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Relationship between carbohydrate-to-fat intake ratio and the development of chronic kidney disease: A community-based prospective cohort study.

Clin Nutr 2021 Sep 9;40(10):5346-5354. Epub 2021 Sep 9.

Division of Nephrology, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea; Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea. Electronic address:

Background & Aims: It is well-known that high protein intake is associated with renal hyperfiltration and faster renal function decline, but the association of other macronutrients, carbohydrate and fat, with development of chronic kidney disease (CKD) is still inconclusive. Therefore, we aimed to examine the relationship between fat-to-carbohydrate intake ratio (F/C ratio) and incident CKD.

Methods: We included 9226 subjects from the Korean Genome and Epidemiology Study. Read More

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September 2021

Diversity of HLA class I and class II alleles in Iran populations: Systematic review and Meta-Analaysis.

Transpl Immunol 2021 Sep 20:101472. Epub 2021 Sep 20.

Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

The human leukocyte antigen (HLA) system plays an essential role in the peptides antigen presentation and more regulation of immune responses. Regarding all HLA molecules' associations with various diseases and their clinical utilities in understanding drug reactions or prediction of transplantation outcome, there is a need for much more extensive HLA data generated from Asian countries.

Method: A comprehensive search was conducted in electronic databases between 1990 and 2021 to identify relevant articles to HLA frequency in the normal Iranian population. Read More

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September 2021

Inactive Lifestyles among Young Children with Innocent Murmurs or Congenital Heart Disease Regardless of Disease Severity or Treatment.

Can J Cardiol 2021 Sep 20. Epub 2021 Sep 20.

Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada; University of Ottawa, Faculty of Medicine, Ottawa, Canada; Children's Hospital of Eastern Ontario, Ottawa, Canada.

Background: Sedentary lifestyle morbidities are common among children with congenital heart disease (CHD). Understanding the physical activity trajectory from early childhood could enhance intervention timing/effectiveness.

Methods: 154 children (56% male) were recruited at 12-47 months of age for this prospective, longitudinal, observational study. Read More

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September 2021

Racial, ethnic and socioeconomic disparities in patients undergoing transcatheter mitral edge-to-edge repair.

Int J Cardiol 2021 Sep 20. Epub 2021 Sep 20.

London Health Sciences Centre, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute of Primary Care and Health Sciences, Keele University, Stoke-on-Trent, United Kingdom. Electronic address:

Background: Transcatheter mitral edge-to-edge repair (TEER) is an increasingly common procedure performed on patients with mitral regurgitation. To assess the impact of race/ethnicity and socioeconomic status on in-hospital complications after TEER.

Methods: Cohort-based observational study using the National Inpatient Sample between October 2013 and December 2018. Read More

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September 2021

Role of matrix metalloproteinase MMP-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP-1) in the clinical progression of pediatric acute lymphoblastic leukemia.

Hematology 2021 Dec;26(1):758-768

Clinical Pathology, National Cancer Institute, Cairo University, Giza, Egypt.

Background: Matrix metalloproteinases (MMPs) play a crucial role in cancer progression and metastasis, however their role in pediatric Acute lymphoblastic leukemia (ALL) is still unrevealed.

Methods: The diagnostic, prognostic and predictive value of tissue inhibitor of metalloproteinase (TIMP-1), MMP-2, MMP-9 and CD34+CD38- cancer stem cells (CSCs) were assessed in bone marrow (BM) samples of 76 ALL children using Flow Cytometry analysis.

Results: There was a significant increase in TIMP-1 [1. Read More

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December 2021

A comparative study of porcine antihuman lymphocyte globulin versus antithymocyte globulin-fresenius in an allogeneic hematopoietic cell transplantation conditioning regimen for severe aplastic anemia.

Hematology 2021 Dec;26(1):741-750

National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

Objectives: To compare the outcomes of antihuman T lymphocyte globulin (ATG-F) and porcine antihuman lymphocyte globulin (p-ALG) as part of a conditioning regimen in hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA).

Methods: we performed a retrospective analysis, evaluating the outcome of patients with SAA who received ATG-F based conditioning ( = 26) with those receiving p-ALG conditioning ( = 34).

Results: The median time to neutrophil engraftment was 11 days (range, 8 - 38) and 11 days (range, 9 - 24) in the p-ALG and ATG-F groups (= 0. Read More

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December 2021

Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea.

Korean J Intern Med 2021 Sep 24. Epub 2021 Sep 24.

Division of Hematology and Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.

Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare but severe complication of hematopoietic cell transplantation (HCT) showing high mortality. Multiple risk factors for SOS/VOD were identified, but it is often confused with other hepatic complications due to nonspecific clinical features. Therefore, diagnostic and severity criteria have been revised several times. Read More

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September 2021

COVID-19, adaptative immune response and metabolic associated liver disease.

Liver Int 2021 Sep 23. Epub 2021 Sep 23.

Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy.

Metabolic diseases are associated with a higher risk of a severer coronavirus disease 2019 (COVID-19) course, since fatty liver is commonly associated to metabolic disorders, fatty liver itself is considered as a major contributor to low grade inflammation in obesity and diabetes. Recently a comprehensive term, metabolic (dysfunction) associated fatty liver disease (MAFLD), has been proposed. The hepatic inflammatory status observed in MAFLD patients is amplified in presence of severe acute respiratory syndrome coronavirus 2 infection. Read More

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September 2021

Increased Rejection rates in kidney transplantations during the COVID-19 Pandemic.

Transpl Int 2021 Sep 23. Epub 2021 Sep 23.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

The coronavirus disease-19 (COVID-19) pandemic constitutes a major challenge for transplantation medicine. Given the potential risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and adverse disease courses for recently transplanted recipients, many transplant centers have adapted kidney transplantation programs during the pandemic [1-3]. However, the severity of adaptions considerably differed between countries. Read More

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September 2021

SARS-CoV-2 coinfection with additional respiratory virus does not predict severe disease: a retrospective cohort study.

J Antimicrob Chemother 2021 Sep;76(Supplement_3):iii12-iii19

Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.

Background: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) claimed over 4 million lives by July 2021 and continues to pose a serious public health threat.

Objectives: Our retrospective study utilized respiratory pathogen panel (RPP) results in patients with SARS-CoV-2 to determine if coinfection (i.e. Read More

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September 2021

Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.

PLoS One 2021 23;16(9):e0257255. Epub 2021 Sep 23.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Objectives: To investigate whether partner bereavement is associated with adverse cardiovascular and kidney-related events in people with reduced kidney function.

Design: Two parallel matched cohort studies using linked routinely collected health data.

Setting: England (general practices and hospitals using linked Clinical Practice Research Datalink, Hospital Episode Statistics, and Office of National Statistics) and Denmark (hospitals and community pharmacies using the Danish National Patient, Prescription and Education Registries and the Civil Registration System). Read More

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September 2021

An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil.

PLoS Negl Trop Dis 2021 Sep 23;15(9):e0009734. Epub 2021 Sep 23.

Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Background: Treatment of cutaneous leishmaniasis (CL) remains challenging since the drugs currently used are quite toxic, thus contributing to lethality unrelated to the disease itself but to adverse events (AE). The main objective was to evaluate different treatment regimens with meglumine antimoniate (MA), in a reference center in Rio de Janeiro, Brazil.

Methodology: A historical cohort of 592 patients that underwent physical and laboratory examination were enrolled between 2000 and 2017. Read More

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September 2021

Early IL-10 promotes vasculature-associated CD4+ T cells unable to control Mycobacterium tuberculosis infection.

JCI Insight 2021 Sep 23. Epub 2021 Sep 23.

Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.

Cytokine-producing CD4+ T cells play a crucial role in the control of Mycobacterium tuberculosis (Mtb) infection; however, there is a delayed appearance of effector T cells in the lungs following aerosol infection. The immunomodulatory cytokine IL-10 antagonizes control of Mtb infection through mechanisms associated with reduced CD4+ T cell responses. Here, we show that IL-10 overexpression only before the onset of the T cell response impairs control of Mtb growth. Read More

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September 2021

Alleviating Paravertebral Muscle Spasm after Radiofrequency Ablation Treatment of Hypersensitive Basivertebral and Sinuvertebral Nerves for Chronic Discogenic Back Pain.

Pain Physician 2021 Sep;24(6):E883-E892

Department of Neurosurgery, Nanoori Chungdam Seoul Hospital, Seoul, Republic of Korea.

Background: Paraspinal muscle spasm caused by pain from a lumbar degenerative disc is frequently investigated in patients with low back pain. Radiofrequency ablation (RFA) surgery could alleviate paraspinal muscle spasms.

Objectives: We performed RFA surgery on the high-intensity zone (HIZ) and hypersensitive sinuvertebral and basivertebral nerves to evaluate its outcome. Read More

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September 2021

Does Paramedian Approach Preferentially Secure Optimal Drug Delivery Onto Ventral Epidural Space and Subsequent Superior Clinical Efficacy Over a Dorsal Midline Approach During Cervical Interlaminar Epidural Injection?

