21 results match your criteria outbred bear

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Developmental instability and phenotypic evolution in a small and isolated bear population.

Biol Lett 2021 04 21;17(4):20200729. Epub 2021 Apr 21.

Research Institute on Terrestrial Ecosystems, National Research Council, 00015 Montelibretti, Rome, Italy.

We explored fluctuating asymmetry (FA) and morphological integration (MI) in the skull of the small, highly inbred and divergent Apennine bear (), to explore its uniqueness and investigate any potential effects of inbreeding depression. We used 3D geometric morphometrics contrasting Apennine bears with other two large outbred bear populations from Scandinavia and Kamchatka as controls. Shape divergence and variability were explored by a principal component analysis on aligned coordinates of 39 landmarks. Read More

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Generating primary murine vaginal fibroblast cell lines.

MethodsX 2020 14;7:101100. Epub 2020 Oct 14.

Biology Department, Macalester College, Saint Paul, MN, USA.

Primary human vulvovaginal fibroblast cell lines are useful for studying biological mechanisms underlying genital pain, pelvic organ prolapse, and the spread of sexually transmitted infections. However, the vaginal biopsies necessary for establishing these cell lines are invasive and relatively difficult to obtain. Primary mouse fibroblast cell lines derived from pre-clinical animal models of these conditions can be used for better controlled experiments that can help us dissect disease mechanisms. Read More

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October 2020

Behavioral differences of male Wistar rats from different vendors in vulnerability and resilience to chronic mild stress are reflected in epigenetic regulation and expression of p11.

Brain Res 2016 07 19;1642:505-515. Epub 2016 Apr 19.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

Outbred rat lines such as Wistar rats are commonly used for models of depressive disorders. Such rats arise from random mating schedules. Hence, genetic drift occurs in outbred populations which could lead to genotypic and phenotypic heterogeneity between rats from different vendors. Read More

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Gut Microbiota and a Selectively Bred Taste Phenotype: A Novel Model of Microbiome-Behavior Relationships.

Psychosom Med 2016 06;78(5):610-9

From the Department of Veterinary Microbiology and Preventive Medicine, School of Veterinary Medicine (Lyte), Iowa State University, Ames, Iowa; Department of Immunotherapeutics and Biotechnology (Lyte), Texas Tech University Health Sciences Center, Abilene, Texas; Department of Bioinformatics and Genomics (Fodor), University of North Carolina at Charlotte, North Carolina; School of Medicine (Perez-Chanona), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Division of Gastroenterology, Department of Medicine (Jobin), University of Florida College of Medicine, Gainesville, Florida; and Occidental College (Chapman, Martin, Dess), Los Angeles, California.

Objectives: The microbiota-gut-brain axis is increasingly implicated in obesity, anxiety, stress, and other health-related processes. Researchers have proposed that gut microbiota may influence dietary habits, and pathways through the microbiota-gut-brain axis make such a relationship feasible; however, few data bear on the hypothesis. As a first step in the development of a model system, the gut microbiome was examined in rat lines selectively outbred on a taste phenotype with biobehavioral profiles that have diverged with respect to energy regulation, anxiety, and stress. Read More

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Induction of HER2 Immunity in Outbred Domestic Cats by DNA Electrovaccination.

Cancer Immunol Res 2015 Jul 23;3(7):777-86. Epub 2015 Feb 23.

Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.

Domestic cats share human living environments and genetic traits. They develop spontaneous feline mammary carcinoma (FMC) with similar histopathology to human breast cancer. HER2 and AKT phosphorylation was demonstrated in primary FMC by immunoblot analysis, indicating HER2 as a therapeutic target. Read More

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Isolation and Genetic Characterization of Toxoplasma gondii from Black Bears (Ursus americanus), Bobcats (Lynx rufus), and Feral Cats (Felis catus) from Pennsylvania.

J Eukaryot Microbiol 2015 May-Jun;62(3):410-5. Epub 2015 Jan 8.

Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland, 20705-2350.

Toxoplasma gondii infects virtually all warm-blooded hosts worldwide. Recently, attention has been focused on the genetic diversity of the parasite to explain its pathogenicity in different hosts. It has been hypothesized that interaction between feral and domestic cycles of T. Read More

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January 2016

Isolation and characterization of new genetic types of Toxoplasma gondii and prevalence of Trichinella murrelli from black bear (Ursus americanus).

