire and use related skills. The aim of this systematic review was to investigate the impact of MI training on MI-related skills of practitioners who provide diabetes healthcare. Read More

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Literature Review to create Evidence Based Care Pathway for Isolated Adult Orbital Blowout Fractures.

Strabismus 2021 May 10:1-5. Epub 2021 May 10.

Department of Orthoptics, University of Liverpool, Liverpool.

This review aims to develop an evidence-based pathway for isolated adult orbital blowout fractures. Evaluation of assessment methods, outcome measures, imaging modalities, and crucially, the optimal timing of surgical intervention was critically examined to develop a clinically applicable care pathway. A literature search was carried out using Scopus, PubMed and Web of Knowledge. Read More

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Reliability of Outcome Measures to Assess Consonant Proficiency Following Cleft Palate Speech Intervention: The Percentage of Consonants Correct Metric and the Probe Scoring System.

J Speech Lang Hear Res 2021 May 10:1-18. Epub 2021 May 10.

Department of Rehabilitation Sciences, Ghent University, Belgium.

Purpose This study compared the inter- and intrarater reliability of the percentage of consonants correct (PCC) metrics and the probe scoring system between an experienced and a less experienced rater and between two experienced raters. In addition, these outcome measures' ability to reflect changes following speech intervention was measured. Method During Phase 1, two raters (Rater 1 with 5 years of experience in cleft-related speech disorders and Rater 2 with limited experience in cleft-related speech disorders) independently assessed 134 speech samples at the word and sentence levels, which were collected on different data points before, during, and following a cleft palate speech intervention. Read More

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Integration of Patient-reported Outcomes in a Total Joint Arthroplasty Program at a High-volume Academic Medical Center.

J Am Acad Orthop Surg Glob Res Rev 2020 May;4(5):e2000034

From the Department of Orthopaedic Surgery (Ms. Bhatt, Dr. Manning, Dr. Peabody), Northwestern University Feinberg School of Medicine; the Northwestern Memorial HealthCare (Ms. Davis, Dr. Barnard), Northwestern University Center for Healthcare Studies; the Department of Medical Social Sciences (Dr. Rothrock), Northwestern University Feinberg School of Medicine; and the Department of Surgery (Dr. Barnard), Feinberg School of Medicine, Northwestern University, Chicago, IL.

Introduction: Despite widely appreciated barriers to successful clinical implementation, the literature regarding how to operationalize electronic health record-integrated patient-reported outcomes (PROs) remains sparse. We offer a detailed summary of the implementation of PROs into the standard of care at a major tertiary academic medical center.

Methods: Collection of four Patient-Reported Outcomes Measurement Information System computer adaptive tests was piloted in a large academic orthopaedic surgery ambulatory clinic starting in October 2016. Read More

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Povidone-iodine irrigation combined with Vancomycin powder lowers infection rates in pediatric deformity surgery.

Spine Deform 2021 May 10. Epub 2021 May 10.

Department of Orthopedics University of California, Davis, Sacramento, USA.

Background: Surgical site infection is a morbid, devastating complication after spinal procedures. Studies have investigated the effect of wound lavage with 3.5% Povidone-iodine solution or the use of intrawound Vancomycin powder. Read More

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The use of electronic PROMs provides same outcomes as paper version in a spine surgery registry. Results from a prospective cohort study.

Eur Spine J 2021 May 10. Epub 2021 May 10.

IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.

Background And Purpose: Patient-Reported Measured Outcomes (PROMs) are essential to gain a full understanding of a patient's condition, and in spine surgery, these questionnaires are of help when tailoring a surgical strategy. Electronic registries allow for a systematic collection and storage of PROMs, making them readily available for clinical and research purposes. This study aimed to investigate the reliability between the electronic and paper form of ODI (Oswestry Disability Index), SF-36 (Short Form Health Survey 36) and COMI-back (Core Outcome Measures Index for the back) questionnaires. Read More

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Anatomic single vs. double-bundle ACL reconstruction: a randomized clinical trial-Part 1: clinical outcomes.

Knee Surg Sports Traumatol Arthrosc 2021 May 10. Epub 2021 May 10.

Department of Orthopaedic Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: Compare clinical outcomes of anatomic single-bundle (SB) to anatomic double-bundle (DB) anterior cruciate ligament reconstruction (ACLR). It was hypothesized that anatomic DB ACLR would result in better International Knee Documentation Committee Subjective Knee Form (IKDC-SKF) scores and reduced anterior and rotatory laxity compared to SB ACLR.

Methods: Active individuals between 14 and 50 years of age that presented within 12 months of injury were eligible to participate. Read More

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Preeclampsia Prevalence, Risk Factors, and Pregnancy Outcomes in Sweden and China.

JAMA Netw Open 2021 May 3;4(5):e218401. Epub 2021 May 3.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Importance: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. Within-country studies have reported racial differences in the presentation and outcome, but little is known about differences between countries.

Objective: To compare preeclampsia prevalence, risk factors, and pregnancy outcomes between the Swedish and Chinese populations. Read More

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Assessment of Diagnostic Yield of Cystoscopy and Computed Tomographic Urography for Urinary Tract Cancers in Patients Evaluated for Microhematuria: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 May 3;4(5):e218409. Epub 2021 May 3.

