365,995 results match your criteria orthopedic


Using a simple prescription gap to determine warfarin discontinuation can lead to substantial misclassification.

Thromb Haemost 2021 May 13. Epub 2021 May 13.

Brigham & Women's Hospital/Harvard Medical School, Boston, United States.

Background: Warfarin remains widely used and a key comparator in studies of other direct oral anticoagulants. As longer-than-needed warfarin prescriptions are often provided to allow for dosing adjustments according to International Normalized Ratios (INRs), the common practice of using a short allowable gap between dispensings to define warfarin discontinuation may lead to substantial misclassification of warfarin exposure. We aimed to quantify such misclassification and determine the optimal algorithm to define warfarin discontinuation. Read More

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Trainee performed total knee arthroplasty is safe and effective: A systematic review and meta-analysis comparing outcomes between trainees and consultants.

Knee 2021 May 10;30:291-304. Epub 2021 May 10.

Department of Trauma and Orthopaedic Surgery, London North West University Healthcare NHS Trust, United Kingdom.

Background: There are concerns that trainee performed knee arthroplasty (KA) may adversely affect patient outcomes. Demand for KA is projected to increase, and trainees must therefore be competent to perform it.

Methods: A systematic literature search was performed identifying articles comparing outcomes following trainee versus consultant surgeon performed primary KA. Read More

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Simultaneous bilateral opening-wedge high tibial osteotomy with structural allograft impaction results in excellent early recovery and pain reduction similar unilateral osteotomy.

Knee 2021 May 10;30:283-290. Epub 2021 May 10.

Department of Orthopaedic Surgery, AZ Herentals, Herentals, Belgium. Electronic address:

Background: Patients suffering from bilateral combined medial osteoarthritis and varus alignment of the knee are eligible for bilateral high tibial osteotomy (HTO) in two-staged surgery. The impact of bilateral HTO surgery on rehabilitation and early outcomes have not yet been reported in the literature, even though these features are decisive in establishing whether a patient is preferably treated in one or two stages.

Methods: A total of 29 patients were followed after simultaneous bilateral HTO surgery. Read More

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Long-term survivorship of total knee arthroplasty with a single-radius, high-flexion posterior stabilized prosthesis.

Knee 2021 May 10;30:275-282. Epub 2021 May 10.

Department of Orthopaedic Surgery and the Joint & Arthritis Research, Himchan Hospital, 120, Sinmok-ro, Yangcheon-gu, Seoul, Republic of Korea. Electronic address:

Background: The purpose of this study was to determine functional outcomes, implant survival rate, and complications of a single-radius, high-flexion posterior stabilized (PS) total knee prosthesis at a minimum follow up of 10 years for a consecutive series.

Methods: This retrospective observational study included 395 consecutive patients who underwent 585 single-radius, PS total knee arthroplasties (TKAs) between January 2009 and December 2009. Their functional outcomes, implant survival rates, radiological findings, and complications were evaluated. Read More

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Long term follow-up of Maduromycosis treatment: A case review.

Int J Surg Case Rep 2021 May 3;82:105956. Epub 2021 May 3.

Orthopedic and Traumatology Departement, Hasanuddin University, Makassar, Indonesia.

Maduromycosis is a rare deep fungal infection characterized by painless progressive destruction of limb caused by either fungal or filamentous bacteria. Its presentation is usually initiated by trivial penetration injury in farmers or laborers, worsen by immunocompromised status. Due to its painless course, this infection will severely destruct and deform hence leading to high morbidity of patient. Read More

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A low-temperature-printed hierarchical porous sponge-like scaffold that promotes cell-material interaction and modulates paracrine activity of MSCs for vascularized bone regeneration.

Biomaterials 2021 Apr 30;274:120841. Epub 2021 Apr 30.

Clinical and Translational Research Center for 3D Printing Technology, Medical 3D Printing Innovation Research Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China; Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. Electronic address:

Mesenchymal stem cells (MSCs) secrete paracrine trophic factors that are beneficial for tissue regeneration. In this study, a sponge-like scaffold with hierarchical and interconnected pores was developed using low-temperature deposition modeling (LDM) printing. Its effects on the cellular behavior, especially on the paracrine secretion patterns of MSCs, were comprehensively investigated. Read More

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Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines.

