27,244 results match your criteria organs risk


Oncological Properties of Intravenous Leiomyomatosis: Involvement of Mesenchymal Tumor Stem-Like Cells.

Curr Issues Mol Biol 2021 Sep 19;43(2):1188-1202. Epub 2021 Sep 19.

National Hospital Organization Kyoto Medical Center, Department of Obstetrics and Gynecology, Kyoto 612-8555, Japan.

Uterine leiomyoma, also known as fibroids, is the most common benign neoplasm of the female genital tract. Leiomyoma is the most common uterine tumor. The leiomyoma subtypes account for approximately 10% of leiomyomas. Read More

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September 2021

Papillary Meningioma: Case Presentation with Emphasis on Surgical and Medical Therapy of a Rare Variant of Meningioma.

Diseases 2021 Sep 17;9(3). Epub 2021 Sep 17.

Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, 70124 Bari, Italy.

Meningioma is one of the most frequent neoplasms of all in the central nervous system. Different variants are known, and of these some have peculiar characteristics, both from a morphological point of view and from a biological point of view. Here, we present a rare case of relapsed papillary meningioma in a young patient, focusing on histological characteristics, medical-surgical therapy and focusing on the risk of progression and/or recurrence of the lesion if not completely eradicated. Read More

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September 2021

Fast generation of lung SBRT plans with a knowledge-based planning model on ring-mounted Halcyon Linac.

J Appl Clin Med Phys 2021 Sep 25. Epub 2021 Sep 25.

Medical Physics Graduate Program, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.

Purpose: To demonstrate fast treatment planning feasibility of stereotactic body radiation therapy (SBRT) for centrally located lung tumors on Halcyon Linac via a previously validated knowledge-based planning (KBP) model to support offline adaptive radiotherapy.

Materials/methods: Twenty previously treated non-coplanar volumetric-modulated arc therapy (VMAT) lung SBRT plans (c-Truebeam) on SBRT-dedicated C-arm Truebeam Linac were selected. Patients received 50 Gy in five fractions. Read More

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September 2021

Cadmium Uptake and Translocation By Potato in Acid and Calcareous Soils.

Bull Environ Contam Toxicol 2021 Sep 25. Epub 2021 Sep 25.

College of Agriculture, Guizhou University, 550025, Guiyang, China.

Cadmium contamination of agricultural soils threatens food safety. The bioaccumulation (BAF) of Cd in potato tubers ranged from 0.69 to 1. Read More

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September 2021

Optimization of collimator angles in dual-arc volumetric modulated arc therapy planning for whole-brain radiotherapy with hippocampus and inner ear sparing.

Sci Rep 2021 Sep 24;11(1):19035. Epub 2021 Sep 24.

Department of Radiation Oncology and Therapy, The First Hospital of Jilin University, Changchun, 130021, China.

To optimize the collimator angles in dual-arc volumetric modulated arc therapy (VMAT) plans for whole-brain radiotherapy with hippocampus and inner ear sparing (HIS-WBRT). Two sets of dual-arc VMAT plans were generated for 13 small-cell lung cancer patients: (1) The collimator angles of arcs 1 and 2 (θ/θ) were 350°/10°, 350°/30°, 350°/45°, 350°/60°, and 350°/80°, i.e. Read More

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September 2021

Exercise, Physical Activity and Cardiometabolic Health: Pathophysiologic Insights.

Cardiol Rev 2021 Sep 15. Epub 2021 Sep 15.

Division of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Cardiovascular Research Center, Beth Israel Deaconess Medical Center, Boston, MA.

Physical activity and its sustained and purposeful performance - exercise - promote a broad and diverse set of metabolic and cardiovascular health benefits. Regular exercise is the most effective way to improve cardiorespiratory fitness, a measure of one's global cardiovascular, pulmonary and metabolic health and one of the strongest predictors of future health risk. Here, we describe how exercise affects individual organ systems related to cardiometabolic health, including the promotion of insulin and glucose homeostasis through improved efficiency in skeletal muscle glucose utilization and enhanced insulin sensitivity; beneficial changes in body composition and adiposity; and improved cardiac mechanics and vascular health. Read More

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September 2021

An international Delphi consensus for pelvic Stereotactic Ablative Radiotherapy re-irradiation.

