960,282 results match your criteria outcome elderly


Application of a new serratus anterior plane block in modified radical mastectomy under ultrasound guidance: A prospective, randomized controlled trial.

J Clin Anesth 2021 Jun 9;74:110377. Epub 2021 Jun 9.

Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address:

Study Objectives: Post-operative pain is a significant concern following modified radical mastectomy in breast cancer patients. The serratus anterior plane block has recently been described as an effective technique for post-operative analgesia of modified radical mastectomy. The purpose of this study was to evaluate the analgesic efficacy and safety of a new serratus anterior plane (SAP) block for post-operative pain of mastectomy. Read More

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Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis.

Clin Microbiol Infect 2021 Jun 9. Epub 2021 Jun 9.

Department of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/University Hospital Virgen del Rocio, 41013 Seville, Spain. Electronic address:

Background: Long-term care facilities (LTCFs) are health care settings with high antimicrobial consumption and hence need to develop effective antimicrobial stewardship programs (ASPs).

Objective: To assess the effects of ASPs on care-related, clinical, and ecological outcomes in LTCFs.

Methods: Data sources were PubMed, EMBASE, CINAHL, and SCOPUS. Read More

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Arteriovenous Access Type and Risk of Mortality, Hospitalization, and Sepsis Among Elderly Hemodialysis Patients: A Target Trial Emulation Approach.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health; Madison, Wisconsin; Department of Medicine, University of Wisconsin School of Medicine and Public Health; Madison, Wisconsin. Electronic address:

Rationale & Objective: Evidence is mixed regarding the optimal choice of the first permanent vascular access for elderly patients on hemodialysis (HD). Lacking data from randomized controlled trials (RCT), we used a target trial emulation approach to compare arteriovenous fistula (AVF) versus arteriovenous graft (AVG) placement among elderly patients on HD.

Study Design: Retrospective cohort study. Read More

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Swallowing dysfunction and the onset of fever in older residents with special care needs: a thirteen-month longitudinal prospective study.

Odontology 2021 Jun 12. Epub 2021 Jun 12.

School of Oral Health Sciences, Faculty of Dentistry, Kyushu Dental University, 2-6-1, Manazuru, Kokurakita-ku, Kitakyushu , Fukuoka, 803-8580, Japan.

A decline in swallowing function is frequently observed among older residents in nursing homes. We investigated whether swallowing dysfunction was related to the onset of fever in such individuals. Older residents aged ≥ 65 years from three nursing homes were included in this prospective study conducted from July 2017 to May 2019. Read More

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Treatment of juvenile recurrent parotitis with irrigation therapy without anesthesia.

Eur Arch Otorhinolaryngol 2021 Jun 12. Epub 2021 Jun 12.

Department of Otolaryngology, Head and Neck Surgery, Philipps-University, Marburg, 35043, Baldingerstraße, Germany.

Purpose: No standardized treatment regimen exists for juvenile recurrent parotitis (JRP). The investigators hypothesized that irrigation with saline only without local anesthesia will be an effective and beneficial option.

Methods: Using a retrospective study design, a series of children with typical symptoms of JRP who were treated with at least one irrigation therapy were evaluated. Read More

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Cost effectiveness and impact of a targeted age- and incidence-based West Nile virus vaccine strategy.

Clin Infect Dis 2021 Jun 12. Epub 2021 Jun 12.

Division of Vector-Borne Diseases, Centers for Disease Control and Prevention (CDC), Fort Collins, Colorado, USA.

Background: West Nile virus (WNV) is the leading cause of arboviral disease in the United States and is associated with significant morbidity and mortality. A previous analysis found that a vaccination program targeting persons aged ≥60 years was more cost effective than universal vaccination, but costs remained high.

Methods: We used a mathematical Markov model to evaluate cost-effectiveness of an age- and incidence-based WNV vaccination program. Read More

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National Early Warning Score for predicting intensive care unit admission among elderly patients with influenza infections in the emergency department: an effective disposition tool during the influenza season.

