267,859 results match your criteria organ transplantation


Efficacy and Safety of Washed Microbiota Transplantation to Treat Patients with Mild-to-Severe COVID-19 and Suspected of Having Gut Microbiota Dysbiosis: Study Protocol for a Randomized Controlled Trial.

Curr Med Sci 2021 Nov 30. Epub 2021 Nov 30.

Department of Gastroenterology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080, China.

Objective: Coronavirus disease 2019 (COVID-19) is often accompanied by gastrointestinal symptoms, which are related to gut microbiota dysbiosis (GMD). Whether washed microbiota transplantation (WMT) is an effective treatment for COVID-19 patients suspected of having GMD by restoring the gut microbiota is unknown. This study is designed to explore the efficacy and safety of WMT in COVID-19 patients suspected of having GMD. Read More

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November 2021

Editorial: Novel therapeutic approaches in chronic kidney disease and kidney transplantation: the draw of evolving integrated multimodal approaches in the targeted therapy era.

Curr Opin Nephrol Hypertens 2022 Jan;31(1):1-5

Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange.

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January 2022

Isolated nocturnal hypertension in pediatric kidney transplant recipients.

Pediatr Transplant 2021 Nov 29:e14192. Epub 2021 Nov 29.

Department of Pediatrics, Division of Pediatric Nephrology, Cohen Children's Medical Center, Northwell Health, New Hyde Park, New York, USA.

Background: Isolated nocturnal hypertension (INH) is defined as nighttime hypertension in the setting of normal daytime blood pressure (BP), diagnosed by ambulatory BP monitoring (ABPM).

Methods And Results: Hypertension affects 60%-80% of pediatric kidney transplant recipients, and INH is the most common type of ambulatory hypertension. INH is associated with an increased prevalence of hypertension-mediated target organ damage such as left ventricular hypertrophy in adults and in pediatric kidney transplant recipients. Read More

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November 2021

LDH and GGT/ALT Ratio as Novel Prognostic Biomarkers in Hepatocellular Carcinoma Patients after Liver Transplantation.

Comput Math Methods Med 2021 20;2021:9809990. Epub 2021 Nov 20.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Liver inflammation indices reflect its inflammatory microenvironment, which may play a role in the proliferation, invasion, and migration of carcinoma. This study is aimed at exploring the prognostic significance of serum lactate dehydrogenase (LDH) levels and gamma-glutamyl transferase (GGT)/alanine aminotransferase (ALT) ratio in hepatocellular carcinoma after liver transplant (LT).

Methods: We retrospectively analyzed data from 155 patients with a pathologically confirmed diagnosis of hepatocellular carcinoma who received LT between January 2013 and September 2017. Read More

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November 2021

Is tumour volume an independent predictor of outcome after radical prostatectomy for high-risk prostate cancer?

Prostate Cancer Prostatic Dis 2021 Nov 29. Epub 2021 Nov 29.

Imperial Urology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.

Background: Preoperative PSA, ISUP grade group (GG), prostate examination and multiparametric MRI (mpMRI) form the basis of prostate cancer staging. Unlike other solid organ tumours, tumour volume (TV) is not routinely used aside from crude estimates such as maximum cancer core length. The aim of this study is to assess the role of TV as a marker for oncological outcomes in high-risk non-metastatic prostate cancer. Read More

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November 2021

Towards regulatory cellular therapies in solid organ transplantation.

Trends Immunol 2021 Nov 26. Epub 2021 Nov 26.

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. Electronic address:

Organ transplantation is a modern medical success story. However, since its inception it has been limited by the need for pharmacological immunosuppression. Regulatory cellular therapies offer an attractive solution to these challenges by controlling transplant alloresponses through multiple parallel suppressive mechanisms. Read More

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November 2021

Identification of Anxiety and Depression Among Adolescent Kidney Transplant Recipients: A Cross-Sectional Observational Study.

J Pediatr Health Care 2021 Nov 26. Epub 2021 Nov 26.

Introduction: Studies demonstrate an association between mental health disorders and organ transplantation, with adolescents five times more likely to experience anxiety and depression than their nontransplant peers. The purpose of this study is to describe the prevalence of anxiety and depression in adolescent kidney transplant recipients using standardized mental health screening tools.

