7,312 results match your criteria osteochondral grafting


Treatment strategies for osteochondral lesions of the talus: A review of the recent evidence.

Foot (Edinb) 2021 Apr 20;47:101805. Epub 2021 Apr 20.

East Kent Hospitals NHS University Foundation Trust, Ashford, United Kingdom.

Background: There has been no consensus regarding the treatment of osteochondral lesions of the talus, there has been many attempts to formulate a treatment pathway, with multiple proposed modalities and adjuncts used.

Objectives: The aim of this paper was to investigate the evidence published in the recent history, identify the relevant papers, review and summarize the findings, to help clarify the available operative treatment options and their respective efficacies based on the level of evidence provided.

Study Design & Methods: A literature search through electronic databases MEDLINE and EMBASE was done, these databases were screened for publications and papers form June 2004 to June 2019. Read More

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Osteochondral allograft transplantation in the knee, after prolonged fresh storage at 37°C. Determination of viability of human cartilage allografts, indications, technique, and evidence. Follow up 10 years.

Rev Esp Cir Ortop Traumatol 2021 Apr 28. Epub 2021 Apr 28.

Servicio COT, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España.

Background: Osteochondral allografts (OA) kept fresh for a long time, are presented as a viable option for the treatment of large chondral and osteochondral lesions.

Goals: Chondrocyte viability decreases substantially when allografts are stored for more than 15 days. The objective of this work is to validate the viability and clinical and functional results of OA transplantation stored at 37°C in a cell culture medium, applied in cartilage defects of the knee, defining the means and limits of allograft storage, among 15 and 28 days after extraction. Read More

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Clinical-grade human dental pulp stem cells suppressed the activation of osteoarthritic macrophages and attenuated cartilaginous damage in a rabbit osteoarthritis model.

Stem Cell Res Ther 2021 May 1;12(1):260. Epub 2021 May 1.

Beijing Institute of Radiation Medicine, Road Taiping 27, Beijing, 100850, P. R. China.

Background: Although increasing evidence has demonstrated that human dental pulp stem cells (hDPSCs) are efficacious for the clinical treatment of skeletal disorders, the underlying mechanisms remain incompletely understood. Osteoarthritis (OA) is one of the most common degenerative disorders in joints and is characterized by gradual and irreversible cartilaginous tissue damage. Notably, immune factors were newly identified to be closely related to OA development. Read More

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Bilayer Scaffolds for Interface Tissue Engineering and Regenerative Medicine: A Systematic Reviews.

Adv Exp Med Biol 2021 May 2. Epub 2021 May 2.

Department of Clinical Biochemistry and Applied Cell Science, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Purpose: This systematic review focus on the application of bilayer scaffolds as an engaging structure for the engineering of multilayered tissues, including vascular and osteochondral tissues, skin, nerve, and urinary bladder. This article provides a concise literature review of different types of bilayer scaffolds to understand their efficacy in targeted tissue engineering.

Methods: To this aim, electronic search in the English language was performed in PMC, NBCI, and PubMed from April 2008 to December 2019 based on the PRISMA guidelines. Read More

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Diagnostic Value of MRI and Radiographs of the Knee to Identify Osteochondral Lesions in Acute Patellar Instability.

J Knee Surg 2021 Apr 30. Epub 2021 Apr 30.

Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago, Chicago, Illinois.

The purpose of this study was to define the diagnostic value of magnetic resonance imaging (MRI) and plain radiographs (X-ray [XR]) in identifying an osteochondral defect or loose body in patients undergoing operative treatment for patellar instability. A total of 87 patients treated operatively for patellar instability with medial patellofemoral ligament (MPFL) reconstruction between 2015 and 2019 were identified. Inclusion criteria were evidence of clinical patellar instability, preoperative XR and MRI studies, and concomitant diagnostic knee arthroscopy and MPFL reconstruction performed to address patellar instability. Read More

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Comparison of All Arthroscopic Implantation of Chitosan-Based Liquid Scaffold and Hyaluronan-Based Soft Scaffold in the Treatment of Condylar Osteochondral Lesions in the Knee.