BMJ Open 2021 Jun 11;11(6):e044496. Epub 2021 Jun 11.

Department of Emergency Medicine, Cathay General Hospital, Taipei, Taiwan

Objective: During the influenza epidemic season, the fragile elderlies are not only susceptible to influenza infections, but are also more likely to develop severe symptoms and syndromes. Such circumstances may pose a significant burden to the medical resources especially in the emergency department (ED). Disposition of the elderly patients with influenza infections to either the ward or intensive care unit (ICU) accurately is therefore a crucial issue. Read More

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Integrating pharmacists into aged care facilities to improve the quality use of medicine (PiRACF Study): protocol for a cluster randomised controlled trial.

Trials 2021 Jun 11;22(1):390. Epub 2021 Jun 11.

Health Research Institute, Faculty of Health, University of Canberra, Bruce, ACT, Australia.

Background: Medication management in residential aged care facilities is an ongoing concern. Numerous studies have reported high rates of inappropriate prescribing and medication use in aged care facilities, which contribute to residents' adverse health outcomes. There is a need for new models of care that enhance inter-disciplinary collaboration between residential aged care facility staff and healthcare professionals, to improve medication management. Read More

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Assessment of Morbidity and Mortality after Periprosthetic Hip Fracture. Influence of Vancouver Stage in a Retrospective Single-Centre Study of 88 Patients.

Orthop Traumatol Surg Res 2021 Jun 8:102985. Epub 2021 Jun 8.

Service de Chirurgie de l'Arthrose et du Sport, Urgences Traumatiques des Membres. CHU de Grenoble-Alpes, Hôpital Sud, Avenue de Kimberley, BP 338, 38434 Echirolles Cedex, France.

Background: Peri-prosthetic hip fractures (PPHFs) are serious complications whose treatment is generally difficult due to their predominance in elderly patients with bone frailty and other comorbidities. The Vancouver classification is the most widely used and is helpful for assisting treatment decisions. However, its value for predicting morbidity and mortality has not been assessed. Read More

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A tailored telehealth group tobacco cessation treatment program for people with HIV: Study protocol for a randomized controlled trial.

Contemp Clin Trials 2021 Jun 8:106475. Epub 2021 Jun 8.

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, United States of America. Electronic address:

Background: Smoking-related illnesses are the leading cause of death among people with HIV (PWH). Yet, there are few effective evidence-based interventions that help PWH quit smoking. The group-based program Positively Smoke Free is a biobehavioral cessation intervention for PWH with a growing evidence base. Read More

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Medical contraindications to combined hormonal contraceptive use among women using methods prescribed by a pharmacist.

Contraception 2021 Jun 8. Epub 2021 Jun 8.

Center for Health Systems Effectiveness, Oregon Health & Science University.

Objective: To determine whether pharmacist prescription of combined hormonal contraception is associated with inappropriate prescription to women with medical contraindications.

Study Design: We conducted a retrosopective cohort study of all short-acting, hormonal contraceptive users (pill, patch, ring, injectable) in Oregon's All Payer All Claims database from January 1, 2016 to December 31, 2018. Our primary outcome was the proportion of women receiving a combined hormonal method who had a Medical Eligibility Category (MEC) 3 or 4 condition. Read More

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Prenatal Antidepressant Use and the Implication of Hypertensive Disorders during Pregnancy.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

School of Pharmacy, College of Pharmacy, Taipei Medical University. Electronic address:

Background: Evidence regarding prenatal antidepressant use and the development of hypertensive disorders during pregnancy is inconsistent. Previous studies have reported that antidepressant use during pregnancy increases the risk of gestational hypertension and preeclampsia, but the results of these studies are potentially confounded by important methodologic limitations. Furthermore, it remains unknown whether a higher cumulative dose of antidepressant increases the risk of hypertensive disorders of pregnancy. Read More

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Prevalence of active tuberculosis disease among healthcare workers and support staff in healthcare settings of the Amhara region, Ethiopia.

