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Evaluating the Effectiveness of a One-Week Multimodal Prevention Program for Slowing down and Stress Reduction Performed in a German Health Resort: Results of a Randomized Controlled Trial.

Complement Med Res 2021 May 5:1-11. Epub 2021 May 5.

Chair of Public Health and Health Services Research, Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Pettenkofer School of Public Health, Ludwig-Maximilians-Universität München, Munich, Germany.

Background: Effective concepts are required to overcome the negative impact of daily stressful overwhelming. We investigated the effectiveness of a 1-week multimodal program for stress reduction.

Methods: We performed a randomized controlled trial including adults with above-average stress level. Read More

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Cortical [ F]PI-2620 Binding Differentiates Corticobasal Syndrome Subtypes.

Mov Disord 2021 May 5. Epub 2021 May 5.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

Background: Corticobasal syndrome is associated with cerebral protein aggregates composed of 4-repeat (~50% of cases) or mixed 3-repeat/4-repeat tau isoforms (~25% of cases) or nontauopathies (~25% of cases).

Objectives: The aim of this single-center study was to investigate the diagnostic value of the tau PET-ligand [ F]PI-2620 in patients with corticobasal syndrome.

Methods: Forty-five patients (71. Read More

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Paying for performance to improve the delivery of health interventions in low- and middle-income countries.

Cochrane Database Syst Rev 2021 05 5;5:CD007899. Epub 2021 May 5.

Institute for Global Health and Development, Queen Margaret University, Edinburgh, UK.

Background: There is growing interest in paying for performance (P4P) as a means to align the incentives of healthcare providers with public health goals. Rigorous evidence on the effectiveness of these strategies in improving health care and health in low- and middle-income countries (LMICs) is lacking; this is an update of the 2012 review on this topic.

Objectives: To assess the effects of paying for performance on the provision of health care and health outcomes in low- and middle-income countries. Read More

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Couples' decision-making on post-partum family planning and antenatal counselling in Uganda: A qualitative study.

PLoS One 2021 5;16(5):e0251190. Epub 2021 May 5.

Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

Background: Although health workers have been trained to provide post-partum family planning (PPFP), uptake remains low in Uganda. An important reason is that women want the agreement of their partner, who is often absent at the time of delivery. In order to address this, we aimed to understand the views of couples and explore barriers and facilitators to implementation of antenatal couples' counselling on PPFP in Uganda. Read More

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Do women prefer caesarean sections? A qualitative evidence synthesis of their views and experiences.

PLoS One 2021 5;16(5):e0251072. Epub 2021 May 5.

UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.

Background: Caesarean sections (CS) continue to increase worldwide. Multiple and complex factors are contributing to the increase, including non-clinical factors related to individual women, families and their interactions with health providers. This global qualitative evidence synthesis explores women's preferences for mode of birth and factors underlying preferences for CS. Read More

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The hierarchical packing of euchromatin domains can be described as multiplicative cascades.

PLoS Comput Biol 2021 May 5;17(5):e1008974. Epub 2021 May 5.

Institute of Biological and Chemical Systems, Dept. Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.

The genome is packed into the cell nucleus in the form of chromatin. Biochemical approaches have revealed that chromatin is packed within domains, which group into larger domains, and so forth. Such hierarchical packing is equally visible in super-resolution microscopy images of large-scale chromatin organization. Read More

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No support for white matter connectivity differences in the combined and inattentive ADHD presentations.

PLoS One 2021 5;16(5):e0245028. Epub 2021 May 5.

The Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.

Evidence from functional neuroimaging studies support neural differences between the Attention Deficit Hyperactivity Disorder (ADHD) presentation types. It remains unclear if these neural deficits also manifest at the structural level. We have previously shown that the ADHD combined, and ADHD inattentive types demonstrate differences in graph properties of structural covariance suggesting an underlying difference in neuroanatomical organization. Read More

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MicroRNA-363-3p promote the development of acute myeloid leukemia with RUNX1 mutation by targeting SPRYD4 and FNDC3B.

Medicine (Baltimore) 2021 May;100(18):e25807

Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University.

