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Time to say good-bye? Homeopathy, skeptics and thoughts on how to proceed.

J Complement Integr Med 2021 May 6. Epub 2021 May 6.

homöopathie-pannek, Basel, Switzerland.

Background: Although homeopathy is frequently used by many health professionals, there are ongoing debates concerning its effectiveness. Currently no unifying explanation how homeopathy works exists. Homeopaths are frequently challenged by skeptics, and in public opinion, the swan song for homeopathy is frequently sung. Read More

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Photon-in/Photon-out Spectroscopy at the I20-Scanning Beamline at Diamond Light Source.

J Phys Condens Matter 2021 May 6. Epub 2021 May 6.

Science Division, Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, Oxon, OX11 0DE, Didcot, Oxfordshire, OX11 0DE, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

A scanning multi-crystal x-ray emission spectrometer to perform photon-in/photon-out spectroscopy at the I20-Scanning beamline at Diamond Light Source is described. The instrument, equipped with three analyzer crystals, is based on a 1m Rowland circle spectrometer operating in the vertical plane. The energy resolution of the spectrometer is of the order of 1 eV, having sufficient resolving power to overcome the core-hole lifetime broadening of most of the transition metals K-edges. Read More

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Charge transfer across biomembranes: A solution to the conundrum of high desolvation free energy penalty in ion transport.

Sunil Nath

Biophys Chem 2021 Apr 28;275:106604. Epub 2021 Apr 28.

Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India. Electronic address:

Charge transfer across membranes is an important problem in a wide variety of fundamental physicochemical and biological processes. Since Mitchell's concept of the ion well advanced in 1968, several models of ion translocation across biomembranes, for instance through the membrane-bound F portion of ATP synthase have been proposed. None of these models has considered the large desolvation free energy penalty of ~500 meV incurred in transferring a protonic charge from the aqueous phase into the membrane that hinders such charge transfer processes. Read More

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Care for Incarcerated Patients Hospitalized with COVID-19.

J Gen Intern Med 2021 May 5. Epub 2021 May 5.

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

The COVID-19 pandemic has reshaped health care delivery for all patients but has distinctly affected the most marginalized people in society. Incarcerated patients are both more likely to be infected and more likely to die from COVID-19. There is a paucity of guidance for the care of incarcerated patients hospitalized with COVID-19. Read More

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Missing Value Monitoring to Address Missing Values in Quantitative Proteomics.

Methods Mol Biol 2021 ;2228:401-408

IFOM, FIRC Institute of Molecular Oncology, Milan, Italy.

Many classes of key functional proteins such as transcription factors or cell cycle proteins are present in the proteome at a very low concentration. These low-abundance proteins are almost entirely invisible to systematic quantitative analysis by classical data dependent proteomics methods (DDA). Moreover, DDA runs in shotgun proteomics experiments are plenty of missing values among the replicates due to the stochastic nature of the acquisition method, thus hampering the robustness of the quantitative analysis. Read More

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January 2021

Chitosan and chitosan/PEG nanoparticles loaded with indole-3-carbinol: Characterization, computational study and potential effect on human bladder cancer cells.

Mater Sci Eng C Mater Biol Appl 2021 May 31;124:112089. Epub 2021 Mar 31.

Tiradentes University - UNIT, Av. Murilo Dantas 300, 49032-490 Aracaju, SE, Brazil; Institute of Technology and Research - ITP, Av. Murilo Dantas 300, 49032-490 Aracaju, SE, Brazil. Electronic address:

Indole-3-carbinol (I3C) is a plant molecule known to be active against several types of cancer, but some chemical characteristics limit its clinical applications. In order to overcome these limitations, polymeric nanoparticles can be used as carrier systems for targeted delivery of I3C. In this study, chitosan and chitosan/polyethylene glycol nanoparticles (CS NP and CS/PEG NP, respectively) were prepared to encapsulate I3C by ionic gelation method. Read More

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Cultural implications for disclosure of diagnosis and prognosis toward terminally ill cancer patients in China: A literature review.