Pain Physician 2021 Sep;24(6):E839-E847

Department of Neurosurgery, Kyung Hee University Medical Center, Seoul, South Korea.

Background: There is paucity in the literature directly comparing the clinical results between the paramedian and the midline interlaminar cervical epidural injections.

Objective: To compare the proportion of ventral epidural spread of injectate and consequent clinical outcome between the paramedian and midline approach during interlaminar epidural injection in patients with axial neck and/or interscapular pain triggered from the underlying cervical spine pathologic condition.

Study Design: Retrospective study. Read More

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September 2021

A Randomized Controlled Trial of High Rate rTMS Versus rTMS and Amitriptyline in Chronic Migraine.

Pain Physician 2021 Sep;24(6):E733-E741

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.

Background: The patients with chronic migraine (CM) respond poorly to pharmacological agents including tricyclic antidepressants, beta-blockers, anticonvulsants, calcium channel blockers, flunarizine, and melatonin. The combination of 2 or more pharmacological agents has not shown better efficacy but increased side effects. High rate repetitive transcranial magnetic stimulation (rTMS) has been reported effective in episodic migraine and converts CM to episodic migraine. Read More

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September 2021

Clinical, advanced imaging data and outcome of inflammatory and neoplastic orbital disease in 81 dogs and 16 cats in Australia (2010-2019).

Vet Ophthalmol 2021 Sep 23. Epub 2021 Sep 23.

Department of Ophthalmology, Small Animal Specialist Hospital, Sydney, New South Wales, Australia.

Objective: To characterize the clinical presentation, advanced imaging features, and outcome of orbital disease in a referral population of dogs and cats that underwent computed tomography (CT) or magnetic resonance imaging (MRI).

Animals Studied: Client-owned animals.

Procedures: Animals referred for orbital disease undergoing ophthalmic examination and either head MRI or CT were included. Read More

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September 2021

Covid-19 vaccination during the third trimester of pregnancy: rate of vaccination and the maternal and neonatal outcomes, a multicenter retrospective cohort study.

BJOG 2021 Sep 23. Epub 2021 Sep 23.

Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.

Objective: To evaluate the impact of Covid-19 (Pfizer-BioNTech BNT162b2) vaccination during the third trimester of pregnancy on maternal and neonatal outcomes.

Design: A multicenter, retrospective computerized database.

Population: Women who gave birth>24 weeks, in Isreal, between January-April 2021 with full records of Covid-19 disease and vaccination status. Read More

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September 2021

Biologia Futura: is ADAM 17 the reason for COVID-19 susceptibility in hyperglycemic and diabetic patients?

Authors:
Ganna Stepanova

Biol Futur 2021 Sep 8;72(3):291-297. Epub 2021 Jun 8.

Faculty of Medicine, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary.

COVID-19 is a disease-causing current pandemic. It prevails in patients with pre-existing conditions such as diabetes and hypertension. Renin-angiotensin system was identified as a center of COVID-19 pathophysiology. Read More

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September 2021

From antibodies to living drugs: Quo vadis cancer immunotherapy?

Biol Futur 2021 Mar 1;72(1):85-99. Epub 2021 Feb 1.

Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem tér 1., 4032, Debrecen, Hungary.

In the last few decades, monoclonal antibodies targeting various receptors and ligands have shown significant advance in cancer therapy. However, still a great percentage of patients experiences tumor relapse despite persistent antigen expression. Immune cell therapy with adoptively transferred modified T cells that express chimeric antigen receptors (CAR) is an engaging option to improve disease outcome. Read More

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Impact of preoperative comorbidities on postoperative complication rate and outcome in surgically resected non-small cell lung cancer patients.

Gen Thorac Cardiovasc Surg 2021 Sep 23. Epub 2021 Sep 23.

Department of Thoracic Surgery, Zurich University Hospital, Raemistrasse 100, 8091, Zurich, Switzerland.

Objective: This study aimed to analyze whether comorbidities impact postoperative complication rate or survival after anatomical lung resection for non-small cell lung cancer (NSCLC).

Methods: A retrospective analysis of 1219 patients who underwent NSCLC resection between 2000 and 2015 was performed. Analyzed comorbidities included chronic obstructive lung disease (COPD), hypertension, coronary artery disease (CAD), peripheral artery disease, myocardial infarction history, diabetes mellitus, renal insufficiency and other malignancies. Read More

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September 2021

COVID-19 risk index (CRI): a simple and validated emergency department risk score that predicts mortality and the need for mechanical ventilation.