J Knee Surg 2021 Apr 30. Epub 2021 Apr 30.

Department of Histology and Embryology, Ankara University, Ankara, Turkey.

Cell-free scaffolds used in cartilage regeneration are produced from different materials. The aim of this study is to compare the clinical and radiological results of two different scaffolds with hyaluronan- or chitosan-based structure used in the treatment of symptomatic condylar osteochondral lesions. The study comprises 69 patients who were operated for osteochondral lesion repair with hyaluronan- ( = 37) or chitosan-based ( = 32) scaffold. Read More

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Treatment of osteochondritis dissecans of the patella in adolescents with nanofractured autologous matrix-induced chondrogenesis (NAMIC): A report of five cases.

Knee 2021 Apr 27;30:157-162. Epub 2021 Apr 27.

Knee Unit, Department of Orthopedic Surgery and Traumatology, Parc Taulí University Hospital, Institut d'Investigació i Innovació Parc Taulí CSPT, Autonomous University of Barcelona, Sabadell, Spain.

Purpose: Osteochondritis dissecans (OCD) of the patella is a very rare affliction. The aim of this case series is to evaluate the effectiveness of the Nanofractured Autologous Matrix-Induced Chondrogenesis (NAMIC) technique for the treatment of OCD in young adults.

Methods: Five consecutive patients with patellar osteochondral lesions treated with NAMIC were prospectively studied. Read More

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Bilayered, Peptide-Biofunctionalized Hydrogels for In Vivo Osteochondral Tissue Repair.

Acta Biomater 2021 Apr 27. Epub 2021 Apr 27.

Department of Bioengineering, Rice University, Houston, TX. Electronic address:

Osteochondral defects present a unique clinical challenge due to their combination of phenotypically distinct cartilage and bone, which require specific, stratified biochemical cues for tissue regeneration. Furthermore, the articular cartilage exhibits significantly worse regeneration than bone due to its largely acellular and avascular nature, prompting significant demand for regenerative therapies. To address these clinical challenges, we have developed a bilayered, modular hydrogel system that enables the click functionalization of cartilage- and bone-specific biochemical cues to each layer. Read More

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Use of Osteochondral and Meniscal Allografts from Bone Cuts of Total Knee Arthroplasty for the Treatment of Tibial Plateau Malunions: A Case Series of Four Patients Showing Early Results.

Indian J Orthop 2021 Apr 28;55(2):375-383. Epub 2021 Jan 28.

Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, India.

Purpose: Intra-articular malunion of tibial plateau fracture is a complex problem to treat. We are presenting outcomes of our series of patients of malunited tibial plateau fractures treated with osteo-chondro-meniscal allograft from lateral tibial plateau harvested from patients undergoing total knee arthroplasty (TKA).

Methods: The technique was used in four patients. Read More

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Role of Arthroscopy in Various Ankle Disorders.

Indian J Orthop 2021 Apr 12;55(2):333-341. Epub 2021 Feb 12.

Ortho One Orthopaedic Speciality Centre, 657, Trichy Road, Singanallur, Coimbatore, Tamil Nadu India.

Introduction: Ankle arthroscopy has come a long way since it was thought, it is not feasible because of tight joint and anatomical characteristics of ankle joint. The same anatomical features like capsular attachment and safe accessory portals are used to access the whole joint even with a rigid arthroscope. Ankle distraction method was routinely used to access the anterior ankle. Read More

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Managing Chondral Lesions: A Literature Review and Evidence-Based Clinical Guidelines.

Indian J Orthop 2021 Apr 26;55(2):252-262. Epub 2021 Jan 26.

Ortho-One Orthopedic Speciality Centre, Coimbatore, Tamil Nadu 641005 India.

Background: Articular cartilage lesions are becoming increasingly common. Optimum diagnosis and management of chondral defects cause a lot of dilemma. A number of surgical methods have been reported in the literature for treating focal cartilage defects. Read More

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PHB/CHIT Scaffold as a Promising Biopolymer in the Treatment of Osteochondral Defects-An Experimental Animal Study.