Vet Parasitol 2013 Sep 28;196(1-2):24-30. Epub 2013 Feb 28.

United States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD 20705-2350, USA.

Black bears (Ursus americanus) are hosts for two important zoonotic parasites, Toxoplasma gondii and Trichinella spp. and bears are hunted for human consumption in the USA. Little is known of the genetic diversity of T. Read More

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September 2013

Molecular characterization of swine leucocyte antigen class I genes in outbred pig populations.

Anim Genet 2009 Aug 20;40(4):468-78. Epub 2009 Mar 20.

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

The highly polymorphic swine leucocyte antigen (SLA) genes are one of the most important determinants in swine immune responses to infectious diseases, vaccines, and in transplantation success. Study of SLA influence requires accurate and effective typing methods. We developed a simple and rapid method to type alleles at the three classical SLA class I loci (SLA-1, SLA-3 and SLA-2) using the PCR-sequence-specific primer (PCR-SSP) strategy. Read More

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Onset of sexual maturation in female mice as measured in behavior and fertility: Interactions of exposure to males, phytoestrogen content of diet, and ano-genital distance.

Physiol Behav 2008 Feb 30;93(3):588-94. Epub 2007 Oct 30.

Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ontario, Canada L8S 4K1.

Age of puberty was examined in female mice through non-invasive behavioral and fertility measures, in relationship to ano-genital distance, phytoestrogen content of diet, and exposure to males post-weaning. Throughout gestation and post-natal development, females were exposed to a regular diet or one that was nutritionally similar but deficient in phytoestrogens. After segregation at weaning on the basis of a short or long ano-genital distance index (AGDI), an indirect measure of in utero androgen exposure, females were housed alone or underneath two outbred adult males for two weeks. Read More

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February 2008

Genetic estimates of annual reproductive success in male brown bears: the effects of body size, age, internal relatedness and population density.

J Anim Ecol 2007 Mar;76(2):368-75

Institute for Wildlife Biology and Game Management, Department for Integrative Ecology, University of Natural Resources and Applied Life Sciences, Vienna, Austria.

1. We studied male yearly reproductive success (YRS) and its determinants (phenotypic characteristics, age, population density) in two Scandinavian brown bear populations, using molecular techniques to determine paternity. 2. Read More

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Mapping quantitative trait loci for hearing loss in Black Swiss mice.

Hear Res 2006 Feb 19;212(1-2):128-39. Epub 2006 Jan 19.

Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA.

In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, and Black Swiss strains exhibited hearing profiles characteristic of progressive, sensorineural hearing impairment. Read More

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February 2006

Molecular and biologic characteristics of Toxoplasma gondii isolates from wildlife in the United States.

J Parasitol 2004 Feb;90(1):67-71

Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Building 1001, Beltsville, Maryland 20705-2350, USA.

Toxoplasma gondii isolates can be grouped into 3 genetic lineages. Type I isolates are considered more virulent in outbred mice and have been isolated predominantly from clinical cases of human toxoplasmosis, whereas types II and III isolates are considered less virulent for mice and are found in humans and food animals. Little is known of genotypes of T. Read More

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February 2004

A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy.

J Mol Cell Cardiol 2001 Nov;33(11):2055-60

Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.

Familial hypertrophic cardiomyopathy (FHC), an autosomal dominant disorder caused by mutationally altered dominant-acting sarcomere proteins, exhibits significant clinical heterogeneity. To determine whether genetic background could influence the expression of this disease, we studied a murine model for this human condition. Hypertrophic responses to the Arg403Gln missense mutation in a cardiac myosin heavy chain gene were compared in 129SvEv (inbred; designated 129SvEv- alpha MHC403/+) and Black Swiss (outbred; designated BSw- alpha MHC403/+) strains. Read More

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November 2001

Genetic control of the antibody repertoire against excretory/secretory products and acetylcholinesterases of Dictyocaulus viviparus.

Parasite Immunol 1994 May;16(5):251-60

Department of Veterinary Parasitology, University of Glasgow, Scotland, UK.