Palliat Support Care 2021 May 5:1-7. Epub 2021 May 5.

Faculty of Medicine, Department of Palliative Care, RWTH Aachen University, Aachen, Germany.

Objective: Health professionals in China tend to avoid open communication with terminally ill cancer patients concerning their diagnosis and prognosis. This review aims to explore Chinese cultural beliefs and attitudes concerning disclosure and death among health professionals and cancer patients in China and to investigate preferences of terminally ill cancer patients for a "good death."

Method: A narrative literature review was conducted in May 2020 on MEDLINE, EMBASE, and WEB OF SCIENCE to include all studies with clear study design which presented its own study data or referred to data within underlying studies, published between January 2000 and May 2020, having cancer patients and/or healthcare professionals as participants, conducted in Mainland China, Hong Kong, or Taiwan and containing relevant data concerning "medical disclosure" or "good death. Read More

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Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management.

Nutrients 2021 Apr 29;13(5). Epub 2021 Apr 29.

Agroscope, Federal Department of Economic Affairs, Education and Research EAER, 3003 Bern, Switzerland.

Recent discoveries in the "omics" field and the growing focus on preventive health have opened new avenues for personalized nutrition (PN), which is becoming an important theme in the strategic plans of organizations that are active in healthcare, food, and nutrition research. PN holds great potential for individual health optimization, disease management, public health interventions, and product innovation. However, there are still multiple challenges to overcome before PN can be truly embraced by the public and healthcare stakeholders. Read More

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Bulb Dormancy In Vitro-: Initiation, Release and Physiological Parameters.

Plants (Basel) 2021 Apr 30;10(5). Epub 2021 Apr 30.

Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.

In ornamental geophytes, conventional vegetative propagation is not economically feasible due to very slow development and ineffective methods. It can take several years until a new plant is formed and commercial profitability is achieved. Therefore, micropropagation techniques have been developed to increase the multiplication rate and thus shorten the multiplication and regeneration period. Read More

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Micro and nanoemulsions of Carissa spinarum fruit polyphenols, enhances anthocyanin stability and anti-quorum sensing activity: Comparison of degradation kinetics.

Food Chem 2021 Apr 20;359:129876. Epub 2021 Apr 20.

Plant Cell Biotechnology Department, Council of Scientific and Industrial Research - Central Food Technological Research Institute, Mysuru 570020, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; University of Mysore, Mysuru 570005, India. Electronic address:

The low stability of anthocyanins is a constraint in the food industry. The present work has been carried out to overcome this low stability by encapsulating fruit concentrate of underutilized plant Carissa spinarum (CS) with polyphenols in microemulsions (CSME) and nanoemulsions (CSNE). Increasing the amount of CS reduced the particle size from 1154 to 70-300 nm whereas addition of Tween 80 reduced it optimally to 5-25 nm. Read More

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Methodological and technical considerations for video-based auditing of hand hygiene compliance in clinical practice: an exploratory study.

Am J Infect Control 2021 Apr 30. Epub 2021 Apr 30.

Faculty of Medicine and Health, Susan Wakil School of Nursing and Midwifery, University of Sydney, Camperdown, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, Faculty of Medicine and Health, University of Sydney, NSW, Australia; Department of Infection Prevention and Control, Division of Infectious Diseases and Sexual Health, Westmead Hospital and Western Sydney Local Health District, Westmead, NSW, Australia; New South Wales Biocontainment Centre, Western Sydney Local Health District and New South Wales Health, NSW, Australia.

Background: Direct observation is the gold standard method for measuring hand hygiene compliance but its utility is increasingly being questioned. Various alternative electronic methods have been proposed, yet there is a paucity of research examining the use of these according to the World Health Organization's (WHO) '5 Moments for Hand Hygiene'. As a part of the process of developing a video-based monitoring system (VMS) capable of measuring hand hygiene compliance against the 5 moments criteria this paper reports methodological and technical issues that might arise from the use of a VMS for auditing in clinical practice. Read More

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Physical Demands of Women's Soccer Matches: A Perspective Across the Developmental Spectrum.