Polymers (Basel) 2021 Apr 11;13(8). Epub 2021 Apr 11.

Department of Morphological Disciplines, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 04181 Kosice, Slovakia.

Biopolymer composites allow the creation of an optimal environment for the regeneration of chondral and osteochondral defects of articular cartilage, where natural regeneration potential is limited. In this experimental study, we used the sheep animal model for the creation of knee cartilage defects. In the medial part of the trochlea and on the medial condyle of the femur, we created artificial defects (6 × 3 mm) with microfractures. Read More

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Greater heterogeneity of the bone mineralisation density distribution and low bone matrix mineralisation characterise tibial subchondral bone marrow lesions in knee osteoarthritis patients.

Bone 2021 Apr 27;149:115979. Epub 2021 Apr 27.

Discipline of Orthopaedics and Trauma, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia. Electronic address:

Tibial subchondral bone marrow lesions (BMLs) identified by MRI have been recognised as potential disease predictors in knee osteoarthritis (KOA), and may associate with abnormal bone matrix mineralisation and reduced bone quality. However, these tissue-level changes of BMLs have not been extensively investigated. Thus, the aim of this study was to quantify the degree of subchondral bone matrix mineralisation (both plate and trabeculae) in relation to histomorphometric parameters of bone remodelling and osteocyte lacunae (OL) characteristics in the tibial plateau (TP) of KOA patients with and without BMLs (OA-BML and OA No-BML, respectively) in comparison to nonOA cadaveric controls (CTL). Read More

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Engineering a Highly Biomimetic Chitosan-Based Cartilage Scaffold by Using Short Fibers and a Cartilage-Decellularized Matrix.

Biomacromolecules 2021 Apr 29. Epub 2021 Apr 29.

College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, China.

Engineering scaffolds with structurally and biochemically biomimicking cues is essential for the success of tissue-engineered cartilage. Chitosan (CS)-based scaffolds have been widely used for cartilage regeneration due to its chemostructural similarity to the glycosaminoglycans (GAGs) found in the extracellular matrix of cartilage. However, the weak mechanical properties and inadequate chondroinduction capacity of CS give rise to compromised efficacy of cartilage regeneration. Read More

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Bioinspired mineral-polymeric hybrid hyaluronic acid/poly (γ-glutamic acid) hydrogels as tunable scaffolds for stem cells differentiation.

Carbohydr Polym 2021 Jul 7;264:118048. Epub 2021 Apr 7.

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China. Electronic address:

Aiming at the difficulty of integrated repair of osteochondral tissue, we designed a hybrid hydrogel scaffold that mimicked the microenvironment of osteochondral niches. Besides, the nano-hydroxyapatite (nHAP) was specially introduced into the hydrogel for its natural ability to promote bone regeneration. The hydrogel also exhibited good toughness (7500 KJ/m), strength (1000 kPa), viscoelasticity, and in vitro cell experiments showed that hydrogels had quite good cytocompatibility (near 100 % viability). Read More

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Persistent Pain After Operative Treatment for Chronic Lateral Ankle Instability.

Orthop Res Rev 2021 19;13:47-56. Epub 2021 Apr 19.

Department of Orthopaedic Surgery, Chungbuk National University Hospital, Cheongju, South Korea.

A high frequency of associated injuries is seen in patients with chronic lateral ankle instability. Comorbidities include intraarticular pathologies (osteochondral lesion, soft tissue or bony impingement syndrome, loose body, synovitis, etc.), peroneal tendon pathologies, neural injuries, and other extraarticular pathologies. Read More

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Treatment of Patellofemoral Chondral Lesions Using Microfractures Associated with a Chitosan Scaffold: Mid-Term Clinical and Radiological Results.

Cartilage 2021 Apr 27:19476035211011506. Epub 2021 Apr 27.

Clinica Alemana-Universidad del Desarrollo, Santiago, Chile.

Objective: To assess the clinical and radiological results of patellofemoral osteochondral lesions treated with microfractures associated with a chitosan scaffold.

