26,504 results match your criteria outcome diabetic


Impact of lower vs higher LDL cholesterol targets on cardiovascular events after ischemic stroke in diabetic patients.

Diabetes 2021 May 12. Epub 2021 May 12.

APHP, Department of Biostatistics, Université Paris-Diderot, Sorbonne-Paris Cité, Fernand Widal hospital, Paris, France.

After an ischemic stroke with evidence of atherosclerosis, lipid lowering treatment with a target LDL cholesterol of less than 70 mg/dL compared to 100±10 mg/dL, reduced the risk of subsequent cardiovascular events. In this analysis, we explored the effect in the diabetic compared to nondiabetic subgroup and newly diagnosed diabetes.Patients with ischemic stroke in the previous 3 months or TIA within the previous 15 days and evidence of cerebrovascular or coronary artery atherosclerosis were randomly assigned in a 1:1 ratio to a target LDL cholesterol of less than 70 mg/dL or 100±10 mg/dL, using statin or ezetimibe. Read More

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Rate of glycemic control and associated factors among type two diabetes mellitus patients in Ethiopia: A cross sectional study.

PLoS One 2021 11;16(5):e0251506. Epub 2021 May 11.

Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Objective: To assess the rate of glycemic control and associated factors among type 2 diabetes mellitus patients at Dilchora Referral Hospital, Dire Dawa, Eastern Ethiopia.

Methods: A cross-sectional study was conducted from 13 May to 16 August 2019. Type 2 diabetic patients on follow up at Dilchora Referral Hospital who fulfilled the inclusion criteria of the study were included. Read More

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Comparing patient characteristics and outcomes in type 1 versus type 2 diabetes with diabetic ketoacidosis: a review and a propensity-matched nationwide analysis.

J Investig Med 2021 May 10. Epub 2021 May 10.

CMU Medical Education Partners, Saginaw, Michigan, USA.

Diabetic ketoacidosis (DKA) is a known complication of patients with type 1 diabetes mellitus (T1DM), but less common in type 2 diabetes mellitus (T2DM). The aim of this study was to compare the outcomes of patients admitted to the hospital with DKA in T1DM versus T2DM. This was a population-based, retrospective, cohort study using data from the Nationwide Inpatient Sample. Read More

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Transposition of cardiovascular outcome trial effects to the real-world population of patients with type 2 diabetes.

Cardiovasc Diabetol 2021 May 10;20(1):103. Epub 2021 May 10.

Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.

Background: Transferring results obtained in cardiovascular outcome trials (CVOTs) to the real-world setting is challenging. We herein transposed CVOT results to the population of patients with type 2 diabetes (T2D) seen in routine clinical practice and who may receive the medications tested in CVOTs.

Methods: We implemented the post-stratification approach based on aggregate data of CVOTs and individual data of a target population of diabetic outpatients. Read More

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Pre-operative glycaemic control and long-term survival in diabetic patients after coronary artery bypass grafting.

Eur J Cardiothorac Surg 2021 May 10. Epub 2021 May 10.

Surgical Services, Louis Stokes Cleveland VA Medical Center, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.

Objectives: We analysed the Veteran Affairs data to evaluate the association of pre-operative glycated haemoglobin (HbA1c) and long-term outcome after isolated coronary artery bypass grafting (CABG).

Methods: Veterans with diabetes mellitus and isolated CABG (2006-2018) were divided into 4 groups (I: HbA1c <6.5%, II: HbA1c 6. Read More

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Reduced Mortality Associated With the Use of Metformin Among Patients With Autoimmune Diseases.

Front Endocrinol (Lausanne) 2021 23;12:641635. Epub 2021 Apr 23.

Division of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Objective: Metformin has been linked to anti-proliferative and anti-inflammatory mechanisms. In this study, we aimed to examine the long-term impact of metformin on mortality and organ damage in patients with autoimmune diseases and type 2 diabetes mellitus (T2DM).

Methods: We conducted a cohort study using the National Health Insurance Research Database in Taiwan between 1997 and 2013. Read More

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Acute fixation of displaced intra-articular calcaneus fractures is safe using the sinus tarsi approach.

