373,952 results match your criteria orthopaedic


Ischemic toe after surgery for lesser toe deformities: An algorithm.

Foot (Edinb) 2021 May 4;48:101817. Epub 2021 May 4.

Foot & Ankle Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex HA7 4LP, United Kingdom. Electronic address:

Ischemia after correction of lesser toe deformities is usually due to temporary vasospasm and can rarely cause gangrene. The published literature on dealing with the issue and been reviewed and used to suggest an algorithm for a logical step by step approach to a pale or white toe when encountered in the postoperative period. Read More

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Lesser toe deformity classification: A simplified approach with treatment influence.

Foot (Edinb) 2021 May 4;48:101819. Epub 2021 May 4.

Podiatric Medicine and Surgery Residency and Fellowship Program, Director, Department of Orthopedics, University of Louisville, 142 Chenoweth Lane, Louisville, KY, 40207, USA.

Deformities of the lesser toes are one of the most commonly treated conditions by foot and ankle surgeons. Despite their frequency, a standardized classification has yet to take hold among providers. Generic nomenclature with the addition of multiple adjunctive descriptors continues to be the standard leading to international confusion. Read More

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Automatic bone maturity grading from EOS radiographs in Adolescent Idiopathic Scoliosis.

Comput Biol Med 2021 Jul 23;136:104681. Epub 2021 Jul 23.

Department of Software and IT Engineering, École de Technologie Supérieure, Montreal, Canada.

Adolescent Idiopathic Scoliosis (AIS) is a deformation of the spine and it is routinely diagnosed using posteroanterior and lateral radiographs. The Risser sign used in skeletal maturity assessment is commonly accepted in AIS patient's management. However, the Risser sign is subject to inter-observer variability and it relies mainly on the observation of ossification on the iliac crests. Read More

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Do clinical criteria based on PROMIS outcomes identify acceptable symptoms and function for patients with musculoskeletal problems.

Musculoskelet Sci Pract 2021 Jul 5;55:102423. Epub 2021 Jul 5.

George Fox University, Newberg, OR, USA.

Background: Understanding how symptoms influence patient judgements of their health informs providers where to direct care. Patient reported physical outcomes (physical function, pain interference) and self-efficacy of symptom management (SEsm)) predict a patient's health state (i.e. Read More

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Pilot evaluation of changes in motor control after wearable robotic resistance training in children with cerebral palsy.

J Biomech 2021 Jul 8;126:110601. Epub 2021 Jul 8.

College of Medicine - Phoenix, University of Arizona, Phoenix, AZ, USA; Department of Mechanical Engineering, Northern Arizona University, Flagstaff, AZ, USA. Electronic address:

Cerebral palsy (CP) is characterized by deficits in motor function due to reduced neuromuscular control. We leveraged the guiding principles of motor learning theory to design a wearable robotic intervention intended to improve neuromuscular control of the ankle. The goal of this study was to determine the neuromuscular and biomechanical response to four weeks of exoskeleton ankle resistance therapy (exo-therapy) in children with CP. Read More

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Decreased ventricular size and mass mediate the reduced exercise capacity in adolescents and adults born premature.

Early Hum Dev 2021 Jul 24;160:105426. Epub 2021 Jul 24.

Department of Pediatrics, Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, United States of America.

Background: Premature birth is associated with lower levels of cardiorespiratory fitness (CRF) but the underlying mechanisms responsible remain unclear. This study assessed whether differences in cardiac morphology or function mediate differences in CRF among adolescents and young adults born preterm.

Methods: Adolescents and young adults born moderately to extremely premature (gestational age ≤ 32 weeks or birth weight < 1500 g) and age-matched term born participants underwent resting cardiac MRI and maximal exercise testing. Read More

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Dural Tear Does Not Increase the Rate of Venous Thromboembolic Disease in Patients Undergoing Elective Lumbar Decompression with Instrumented Fusion.

World Neurosurg 2021 Jul 28. Epub 2021 Jul 28.

Department of Orthopaedic Surgery, University of Maryland Medical Center, Baltimore, MD. Electronic address:

Objective: Evaluate if dural tears (DT) are an indirect risk factor for venous thromboembolic disease through increased recumbency in patients undergoing elective lumbar decompression and instrumented fusion.

Methods: A retrospective cohort study of consecutive patients undergoing elective lumbar decompression and instrumented fusion at a single institution between 2016 and 2019. Patients were divided into cohorts: those who sustained a dural tear and those who did not. Read More

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Comparison of Surgical Invasiveness and Morbidity of Adult Spinal Deformity Surgery to Other Major Operations.

Spine J 2021 Jul 28. Epub 2021 Jul 28.

