Psychosom Med 2016 06;78(5):610-9
From the Department of Veterinary Microbiology and Preventive Medicine, School of Veterinary Medicine (Lyte), Iowa State University, Ames, Iowa; Department of Immunotherapeutics and Biotechnology (Lyte), Texas Tech University Health Sciences Center, Abilene, Texas; Department of Bioinformatics and Genomics (Fodor), University of North Carolina at Charlotte, North Carolina; School of Medicine (Perez-Chanona), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Division of Gastroenterology, Department of Medicine (Jobin), University of Florida College of Medicine, Gainesville, Florida; and Occidental College (Chapman, Martin, Dess), Los Angeles, California.
Objectives: The microbiota-gut-brain axis is increasingly implicated in obesity, anxiety, stress, and other health-related processes. Researchers have proposed that gut microbiota may influence dietary habits, and pathways through the microbiota-gut-brain axis make such a relationship feasible; however, few data bear on the hypothesis. As a first step in the development of a model system, the gut microbiome was examined in rat lines selectively outbred on a taste phenotype with biobehavioral profiles that have diverged with respect to energy regulation, anxiety, and stress. Read More