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Effects of Mediterranean Diet on plasma metabolites and their relationship with insulin resistance and gut microbiota composition in a crossover randomized clinical trial.

Clin Nutr 2021 Apr 27;40(6):3798-3806. Epub 2021 Apr 27.

Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Rovira i Virgili (URV), Reus, Spain; Institute of Health Pere Virgili, IISPV, University Hospital Sant Joan, Reus, Spain; Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background & Aims: The Mediterranean Diet (MedDiet) may decrease the cardiometabolic risk through modulation of metabolic pathways. Furthermore, the interplay between MedDiet, metabolites and microbial metabolism may improve our understanding on the metabolic effects of this diet. We aimed to evaluate the effect of the MedDiet compared to nuts supplementation on circulating metabolites and their relationship with cardiometabolic health. Read More

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Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs.

Mol Cell Proteomics 2021 Jun 12:100109. Epub 2021 Jun 12.

Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Many small open reading frames (smORFs) embedded in lncRNA transcripts have been shown to encode biologically functional polypeptides (smORFs-encoded polypeptides, SEPs) in different organisms. Despite significant advances in genomics, bioinformatics and proteomics that largely enabled the discovery of novel SEPs, their identification across different biological samples is still hampered by their poor predictability, diminutive size and low relative abundance. Here, we take advantage of NONCODE, a repository containing the most complete collection and annotation of lncRNA transcripts from different species, to build a novel database that attempts to maximize a collection of SEPs from human and mouse lncRNA transcripts. Read More

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Pitfalls in HLA ligandomics - How to catch a li(e)gand.

Mol Cell Proteomics 2021 Jun 12:100110. Epub 2021 Jun 12.

Immatics Biotechnologies GmbH, Paul-Ehrlich-Str. 15-17, 72076 Tübingen, Germany; Immatics US, Inc. 2201 W. Holcombe Blvd., Suite 205, Houston, Texas 77030, USA. Electronic address:

Knowledge about the peptide repertoire presented by human leukocyte antigens (HLA) holds the key to unlock target-specific cancer immunotherapies like adoptive cell therapies or bispecific T cell engaging receptors. Therefore, comprehensive and accurate characterization of HLA peptidomes by mass spectrometry (immunopeptidomics) across tissues and disease states is essential. With growing numbers of immunopeptidomics datasets and the scope of peptide identification strategies reaching beyond the canonical proteome, the likelihood for erroneous peptide identification as well as false annotation of HLA-independent peptides as HLA ligands is increasing. Read More

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Treatment of open tibia fractures in Sub-Saharan African countries : a systematic review.

Acta Orthop Belg 2021 Mar;87(1):85-92

Open tibia fracture (OTF) treatment is well documented in developed countries. Yet, this fracture pattern remains challenging because it is associated with an increased risk of infection and delayed union, particularly in case of Gustilo III B and C open fractures. Since access to healthcare is limited in Sub- Saharan African countries, this paper explores the results of OTF management in this setting. Read More

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The selection of indicators from initial blood routine test results to improve the accuracy of early prediction of COVID-19 severity.

PLoS One 2021 15;16(6):e0253329. Epub 2021 Jun 15.

The Geriatric Respiratory Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

The global pandemic of COVID-19 poses a huge threat to the health and lives of people all over the world, and brings unprecedented pressure to the medical system. We need to establish a practical method to improve the efficiency of treatment and optimize the allocation of medical resources. Due to the influx of a large number of patients into the hospital and the running of medical resources, blood routine test became the only possible check while COVID-19 patients first go to a fever clinic in a community hospital. Read More

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Dynamic capabilities, value creation and value capture: Evidence from SMEs under Covid-19 lockdown in Poland.

PLoS One 2021 15;16(6):e0252423. Epub 2021 Jun 15.

Department of Enterprise Management, Nicolaus Copernicus University, Torun, Poland.

Dynamic capabilities, resulting from activities that allow conscious and skillful modification of a firm's strategic potential, are seen as one of the key drivers of a firm's value creation, competitive advantage and above-average performance in changing environments. However, little is known about how dynamic capabilities can shape business survival and performance during crises. The research objective of this paper is twofold. Read More

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Assessment of the Prognostic Effect of Blood Urea Nitrogen to Serum Albumin Ratio in Patients with Fournier's Gangrene in a Referral Center.