J Orthop Trauma 2021 Mar 16. Epub 2021 Mar 16.

Department of Orthopaedic Surgery, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106.

Objective: Analyze the correlation between surgical timing and outcomes for calcaneus fractures treated using a sinus tarsi approach (STA).

Setting: Single level 1 Trauma Center.

Design: Retrospective. Read More

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Non-adherence to antidiabetic and cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes: A narrative review.

J Diabetes Complications 2021 Apr 16:107931. Epub 2021 Apr 16.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, Austria.

Cardiovascular and renal complications are a major burden for individuals with type 2 diabetes mellitus (T2DM). Besides lifestyle interventions, current guidelines recommend combination drug therapy to prevent or delay the incidence and progression of comorbidities. However, non-adherence to pharmacotherapy is common in chronic conditions such as T2DM and a barrier to successful disease management. Read More

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A UK nationwide study of people with type 1 diabetes admitted to hospital with COVID-19 infection.

Diabetologia 2021 May 8. Epub 2021 May 8.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Aims/hypothesis: The aim of this work was to describe the clinical characteristics of adults with type 1 diabetes admitted to hospital and the risk factors associated with severe coronavirus disease-2019 (COVID-19) in the UK.

Methods: A retrospective cohort study was performed using data collected through a nationwide audit of people admitted to hospital with diabetes and COVID-19, conducted by the Association of British Clinical Diabetologists from March to October 2020. Prespecified demographic, clinical, medication and laboratory data were collected from the electronic and paper medical record systems of the participating hospitals by local clinicians. Read More

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Assessment of Inflammation Biomarkers in Diabetic Macular Edema Treated with Intravitreal Dexamethasone Implant.

J Ocul Pharmacol Ther 2021 May 7. Epub 2021 May 7.

Department of Ophthalmology, Dicle University School of Medicine, Diyarbakır, Turkey.

To evaluate inflammation biomarkers in diabetic macular edema (DME) treated with intravitreal dexamethasone implant (Ozurdex). This retrospective single-center study investigated 64 eyes of 64 patients with DME who were nonresponsive to prior antivascular endothelial growth factor and treated with intravitreal Ozurdex. The neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio were calculated. Read More

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Efficacy and Safety of Biosimilar FYB201 Compared With Ranibizumab in Neovascular Age-Related Macular Degeneration.

Ophthalmology 2021 May 3. Epub 2021 May 3.

Department of Ophthalmology, University of Bonn, Bonn, Germany;; Department of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, UT, USA.

Purpose: This trial was conducted to investigate the clinical equivalence of the proposed biosimilar FYB201 and reference ranibizumab in patients with treatment-naive, subfoveal choroidal neovascularization caused by neovascular age-related macular degeneration (nAMD).

Design: This was a prospective, multicenter, evaluation-masked, parallel-group, 48-week, phase III randomized study.

Participants: A total of 477 patients were randomly assigned to receive FYB201 (n = 238) or reference ranibizumab (n = 239). Read More

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Visual Acuity, Vitreous Hemorrhage, and Other Ocular Outcomes After Vitrectomy vs Aflibercept for Vitreous Hemorrhage Due to Diabetic Retinopathy: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Ophthalmol 2021 May 6. Epub 2021 May 6.

Joslin Diabetes Center, Beetham Eye Institute, Harvard Department of Ophthalmology, Boston, Massachusetts.

Importance: Although there were no differences in mean visual acuity (VA) over 24 weeks after vitrectomy with panretinal photocoagulation (PRP) vs aflibercept in a randomized clinical trial among eyes with vitreous hemorrhage due to proliferative diabetic retinopathy (PDR), post hoc analyses may influence treatment choices.

Objective: To compare exploratory outcomes between treatment groups that may affect treatment choices for patients with vitreous hemorrhage due to PDR.