Outbred Dunkin-Hartley and inbred strain 2 and strain 13 guinea pigs were immunized with Dictyocaulus viviparus adult ES products prior to challenge with third stage larvae. Antibody responses of the three strains to adult ES products and the acetylcholinesterase (AChE) isoforms which they contain were examined. Using immunoprecipitation and ELISA, it was observed that responses in the three strains to adult ES products were distinct: considerable heterogeneity in the antibody repertoire was observed between outbred Dunkin-Hartley animals, with only slight variation occurring amongst the inbred individuals. Read More

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The antibody repertoire in infection and vaccination with Dictyocaulus viviparus: heterogeneity in infected cattle and genetic control in guinea pigs.

Vet Immunol Immunopathol 1992 Mar;31(3-4):313-22

Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden, UK.

The antigen recognition profiles of serum antibody from calves infected or vaccinated with irradiated Dictyocaulus viviparus larvae were analysed by immunoprecipitation of radio-iodinated in vitro-released excretory-secretory materials from live adult parasites. Immunoprecipitates were analysed by SDS-PAGE and considerable heterogeneity in antigen recognition between individual animals was observed, regardless of infection regimen. This heterogeneity was also found to occur amongst outbred guinea pigs infected with the parasite and permitted an examination of the genetics of the effect using inbred guinea pigs (Strains 2 and 13). Read More

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Prostaglandin-mediated inactivation of natural killer cells in the murine decidua.

Cell Immunol 1990 May;127(2):352-67

Department of Anatomy, University of Western Ontario, London, Canada.

Previous studies from this laboratory have demonstrated a large influx of null lymphocytes into the murine decidua during pregnancy. We had also shown that trophoblast cells of the murine placenta bear target structures recognized by NK cells. Since NK lineage cells belong to the null category of lymphocytes, we examined whether cells of this lineage appear in the murine decidua, and if so, whether their activity is locally regulated by NK suppressor cells. Read More

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Analysis of a novel VHS107 haplotype in CLA-2 and WSA mice. Evidence for gene conversion among IgVH genes in outbred populations.

J Exp Med 1989 Dec;170(6):1811-23

Program in Molecular and Cellular Biology, University of Massachusetts, Amherst 01003.

Gene conversion has been suggested as the basis for many VH allelic differences, particularly in the murine VHS107 family. Whether conversion among IgVH genes is likely to have occurred in outbred populations has not been directly addressed. The CLA-2/Cn and WSA strains, which were recently and independently derived from a feral population exhibiting low responsiveness to PC, provide the opportunity to approach this question. Read More

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December 1989

Inbred and wild mice carry identical deletions in their E alpha MHC genes.

EMBO J 1985 Jan;4(1):127-31

Several inbred strains and a certain percentage of wild mice bear a deletion in the E alpha gene of the mouse major histocompatibility complex (H-2). This mutation prevents transcription of the E alpha gene and hence functional expression of the E alpha E beta dimer on the cell surface. Two strains were selected for a more precise localization of this deletion. Read More

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January 1985

Induction of colonic adenocarcinoma in the rat by X-irradiation.

Cancer Res 1978 Jul;38(7):1899-905

In work to determine whether X-radiation could be used to induce tumors of the colon in outbred Holtzman rats, a technique was devised so that only the descending colon could be irradiated with a collimated X-ray beam and tumorigenic exposures in the kilo-Roentgen range were delivered. Ninety male Holtzman rats were divided into 6 exposure groups of 15 animals each. In the first group only the colon was exposed to 2500 R; in the second group the colon was exposed to 3500 R and the exposures were increased by 1000-R increments up through 6500 R; the sixth group was sham irradiated. Read More

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Carcinogenic bioassay of the herbicide, 2,4,5-trichlorophenoxyethanol (TCPE) with different 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) content in Swiss mice.

Prog Biochem Pharmacol 1978 ;14:82-93

The carcinogenic effect of a herbicide trichlorophenoxyethanol (TCPE) was investigated. The substance always contains 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) as a trace contaminant. Outbred Swiss-H/Riop mice were treated for 1 year with different doses of the various admixtures of the two compounds and those of dioxin alone to determine whether their carcinogenic effects are dose-dependent. Read More

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The major histocompatibility complex of the guinea pig. I. Serologic and genetic studies.

J Immunol 1975 Dec;115(6):1704-10

Serologic and genetic studies of the antigens which comprise the guinea pig MHC have demonstrated three distinct but linked genetic regions. Antisera to the B region were raised by cross-immunization of random-bred animals; this region controls antigens B.1, B. Read More

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December 1975
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