Cancer Treat Rev 2021 Apr 16;98:102209. Epub 2021 Apr 16.

Department of Orthopaedic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan.

Children and adolescents and young adults (AYAs) with cancer are often treated with a multidisciplinary approach. This includes use of radiotherapy, which is important for local control, but may also cause adverse events in the long term, including second cancer. The risks for limited growth and development, endocrine dysfunction, reduced fertility and second cancer in children and AYAs are reduced by proton beam therapy (PBT), which has a dose distribution that decreases irradiation of normal organs while still targeting the tumor. Read More

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Venous thromboembolism.

Lancet 2021 May 10. Epub 2021 May 10.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada; Department of Medicine, McGill University, Montreal, QC, Canada. Electronic address:

Venous thromboembolism, comprising both deep vein thrombosis and pulmonary embolism, is a chronic illness that affects nearly 10 million people every year worldwide. Strong provoking risk factors for venous thromboembolism include major surgery and active cancer, but most events are unprovoked. Diagnosis requires a sequential work-up that combines assessment of clinical pretest probability for venous thromboembolism using a clinical score (eg, Wells score), D-dimer testing, and imaging. Read More

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Are extracapsular and intracapsular hip-fracture patients two distinct rehabilitation subpopulations?

Disabil Rehabil 2021 May 13:1-6. Epub 2021 May 13.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To assess whether intracapsular and extracapsular hip fracture patients in a post-acute rehabilitation setting differ in their background characteristics and whether fracture type affects rehabilitation outcome.

Methods: A retrospective cohort study.

Outcome Measures: Functional Independence Measure (FIM), motor FIM (mFIM), mFIM effectiveness, length of stay (LOS), and discharge destination. Read More

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Assessment of Skeletal Maturity and Postoperative Growth Disturbance After Anterior Cruciate Ligament Reconstruction in Skeletally Immature Patients: A Systematic Review.

Am J Sports Med 2021 May 13:3635465211008656. Epub 2021 May 13.

Boston Children's Hospital, Division of Sports Medicine, Department of Orthopaedics, Harvard Medical School, Boston, Massachusetts, USA.

Background: Growth disturbance is an uncommon but potentially serious complication after anterior cruciate ligament (ACL) reconstruction in skeletally immature patients.

Purpose: To describe how the pediatric ACL literature has assessed preoperative skeletal maturity and the amount of growth remaining and to comprehensively review the incidence, reporting, and monitoring of postoperative growth disturbance.

Study Design: Systematic review; Level of evidence, 4. Read More

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Nonsurgical maxillary expansion in a 60-year-old patient with gingival recession and crowding.

Korean J Orthod 2021 May;51(3):217-227

Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Korea.

Maxillary transverse deficiency often manifests as a posterior crossbite or edge-to-edge bite and anterior crowding. However, arbitrary arch expansion in mature patients has been considered to be challenging due to the possible periodontal adverse effects such as alveolar bone dehiscence and gingival recession. To overcome these limitations, nonsurgical maxillary expansion of the basal bone has been demonstrated in young adults. Read More

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A comparison of adductor canal block before and after thigh tourniquet during knee arthroscopy: A randomized, blinded study.

Korean J Anesthesiol 2021 May 13. Epub 2021 May 13.

Department of Anesthesiology, Istanbul Medipol University, School of Medicine, Istanbul, Turkey.

Background: Adductor canal block (ACB) provides effective analgesia management after arthroscopic knee surgery. However, there is insufficient data about performing ACB before or after inflation of a thigh tourniquet. We aimed to investigate the efficacy of ACB when it is performed before and after thigh tourniquet and evaluate motor weakness. Read More

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Silencing Hoxa2 reverses dexamethasone-induced dysfunction of MC3T3-E1 osteoblasts and osteoporosis in rats.

Adv Clin Exp Med 2021 May 13. Epub 2021 May 13.

Department of Orthopedics, Liuzhou People's Hospital, Guangxi Medical University, China.