Urol J 2021 Jun 15. Epub 2021 Jun 15.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To assess the prognostic effect of blood urea nitrogen to serum albumin ratio in patients with Fournier's gangrene (FG) in a referral center in order to reduce the mortality of FG patients.

Materials And Methods: Patients with FG were admitted and enrolled consecutively in this study from March 2008 to April 2020. Statistical analysis was done to evaluate the differences between the two groups and to identify the best cutoff value to predict mortality and the need for intensive care. Read More

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Effects of atorvastatin on the insulin resistance in women of polycystic ovary syndrome: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26289

Department of Gynecology, Tongde Hospital of Zhejiang Province, Hangzhou, China.

Background: Atorvastatin treatment has been suggested as a therapeutic method for women with polycystic ovary syndrome (PCOS) in many clinical studies. Nonetheless, the effects of atorvastatin on insulin resistance in PCOS patients still remain controversial.

Objective: The aim of this report was to evaluate the effects of atorvastatin therapy on the insulin resistance in the treatment of PCOS compared to that of placebo, in order to confer a reference for clinical practice. Read More

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A comparative study of the efficiency and safety of chemotherapy as a therapeutic method for recurrent or resistant gestational trophoblastic neoplasia: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26263

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.

Background: Gestational trophoblastic neoplasia (GTN) is an infrequent spectrum of placental malignant cases. Generally, single-agent or multiple-agent chemotherapy is used to treat the condition. The condition has a significant impact on women in the childbearing age, which makes post-chemo fertility and obstetrical results a significant contemplation. Read More

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Predicting Antimicrobial Resistance Using Partial Genome Alignments.

mSystems 2021 Jun 15:e0018521. Epub 2021 Jun 15.

Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.

Antimicrobial resistance (AMR) is an important global health threat that impacts millions of people worldwide each year. Developing methods that can detect and predict AMR phenotypes can help to mitigate the spread of AMR by informing clinical decision making and appropriate mitigation strategies. Many bioinformatic methods have been developed for predicting AMR phenotypes from whole-genome sequences and AMR genes, but recent studies have indicated that predictions can be made from incomplete genome sequence data. Read More

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Investigation of patterns and dynamics of substance users: A long-term toxicology study on a sample of the Greek population between 2005 and 2019.

J Forensic Sci 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Forensic Sciences, Democritus University of Thrace - School of Medicine, Alexandroupolis, Greece.

The purpose of the present study is to investigate dynamics underlying drug abuse and identify statistical correlations/patterns of forensic findings and sociodemographic factors in a population of illicit substance users. The following long-term studies were conducted: (a) a retrospective autopsy cohort study on autopsy incidents with available toxicological screening results (N = 482) in investigation of any possible forensic associations of exposure to illicit drugs; and (b) a cross-sectional study on a sample of arrested drug law offenders with available toxicological screening results (N = 195) as well as cluster analysis in order to possibly identify user profiles. Although outside the scope of the present study, ethanol was generally considered to be the main substance of abuse, as more than half of the premature deaths reported tested positive on the ethanol toxicology screen. Read More

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Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy.

Sci Rep 2021 06 14;11(1):12412. Epub 2021 Jun 14.

Institute of Crystallography, Consiglio Nazionale delle Ricerche CNR, via Salaria Km 29.300, Monterotondo, 00015, Rome, Italy.

The control of Covid 19 epidemics by public health policy in Italy during the first and the second epidemic waves has been driven by using reproductive number R(t) to identify the supercritical (percolative), the subcritical (arrested), separated by the critical regime. Here we show that to quantify the Covid-19 spreading rate with containment measures there is a need of a 3D expanded parameter space phase diagram built by the combination of R(t) and doubling time T(t). In this space we identify the Covid-19 dynamics in Italy and its administrative Regions. Read More

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Updating recommendations of the Brazilian Group of Flow Cytometry (GBCFLUX) for diagnosis of acute leukemias using four-color flow cytometry panels.