Design, Setting, And Participants: This post hoc analysis of a randomized clinical trial conducted at 39 DRCR Retina Network sites included adults with vision loss due to PDR-related vitreous hemorrhage for whom vitrectomy was considered. Read More

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Outpatient Management of Diabetic Hand Infections.

Cureus 2021 Apr 2;13(4):e14263. Epub 2021 Apr 2.

Surgery, Henry Ford Health System, Detroit, USA.

Purpose For many providers, hand infections among diabetic patients is a condition that necessitates focused inpatient care. These patients are believed to have decreased innate immunity to fight infection, a more virulent course, and difficulty with recovery. Diabetes is considered by some to represent an additional risk factor that can result in an unfavorable outcome if not managed in an aggressive manner. Read More

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Effects of liraglutide on sperm characteristics and fertilization potential following experimentally induced diabetes in mice.

Vet Res Forum 2021 15;12(1):109-116. Epub 2021 Mar 15.

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

The current study was conducted to analyze the dose-dependent effects of liraglutide against the diabetes-induced detrimental impact on sperm parameters and fertilization potential. For this purpose, 42 adult male mice were randomly divided into control (with no intervention) and experimental groups. Next, the experimental group was subdivided into diabetic, 1. Read More

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Investigating the neuroPRotective effect of Oral Omega-3 Fatty acid Supplementation in type 1 diabetes (nPROOFS1): a randomised, placebo-controlled trial.

Diabetes 2021 May 5. Epub 2021 May 5.

Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Australia.

This randomised, double-masked, placebo-controlled trial (ACTRN12618000705280) evaluated the effects of oral omega-3 fatty acid supplementation on peripheral nerves in type 1 diabetes. Participants with type 1 diabetes were assigned (1:1) to omega-3 (fish oil; 1800 mg/day) or placebo (olive oil; 600 mg/day) supplements for 180 days. Primary outcome was change from baseline in central corneal nerve fibre length (CNFL) at day 180. Read More

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Microvascular Disease and Risk of Cardiovascular Events and Death From Intensive Treatment in Type 2 Diabetes: The ACCORDION Study.

Mayo Clin Proc 2021 May 2. Epub 2021 May 2.

Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, United Kingdom; Leicester Real World Evidence Unit, Leicester Diabetes Centre, Leicester General Hospital, United Kingdom.

Objective: To assess whether the presence of microvascular complications modifies the effect of intensive glucose reduction on long-term outcomes in patients with type 2 diabetes.

Patients And Methods: Using ACCORD and ACCORDION study data, we investigated the risk of the primary outcome (nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death) or death in relation to the prerandomization type and extent of microvascular complications. Interaction terms were fitted in survival models to estimate the risk of both outcomes across levels of an overall microvascular disease score (range 0 to 100) and its individual components: diabetic nephropathy, retinopathy, and neuropathy. Read More

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The relationship between financial hardship and incident diabetic kidney disease in older US adults - a longitudinal study.

BMC Nephrol 2021 May 5;22(1):167. Epub 2021 May 5.

Center for Advancing Population Science, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA.

Background: Financial hardship is associated with poor health, however the association of financial hardship and incident diabetic kidney disease (DKD) is unknown. This study aimed to examine the longitudinal relationship between financial hardship and incident DKD among older adults with diabetes.

Methods: Analyses were conducted in 2735 adults age 50 or older with diabetes and no DKD using four waves of data (2006-2012) from the Health and Retirement Study, a national longitudinal cohort. Read More

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Effect of empagliflozin on cardiorenal outcomes and mortality according to body-mass index: A subgroup analysis of the EMPA-REG OUTCOME trial with a focus on Asia.

Diabetes Obes Metab 2021 May 5. Epub 2021 May 5.

Boehringer Ingelheim Norway KS, Asker, Norway.

We investigated whether the cardiorenal benefits of the sodium-glucose co-transporter-2 inhibitor empagliflozin were affected by body mass index (BMI) in the EMPA-REG OUTCOME trial in type 2 diabetes patients with established cardiovascular disease, which included Asians. In this exploratory analysis, we used Cox regression to evaluate the effects of empagliflozin on all-cause mortality, hospitalization for heart failure (HHF) or CV death, and incident or worsening nephropathy by baseline BMI category. Of the 7020 participants (1517 Asians [21. Read More

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Treatment for diabetic peripheral neuropathy: What have we learned from animal models?