Department of Orthopaedic Surgery, Och Spine Hospital, Columbia University Medical Center, New York, NY; Department of Neurological Surgery, Vanderbilt University, Nashville, TN. Electronic address:

Background Context: Adult spinal deformity (ASD) surgeries are complex, involving long operative times and surgical morbidity. It is currently unclear how the invasiveness of ASD surgery compares to other major operations.

Purpose: To: a) develop a quantitative metric of surgical morbidity and invasiveness, and b) compare this score between ASD surgery and other major operations. Read More

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Impact of scandium on mechanical properties, corrosion behavior, friction and wear performance, and cytotoxicity of a β-type Ti-24Nb-38Zr-2Mo alloy for orthopedic applications.

Acta Biomater 2021 Jul 28. Epub 2021 Jul 28.

Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

β-type titanium (Ti) alloys have been extensively investigated as orthopedic implant materials due to their unique combination of low elastic modulus, high specific strength, corrosion resistance, and biocompatibility. In this study the mechanical properties, corrosion behavior, friction and wear performance, and cytotoxicity of β-type Ti-24Nb-38Zr-2Mo (TNZM) and Ti-24Nb-38Zr-2Mo-0.1Sc (TNZMS) have been comparatively investigated for orthopedic applications. Read More

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Prednisolone suppresses collagen-encoding gene expression causing cartilage defects in zebrafish larvae.

Environ Toxicol Pharmacol 2021 Jul 28:103719. Epub 2021 Jul 28.

Department of Orthopedics, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, 214000, China. Electronic address:

Glucocorticoid-induced osteoporosis (GIOP) is a clinically important disease. Despite many studies, the intrinsic pathogenesis of GIOP is still not fully understood. Cartilage is the target tissue of the glucocorticoid prednisolone (PN). Read More

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Male Sex, Cartilage Surgery, Tobacco Use, and Opioid Disorders are Associated with an Increased Risk of Infection after ACL Reconstruction.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, VA. Electronic address:

Purpose: To identify patient-related risk factors for infection following anterior cruciate ligament reconstruction (ACLR).

Methods: The Mariner database within PearlDiver was queried for patients from 2010 to 2019 undergoing primary arthroscopic ACLR. Patients undergoing ACLR with concomitant open surgery or additional ligament reconstructions were excluded. Read More

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Bone Block Augmentation of the Posterior Glenoid for Recurrent Posterior Shoulder Instability is Associated with High Rates of Clinical Failure: A Systematic Review.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

San Antonio Military Medical Center, San Antonio, Texas.

Purpose: To determine if posterior glenoid bone block augmentation performed for the treatment of recurrent posterior shoulder instability succeeds in restoring stability and is associated with rates of complications and/or clinical failures comparable to other glenoid bone augmentation procedures.

Methods: A comprehensive search of the PubMed, MEDLINE, and EMBASE databases was performed. Level of evidence studies I-IV pertaining to posterior bone block augmentation reporting on outcomes and/or complications were included. Read More

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All-Suture Anchor Versus Intramedullary Unicortical Button for Onlay Distal Biceps Repair: A Biomechanical Comparison.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Department of Orthopaedic Surgery, Inova Health System, Fairfax, VA, USA.

Purpose: To evaluate the biomechanical profile of onlay distal biceps repair with an intramedullary unicortical button versus all-suture anchors under cyclic loading and maximal load to failure.

Methods: Twenty paired fresh-frozen human cadaveric elbows were randomized to onlay distal biceps repair with either a single intramedullary button or with two 1.35 mm all-suture anchors. Read More

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Inkk Trial - Intraoperative ketamine for perioperative pain management following total knee endoprosthetic replacement in oncology: a double-blinded randomized trial.

Braz J Anesthesiol 2021 Jul 28. Epub 2021 Jul 28.

Tata Memorial Hospital and Homi Bhabha National Institute, Department of Physiotherapy, Mumbai, India.

Background: There has been a growing interest in the use of ketamine following orthopedic surgeries. We hypothesized that low dose intravenous ketamine during surgery would help in mobilization following total knee replacement (TKR) in oncology patients as assessed by the timed to up and go (TUG) test at 72 hours post-surgery. Our secondary objectives were to compare the opioid requirement at end of 72 hours, pain scores, satisfaction with pain management, adverse effects, range of joint movement achieved in the post-operative period and the functional recovery at the end of 1 month. Read More

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Identification of N-glycoproteins of hip cartilage in patients with osteonecrosis of femoral head using quantitative glycoproteomics.

Int J Biol Macromol 2021 Jul 28. Epub 2021 Jul 28.