Background: Osteoporosis is damaging the health of women worldwide. Osteoporosis results from the imbalance between bone resorption and formation, which may be regulated by homeobox A2 (Hoxa2). However, the specific role and mechanism of Hoxa2 in osteogenesis and dexamethasone (Dex)-induced osteoporosis remain unknown. Read More

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The use of 33 MHz ultra-high-frequency ultrasonography for the evaluation of sweat glands in the axilla with osmidrosis.

PLoS One 2021 13;16(5):e0251600. Epub 2021 May 13.

ViewClinic Momonosato, Tamano, Japan.

Background: This study aimed to assess the use of 33 MHz ultra-high-frequency ultrasonography (33MHz-UHFUS) for evaluating axillary sweat glands with osmidrosis in comparison with histological techniques. Axillary osmidrosis is a common problem in Asian societies, and the number and size of apocrine sweat glands have a strong relationship with osmidrosis severity. Currently, there are no methods to evaluate sweat gland distribution non-invasively. Read More

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A novel (targeted) kinesio taping application on chronic low back pain: Randomized clinical trial.

PLoS One 2021 13;16(5):e0250686. Epub 2021 May 13.

Department of Orthopaedic Surgery, Hospital Arnau de Vilanova, Valencia, Spain.

The aim of the present clinical trial is to evaluate the efficacy of kinesio taping on patients with chronic low back pain, when the exploration identifies skin/fascia mobilization as a factor that could modify the treatment effect. This study is a randomized controlled trial with intention-to-treat analysis. Sixty-two participants with chronic low back pain were therefore recruited from a tertiary referral hospital. Read More

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Treatment of grossly dislocated supracondylar humerus fractures after failed closed reduction: a retrospective analysis of different surgical approaches.

Arch Orthop Trauma Surg 2021 May 13. Epub 2021 May 13.

Department of Trauma and Orthopedic Surgery, BG Unfallklinik Frankfurt Am Main, Friedberger Landstr. 430, 60389, Frankfurt am Main, Germany.

Introduction: The supracondylar humerus fracture (SCHF) is one of the most common pediatric injuries. Highly displaced fractures can be very challenging. If closed reduction fails, the therapy algorithm remains controversial. Read More

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STRYDE versus PRECICE magnetic internal lengthening nail for femur lengthening.

Arch Orthop Trauma Surg 2021 May 13. Epub 2021 May 13.

Limb Lengthening and Complex Reconstruction Service, Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Medical College Cornell University, New York, NY, USA.

Introduction: Magnetic internal lengthening nails (MILNs) have been used for femoral lengthening to avoid complications associated with external fixation. The titanium version of the MILN (PRECICE) has been in use since 2011 but had limitations (50-75 lb) in post-operative weight bearing. A new stainless-steel version of the MILN (STRYDE) allows 150-250 lb of post-operative weight bearing. Read More

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Recommendations in the rehabilitation of patients undergoing hip abductor tendon repair: a systematic literature search and evidence based rehabilitation protocol.

Arch Orthop Trauma Surg 2021 May 13. Epub 2021 May 13.

Perth Orthopaedic and Sports Medicine Centre, 31 Outram Street, West Perth, WA, 6005, Australia.

Introduction: Advanced hip imaging and surgical findings have demonstrated that a common cause of greater trochanteric pain syndrome (GTPS) is hip abductor tendon (HAT) tears. Traditionally, these patients have been managed non-operatively, often with temporary pain relief. More recently, there has been an increase in published work presenting the results of surgical intervention. Read More

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Non-anatomic tunnel position increases the risk of revision anterior cruciate ligament reconstruction.

Knee Surg Sports Traumatol Arthrosc 2021 May 13. Epub 2021 May 13.

UPMC Freddie Fu Sports Medicine Center Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Suite 1011, Pittsburgh, PA, USA.