Design: A retrospective observational analytical study was performed. Fifteen patients with full-thickness patellofemoral osteochondral lesions were included. Read More

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Outcomes of Osteochondral Autograft Transplantation in Pediatric Patients With Osteochondritis Dissecans of the Capitellum.

J Hand Surg Am 2021 Apr 23. Epub 2021 Apr 23.

Department of Orthopedic Surgery, Shriners Hospitals for Children, Philadelphia, PA.

Purpose: To assess the outcomes of osteochondral autograft transplantations in the treatment of osteochondritis dissecans of the capitellum in the pediatric population.

Methods: Between 2011 and 2016, 15 patients who had undergone osteochondral autograft transplantation at a mean age of 13.7 years at surgery were identified. Read More

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An experimental simulation model to assess wear of the porcine patellofemoral joint.

PLoS One 2021 26;16(4):e0250077. Epub 2021 Apr 26.

Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom.

A range of surgical techniques and osteochondral interventions have been developed for early stage chondral/osteochondral repair interventions in the knee however, methods for functional, pre-clinical assessment of these therapies are limited. In this study, a method for simulating physiological loading and motion in the porcine patellofemoral joint was developed using a 6-axis simulator. As an example of how the method can be used, the influence of surgical positioning of osteochondral allografts in the patella on cartilage wear, deformation and damage and graft stability was investigated in this porcine patellofemoral joint model. Read More

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Treatment of big osteochondral defects in the lateral femoral condyle in young patients with autologous graft and collagen mesh.

Rev Esp Cir Ortop Traumatol 2021 Apr 22. Epub 2021 Apr 22.

Unidad de Rodilla, Servicio de Cirugía Ortopédica, UAB, Consorci Sanitari Parc Taulí, Sabadell, Barcelona, España.

The treatment of massive osteochondral defects in young patients constitutes a challenge for the orthopaedic surgeon. On the one hand, facing the biological filling and on the other, guaranteeing the function in the short and long term. Defects in the lateral femoral condyle are extremely rare. Read More

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Editorial Commentary: Osteochondral Allografting Is a "Kid-Friendly" Cartilage Repair Procedure.

Authors:
William Bugbee

Arthroscopy 2021 May;37(5):1597-1598

La Jolla, California.

Fresh osteochondral allograft transplantation has been my preferred procedure for chondral and osteochondral lesions for many decades. This is particularly true for patients younger than 18 years of age, where diagnoses such as osteochondritis dissecans, osteochondral fractures, and osteonecrosis predominate, rendering the situation as much a "bone problem" as a "cartilage problem." In the universe of cartilage-repair techniques, osteochondral allografts are particularly useful when bone defects must be managed. Read More

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Articular Cartilage Restoration Requires Cells, Scaffolds, Growth Factors, and Mechanical Stimulation.

Arthroscopy 2021 May;37(5):1359-1360

Assistant Editor-in-Chief.

Tissue engineering requires cells, scaffolds, growth factors, and mechanical stimulation. In terms of cartilage restoration or repair, various innovative approaches are evolving, using host or allograft cells, biomimetic scaffolds, matrices, or membranes including hyaluronic acid, as well as diverse biological and growth factors. A current approach for the treatment of chondral or osteochondral defects enhances a microfracture procedure (introducing autologous, mesenchymal stem cells) with dehydrated micronized allograft extracellular matrix (scaffold), platelet-rich plasma (containing anabolic, anticatabolic, and anti-inflammatory growth factors), a fibrin glue sealant, and careful rehabilitation providing mechanical stimulation. Read More

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A 3D-printed PRP-GelMA hydrogel promotes osteochondral regeneration through M2 macrophage polarization in a rabbit model.

Acta Biomater 2021 Apr 21. Epub 2021 Apr 21.

Department of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. Electronic address:

Osteochondral regeneration is an orchestrated process of inflammatory immunity, host cell response, and implant degradation in tissue engineering. Here, the effects of a platelet-rich plasma (PRP)-gelatin methacryloyl (GelMA) hydrogel scaffold fabricated using the digital micro-mirror device (DMD) technique for osteochondral repair were investigated in a rabbit model. GelMA hydrogels with different PRP concentrations were fabricated, and their roles in bone marrow mesenchymal stem cells (BMSCs) and macrophage polarization in vitro were investigated. Read More

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Bilateral osteochondral defects of the patellae in an 11-year-old girl.