Department of Orthopedics, the Second Affiliated Hospital, Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an 710004, China. Electronic address:

N-glycosylation is a major post-translational modification of proteins and involved in many diseases, however, the state and role of N-glycosylation in cartilage degeneration of osteonecrosis of femoral head (ONFH) remain unclear. The aim of this study is to identify the glycoproteins of ONFH hip cartilage. Cartilage tissues were collected from nine patients with ONFH and nine individuals with traumatic femoral neck fracture. Read More

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Isolated pelvic bone involvement as a presentation of alveolar echinococcosis.

Lancet Infect Dis 2021 Aug;21(8):1192

ECHINO-LIEGE, CHU de Liège, Liège, Belgium; Department of General Internal Medicine and Infectious Diseases, CHU de Liège, Liège, Belgium.

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Osteopathic Manual Treatment Compared to Kaltenborn-Evjenth Orthopedic Manual Therapy for Chronic Low Back Pain: A Randomized Study.

Altern Ther Health Med 2021 Jul 31. Epub 2021 Jul 31.

Context: Low back pain (LBP) is a painful pathology causing pain and disability despite treatment with the best evidence-based therapies. Osteopathic manual therapy (OMT) and Kaltenborn-Evjenth orthopedic manual therapy (KEOMT) are alternative treatments for LBP.

Objective: The study intended to evaluate the efficacy of OMT compared to that of KEOMT for patients with chronic LBP. Read More

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Bombyx mori U-shaped regulates the melanization cascade and immune response via binding with the Lozenge protein.

Insect Sci 2021 Jul 31. Epub 2021 Jul 31.

State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass sciences, Southwest University, Chongqing, China.

Zinc finger protein, an important transcription factor, regulates gene expression associated with various physiological and pathological processes. U-shaped, belong to the Friend of GATA (FOG) transcription factor, play a crucial role in hematopoiesis by interacting with the GATA transcription factor as a co-factor. However, little is known about its functions in insects. Read More

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Identifying high-risk surgical patients: A study of older adults whose code status changed to Do-Not-Resuscitate.

J Am Geriatr Soc 2021 Jul 31. Epub 2021 Jul 31.

Department of Surgery, Durham VA Health Care System, Durham, North Carolina, USA.

Background: There is a paucity of data on older adults (age ≥65 years) undergoing surgery who had an inpatient do-not-resuscitate (DNR) order, and the association between timing of DNR order and outcomes.

Methods: This was a retrospective analysis of 1976 older adults in the American College of Surgeons National Surgical Quality Improvement Program geriatric-specific database (2014-2018). Patients were stratified by institution of a DNR order during their surgical admission ("new-DNR" vs. Read More

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Peripheral Nerve Stimulation: A Review of Techniques and Clinical Efficacy.

Pain Ther 2021 Jul 31. Epub 2021 Jul 31.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Chronic pain is a common source of morbidity in many patient populations worldwide. There are growing concerns about the potential side effects of currently prescribed medications and a continued need for effective treatment. Related to these concerns, peripheral nerve stimulation has been regaining popularity as a potential treatment modality. Read More

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May bending radiographs be replaced by recumbent CT scans in patients with adolescent idiopathic scoliosis?

Eur Spine J 2021 Jul 31. Epub 2021 Jul 31.

Department of Orthopedic and Trauma Surgery, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany.

Purpose: There is no data that show if it is possible to determine if a curve is structural or non-structural or to assess flexibility of an adolescent idiopathic scoliosis (AIS) by recumbent images like a CT scan (CTS) instead of bending radiographs (BR). We investigated if the results of BR may be compared to those of CTS.

Methods: We retrospectively analyzed prospectively collected data of patients with AIS in whom a selective spinal fusion was performed and in whom a CTS, BR, and full spine x-rays were made preoperatively. Read More

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The accuracy of patient-reported weight prior to total joint arthroplasty and arthroscopy of the lower extremity.

Arch Orthop Trauma Surg 2021 Jul 31. Epub 2021 Jul 31.

Department of Orthopaedic Surgery, Center for Hip Preservation, Orthopaedic and Rheumatologic Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Mail code A41, Cleveland, OH, 44195, USA.

Purpose: The accuracy of preoperative patient-reported weight was never evaluated in patients undergoing lower extremity procedures. The purpose of this study was to: (1) compare the disparity between patient-reported and measured weights in patients undergoing lower extremity total joint arthroplasty (LE-TJA) and arthroscopy; and (2) investigate the association between patient-specific factors (patient age, BMI, zip code, and psychiatric comorbidities) and the accuracy of patient-reported weight.

Methods: Preoperative self-reported weights were retrospectively compared to measured weights in 400 LE-TJA and 85 control arthroscopy patients. Read More

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Primary stability of single-stage revision reconstruction of the anterior cruciate ligament in case of failure of dynamic intraligamentary stabilization depends on implant position during ACL repair.

Arch Orthop Trauma Surg 2021 Jul 31. Epub 2021 Jul 31.