Background: Runt-related transcription factor 1 (RUNX1) is one of the most frequently mutated genes in most of hematological malignancies, especially in acute myeloid leukemia. In the present study, we aimed to identify the key genes and microRNAs based on acute myeloid leukemia with RUNX1 mutation. The newly finding targeted genes and microRNA associated with RUNX1 may benefit to the clinical treatment in acute myeloid leukemia. Read More

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Experiences of general practice care for self-harm: a qualitative study of young people's perspectives.

Br J Gen Pract 2021 May 4. Epub 2021 May 4.

Keele University, School of Medicine, Keele, United Kingdom.

Background: Self-harm is a growing concern and rates of self-harm in young people presenting to general practice are rising. There is however an absence of evidence on young people's experiences of GP care and on accessing general practice.

Aim: To explore the help-seeking behaviours, experiences of GP care, and access to general practice for young people who self-harm. Read More

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Estimating the COVID-19 spread through real-time population mobility patterns: surveillance in Low- and Middle- income countries.

J Med Internet Res 2021 Feb 21. Epub 2021 Feb 21.

School of Nursing, Hong Kong Ppolytechnic University, Hong Kong, HK.

Background: On January 30, 2020, the World Health Organization (WHO) declared the current novel coronavirus disease 2019 (COVID-19) as a public health emergency of international concern and later characterized it as a pandemic. Since then, the virus has also rapidly spread among Latin American, Caribbean and African countries. The first aim of this study was to identify new emerging COVID-19 clusters over time and in space in Latin American, Caribbean, and African regions [mostly low- and middle-income countries (LMICs)], using a prospective space-time scan measurement approach. Read More

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February 2021

Assessing the Educational Value of a Zoo Placement for Veterinary Students: A Report on Student Feedback and Perceptions.

J Vet Med Educ 2021 Apr 21:e20200064. Epub 2021 Apr 21.

Zoological medicine is an expanding field with limited practical training opportunities for veterinary students. Those training programs that do exist require significant financial and resource investment by both veterinary schools and the zoological organizations involved. This article summarizes the findings of a retrospective survey of students carried out to ascertain the educational value of a compulsory 5-day-long zoo clinical placement for final-year veterinary students. Read More

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A Qualitative Analysis of Maternal and Child Health Public Health Leadership Institute (MCH PHLI) Leaders: Assessing the Application of Leadership Skills at the "Others" and "Wider Community" Levels of the MCH Leadership Competencies 4.0.

Matern Child Health J 2021 May 5. Epub 2021 May 5.

Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Objectives: To gain insight into how participants in the Maternal and Child Health Public Health Leadership Institute (MCH PHLI) report applying the leadership skills gained through the program at the "Others" and "Wider Community" levels of the MCH Leadership Competencies 4.0.

Methods: 111 mid- to senior-level MCH leaders participating in the MCH PHLI gave < 5 min oral presentations detailing the impacts resulting from implementation of the skills gained through the leadership development training. Read More

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Phase III trials of JAK1 selective inhibitors in rheumatoid arthritis.

Rheumatology (Oxford) 2021 May;60(Supplement_2):ii17-ii23

Department of Rheumatology, OMI (Medical Research Organization), Uruguay, Buenos Aires, Argentina.

Upadacitinib and filgotinib, two JAK1 selective drugs have undergone extensive phase III clinical trials in RA and have demonstrated rapid improvements in disease activity, function and patient reported outcomes. Six global phase III randomized controlled clinical trials (SELECT phase III program) evaluated the efficacy and safety of upadacitinib and four clinical phase III trials (the FINCH program) evaluated the efficacy and safety of filgotinib. This article is a critical review of all these studies with focus on the therapeutic efficacy in RA. Read More

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Nursing care for patient in post operatory heart surgery in the Intensive Care Unit.

Rev Bras Enferm 2021 3;74(2):e20200163. Epub 2021 May 3.

Universidade do Vale do Rio dos Sinos. Porto Alegre, Rio Grande do Sul, Brazil.

Objective: To investigate the critical nodes related to nursing care for patients in the postoperative period of cardiac surgery.

Methods: Exploratory study with a qualitative approach. Data collected through semi-structured interviews with 27 members of the nursing team working in the Intensive Care Unit. Read More

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Personalized analytics and wearable biosensor platform for early detection of COVID-19 decompensation (DeCODe: Detection of COVID-19 Decompensation): protocol for development of COVID-19 Decompensation Index.