Radiother Oncol 2021 Sep 21. Epub 2021 Sep 21.

Leeds Teaching Hospitals NHS Trust, Beckett Street, Leeds, LS9 7TF, UK; University of Leeds, Leeds, LS2 9JT, UK. Electronic address:

Introduction: Stereotactic Ablative Radiotherapy (SABR) is increasingly used to treat metastatic oligorecurrence and locoregional recurrences but limited evidence/guidance exists in the setting of pelvic re-irradiation. An international Delphi study was performed to develop statements to guide practice regarding patient selection, pre-treatment investigations, treatment planning, delivery and cumulative organs at risk (OARs) constraints.

Materials And Methods: Forty-one radiation oncologists were invited to participate in three online surveys. Read More

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September 2021

Concentration, Source, and Health Risk of Trace Metals in Some Liquid Herbal Medicine Sold in Nigeria.

Biol Trace Elem Res 2021 Sep 24. Epub 2021 Sep 24.

Department of Community Medicine, Faculty of Clinical Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.

The ingestion of toxic metals through liquid herbal medicine over a long period of time, and in excessive dose, may result in chronic accumulation that could cause disorder to several organs of the body. This study evaluated the concentration, source, and probable health risk of 8 trace metals in liquid herbal medicines sold in Nigeria. Triplicate samples of 10 different brands of liquid herbal formulations were analyzed using flame atomic absorption spectrophotometer. Read More

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September 2021

Role of Imaging in a Case of Toxoplasmosis Presenting as Generalized Lymphadenopathy.

Indian J Radiol Imaging 2021 Apr 28;31(2):445-450. Epub 2021 Jul 28.

Department of Nuclear Medicine, VPS Lakeshore Hospital, Kochi, Kerala, India.

Toxoplasmosis is caused by an obligate protozoan intracellular parasite. The disease has variable prevalence globally and is usually asymptomatic. Pregnant and immunocompromised people are at risk of getting infected. Read More

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Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease.

Bone Marrow Transplant 2021 Sep 23. Epub 2021 Sep 23.

Instituto de Biomedicina de Sevilla (IBIS/CSIC), CIBERONC, Universidad de Sevilla, Sevilla, Spain.

In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation (allo-BMT) by using the proteasome inhibitor ixazomib (IXZ) at the late stages of the post-transplant period. This approach facilitated the immune reconstitution after transplantation. IXZ significantly prolonged survival and decreased the risk of chronic graft-versus-host disease (cGvHD) in two different murine models without hampering the graft-versus-leukemia (GvL) effect, as confirmed by bioluminescence assays. Read More

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September 2021

Embedding similarities between embryos and circulating tumor cells: fundamentals of abortifacients used for cancer metastasis chemoprevention.

J Exp Clin Cancer Res 2021 Sep 23;40(1):300. Epub 2021 Sep 23.

College of Materials and Chemical Engineering, Minjiang University, 350108, Fuzhou, China.

Background: The global epidemiological studies reported lower cancer risk after long-term use of contraceptives. Our systematic studies demonstrated that abortifacients are effective in preventing cancer metastases induced by circulating tumor cells (CTCs). However, the molecular and cellular mechanisms by which abortifacients prevent CTC-based cancer metastases are almost unknown. Read More

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September 2021

Sexually dimorphic expression of sexual differentiation genes in the internal genital organs of Japanese quail embryos.

Gen Comp Endocrinol 2021 Sep 20:113917. Epub 2021 Sep 20.

Research Office for Environmental Risk Science, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan.

