iScience 2020 Apr 13;23(4):100976. Epub 2020 Mar 13.
Department of Orthopaedic Surgery, Amsterdam University Medical Centres, Amsterdam Movement Sciences, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands; Department of Medical Biology, Amsterdam University Medical Centres, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands. Electronic address:
Somitogenesis, the primary segmentation of the vertebrate embryo, is associated with oscillating genes that interact with a wave of cell differentiation. The necessity of cell-matrix adherence and embryonic tension, however, suggests that mechanical cues are also involved. To explicitly investigate this, we applied surplus axial strain to live chick embryos. Read More