Method: The standardized screening tools, generalized anxiety disorder-7 for anxiety and Patient Health Questionnaire-9 for depression, were administered over 6 months to kidney transplant recipients aged 12-21 years during the transplant clinic visit. Read More

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November 2021

Uterine transplantation: A maternal-fetal medicine perspective.

Authors:
Steven J Ralston

Semin Perinatol 2021 Nov 9:151522. Epub 2021 Nov 9.

Vice Chair and Chief of Obstetrics, Department of OB/GYN, Howard University Hospital, Clinical Professor of OB/GYN, Howard University College of Medicine. Electronic address:

Uterine transplantation is a novel approach to solving a clinical problem faced by women with uterine factor infertility whose desire to parent includes a desire to give birth. The ethical precepts used for other solid organ transplants are helpful in developing normative frameworks for understanding this experimental therapy. Nevertheless, both fetal and neonatal risks complicate this calculus and therefore it is useful to incorporate analyses used in other realms of maternal-fetal medicine to understand and justify this research. Read More

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November 2021

The attitude towards organ donation: Differences between students of medicine and nursing. A preliminary study at Unizkm - Catholic University "Our Lady of Good Counsel" of Tirana.

Nurse Educ Today 2021 Nov 8:105208. Epub 2021 Nov 8.

Department of Clinical, Diagnostic and Pediatric Sciences. University of Pavia, Italy; IRCCS Policlinico San Matteo Foundation, General Surgery, Pavia, Italy. Electronic address:

Background: A favourable attitude towards organ donation and transplantation is fundamental among health professionals to promote consent, especially in a young healthcare system like Albania.

Objective: To analyse the differences in the attitude towards organ donation and transplantation and the influencing factors among medical doctors- and nurses-to-be.

Methods And Design: The article is based on an observational, descriptive, cross-sectional study. Read More

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November 2021

The Audiovisual Creation in Educational Proposals on Organ Donation: Attitude Towards Organ Donation and Transplantation of Secondary School Teachers.

Transplant Proc 2021 Nov 26. Epub 2021 Nov 26.

Transplant Unit, General Surgery Service, Virgen de la Arrixaca University Hospital, Murcia, Spain, Instituto Murciano de Investigaciones Biosanitaria IMIB-Arrixaca, Murcia, Spain; Department of Surgery, Pediatrics, Gynecology and Obstetrics, School of Medicine, University of Murcia, Murcia, Spain.

Background: Audiovisual creation allows teachers and students to become consumers and producers of information, creating collaborative environments. In the field of organ donation and transplantation (ODT), most of the educational proposals analyzed to date consist of presentations. The teacher does not usually have a decisive role in this type of methodologies, in addition to not having the appropriate training to be able to participate actively. Read More

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November 2021

Waiting time and mortality rate on lung transplant candidates in Japan: a single-center retrospective cohort study.

BMC Pulm Med 2021 Nov 29;21(1):390. Epub 2021 Nov 29.

Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University Hospital, 4-1 Seiryomachi, Sendai, Miyagi, 980-8575, Japan.

Background: As lung transplantation (LTX) is a valuable treatment procedure for end-stage pulmonary disease, delayed referral to a transplant center should be avoided. We aimed to conduct a single-center analysis of the survival time after listing for LTX and waitlist mortality in each disease category in a Japanese population.

Methods: We included patients listed for LTX at Tohoku University Hospital from January 2007 to December 2020 who were followed up until March 2021. Read More

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November 2021

New insights on the monitoring of solid-organ allografts based on immune cell signatures.

Transpl Immunol 2021 Nov 26:101509. Epub 2021 Nov 26.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.. Electronic address:

Attaining a fair long-term allograft survival remains a challenge for allogeneic transplantation worldwide. Although the emergence of immunosuppressants has caused noticeable progress in the management of immunologic rejection, proper application of these therapeutics and dose adjustments require delicate and real-time monitoring of recipients. Nevertheless, the majority of conventional allograft monitoring approaches are based on organ damage or functional tests that render them unable to predict the rejection events in early time points before the establishment of a functional alloimmune response. Read More

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November 2021

Role of the macula densa sodium glucose cotransporter type 1-nitric oxide synthase 1-tubuloglomerular feedback pathway in diabetic hyperfiltration.