Front Sports Act Living 2021 16;3:634696. Epub 2021 Apr 16.

Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.

Female soccer players are exposed to specific physical demands during matches, which vary according to the standard of play. Existing studies have largely focused on quantifying the distances covered for professional and international level players. This approach is limited in scope regarding the broader aspects around physical demands and is detached from development pathway models. Read More

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Microbial Nano-Factories: Synthesis and Biomedical Applications.

Front Chem 2021 16;9:626834. Epub 2021 Apr 16.

Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry, Indian Institute of Technology Delhi, New Delhi, India.

In the recent times, nanomaterials have emerged in the field of biology, medicine, electronics, and agriculture due to their immense applications. Owing to their nanoscale sizes, they present large surface/volume ratio, characteristic structures, and similar dimensions to biomolecules resulting in unique properties for biomedical applications. The chemical and physical methods to synthesize nanoparticles have their own limitations which can be overcome using biological methods for the synthesis. Read More

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Antimicrobial mechanisms and applications of yeasts.

Adv Appl Microbiol 2021 13;114:37-72. Epub 2020 Dec 13.

Teagasc Food Research Centre, Moorepark, Fermoy, Ireland. Electronic address:

Yeasts and humans have had a close relationship for millenia. Yeast have been used for food production since the first human societies. Since then, alternative uses have been discovered. Read More

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December 2020

Short-term prediction of future continuous glucose monitoring readings in type 1 diabetes: Development and validation of a neural network regression model.

Int J Med Inform 2021 Apr 24;151:104472. Epub 2021 Apr 24.

Department of Health Science and Technology, Aalborg University, Denmark.

Background And Objective: CGM systems are still subject to a time-delay, which especially during rapid changes causes clinically significant difference between the CGM and the actual BG level. This study had the aim of exploring the potential of developing and validating a model for prediction of future CGM measurements in order to overcome the time-delay.

Methods: An artificial neural network regression (NN) approach were used to predict CGM values with a lead-time of 15 min. Read More

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Manipulating macrophage polarization in cancer patients: From nanoparticles to human chimeric antigen receptor macrophages.

Biochim Biophys Acta Rev Cancer 2021 Apr 29;1876(1):188547. Epub 2021 Apr 29.

Oncology Unit, Macerata Hospital, via Santa Lucia 2, 62100 Macerata, Italy. Electronic address:

Chimeric antigen receptor (CAR) T cell treatment has provided notable results in hematological tumors. Unfortunately, this evidence has not been translated into improved outcomes in solid malignancies so far, where several reports have suggested that T cells encounter substantial difficulties in penetrating and surviving in the tumor microenvironment (TME). Thus, researchers have recently investigated other immune cell types as CAR platforms, in order to overcome the limitations of CAR T cells. Read More

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Virtual-Reality Performance-Based Assessment of Cognitive Functions in Adult Patients With Acquired Brain Injury: A Scoping Review.

Neuropsychol Rev 2021 Apr 30. Epub 2021 Apr 30.

Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy.

Individuals with acquired brain injury (ABI) commonly present with impairments in cognitive abilities. As these competencies seem to be predictive of patients' abilities to reintegrate into the everyday settings, it is crucial to assess them properly. However, previous research has indicated that patients may perform relatively well on standard tests of cognitive functioning, but may nonetheless encounter significant difficulties in organizing and executing everyday tasks. Read More

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Computed tomography imaging spectrometry based on superiorization and guided image filtering.