Hematol Transfus Cell Ther 2021 May 21. Epub 2021 May 21.

Hospital Amaral Carvalho, Jaú, SP, Brazil.

Introduction: Flow cytometry has become an increasingly important tool in the clinical laboratory for the diagnosis and monitoring of many hematopoietic neoplasms. This method is ideal for immunophenotypic identification of cellular subpopulations in complex samples, such as bone marrow and peripheral blood. In general, 4-color panels appear to be adequate, depending on the assay. Read More

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[Current challenges in cancer care in Brussels-capital region: A qualitative study].

Bull Cancer 2021 Jun 11. Epub 2021 Jun 11.

Centre de recherche Politiques et systèmes de santé, École de Santé Publique, Université libre de Bruxelles (ULB), route de Lennik 808, 1070 Bruxelles, Belgique.

Cancer is a disease with multidimensional consequences accompanied by new challenges in order to guarantee optimal care involving physical, psychological and social consequences of the disease and his treatments. The objective of this study is to identify the main challenges encountered by different stakeholders around cancer, including patients, in Brussels. This qualitative study was carried out with various stakeholders in the field of oncology. Read More

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Proteomics based drug repositioning applied to improve in vitro fertilization implantation: an artificial intelligence model.

Syst Biol Reprod Med 2021 Jun 14:1-17. Epub 2021 Jun 14.

Anaxomics Biotech S.L., Barcelona, Spain.

Embryo implantation is one of the most inefficient steps in assisted reproduction, so the identifying drugs with a potential clinical application to improve it has a strong interest. This work applies artificial intelligence and systems biology-based mathematical modeling strategies to unveil potential treatments by computationally analyzing and integrating available molecular and clinical data from patients. The mathematical models of embryo implantation computationally generated here simulate the molecular networks underneath this biological process. Read More

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Palliative Care for Extracorporeal Life Support: Insights From the National Inpatient Sample.

Am Surg 2021 Jun 14:31348211024232. Epub 2021 Jun 14.

Division of Cardiac Surgery, Cardiovascular Outcomes Research Laboratories (CORELAB), David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Background: Providing temporary cardiopulmonary support, extracorporeal membrane oxygenation (ECMO) carries a high risk of mortality. Palliative care (PC) may facilitate a patient-centered approach to end-of-life care in order to aid symptom management and provide psychosocial support to families. The present study aimed to identify factors associated with PC consultation and its impact on resource utilization in ECMO. Read More

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Shape-directed self-assembly of nanodumbbells into superstructure polymorphs.

Chem Sci 2020 Mar 27;11(16):4065-4073. Epub 2020 Mar 27.

Department of Chemistry, Shenzhen Engineering Research Center for Frontier Materials Synthesis at High Pressures, Southern University of Science and Technology (SUSTech) Shenzhen Guangdong 518055 China

Self-assembly of colloidal nanoparticles into ordered superstructures provides a promising route to create novel/enhanced functional materials. Much progress has been made in self-assembly of anisotropic nanoparticles, but the complexity and tunability of superstructures remain restricted by their available geometries. Here we report the controlled packing of nanodumbbells (NDs) with two spherical lobes connected by one rod-like middle bar into varied superstructure polymorphs. Read More

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Effect of Thickness and Stacking Order on Raman Spectrum of Layered CrCl3.

J Phys Condens Matter 2021 Jun 14. Epub 2021 Jun 14.

School of Physics and Electronic Sciences, Changsha University of Science and Technology, Changsha, Hunan Province, Hunan 410004, Changsha, 410114, CHINA.

Layer- and stacking-dependent physical properties discovered in van der Waals materials have attracted a lot of attention recently. In this work, we have investigated the Raman spectrum of layered magnetic CrCl3with different atomic thickness and stacking order from first principles. Our study indicates Raman shift of Rand C2/m phase is near degenerate except that the first and fourth Raman resonant modes exhibit a marked peak difference about 3 cm-1, which can be understood by stacking-dependent vibrational eigenvectors. Read More

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Soft-matter properties of multilayer chromosomes.