Purpose: Anterior cruciate ligament (ACL) graft failure is a complication that may require revision ACL reconstruction (ACL-R). Non-anatomic placement of the femoral tunnel is thought to be a frequent cause of graft failure; however, there is a lack of evidence to support this belief. The purpose of this study was to determine if non-anatomic femoral tunnel placement is associated with increased risk of revision ACL-R. Read More

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A seven week observational analysis of clinical activities in a North Italian orthopaedic hospital during the second wave of SARS-CoV-2 pandemic: far from usual volumes, but different from the first wave.

Int Orthop 2021 May 13. Epub 2021 May 13.

Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Purpose: We previously described the radical changes occurred in an orthopaedic hospital in Milan (Italy) during the first SARS-CoV-2 pandemic outbreak. Currently, during the second wave, the situation is still far from normality. Here we describe the changes that took place, and are still ongoing, in the clinical practice. Read More

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Pain Fellows Survey: COVID-19 Impact on the Training and Job Market.

Pain Med 2021 May 13. Epub 2021 May 13.

The Spine and Nerve Center of the Virginias, Inc., Charleston, WV, USA.

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Do Medical Students Who Participate in a Research Gap Year Produce More Research During Residency?

J Am Acad Orthop Surg Glob Res Rev 2021 May 13;5(5). Epub 2021 May 13.

From the Hospital for Special Surgery, Orthopaedic Surgery, New York, NY (Dr. Wright-Chisem, and Dr. Osei), and the Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL (Dr. Cohn, Yang, and Dr. Kogan).

Background: The research gap year has become increasingly popular among medical students. It is also a well-known factor in consideration for orthopaedic surgery residency programs. Although medical students who participated in a research gap year typically enter residency with more research experience than their counterparts, it is unknown whether this translates to increased research productivity during residency compared with their peers. Read More

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Clinical Trial Registry Use in Orthopaedic Surgery Systematic Reviews.

J Bone Joint Surg Am 2021 May;103(10):e41

Department of Orthopedic Surgery, Oklahoma State University Medical Center, Tulsa, Oklahoma.

Background: Results from systematic reviews and meta-analyses, which have the highest level of evidence (Level I), often drive clinical decision-making and health policy. Often, unpublished trial data are omitted from systematic reviews, raising concerns about the extent of the reliability and validity of results that have been drawn from systematic reviews. We aimed to determine the extent to which systematic review authors include searches of clinical trial registries for unpublished data when conducting systematic reviews in orthopaedic surgery. Read More

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What's Important: The Power of Touch.

J Bone Joint Surg Am 2021 May;103(10):947-948

Division of Orthopaedic Trauma, Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, Ohio.

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Value Analysis of Anatomic and Reverse Shoulder Arthroplasty for Glenohumeral Osteoarthritis with an Intact Rotator Cuff.

J Bone Joint Surg Am 2021 May;103(10):913-920

Holy Cross Orthopedic Institute, Fort Lauderdale, Florida.

Background: While anatomic total shoulder arthroplasty (TSA) has historically been considered the ideal treatment for end-stage glenohumeral osteoarthritis, reverse shoulder arthroplasty (RSA) has recently gained popularity. With substantial differences in implant design and cost between TSA and RSA, further investigation of outcomes and value is needed to support recent trends. The purpose of this study was to use the average and incremental cost-effectiveness ratio (ACER and ICER) and the procedure value index (PVI) to examine differences in outcomes and value between TSA and RSA for treatment of glenohumeral osteoarthritis with an intact rotator cuff. Read More

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Anatomical Study of the Interosseous Ligament of the Tibiofibular Syndesmosis: An Analysis of Osseous Morphology and Attaching Interposing Structures.

J Bone Joint Surg Am 2021 May;103(10):905-912

Departments of Clinical Anatomy (A.T., M.T., R.Y., and K.A.), Orthopaedic and Spinal Surgery (A.T. and A.O.), and Functional Joint Anatomy (A.N.), Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Background: The morphological features of the interosseous tibiofibular area in relation to the tensile stress of the interosseous ligament (IOL) have rarely been discussed. The purpose of the present study was to investigate the IOL on the basis of osseous surface morphology and macroscopic and histological anatomy. We hypothesized that the osseous surface of the interosseous tibiofibular area has a specific feature corresponding to the fibrous structure in the IOL. Read More

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