Opt Lett 2021 May;46(9):2208-2211

Computed tomography imaging spectrometry (CTIS) is a snapshot hyperspectral imaging technique that can obtain a three-dimensional (${2D +}\lambda$) data cube of the target scene within a single exposure. Previous studies of CTIS suggest that reconstructions usually suffer from severe artifacts due to the limited number of projections available. To overcome this limitation, an iterative algorithm combining superiorization and guided image filtering is proposed to explore the intrinsic properties of the hyperspectral data cube as well as the characteristics of zero-order diffraction for the first time, to the best of our knowledge. Read More

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Material selection in design for deconstruction using Kano model, fuzzy-AHP and TOPSIS methodology.

Waste Manag Res 2021 Apr 30:734242X211013904. Epub 2021 Apr 30.

Department of Building and Architectural Engineering, Politecnico di Milano, Milan, Italy.

During last decade, design for deconstruction (DfD) has attracted the attention of researchers and project managers as an environmentally friendly alternative to the conventional demolition of buildings. Yet, the intensity of raw materials consumption, waste generation and greenhouse gas (GhG) emission in the construction industry proves that current methods of selecting building components have failed to make the deconstruction effectively feasible. Specifically, in the material selection process, most research studies concentrate on assessing environmental and economic aspects while in selecting material for DfD various factors must be considered. Read More

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Cost-Effective Machine Learning Based Clinical Pre-Test Probability Strategy for DVT Diagnosis in Neurological Intensive Care Unit.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211008650

439679West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China.

In order to overcome the shortage of the current costly DVT diagnosis and reduce the waste of valuable healthcare resources, we proposed a new diagnostic approach based on machine learning pre-test prediction models using EHRs. We examined the sociodemographic and clinical factors in the prediction of DVT with 518 NICU admitted patients, including 189 patients who eventually developed DVT. We used cross-validation on the training data to determine the optimal parameters, and finally, the applied ROC analysis is adopted to evaluate the predictive strength of each model. Read More

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How Quality Control Systems AID Sec-Dependent Protein Translocation.

Front Mol Biosci 2021 13;8:669376. Epub 2021 Apr 13.

School of Biosciences and the Institute for Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.

The evolutionarily conserved Sec machinery is responsible for transporting proteins across the cytoplasmic membrane. Protein substrates of the Sec machinery must be in an unfolded conformation in order to be translocated across (or inserted into) the cytoplasmic membrane. In bacteria, the requirement for unfolded proteins is strict: substrate proteins that fold (or misfold) prematurely in the cytoplasm prior to translocation become irreversibly trapped in the cytoplasm. Read More

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COVID-19 in Singapore: Our Experience as a Country, and at Singapore General Hospital's Department of Emergency Medicine.

J Acute Med 2021 Mar;11(1):1-11

Singapore General Hospital Department of Emergency Medicine Singapore.

COVID-19 has changed our lives as we knew it. The world is not naive to infectious disease outbreaks, having experienced pandemics such as the H1N1 outbreak in 2009 with up to 400,000 deaths, and the "Spanish flu" in 1919 with up to 50 million deaths worldwide respectively (https://www.euro. Read More

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Combination of Cyclosporine A and Levosimendan Induces Cardioprotection under Acute Hyperglycemia.

Int J Mol Sci 2021 Apr 26;22(9). Epub 2021 Apr 26.

Department of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.

Prognosis of patients with myocardial infarction is detrimentally affected by comorbidities like diabetes mellitus. In the experimental setting, not only diabetes mellitus but also acute hyperglycemia is shown to hamper cardioprotective properties by multiple pharmacological agents. For Levosimendan-induced postconditioning, a strong infarct size reducing effect is demonstrated in healthy myocardium. Read More

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In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment.

Cells 2021 Apr 26;10(5). Epub 2021 Apr 26.

Department of Hematology and Oncology, Children's Hospital, University Hospital Tuebingen, 72076 Tuebingen, Germany.