Department of Traumatology and Orthopedics, Maria-Josef-Hospital Greven, Lindenstraße 29, 48268, Greven, Germany.

Introduction: The object of this study was to evaluate the primary stability of tibial interference screw (IFS) fixation in single-stage revision surgery of the anterior cruciate ligament (ACL) in the case of recurrent instability after ACL repair with dynamic intraligamentary stabilization (DIS), dependent on the implant position during DIS.

Materials And Methods: Tibial aperture fixation in ACL reconstruction (ACL-R) was performed in a porcine knee model using an IFS. Native ACL-R was performed in the control group (n = 15). Read More

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Locally developed external fixators as definitive treatment of open tibia diaphyseal fractures: a clinical prospective study conducted in Ivory Coast.

Int Orthop 2021 Jul 31. Epub 2021 Jul 31.

Experimental and Clinical Research Institute (IREC), Neuro-Musculo-Skeletal Pole (NMSK), Université Catholique de Louvain, Brussels, Belgium.

Background: This study sought to evaluate the effectiveness of locally developed external fixators (LDEF) as definitive treatment for open tibia diaphyseal fractures (OTDF) in Ivory Coast.

Methods: Gustilo I, II, and IIIA OTDFs of patients admitted within 24 hours of injury were prospectively included and treated with LDEF. The rates of union, mal-union, septic complications, as well as the functional results were assessed, in addition to the LDEF construct's integrity. Read More

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Whole-body Computed Tomography Versus Dual Energy X‑ray Absorptiometry for Assessing Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva.

Calcif Tissue Int 2021 Jul 31. Epub 2021 Jul 31.

Departments of Radiology, Medicine and Orthopaedic Surgery, University of California, San Francisco, CA, USA.

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder that leads to heterotopic ossification (HO), resulting in progressive restriction of physical function. In this study, low-dose, whole-body computed tomography (WBCT) and dual energy X-ray absorptiometry (DXA) were evaluated to determine the preferred method for assessing total body burden of HO in patients with FOP. This was a non-interventional, two-part natural history study in patients with FOP (NCT02322255; date of registration: December 2014). Read More

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Prediction intervals reporting in orthodontic meta-analyses.

Eur J Orthod 2021 Jul 31. Epub 2021 Jul 31.

Department of Orthodontics and Dentofacial Orthopedics, Dental School/Medical Faculty, University of Bern, Switzerland.

Background: A prediction interval represents a clinical interpretation of heterogeneity. The aim of this study was to determine the prevalence of prediction interval reporting in orthodontic random effect meta-analyses. The corroboration between effect size estimates with 95% confidence intervals (CIs) and prediction intervals were also explored. Read More

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Innervation Patterns of the Pronator Teres Muscle and Their Possible Role in Neurotization: A Systematic Review of Cadaveric Studies.

Acta Medica (Hradec Kralove) 2021 ;64(2):77-84

Department of Anatomy, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Background: Contrary to the classic anatomical description, many recent studies have reported wide variations in branching patterns and location of motor branches that are supplying the pronator teres muscle. To understand these variations and their implications in surgical procedures of the nerve transfers, a systematic review was performed on the innervation of pronator teres muscle from cadaveric studies.

Methods: A systematic literature search was performed in databases such as Medline, PubMed, Google Scholar, SciELO, ScienceDirect, Cochrane reviews and orthopedics textbooks using the search terms "pronator teres nerve branches"; AND "number" OR "location" OR "length" OR "diameter" yielded 545 article links. Read More

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January 2021

Multicolor 3D Confocal Imaging of Thick Tissue Sections.

Methods Mol Biol 2021 ;2350:95-104

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.

In multicellular organisms, most physiological and pathological processes involve an interplay between various cells and molecules that act both locally and systemically. To understand how these complex and dynamic processes occur in time and space, imaging techniques are key. Advances in tissue processing techniques and microscopy now allow us to probe these processes at a large scale and at the same time at a level of detail previously unachievable. Read More

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January 2021

What should progress in response-shift research look like?

Qual Life Res 2021 Jul 30. Epub 2021 Jul 30.

DeltaQuest Foundation, Inc., 31 Mitchell Road, Concord, MA, 01742, USA.

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Analysis of the main soft tissue stress associated with flexible flatfoot deformity: a finite element study.

Biomech Model Mechanobiol 2021 Jul 30. Epub 2021 Jul 30.

Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People's Republic of China.

A better understanding of soft tissue stress and its role in supporting the medial longitudinal arch in flexible flatfoot could help to guide the clinical treatment. In this study, a 3-Dimensional finite element (FE) foot model was reconstructed to measure the stress of the soft tissue, and its variation in different scenarios related to flexible flatfoot. All bones, cartilages, ligaments and related tendons around the ankle, and fat pad were included in the finite element model. Read More

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