Authors:
Mark Yorek

Curr Diabetes Rev 2021 May 3. Epub 2021 May 3.

Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242 . United States.

Introduction: Animal models have been widely used to investigate the etiology and potential treatments for diabetic peripheral neuropathy. What we have learned from these studies and the extent that this information has been adaptable to the human condition will be the subject of this review article.

Methods: A comprehensive search of the PubMed database was performed, and relevant articles on the topic were included in this review. Read More

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The Incidence of Congenital Heart Defects in Offspring Among Women With Diabetes in Saudi Arabia.

Cureus 2021 Mar 31;13(3):e14225. Epub 2021 Mar 31.

Biostatistics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, SAU.

Background: The risk of congenital anomalies is increased in infants of diabetic mothers (IDM). The most frequent cardiac anomalies in IDMs include ventricular septal defect, transposition of great arteries, and aortic stenosis.

Objective: Estimating the incidence of infants with congenital heart defects (CHD) whose mothers have diabetes in Saudi Arabia at a tertiary hospital in the National Guard Health Affairs (NGHA) system. Read More

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COVID-19 and Diabetic Ketoacidosis: Report of Eight Cases.

Cureus 2021 Mar 31;13(3):e14223. Epub 2021 Mar 31.

Hematology and Oncology, Saint Joseph's University Medical Center, Paterson, USA.

Aim To describe the clinical characteristics and outcome of hospitalized COVID-19 patients with diabetic ketoacidosis (DKA). Methods We report eight cases of diabetic ketoacidosis in COVID-19 who presented to our institution in New Jersey, USA. COVID-19 was diagnosed by nasopharyngeal swab reverse transcription polymerase chain reaction (RT-PCR). Read More

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Perceived facilitators and barriers to chronic disease management in primary care networks of Singapore: a qualitative study.

BMJ Open 2021 May 4;11(5):e046010. Epub 2021 May 4.

Health Systems and Behavioural Sciences Domain, Saw Swee Hock School of Public Health, National University Singapore, Singapore.

Objective: The increasing chronic disease burden has placed tremendous strain on tertiary healthcare resources in most countries, necessitating a shift in chronic disease management from tertiary to primary care providers. The Primary Care Network (PCN) policy was promulgated as a model of care to organise private general practitioners (GPs) into groups to provide GPs with resources to anchor patients with chronic conditions with them in the community. As PCN is still in its embryonic stages, there is a void in research regarding its ability to empower GPs to manage patients with chronic conditions effectively. Read More

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Glycemic and lipid variability for predicting complications and mortality in diabetes mellitus using machine learning.

BMC Endocr Disord 2021 May 4;21(1):94. Epub 2021 May 4.

School of Life Sciences, Chinese University of Hong Kong, Hong Kong, China.

Introduction: Recent studies have reported that HbA1c and lipid variability is useful for risk stratification in diabetes mellitus. The present study evaluated the predictive value of the baseline, subsequent mean of at least three measurements and variability of HbA1c and lipids for adverse outcomes.

Methods: This retrospective cohort study consists of type 1 and type 2 diabetic patients who were prescribed insulin at outpatient clinics of Hong Kong public hospitals, from 1st January to 31st December 2009. Read More

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A comparison of revascularization methods for peripheral arterial disease in diabetics: Changing trends in lower extremity revascularization from 2008 to 2014.

Vascular 2021 May 4:17085381211012564. Epub 2021 May 4.

Department of Surgery, The University of Toledo College of Medicine and Life Sciences, Toledo, USA.

Objectives: This study examined the current demographic and outcome trends regarding endovascular and open revascularization for people with diabetes.

Methods: The National Inpatient Sample database was utilized to identify diabetic patients who underwent lower extremity revascularization and amputation procedures between 2008 and 2014. International Classification of Diseases 9th edition codes were used to identify the procedures, diagnoses, and comorbidities. Read More

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Beaming in the Charcot foot: A case series with 12-month minimum follow-up.