Background: Melanoma is the most lethal of all skin-related cancers with incidences continuously rising. Novel therapeutic approaches are urgently needed, especially for the treatment of metastasizing or therapy-resistant melanoma. CAR-modified immune cells have shown excellent results in treating hematological malignancies and might represent a new treatment strategy for refractory melanoma. Read More

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Enhancing COVID-19 Vaccines Acceptance: Results from a Survey on Vaccine Hesitancy in Northern Italy.

Vaccines (Basel) 2021 Apr 13;9(4). Epub 2021 Apr 13.

Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.

In March 2021, the coronavirus disease 2019 (COVID-19) pandemic still poses a threat to the global population, and is a public health challenge that needs to be overcome. Now more than ever, action is needed to tackle vaccine hesitancy, especially in light of the availability of effective and safe vaccines. A cross-sectional online survey was carried out on a representative random sample of 1011 citizens from the Emilia-Romagna region, in Italy, in January 2021. Read More

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Bhattacharyya Parameter of Monomial Codes for the Binary Erasure Channel: From Pointwise to Average Reliability.

Sensors (Basel) 2021 Apr 23;21(9). Epub 2021 Apr 23.

Faculty of Exact Sciences, Aurel Vlaicu University of Arad, 2 Elena Dragoi Street, 310130 Arad, Romania.

Monomial codes were recently equipped with partial order relations, a fact that allowed researchers to discover structural properties and efficient algorithm for constructing polar codes. Here, we refine the existing order relations in the particular case of the binary erasure channel. The new order relation takes us closer to the ultimate order relation induced by the pointwise evaluation of the Bhattacharyya parameter of the synthetic channels, which is still a partial order relation. Read More

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A Joint Energy Replenishment and Data Collection Strategy in Heterogeneous Wireless Rechargeable Sensor Networks.

Sensors (Basel) 2021 Apr 22;21(9). Epub 2021 Apr 22.

The College of Information Science and Technology, Nanjing Forestry University, Nanjing 210037, China.

In wireless rechargeable sensor networks, mobile vehicles (MVs) combining energy replenishment and data collection are studied extensively. To reduce data overflow, most recent work has utilized more vehicles to assist the MV to collect buffered data. However, the practical network environment and the limitations of the vehicle in the data collection are not considered. Read More

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Photoplethysmography in Normal and Pathological Sleep.

Sensors (Basel) 2021 Apr 22;21(9). Epub 2021 Apr 22.

Department of Pulmonary Medicine, CHU Brugmann, Université Libre de Bruxelles (ULB), 1020 Brussels, Belgium.

This article presents an overview of the advancements that have been made in the use of photoplethysmography (PPG) for unobtrusive sleep studies. PPG is included in the quickly evolving and very popular landscape of wearables but has specific interesting properties, particularly the ability to capture the modulation of the autonomic nervous system during sleep. Recent advances have been made in PPG signal acquisition and processing, including coupling it with accelerometry in order to construct hypnograms in normal and pathologic sleep and also to detect sleep-disordered breathing (SDB). Read More

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Calculation Method of Permanent Deformation of Asphalt Mixture Based on Interval Number.

Materials (Basel) 2021 Apr 22;14(9). Epub 2021 Apr 22.

College of Materials Science and Engineering, Hunan University, Changsha 410082, China.

There are great uncertainties in road design parameters, and the traditional point numerical calculation results cannot reflect the complexity of the actual project well. Additionally, the calculation method of road design theory based on interval analysis is more difficult in the use of uncertain design parameters. In order to simplify the calculation process of the interval parameters in the road design theory, the asphalt pavement design is taken as the analysis object, and the permanent deformation of the asphalt mixture is simplified by combining the interval analysis theory. Read More

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Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing.

Int J Mol Sci 2021 Apr 19;22(8). Epub 2021 Apr 19.

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.

Millions of experimental animals are widely used in the assessment of toxicological or biological effects of manufactured nanomaterials in medical technology. However, the animal consciousness has increased and become an issue for debate in recent years. Currently, the principle of the 3Rs (i. Read More

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