Department of Urology, Spital-Limmattal, Schlieren, Switzerland.

Importance: Microhematuria (MH) is a common finding that often leads to further evaluation for urinary tract cancers. There is ongoing debate about the extent to which patients with MH should be evaluated for cancer.

Objective: To assess the diagnostic yield for detection of urinary tract cancers, specifically bladder cancer, upper tract urothelial carcinoma (UTUC), and kidney cell carcinoma, among patients evaluated for MH using cystoscopy and computed tomographic (CT) urography. Read More

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Patient-Reported Outcomes of Treatment of Opioid Dependence With Weekly and Monthly Subcutaneous Depot vs Daily Sublingual Buprenorphine: A Randomized Clinical Trial.

JAMA Netw Open 2021 May 3;4(5):e219041. Epub 2021 May 3.

Camurus, Lund, Sweden.

Importance: Patient-reported outcomes in the treatment of opioid dependence may differ between subcutaneously administered depot buprenorphine and daily sublingual buprenorphine.

Objective: To compare patient satisfaction between depot buprenorphine and sublingual buprenorphine in adult outpatients with opioid dependence.

Design, Setting, And Participants: This open-label, randomized clinical trial was conducted among adult patients with opioid dependence at 6 outpatient clinical sites in Australia from October 2018 to September 2019. Read More

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Assessment of Recurrent Stroke Risk in Patients With a Carotid Web.

JAMA Neurol 2021 May 10. Epub 2021 May 10.

Department of Neurology, Amsterdam UMC, University of Amsterdam, Neurology, Amsterdam, the Netherlands.

Importance: A carotid web (CW) is a shelf-like lesion along the posterior wall of the internal carotid artery bulb and an underrecognized cause of young stroke. Several studies suggest that patients with symptomatic CW have a high risk of recurrent stroke, but high-quality data are lacking.

Objective: To assess the 2-year risk of recurrent stroke in patients with a symptomatic CW. Read More

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Fortification of Breast Milk With Preterm Formula Powder vs Human Milk Fortifier in Preterm Neonates: A Randomized Noninferiority Trial.

JAMA Pediatr 2021 May 10. Epub 2021 May 10.

Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Importance: Fortification of expressed breast milk (EBM) using commercially available human milk fortifiers (HMF) increases short-term weight and length in preterm very low-birth-weight (VLBW) neonates. However, the high cost and increased risk of feed intolerance limit their widespread use. Preterm formula powder fortification (PTF) might be a better alternative in resource-limited settings. Read More

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The Association of Unfairness with Mental and Physical Health in a Multiethnic Sample of Adults: Cross-sectional Study.

JMIR Public Health Surveill 2021 May 10;7(5):e26622. Epub 2021 May 10.

Arab Community Center for Economic and Social Services, Dearborn, MI, United States.

Background: Two psychosocial constructs that have shown consistent associations with negative health outcomes are discrimination and perceived unfairness.

Objective: The current analyses report the effects of discrimination and unfairness on medical, psychological, and behavioral outcomes from a recent cross-sectional survey conducted in a multiethnic sample of adults in Michigan.

Methods: A cross-section survey was collected using multiple approaches: community settings, telephone-listed sample, and online panel. Read More

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Does a Recumbent Lateral Stability Trainer Improve Balance Scores Among Older Adults Within 4 Weeks?

Perm J 2021 May;25

College of Saint Mary, Omaha, NE.

Backgroud: Past literature has shown that balance and strength are important in preventing falls, but few studies have focused on developing strength and power in a lateral plane. The purpose of this study was to determine if a lateral pedal recumbent training device can improve balance scores among older adults in 4 weeks.

Methods: A 2-group experimental-control multivariate design (43 women, 13 men; age, 77. Read More

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Functional joint models for chronic kidney disease in kidney transplant recipients.

Stat Methods Med Res 2021 May 10:9622802211009265. Epub 2021 May 10.

Division of Nephrology, University of Nebraska Medical Center, NE, USA.

This functional joint model paper is motivated by a chronic kidney disease study post kidney transplantation. The available kidney organ is a scarce resource because millions of end-stage renal patients are on the waiting list for kidney transplantation. The life of the transplanted kidney can be extended if the progression of the chronic kidney disease stage can be slowed, and so a major research question is how to extend the transplanted kidney life to maximize the usage of the scarce organ resource. Read More

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Alternating pressure (active) air surfaces for preventing pressure ulcers.

Cochrane Database Syst Rev 2021 May 10;5:CD013620. Epub 2021 May 10.

Nursing Research Institute, St Vincent's Health Australia Sydney, St Vincent's Hospital Melbourne & Australian Catholic University, Fitzroy, Melbourne, Australia.

Background: Pressure ulcers (also known as pressure injuries, pressure sores, decubitus ulcers and bed sores) are localised injuries to the skin or underlying soft tissue, or both, caused by unrelieved pressure, shear or friction. Alternating pressure (active) air surfaces are widely used with the aim of preventing pressure ulcers.

Objectives: To assess the effects of alternating pressure (active) air surfaces (beds, mattresses or overlays) compared with any support surface on the incidence of pressure ulcers in any population in any setting. Read More

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