Japanese quail (Coturnix japonica) is an avian model used to evaluate the reproductive and developmental toxicity of chemicals. The National Institute for Environmental Studies (NIES) of Japan established a strain of Japanese quail, NIES-L, which may be a better model because of its highly inbred characteristics. To understand sexual differentiation of the reproductive organs and the value of using NIES-L quails for avian toxicity assessment, we profiled estradiol and androgen plasma levels by enzyme-linked immunosorbent assay; the mRNA levels of estrogen receptor-α (ERα), ERβ, and androgen receptor (AR) in the gonads, Müllerian ducts, Wolffian ducts; and the mRNA levels of steroidogenic enzymes, cholesterol side chain cleavage enzyme (P450), 17α-hydroxylase/C lyase (P450), 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β-hydroxysteroid dehydrogenase (17β-HSD), and aromatase (P450), anti-Müllerian hormone (AMH), and AMH receptor type 2 (AMHR2) in the gonads of NIES-L Japanese quails on embryonic days 9, 12, and 15 using a real-time quantitative PCR method. Read More

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September 2021

Chemotherapy, Target Therapy and Immunotherapy: Which Drugs Can Be Safely Used in The Solid Organ Transplant Recipients?

Transpl Int 2021 Sep 23. Epub 2021 Sep 23.

Renal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA.

In solid organ transplant recipients, cancer is associated with worse prognosis than in the general population. Among the causes of increased cancer-associated mortality, are the limitations in selecting the optimal anticancer regimen in solid organ transplant recipients, because of the associated risks of graft toxicity and rejection, drug-to-drug interactions, reduced kidney or liver function, and patient frailty and comorbid conditions. The advent of immunotherapy has generated further challenges, mainly because checkpoint inhibitors increase the risk of rejection, which may have life-threatening consequences in recipients of life-saving organs. Read More

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September 2021

Deep-Learning-Based Automatic Segmentation of Head and Neck Organs for Radiation Therapy in Dogs.

Front Vet Sci 2021 6;8:721612. Epub 2021 Sep 6.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.

This study was conducted to develop a deep learning-based automatic segmentation (DLBAS) model of head and neck organs for radiotherapy (RT) in dogs, and to evaluate the feasibility for delineating the RT planning. The segmentation indicated that there were potentially 15 organs at risk (OARs) in the head and neck of dogs. Post-contrast computed tomography (CT) was performed in 90 dogs. Read More

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September 2021

Hepatocellular injury and the mortality risk among patients with COVID-19: A retrospective cohort study.

World J Hepatol 2021 Aug;13(8):939-948

Department of Internal Medicine, Faculty of Medicine, Al-Azhar University-Assiut, Assiut 71524, Egypt.

Background: Clearly, infection with severe acute respiratory syndrome coronavirus 2 is not limited to the lung but also affects other organs. We need predictive models to determine patients' prognoses and to improve health care resource allocation during the coronavirus disease 2019 (COVID-19) pandemic. While treating COVID-19, we observed differential outcome prediction weights for markers of hepatocellular injury among hospitalized patients. Read More

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Kidney transplant from donors with hepatitis B: A challenging treatment option.

World J Hepatol 2021 Aug;13(8):853-867

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Utilizing kidneys from donors with hepatitis B is one way to alleviate the current organ shortage situation. However, the risk of hepatitis B virus (HBV) transmission remains a challenge that undermines the chance of organs being used. This is particularly true with hepatitis B surface antigen (HBsAg) positive donors despite the comparable long-term outcomes when compared with standard donors. Read More

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Antibiotic prophylaxis in patients with cirrhosis: Current evidence for clinical practice.

World J Hepatol 2021 Aug;13(8):840-852

Department of Gastroenterology, Verona University Hospital, Verona 37124, Italy.

Patients with cirrhosis show an increased susceptibility to infection due to disease-related immune-dysfunction. Bacterial infection therefore represents a common, often detrimental event in patients with advanced liver disease, since it can worsen portal hypertension and impair the function of hepatic and extra-hepatic organs. Among pharmacological strategies to prevent infection, antibiotic prophylaxis remains the first-choice, especially in high-risk groups, such as patients with acute variceal bleeding, low ascitic fluid proteins, and prior episodes of spontaneous bacterial peritonitis. Read More

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Validation and Reliability of a Novel Vagus Nerve Neurodynamic Test and Its Effects on Heart Rate in Healthy Subjects: Little Differences Between Sexes.