Foot (Edinb) 2021 Apr 18;47:101814. Epub 2021 Apr 18.

Department of Orthopaedics and Trauma Surgery, 'Gregorio Marañón' University Hospital, Madrid, Spain. Electronic address:

Background: Charcot neuropathic arthropathy is a progressive degeneration of the weightbearing joints of the foot induced by denervation and disturbance of sensorial perception. This entity clinically behaves as a destructive fast-progressive arthropathy, resulting in loss of independent walking and often requiring amputation of the leg. This study analyzes our experience with midfoot realignment arthrodesis and stabilization by intramedullary beaming in patients with Charcot diabetic foot as a limb-sparing procedure. Read More

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Cardiometabolic therapy and mortality in very old patients with diabetes hospitalized due to COVID-19.

J Gerontol A Biol Sci Med Sci 2021 May 4. Epub 2021 May 4.

Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), Málaga, Spain.

Background: The effects of cardiometabolic drugs on the prognosis of diabetic patients with COVID-19, especially very old patients, are not well-known. This work aims to analyze the association between preadmission cardiometabolic therapy (antidiabetic, antiaggregant, antihypertensive, and lipid-lowering drugs) and in-hospital mortality among patients ≥80 years with type 2 diabetes mellitus hospitalized for COVID-19.

Methods: We conducted a nationwide, multicenter, observational study in patients ≥80 years with type 2 diabetes mellitus hospitalized for COVID-19 between March 1 and May 29, 2020. Read More

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Glargine versus regular insulin protocol in feline diabetic ketoacidosis.

J Vet Emerg Crit Care (San Antonio) 2021 May 4. Epub 2021 May 4.

School of Veterinary Science, The University of Queensland, Australia.

Objectives: To determine whether basal-bolus administration of glargine insulin is a safe and effective alternative treatment compared to the standard continuous rate infusion (CRI) protocol.

Design: Prospective randomized clinical trial.

Setting: University teaching hospital. Read More

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Long-term outcomes of intravitreal therapy for symptomatic diabetic macular oedema in a real-world setting in Switzerland.

Graefes Arch Clin Exp Ophthalmol 2021 May 4. Epub 2021 May 4.

Berner Augenklinik Am Lindenhofspital, Bremgartenstrasse 119, CH - 3012, Bern, Switzerland.

Objective: To assess the long-term visual outcomes in eyes with symptomatic diabetic macular oedema (DME) under intravitreal treatment (IVT) in a clinical routine setting.

Methods: Patients with newly diagnosed DME were included in this retrospective study if they had received at least three IVTs and a follow-up period ≥ 2 years. Due to altered treatment patterns since the approval of ranibizumab for DME in 2012, patients were subdivided according to their first IVT before 2013 (group 1) or thereafter (group 2). Read More

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Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants.

J Diabetes Res 2021 13;2021:8820216. Epub 2021 Apr 13.

Department of Ophthalmology, Charité Universtätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.

Purpose: Diabetic macular edema (DME) is the most common cause of blindness in the working-age population. Spectral-domain optical coherence tomography (SD-OCT) allows detection and monitoring of the edema and a detailed analysis of the retinal structure. Hyperreflective foci (HF) are small, circumscribed lesions on OCT, and their origin is yet to be determined. Read More

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Transcriptomic and microRNA Expression Profiles Identify Biomarkers for Predicting Neo-Chemoradiotherapy Response in Esophageal Squamous Cell Carcinomas (ESCC).

Front Pharmacol 2021 15;12:626972. Epub 2021 Apr 15.

Department of Radiotherapy, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Jiangsu, China.

Neo-chemoradiotherapy (nCRT) before surgery is a standard treatment for locally advanced esophageal cancers. However, the treatment outcome of nCRT varied with different patients. This study aimed to identify potential biomarkers for prediction of nCRT-response in patients with esophageal squamous cell carcinoma (ESCC). Read More

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