J Thromb Thrombolysis 2021 Sep 23. Epub 2021 Sep 23.

Division of Cardiovascular Diseases, Henry Ford Hospital, Detroit, MI, USA.

Although certain risk factors have been associated with morbidity and mortality, validated emergency department (ED) derived risk prediction models specific to coronavirus disease 2019 (COVID-19) are lacking. The objective of this study is to describe and externally validate the COVID-19 risk index (CRI). A large retrospective longitudinal cohort study was performed to analyze consecutively hospitalized patients with COVID-19. Read More

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September 2021

Testing microbiome association using integrated quantile regression models.

Bioinformatics 2021 Sep 23. Epub 2021 Sep 23.

Department of Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

Motivation: Most existing microbiome association analyses focus on the association between microbiome and conditional mean of health or disease-related outcomes, and within this vein, vast computational tools and methods have been devised for standard binary or continuous outcomes. However, these methods tend to be limited either when the underlying microbiome-outcome association occurs somewhere other than the mean level, or when distribution of the outcome variable is irregular (e.g. Read More

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September 2021

Plasma calprotectin in the emergency department: a potential clinical biomarker for patients with infectious diseases.

Scand J Clin Lab Invest 2021 Sep 23:1-5. Epub 2021 Sep 23.

Department of Emergency and Internal Medicine, Skånes University Hospital, Malmö, Sweden.

Increased levels of plasma calprotectin are reported in patients with infectious diseases. However, the clinical usefulness of calprotectin as a biomarker to identify patients with infectious diseases in the emergency department (ED) setting has not been investigated. To study the ability of calprotectin to discriminate patients with acute infectious diseases and dyspnea from patients with other causes of acute dyspnea in the ED setting. Read More

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September 2021

Follow-up outcomes of different bypass surgical modalities for adults with ischaemic-type moyamoya disease.

Br J Neurosurg 2021 Sep 23:1-10. Epub 2021 Sep 23.

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Henan, China.

Purpose: The preferred surgical method for treating adults with moyamoya disease (MMD) remains controversial. The purpose of this study was to compare the efficacy of different surgical methods in the treatment of adults with ischaemic-type MMD.

Methods: We retrospectively analyzed the data of patients with ischaemic-type MMD who underwent indirect bypass (IB), direct bypass (DB), or combined bypass (CB) at the First Affiliated Hospital of Zhengzhou University from January 2013 to December 2019. Read More

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September 2021

Modified del Nido versus blood cardioplegia in congenital cardiac surgery.

Asian Cardiovasc Thorac Ann 2021 Sep 23:2184923211048332. Epub 2021 Sep 23.

Division of Cardiothoracic Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Lactated Ringer-based del Nido cardioplegia has been reported to be safe for acquired cardiac surgery. The original Plasma-Lyte-based solution has been proved for congenital cardiac surgery but its modification has not been adequately examined. We compared the clinical outcomes of congenital cardiac surgery using lactated Ringer-based del Nido cardioplegia versus cold blood cardioplegia. Read More

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September 2021

Liver Fibrosis Index FIB-4 Is Associated With Mortality in COVID-19.

Hepatol Commun 2021 Mar 10;5(3):434-445. Epub 2020 Dec 10.

Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Coronavirus disease 2019 (COVID-19) is associated with adverse outcomes, including need for invasive mechanical ventilation and death in people with risk factors. Liver enzyme elevation is commonly seen in this group, but its clinical significance remains elusive. In this study, we calculated the Fibrosis-4 (FIB-4) score for a cohort of hospitalized patients with COVID-19 and assessed its association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA, inflammatory cytokine levels, and clinical outcome. Read More

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LncRNA TUG1 Acts as a Competing Endogenous RNA to Mediate CTGF Expression by Sponging miR-133b in Myocardial Fibrosis after Myocardial Infarction.

Cell Biol Int 2021 Sep 22. Epub 2021 Sep 22.

Department of Psychiatry, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Myocardial fibrosis is one of the basic causes of many cardiovascular diseases. Noncoding RNAs (ncRNAs), including microRNA (miRNA) and long noncoding RNA (lncRNA), have been reported to play an indispensable role in myocardial fibrosis. The current work is focused on investigating the biological role of lncRNA TUG1 in activating cardiac myofibroblasts as well as the underlying mechanism. Read More

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September 2021