PLoS One 2021 11;16(6):e0253177. Epub 2021 Jun 11.

KNCV Tuberculosis Foundation, The Hague, The Netherlands.

Background: Health care workers (HCWs) are at an increased risk of acquiring tuberculosis (TB) compared to the general population, because of the frequent face to face contact or potential exposure to TB through shared air or space with infectious patient(s), regardless of economic setting and local TB incidence. Information on the burden of active TB disease among HCWs will help guide control measures, can be utilized to evaluate the effectiveness of TB infection prevention programs in the health care setting, and guide necessary actions. However, data on TB among HCW in Ethiopia is limited. Read More

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Compassionate and respectful care among outpatient clients at public health facilities in Northwest Ethiopia: A mixed-methods study.

PLoS One 2021 11;16(6):e0252444. Epub 2021 Jun 11.

Department of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Compassionate and respectful care is a pillar for improving health-seeking behaviour. It has given much attention globally, following the concerns that healthcare often falls significantly; however, less research emphasis was paid in the last decade. Therefore, this study aims to assess compassionate and respectful care and associated factors among outpatient clients at public health facilities in Northwest Ethiopia, 2020. Read More

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Survival of stainless steel crowns and composite resin restorations in molars affected by Molar-Incisor Hypomineralization (MIH).

Int J Paediatr Dent 2021 Jun 11. Epub 2021 Jun 11.

Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), Araraquara School of Dentistry, Araraquara, São Paulo, Brazil.

Background: Currently, there is no consensus on the superiority of any material for the restorative treatment of molars affected by Molar-Incisor Hypomineralization (MIH).

Aim: To evaluate the survival of restorations with stainless steel crown (SSC) or composite resin (CR) in first permanent molars affected by MIH for 24 months.

Design: In this retrospective cohort study, 61 CR and 54 SSC restorations performed on molars affected by MIH of patients, aged between 7 and 10, that were treated and overseen at a university dental clinic in the period of 2017-2020 were evaluated. Read More

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The diagnostic utility of size and apparent diffusion coefficient values for cervical lymph nodes in patients with osteomyelitis of the jaw bone.

Oral Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Nihon University School of Dentistry At Matsudo, 2-870-1 Sakaecho-Nishi, Matsudo, Chiba, 271-8587, Japan.

Purpose: The purpose of this study was to (1) clarify the size and apparent diffusion coefficient (ADC) value of lymph nodes (LN) in each state in their quantitative evaluation diffusion-weighted imaging, and (2) to determine the diagnostic utility of size and ADC values in the quantitative evaluation of LNs using diffusion-weighted imaging.

Methods: This was a retrospective cohort study at our hospital conducted between April 2017 and March 2019. A total of 50 patients (20 men, 30 women) with 118 LNs, aged 34-90 years (mean age 61. Read More

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Feasibility and Acceptability of a Mobile Phone App Intervention for Coping With Cancer as a Young Adult: Pilot Trial and Thematic Analysis.

J Med Internet Res 2021 Jun 11;23(6):e25069. Epub 2021 Jun 11.

Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, MA, United States.

Background: Many young adult patients do not receive adequate psychosocial services to help them cope with cancer.

Objective: This study aims to assess the feasibility and acceptability of a smartphone app (iaya) intervention that was designed to create an engaged community of young adult patients and help them learn emotional coping skills.

Methods: For this single-group pilot trial, 25 young adult patients aged 18-39 years who were receiving active cancer treatment were asked to use the iaya app for 12 weeks. Read More

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Outcome of childhood acute lymphoblastic leukemia treatment in a single center in Brazil: A survival analysis study.

Cancer Rep (Hoboken) 2021 Jun 11:e1452. Epub 2021 Jun 11.