JMIR Res Protoc 2021 May 4. Epub 2021 May 4.

University of Illinois Health, Chicago, US.

Background: During the COVID-19 pandemic, novel digital health technologies have the potential to improve our understanding of SARS Co-V2/ COVID-19, improve care delivery and produce better health outcomes. The National Institutes of Health called on digital health leaders to contribute to a high-quality data repository that will support the work of researchers to make discoveries not possible through small, limited data sets.

Objective: To this end, we seek to develop a COVID-19 digital biomarker that could provide early detection of a patient's physiologic worsening or decompensation. Read More

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Global birth defects app: An innovative tool for describing and coding congenital anomalies at birth in low resource settings.

Birth Defects Res 2021 May 5. Epub 2021 May 5.

National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.

Background: Surveillance programs in low- and middle-income countries (LMICs) have difficulty in obtaining accurate information about congenital anomalies.

Methods: As part of the ZikaPLAN project, an International Committee developed an app for the description and coding of congenital anomalies that are externally visible at birth, for use in low resource settings. The "basic" version of the app was designed for a basic clinical setting and to overcome language and terminology barriers by providing diagrams and photos, sourced mainly from international Birth Defects Atlases. Read More

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Systems biology for crop improvement.

Plant Genome 2021 May 5:e20098. Epub 2021 May 5.

Center of Excellence in Genomics & Systems Biology, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, Hyderabad, 502 324, India.

In recent years, generation of large-scale data from genome, transcriptome, proteome, metabolome, epigenome, and others, has become routine in several plant species. Most of these datasets in different crop species, however, were studied independently and as a result, full insight could not be gained on the molecular basis of complex traits and biological networks. A systems biology approach involving integration of multiple omics data, modeling, and prediction of the cellular functions is required to understand the flow of biological information that underlies complex traits. Read More

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Diplomatic activities of Iranian Nursing Organization: A qualitative study.

Nurs Forum 2021 May 5. Epub 2021 May 5.

Department of Medical Surgical Nursing, Nursing and Midwifery School, Birjand University of Medical Sciences, Birjand, Iran.

Background: Nursing organizations play an important role in fulfilling the professional demands of nurses. The Iranian Nursing Organization (INO) is also using diplomatic activities in this direction.

Aim: This study was conducted to explain the diplomatic activities of INO. Read More

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Values and preferences of contraceptive methods: a mixed-methods study among sex workers from diverse settings.

Sex Reprod Health Matters 2021 Dec;29(1):1913787

Technical Officer, World Health Organization, Geneva, Switzerland.

There is limited information on contraceptive values and preferences of sex workers. We conducted a mixed-method study to explore contraceptive values and preferences among sex workers. We conducted an online survey with individuals from 38 countries ( = 239), 6 focus group discussions (FGD,  = 68) in Zimbabwe, and 12 in-depth phone interviews (IDI) across 4 world regions, in June and July of 2019. Read More

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December 2021

Long-term consumer involvement in cancer research: Working towards partnership.

Health Expect 2021 May 5. Epub 2021 May 5.

Department of General Practice, Faculty of Medicine, Dentistry and Health Sciences, Primary Care Collaborative Cancer Clinical Trials Group, Centre for Cancer Research, University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, Vic., Australia.

Background: Meaningful consumer involvement in health research is important. There are limited data on how to maintain long-term consumer involvement.

Objective: To identify barriers and facilitators to meaningful long-term consumer involvement in research. Read More

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NeuroCrypt: Machine Learning Over Encrypted Distributed Neuroimaging Data.

Neuroinformatics 2021 May 4. Epub 2021 May 4.

Georgia State University, Atlanta, GA, USA.

The field of neuroimaging can greatly benefit from building machine learning models to detect and predict diseases, and discover novel biomarkers, but much of the data collected at various organizations and research centers is unable to be shared due to privacy or regulatory concerns (especially for clinical data or rare disorders). In addition, aggregating data across multiple large studies results in a huge amount of duplicated technical debt and the resources required can be challenging or impossible for an individual site to build. Training on the data distributed across organizations can result in models that generalize much better than models trained on data from any of organizations alone. Read More

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Usefulness of ultrasound in sub-Saharan patients with a serological diagnosis of schistosomiasis.