Kidney Int 2021 Nov 26. Epub 2021 Nov 26.

Department of Molecular Pharmacology & Physiology, College of Medicine, University of South Florida, Tampa, FL.

An increase of glomerular filtration rate (GFR) is a common observation in early diabetes and is considered a key risk factor for subsequent kidney injury. However, the mechanisms underlying diabetic hyperfiltration have not been fully clarified. Here, we tested the hypothesis that macula densa neuronal nitric oxide synthase (NOS1) is upregulated via sodium glucose cotransporter type 1 (SGLT1) in diabetes, which then inhibits tubuloglomerular feedback (TGF) promoting glomerular hyperfiltration. Read More

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November 2021

Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study.

Lancet Respir Med 2021 Nov 26. Epub 2021 Nov 26.

CHU Necker Enfants Malades-APHP, Paris, France.

Background: Patients with severe COVID-19 have emerged as a population at high risk of invasive fungal infections (IFIs). However, to our knowledge, the prevalence of IFIs has not yet been assessed in large populations of mechanically ventilated patients. We aimed to identify the prevalence, risk factors, and mortality associated with IFIs in mechanically ventilated patients with COVID-19 under intensive care. Read More

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November 2021

West Nile Virus Transmission by Solid Organ Transplantation and Considerations for Organ Donor Screening Practices, United States.

Emerg Infect Dis 2021 Nov 29;28(2). Epub 2021 Nov 29.

West Nile virus (WNV) is the most common domestic arbovirus in the United States. During 2018, WNV was transmitted through solid organ transplantation to 2 recipients who had neuroinvasive disease develop. Because of increased illness and death in transplant recipients, organ procurement organizations should consider screening during region-specific WNV transmission months. Read More

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November 2021

Invasive pulmonary aspergillosis in solid organ transplant patients in the ICU.

Transpl Infect Dis 2021 Nov 29. Epub 2021 Nov 29.

Dept. of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Introduction: Solid organ transplantation (SOT) is a well-known risk factor for invasive pulmonary aspergillosis (IPA). We report on the epidemiology and outcome of SOT patients with IPA in an ICU setting.

Methods: This is a secondary study based on a subset of SOT-patients from a prospective observational multicenter cohort (the AspICU project) including ICU patients with at least one Aspergillus spp. Read More

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November 2021

Heterogeneity in transplant center responses to the minimum acceptance criteria across UNOS regions.

Clin Transplant 2021 Nov 29:e14551. Epub 2021 Nov 29.

Harvard Medical School, Boston, MA, USA.

Transplantation of organs from increased risk donors for infection transmission (IRDs) is increasing. These organs confer survival benefit to recipients. This study examined transplant center acceptance policies for IRD kidneys across United Network for Organ Sharing (UNOS) regions, based on transplant centers' annual responses to the Minimum Acceptance Criteria (MAC) for acceptance of IRD kidneys, and the association with national and regional IRD kidney utilization. Read More

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November 2021

HVAD versus heartmate III bridge to heart transplantation: waitlist and posttransplant outcomes.

Clin Transplant 2021 Nov 29:e14546. Epub 2021 Nov 29.

Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Background: This study compared outcomes of patients bridged with either the Heartware HVAD versus Heartmate 3 (HM3) device to orthotopic heart transplantation (OHT).

Methods: The United Network of Organ Sharing registry was queried to perform two separate analyses of adult, isolated OHT candidates bridged with HVAD or HM3. First, waitlist outcomes were compared among patients waitlisted 1/1/2015-3/20/2020. Read More

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November 2021

Imaging of Biliary Involvement in Sarcoidosis: Computed Tomography, Magnetic Resonance Cholangiopancreatography, and Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid-Enhanced Magnetic Resonance Imaging Findings.

Tomography 2021 Nov 13;7(4):783-791. Epub 2021 Nov 13.

Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Sarcoidosis is a multisystem disease usually affecting the chest, hilar lymph nodes, and lungs, but can potentially involve any organ; therefore, its clinical presentation may vary. Hepatobiliary involvement is rare, and typically asymptomatic; however, it can lead to cirrhosis, and may require liver transplantation. In this report, we present a rare case of a patient affected by sarcoidosis with hepatobiliary involvement. Read More

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November 2021

Skin Mycetoma in an 11-Year-Old African Boy: Case Presentation with Emphasis on Histopathological Features and Differential Diagnosis.

Dermatopathology (Basel) 2021 Oct 26;8(4):509-514. Epub 2021 Oct 26.

Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, 70124 Bari, Italy.

Mycetoma is an uncommon, chronic infective disease of the skin and subcutaneous tissues, characterized by the triad of tumefaction, draining sinuses, and the presence in the exudate of colonial grains. In cases of long-term disease, the presence of colonial grains together with the host's derivative material can lead to the formation of real sinuses. Histological analysis is of fundamental importance to allow an accurate etiological diagnosis and to understand if the basic pathogen is an actinomycete (bacterium) or a real fungus (eumycetic mycetomas) and is also fundamental for therapy, which is quite different. Read More

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October 2021

Engineering non-covalently assembled protein nanoparticles for long-acting gouty arthritis therapy.

J Mater Chem B 2021 Nov 29. Epub 2021 Nov 29.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

As an incurable metabolic disease, gouty arthritis (GA) requires long-term treatment with frequent drug administration several times per day. Compared to non-specific small organic medications, interleukin-1β (IL-1β) blocking therapies, such as IL-1 receptor antagonist (IL-1Ra), show great therapeutic potential in clinical trials of GA. However, IL-1Ra application is starkly limited due to its short half-life and poor bioavailability. Read More

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November 2021

[Culture and application of thymic organoids: a review].

Sheng Wu Gong Cheng Xue Bao 2021 Nov;37(11):3945-3960

Shanghai Biomass Pharmaceutical Product Evaluation Professional Public Service Platform, Center for Pharmacological Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai 200437, China.

The thymus is a pivotal immune organ of the human body, and it is the place where T cells differentiate and mature. The damage of thymus would easily induce autoimmune diseases and even malignant tumors. For years, researchers have been exploring the process of T cell development and revealing the mechanism of thymic injury and regeneration generally through the monolayer culture system of T cells in vitro. Read More

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November 2021

Deep phenotyping of T cell populations under long-term treatment of tacrolimus and rapamycin in patients receiving renal transplantations by mass cytometry.

Clin Transl Med 2021 11;11(11):e629

State Key Laboratory of Oncogenes and Related Genes, School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Tacrolimus (FK506) and rapamycin (RAPA) are widely used to maintain long-term immunosuppression after organ transplantation. However, the impact of accumulative drug administration on the recipients' immune systems remains unclear. We investigated the impact of 3-year FK506 or RAPA treatment after renal transplantation on the human immune systems. Read More

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November 2021

GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma.

Clin Transl Med 2021 11;11(11):e635

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.

Background: Aberrant TAK1 (transforming growth factor β-activated kinase 1) activity is known to be involved in a variety of malignancies, but the regulatory mechanisms of TAK1 remain poorly understood. GRAMD4 (glucosyltransferase Rab-like GTPase activator and myotubularin domain containing 4) is a newly discovered p53-independent proapoptotic protein with an unclear role in HCC (hepatocellular carcinoma).

Results: In this research, we found that GRAMD4 expression was lower in HCC samples, and its downregulation predicted worse prognosis for patients after surgical resection. Read More

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November 2021

Challenges for expansion of thoracic transplant clinical pharmacy in a developing country: comparison with U.S. accredited centres and call for action.

J Clin Pharm Ther 2021 Nov 28. Epub 2021 Nov 28.