Clinical Medicine Post-Graduation Program, College of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Acute lymphoblastic leukemia (ALL) is the most common neoplasm in childhood. The probability of current overall survival (OS) is around 90% in developed countries. There are few studies that demonstrate the results in Brazil. Read More

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Clinical and prognostic role of sarcopenia in elderly patients with classical Hodgkin lymphoma: a multicentre experience.

J Cachexia Sarcopenia Muscle 2021 Jun 11. Epub 2021 Jun 11.

Division of Hematology, ASST Spedali Civili, Brescia, Italy.

Background: Elderly classical Hodgkin lymphoma (cHL) (ecHL) is a rare disease with dismal prognosis and no standard treatment. Fitness-based approaches may help design appropriate treatments. Sarcopenia has been associated with an increased risk of treatment-related toxicities and worse survival in various solid tumours, but its impact in ecHL is unknown. Read More

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Open vs closed surgical exposure of palatally displaced canines: a comparison of clinical and patient-reported outcomes-a multicentre, randomized controlled trial.

Eur J Orthod 2021 Jun 11. Epub 2021 Jun 11.

Postgraduate Dental Education Center, Department of Oral and Maxillofacial Radiology, Örebro, Sweden.

Objectives: To compare treatment time, patients' perceptions during orthodontic treatment, dental fear and side effects, between open and closed surgical exposures in patients with palatally displaced canines (PDCs).

Trial Design: Multicentre, randomized controlled trial, with random 1:1 allocation of two parallel groups.

Materials And Methods: One hundred and twenty patients from three different orthodontic centres were randomized into one of the two intervention arms, open or closed surgical exposure. Read More

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Regional variations of child development index in Bangladesh.

Heliyon 2021 May 27;7(5):e07140. Epub 2021 May 27.

Research & Development Department, Orion Pharma Ltd, Bangladesh.

Early development is a vital phase in childhood life. The study aimed to identify factors that were associated with the early development of 36-59 months children in Bangladesh. The findings of this study will formulate the design of appropriate policy and programmed responses. Read More

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Refractive Error and Visual Impairment Among School Children: Result of a South-Eastern Nigerian Regional Survey.

Clin Ophthalmol 2021 4;15:2345-2353. Epub 2021 Jun 4.

Department of Ophthalmology, College of Medicine, University of Nigeria, Ituku, Enugu, Nigeria.

Purpose: To determine the prevalence refractive errors and causes of visual impairment in school children in the south-eastern region of Nigeria.

Methods: School-based cross-sectional samples of children 5 to 15 of age in both urban and rural areas were profiled through cluster sampling. The main outcome measures were presenting, uncorrected, and best-corrected visual acuity using the Refractive Error in School-age Children (RESC) protocol. Read More

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Risk Preferences of Children and Adolescents in Relation to Gender, Cognitive Skills, Soft Skills, and Executive Functions.

J Econ Behav Organ 2020 Nov 20;179:729-472. Epub 2019 Jul 20.

We conduct experiments eliciting risk preferences with over 1,400 children and adolescents aged 3-15 years old. We complement our data with an assessment of cognitive and executive function skills. First, we find that adolescent girls display significantly greater risk aversion than adolescent boys. Read More

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November 2020

Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML.

Cell Death Discov 2021 Jun 10;7(1):137. Epub 2021 Jun 10.

Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Over the last 50 years, there has been a steady improvement in the treatment outcome of acute myeloid leukemia (AML). However, median survival in the elderly is still poor due to intolerance to intensive chemotherapy and higher numbers of patients with adverse cytogenetics. Fadraciclib (CYC065), a novel cyclin-dependent kinase (CDK) 2/9 inhibitor, has preclinical efficacy in AML. Read More

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Factors associated with the referral of children with severe illnesses at primary care level in Ethiopia: a cross-sectional study.

BMJ Open 2021 Jun 10;11(6):e047640. Epub 2021 Jun 10.

London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, UK.