Infection 2021 May 4. Epub 2021 May 4.

Tropical Medicine Unit, Hospital de Poniente, Ctra de Almerimar 31, 04700, El Ejido, Almería, Spain.

Objective: To evaluate the usefulness of ultrasound examination in patients with just a serological diagnosis of schistosomiasis but no other evidence of active infection.

Methods: 346 sub-Saharan patients with possible schistosomiasis that presented at a Tropical Medicine Unit between 2008 and 2019 were retrospectively selected. Possible schistosomiasis was considered in those patients with a positive serology for schistosomasis in the absence of direct microbiological isolates, hematuria and/or eosinophilia. Read More

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The effects of energy poverty on economic growth: a panel data analysis for BRICS countries.

Environ Sci Pollut Res Int 2021 May 5. Epub 2021 May 5.

Department of Aviation Management, Faculty of Aeronautics and Astronautics, Erciyes University, Kayseri, Turkey.

Energy consumption is an indispensable element for the purpose of achieving economic growth. Clean energy sources must be put into use to achieve a sustainable environment. The aim of this study is to investigate the relationship among growth, energy consumption, employment, education, and inflation with PVAR, FMOLS, and DOLS analysis in BRICS countries. Read More

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Virtual Gastroenterology Fellowship Recruitment During COVID-19 and Its Implications for the Future.

Dig Dis Sci 2021 May 4. Epub 2021 May 4.

Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 702 Rotary Circle, Suite 225, Indianapolis, IN, 46202, USA.

Background And Aims: Amid the COVID-19 pandemic, medical education organizations endorsed a virtual recruitment format, representing a stark change from traditional in-person interviews. We aimed to identify the attitudes and perceptions of Gastroenterology Fellowship Program Directors (PDs) and applicants regarding the virtual interview experience and the role of virtual interviews (VI) in the future.

Methods: We designed separate surveys targeting PDs and applicants using the Qualtrics software. Read More

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Incidence and demographic characteristics of Syrian Civil War-related amputations: A multi-center study.

Turk J Phys Med Rehabil 2021 Mar 4;67(1):48-55. Epub 2021 Mar 4.

Istanbul Leprosy, Skin and Venereal Diseases Hospital, Istanbul, Turkey.

Objectives: The aim of this study was to identify the causes, levels, and rates of amputations performed in civilians during the Syrian Civil War and to present epidemiological data of the amputees.

Patients And Methods: Between August 2017 and February 2019, a total of 363 amputations of 307 amputees (266 males, 41 females; mean age 29.9±13. Read More

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Psychophysical data to study the brain network mechanisms involved in reorienting attention to salient events during goal-directed visual discrimination and search tasks.

Data Brief 2021 Jun 31;36:107020. Epub 2021 Mar 31.

Cognitive Brain Dynamics Laboratory, National Brain Research Centre, Manesar, NH-8, Gurugram, Haryana 122052, India.

This article presents behavior and EEG dataset collected from 19 healthy human volunteers (10 females) in the age group of 21-29 (mean = 26.9, SD = ±2.15) years at National Brain Research Centre, India during a psychophysical paradigm customized to characterize the brain network interactions during saliency processing. Read More

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Using attendance data for social network analysis of a community-engaged research partnership.

J Clin Transl Sci 2020 Dec 21;5(1):e75. Epub 2020 Dec 21.

Community and Collaboration Core, The Rockefeller University, Center for Clinical and Translational Science, New York, NY, USA.

Background: The Rockefeller University Center for Clinical and Translational Science (RU-CCTS) and Clinical Directors Network (CDN), a Practice-Based Research Network (PBRN), fostered a community-academic research partnership involving Community Health Center (CHCs) clinicians, laboratory scientists, clinical researchers, community, and patient partners. From 2011 to 2018, the partnership designed and completed Community-Associated Methicillin-Resistant Project (CAMP1), an observational study funded by the National Center for Advancing Translational Sciences (NCATS), and CAMP2, a Comparative Effectiveness Research Study funded by the Patient-Centered Outcomes Research Institute (PCORI). We conducted a social network analysis (SNA) to characterize this Community-Engaged Research (CEnR) partnership. Read More

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December 2020