Front Neurosci 2021 6;15:698470. Epub 2021 Sep 6.

Department of Mechanics, Politecnico di Milano, Lecco, Italy.

Background: The vagus nerve (VN), also called the pneumogastric nerve, connects the brainstem to organs contained in the chest and abdomen. Physiologically, VN stimulation can rapidly affect cardiac activity and heart rate (HR). VN neuropathy can increase the risk of arrhythmias and sudden death. Read More

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September 2021

Assessment of HDR brachytherapy-replicating prostate radiotherapy planning for tomotherapy, cyberknife and VMAT.

Med Dosim 2021 Sep 19. Epub 2021 Sep 19.

Sir Charles Gairdner Hospital, Perth, Australia; 5D Clinics, Perth, Australia; University of Western Australia, Perth, Australia. Electronic address:

A dosimetric study was undertaken to assess the ability of Cyberknife (CK), Volumetric Modulated Arc Therapy (VMAT), and TomoTherapy (Tomo) to generate treatment plans that mimic the dosimetry of high dose-rate brachytherapy (HDR BT) for prostate cancer. The project aimed to assess the potential of using stereotactic body radiotherapy (SBRT) for boost treatment of high-risk prostate cancer patients where HDR BT in combination with conformal external beam radiotherapy (EBRT) is the standard of care. The datasets of 6 prostate patients previously treated with HDR BT were collated. Read More

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September 2021

Dosimetric effect of intensity-modulated radiation therapy for postoperative non-small cell lung cancer with and without air cavity in the planning target volume.

Med Dosim 2021 Sep 19. Epub 2021 Sep 19.

Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

To evaluate the dosimetric effect of intensity-modulated radiation therapy (IMRT) for postoperative non-small cell lung cancer (NSCLC), with and without the air cavity in the planning target volume (PTV). Two kinds of IMRT plans were made for 21 postoperative NSCLC patients. In Plan-0: PTV included the tracheal air cavity, and in Plan-1: the air cavity was subtracted from the PTV. Read More

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September 2021

[Completion Pneumonectomy].

Authors:
Yasushi Shintani

Kyobu Geka 2021 Sep;74(10):827-832

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

A completion pneumonectomy(CP) is a procedure used to remove remaining lung tissue following an operation previously performed for anatomical resection. During the initial operation, manipulation of the pulmonary artery and vein during incision of the mediastinal pleura can influence dissection of the hilum vessels and bronchus in the mediastinum, causing severe adhesion and tissue fragility, thus making a CP difficult to perform. As compared to a standard pneumonectomy, it is considered to be a more challenging technical procedure, and associated with increased operative mortality and morbidity. Read More

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September 2021

[Total Aortic Arch Replacement after a Prior Ascending Aortic Replacement].

Kyobu Geka 2021 Sep;74(10):770-774

Division of Cardiovascular Surgery, Tohoku University, Sendai, Japan.

Surgeries for non-dissected aortic arch diseases have been performed with increasing frequency in recent years. Accordingly, the awareness of the pitfalls in reoperation after a previous ascending aortic replacement is needed. Indications for redo total aortic arch replacement after a prior ascending aortic replacement include pseudoaneurysm formation at the distal anastomosis site and newly developed aortic arch aneurysms. Read More

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September 2021

Understanding the cross-talk between mediators of infertility and COVID-19.

Reprod Biol 2021 Sep 1;21(4):100559. Epub 2021 Sep 1.

Department of Zoology, Krishna Chandra College, Hetampur, West Bengal, India.

COVID-19 is the ongoing health emergency affecting individuals of all ages around the globe. Initially, the infection was reported to affect pulmonary structures. However, recent studies have delineated the impacts of COVID-19 on the reproductive system of both men and women. Read More

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September 2021

Functional Deficit of Sense Organs as a risk factor for Cognitive Functional Disorder in Chinese Community Elderly People.