Context And Objective: Ethiopia's primary care has a weak referral system for sick children. We aimed to identify health post and child factors associated with referrals of sick children 0-59 months of age and evaluate the healthcare providers' adherence to referral guidelines.

Design: A cross-sectional facility-based survey. Read More

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Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery.

J Cardiothorac Vasc Anesth 2021 May 12. Epub 2021 May 12.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA.

Objectives: The objective of this study was to identify novel serum biomarkers specific to postoperative delirium after major cardiac surgery to provide insight into the pathologic processes involved in delirium and its sequelae.

Design: Nested, case-control study.

Setting: Cardiac surgical intensive care unit in a single-site hospital setting. Read More

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Low preoperative skeletal muscle density is predictive for negative postoperative outcomes in older women with ovarian cancer.

Gynecol Oncol 2021 Jun 7. Epub 2021 Jun 7.

Leiden University Medical Center, Leiden University, Department of Medical Oncology, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.

Objective: To determine the predictive value of lumbar skeletal muscle mass and density for postoperative outcomes in older women with advanced stage ovarian cancer.

Methods: A multicenter, retrospective cohort study was performed in women ≥ 70 years old receiving surgery for primary, advanced stage ovarian cancer. Skeletal muscle mass and density were assessed in axial CT slices on level L3. Read More

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The role of SARC-F scale in predicting progression risk of COVID-19 in elderly patients: a prospective cohort study in Wuhan.

BMC Geriatr 2021 Jun 10;21(1):355. Epub 2021 Jun 10.

Global Health Research Center, Duke Kunshan University, Suzhou, Jiangsu Province, China.

Background: Since the outbreak of COVID-19, it has been documented that old age and underlying illnesses are associated with poor prognosis among COVID-19 patients. However, it is unknown whether sarcopenia, a common geriatric syndrome, is associated with poor prognosis among older COVID-19 patients. The aim of our prospective cohort study is to investigate the association between sarcopenia risk and severe disease among COVID-19 patients aged ≥60 years. Read More

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Topical estrogen, testosterone, and vaginal dilator in the prevention of vaginal stenosis after radiotherapy in women with cervical cancer: a randomized clinical trial.

BMC Cancer 2021 Jun 10;21(1):682. Epub 2021 Jun 10.

Department of Gynecology, Faculty of Medical Sciences, State University of Campinas - UNICAMP, Rua Alexander Fleming, 101, Cidade Universitária Zeferino Vaz, Campinas, SP, 13083-881, Brazil.

Background: We aimed to evaluate the effects of different therapeutic options to prevent the evolution of vaginal stenosis after pelvic radiotherapy in women with cervical cancer.

Methods: open-label randomized clinical trial of 195 women, stage I-IIIB, aged 18-75 years, using topical estrogen (66), topical testosterone (34), water-based intimate lubricant gel (66), and vaginal dilators (29) to assess the incidence and severity of vaginal stenosis after radiotherapy at UNICAMP-Brazil, from January/2013 to May/2018. The main outcome measure was vaginal stenosis assessed using the Common Terminology Criteria for Adverse Events (CTCAE) scale and percental changes in vaginal volume. Read More

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Long-term Patient-Reported Outcome Measures Following Particulated Juvenile Allograft Cartilage Implantation for Treatment of Difficult Osteochondral Lesions of the Talus[Formula: see text].

Foot Ankle Int 2021 Jun 11:10711007211014173. Epub 2021 Jun 11.

Miami Orthopedics & Sports Medicine Institute, Coral Gables, FL, USA.

Background: Conventional methods are not suitable for difficult to treat osteochondral lesions of the talus (OCLTs). The role of particulated juvenile allograft articular cartilage implantation is not well elucidated for long-term patient outcomes.

Methods: Thirteen patients with difficult-to-treat OCLTs underwent arthroscopy-assisted implantation of particulated juvenile articular cartilage graft into defects from 2010 to 2012 by the same surgeon. Read More

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