Division of Cardiology, Graduate Studies in Cardiovascular Sciences, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

What Is Known And Objective: Clinical pharmacists' involvement in the care of solid organ transplant recipients has been discussed worldwide given its potential to improve clinical outcomes. As thoracic transplant activity grows in Brazil, it is important to understand how pharmacists are inserted in transplant programmes nationwide. We conducted a survey to explore clinical pharmacy activities in thoracic transplant centres in Brazil and compared them with accredited programmes in the United States. Read More

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November 2021

Primary Hyperoxaluria Type 1 (PH1) Presenting With End-Stage Kidney Disease and Cutaneous Manifestations in Adulthood: A Case Report.

Can J Kidney Health Dis 2021 22;8:20543581211058931. Epub 2021 Nov 22.

Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Rationale: Primary hyperoxaluria (PH) is a rare autosomal recessive disorder more commonly diagnosed in children or adolescents. Owing to its rarity and heterogeneous phenotype, it is often underrecognized, resulting in delayed diagnosis, including diagnosis after end-stage kidney disease (ESKD) has occurred or recurrence after kidney-only transplantation.

Case Presentation: A 40-year-old Caucasian Canadian woman with a history of recurrent nephrolithiasis since age 19 presented with ESKD and cutaneous symptoms. Read More

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November 2021

Association between the Three Polymorphisms of the Glucocorticoid Receptor Gene and the Early Clinical Outcome in Kidney Transplantation Patients.

Iran J Med Sci 2021 Nov;46(6):444-453

Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Glucocorticoids are pivotal components of immunosuppressive regimens in solid organ transplantations. This study aimed to assess the possible association between the ER22/23EK, N363S, and Bcl1 polymorphisms, and short-term clinical outcomes, including acute rejection and delayed graft function (DGF), in kidney transplantation recipients.

Methods: A case-control study was conducted in a two-year period on adults with transplanted kidneys, comprised of subjects without rejection (n=50, control) and those with documented rejection within one year after transplantation (n=50, case), between April 2017 and September 2018, in Shiraz, Iran. Read More

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November 2021

Pediatric liver failure with massive sinusoidal infiltration of histiocytes.

J Clin Exp Hematop 2021 Nov 26. Epub 2021 Nov 26.

Department of Clinical Research, Saitama Children's Medical Center, Saitama, Japan.

Histiocytic neoplasms, such as Langerhans cell histiocytosis (LCH) and disseminated juvenile xanthogranuloma (JXG), can involve the liver and sometimes cause liver failure. We aimed to classify non-LCH histiocytic proliferating disorders that do not exhibit typical disseminated JXG histology. We examined four pediatric patients who presented with liver failure and splenomegaly. Read More

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November 2021

A retrievable, dual-chamber stent protects against warm ischemia of donor organs in a model of donation after circulatory death.

Surgery 2021 Nov 25. Epub 2021 Nov 25.

Division of Vascular Surgery, University of Pittsburgh Medical Center, PA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, PA; Department of Surgery, University of Pittsburgh Medical Center, PA; Division of Vascular Surgery, Ohio State University Wexner Medical Center, Columbus, OH. Electronic address:

Background: Ischemic injury during the agonal period of donation after circulatory death donors remains a significant barrier to increasing abdominal transplants. A major obstacle has been the inability to improve visceral perfusion, while at the same time respecting the ethics of the organ donor. A retrievable dual-chamber stentgraft could potentially isolate the organ perfusion from systemic hypotension and hypoxia, without increasing cardiac work or committing the donor. Read More

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November 2021

[Comparison of the efficacy of different venous intubation in venous-arterial extracorporeal membrane oxygenation assisted lung transplantation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Sep;33(9):1080-1083

Department of Cardiac Surgery, People's Hospital of Henan Province, People's Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Disease Hospital, Zhengzhou 450000, Henan, China. Corresponding author: Cheng Zhaoyun, Email:

Objective: To compare the curative effects of different venous cannulas and drainage to improve patient's whole body oxygenation during the auxiliary process of venous-arterial extracorporeal membrane oxygenation (VA-ECMO) in lung transplantation.

Methods: From December 2016 to December 2019, 12 patients who were assisted by VA-ECMO in one lung transplantation in People's Hospital of Henan Province were selected as the research objects. According to the number of side holes of venous cannulas, they were divided into two groups: one group with few side holes and other group with multiple side holes. Read More

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September 2021