BMJ Case Rep 2021 Apr 23;14(4). Epub 2021 Apr 23.

Trauma and Orthopaedics, Royal Free London NHS Trust, London, UK.

Osteochondral defect or osteochondritis dissecans (OCD) of the knee usually affects young, active populations. It is a challenging diagnosis as patients typically present with poorly localised activity-related pain, which is non-specific and covers many differentials. We present an active 11-year-old girl with bilateral osteochondral defects of the patellae: a rare clinical disorder which was affecting her sporting activities. Read More

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Use of Small-Pin Distraction and Low-Speed, High-Torque Burring for Talar Osteochondral Allografts: Technique Tip.

Foot Ankle Int 2021 Apr 23:10711007211003105. Epub 2021 Apr 23.

University of California San Diego, La Jolla, CA, USA.

: Level V, expert opinion. Read More

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Fabricating spatially functionalized 3D-printed scaffolds for osteochondral tissue engineering.

J Biol Methods 2021 22;8(1):e146. Epub 2021 Mar 22.

Department of Bioengineering, Lehigh University, Bethlehem, PA 18015, USA.

Three-dimensional (3D) printing of biodegradable polymers has rapidly become a popular approach to create scaffolds for tissue engineering. This technique enables fabrication of complex architectures and layer-by-layer spatial control of multiple components with high resolution. The resulting scaffolds can also present distinct chemical groups or bioactive cues on the surface to guide cell behavior. Read More

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Functional Outcomes for Meniscal Allograft Interposition Arthroplasty of the Hand.

Plast Reconstr Surg Glob Open 2021 Apr 20;9(4):e3520. Epub 2021 Apr 20.

Department of Orthopedic Surgery, Cedars Sinai Hospital, Los Angeles, Calif.

Background: Osteochondral defects of the carpometacarpal (CMC), metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints often necessitate arthrodesis or arthroplasty. Meniscal allograft has been used for large joint resurfacing, but its application to smaller joints is less well understood. We propose its use for hand joint resurfacing as an off-the-shelf alternative to address osteochondral defects and restore articular function. Read More

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Treatment Strategies and Outcomes for Osteochondritis Dissecans of the Capitellum.

Am J Sports Med 2021 Apr 22:3635465211000763. Epub 2021 Apr 22.

Brighton and Sussex University Hospital, Brighton, UK.

Background: The optimum management of osteochondritis dissecans (OCD) of the capitellum is a widely debated subject.

Purpose: To better understand the efficacy of different surgical modalities and nonoperative treatment of OCD as assessed by radiological and clinical outcomes and return to sports.

Study Design: Systematic review; Level of evidence, 4. Read More

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Clinical and Radiographic Outcomes After Treatment of Patellar Chondral Defects: A Systematic Review.

Sports Health 2021 Apr 22:19417381211003515. Epub 2021 Apr 22.

Context: There is currently no evidence-based consensus on how to treat a full-thickness, symptomatic articular cartilage injury of the patella, although numerous treatment options are available.

Objective: To systematically evaluate the functional outcomes after operative treatment of patellar cartilage lesions. Our secondary purpose was to evaluate radiographic outcomes after treatment. Read More

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Delayed osteochondral fracture fixation of the knee in a pediatric patient.

Ulus Travma Acil Cerrahi Derg 2021 May;27(3):369-373

Department of Orthopaedics and Traumatology, Near East University Hospital, Nicosia-TRNC.

The frequency of osteochondral fractures in the knee joint in the pediatric population is not clearly known. Although fragment fixation is generally considered to be the ideal treatment method in acute injuries, the data of the results of late fixation in neglected and/or late-diagnosed cases are very limited. In this paper, we report our findings regarding the fixation of a delayed large osteochondral fracture in lateral femoral condyle in a pediatric patient. Read More

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