Int J Clin Pract 2021 Sep 21:e14905. Epub 2021 Sep 21.

Mental Health Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: To explore the relationship between mild cognitive impairment (MCI) and sense organs functional deficit in community elderly people.

Methods: 3095 community elderly people above 60 years in Hebei Province were selected by cross-sectional random cluster sampling method, who were evaluated face-to-face for general demographic data, the condition of sense organs functional deficit (vision, hearing, gustation, olfactory sensation, taste) and cognitive function by Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).

Results: A total of 3075 valid questionnaires were obtained. Read More

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September 2021

Evaluation of Radiation-induced Pleural Effusions after Radiotherapy to Support Development of Animal Models of Radiation Pneumonitis.

Health Phys 2021 Oct;121(4):434-443

Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.

Abstract: Not all animal models develop radiation-induced pleural effusions (RIPEs) as a form of radiation-induced lung injury (RILI). Such effusions are also not well characterized in humans. The purpose of this study is to identify occurrences of RIPE in humans, provide justification for development of relevant animal models, and further characterize its risk factors in cancer patients. Read More

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October 2021

Patient positioning and immobilization procedures for hybrid MR-Linac systems.

Radiat Oncol 2021 Sep 20;16(1):183. Epub 2021 Sep 20.

Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.

Hybrid magnetic resonance (MR)-guided linear accelerators represent a new horizon in the field of radiation oncology. By harnessing the favorable combination of on-board MR-imaging with the possibility to daily recalculate the treatment plan based on real-time anatomy, the accuracy in target and organs-at-risk identification is expected to be improved, with the aim to provide the best tailored treatment. To date, two main MR-linac hybrid machines are available, Elekta Unity and Viewray MRIdian. Read More

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September 2021

The clinical course of Crohn's disease in a Danish population-based inception cohort with more than 50 years of follow-up, 1962-2017.

Aliment Pharmacol Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Gastroenterology, North Zealand Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Few population-based studies have investigated the long-term prognosis of Crohn's disease (CD).

Aim: To determine the long-term natural disease course of CD with regard to surgery, cancer and mortality in a population-based cohort followed for more than 50 years.

Methods: All patients diagnosed with CD from 1962 to 1987 in Copenhagen County, Denmark were included in a population-based cohort. Read More

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September 2021

Transporter hypothesis in pharmacoresistant epilepsies Is it at the central or peripheral level?

Epilepsia Open 2021 Sep 20. Epub 2021 Sep 20.

Institute for Research in Physiopathology and Clinical Biochemistry (INFIBIOC), Clinical Biochemistry Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.

The multidrug resistance (MDR) phenotype is typically observed in patients with refractory epilepsy (RE) whose seizures are not controlled despite receiving several combinations of more than two antiseizure medications (ASMs) directed against different ion channels or neurotransmitter receptors. Since the use of bromide in 1860, more than 20 ASMs have been developed; however, historically ~30% of cases of RE with MDR phenotype remains unchanged. Irrespective of metabolic biotransformation, the biodistribution of ASMs and their metabolites depends on the functional expression of some ATP-binding cassette transporters (ABC-t) in different organs, such as the blood-brain barrier (BBB), bowel, liver, and kidney, among others. Read More

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September 2021

Association of thrombophilia prospective detection with hemocompatibility related outcomes in left ventricular assist device patients.

Int J Artif Organs 2021 Sep 19:3913988211041639. Epub 2021 Sep 19.

Department of Cardiac Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Introduction: Inherited thrombophilias represent a concerning risk factor due to a proclivity to an aberrant clot formation. However, in patients with left ventricular assist device (LVAD), their impact on bleeding and thrombotic complications remains still poorly understood. The aim of the present study was to evaluate the effect of thrombophilic mutation directed anticoagulation therapy on adverse clinical outcomes in LVAD patients. Read More

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September 2021