Authors:
Joan-Ramon Daban

Phys Biol 2021 Jun 14. Epub 2021 Jun 14.

Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Facultat de Biociències, Bellaterra, Barcelona, 08193, SPAIN.

This perspective aims to identify the relationships between the structural and dynamic properties of chromosomes and the fundamental properties of soft-matter systems. Chromatin is condensed into metaphase chromosomes during mitosis. The resulting structures are elongated cylinders having micrometer-scale dimensions. Read More

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Proteomic profiling and oxidation site analysis of gaseous ozone oxidized myosin from silver carp (Hypophthalmichthys molitrix) with different oxidation degrees.

Food Chem 2021 Jun 6;363:130307. Epub 2021 Jun 6.

College of Food Science and Technology/National R&D Branch Center for Conventional Freshwater Fish Processing (Wuhan), Huazhong Agricultural University, Wuhan, Hubei Province 430070, China; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Wuhan 430070, China. Electronic address:

Ozone is used to in surimi production and affects the conformation of myosin and gelling properties. Amino acid analysis, SDS-PAGE, in-gel trypsin hydrolysis and LC-MS/MS were used to investigate the effect of the ozone treatment time on the oxidation principle of amino acids to identify the oxidation site and oxidation mechanism of myosin with different oxidation degrees. The results showed that the order of ozonation of amino acids from easy to difficult was tyrosine > cysteine > histidine > proline. Read More

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Development and Piloting of a Prevention Assessment and Response Tool for Healthcare-Associated Staphylococcus aureus Bloodstream Infection (the SAB-PART Study) Using a Delphi Method.

J Hosp Infect 2021 Jun 11. Epub 2021 Jun 11.

Infection Prevention & Healthcare Epidemiology Unit, Alfred Health; Department of Infectious Diseases, Alfred Health; Victorian Healthcare-Associated Infection Surveillance Coordinating Centre (VICNISS). Electronic address:

Background: Healthcare-associated Staphylococcus aureus bloodstream infection (HA-SAB) causes preventable harm in hospitalised patients. Currently, there is no standardised method available to review HA-SAB events in order to identify and target preventable risks requiring action at an organisational level.

Aim: To develop a tool to classify SAB events, and the necessary response actions, according to the degree of preventability. Read More

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Significance of hepatitis B surface antigen, IgM/IgG core antibody and hepatitis B virus DNA in blood donors.

Gac Med Mex 2021 ;157(1):35-40

Blood Banks Referral Unit, Centro de Investigación para la Salud en América Latina.

Introduction: Identification of hepatitis B virus carriers in blood donors is imperative in order to avoid transmission of the disease via blood transfusion.

Objective: To determine if blood donors with positive results for serological markers HBsAg and anti-HBc were hepatitis B virus DNA carriers.

Methods: 12,745 samples were collected from six Ecuadorian blood banks and analyzed for HBsAg, anti-HBc and anti-HBs infectious markers by automated ELISA. Read More

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January 2021

Followership in health care clinicians: a scoping review protocol.

JBI Evid Synth 2021 Jun 11. Epub 2021 Jun 11.

Adelaide Nursing School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia Nursing Department, Faculty of Applied Medical Sciences, Jouf University, Jouf, Saudi Arabia The Centre for Evidence-based Practice South Australia (CEPSA): A JBI Centre of Excellence, Adelaide, SA, Australia.

Objective: The main objective of this scoping review is to identify and map followership literature in order to understand the current state of followership research in relation to health care clinicians.

Introduction: Health care clinicians need to be flexible in switching between leader and follower roles as appropriate to advance patient care; however, much of the research effort in this regard has primarily concentrated on leadership. Effective followership in health care organizations may be necessary to enhance clinical team performance in order to improve patient safety and the quality of care. Read More

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An examination into the effect of genetic taste status and intensity of carbonation on swallowing and palatability in healthy young adults.

Int J Lang Commun Disord 2021 Jun 14. Epub 2021 Jun 14.

Department of Clinical Speech and Language Studies, Trinity College Dublin, Ireland.

Background: Dysphagia is a highly prevalent condition and affects a wide range of cohorts. A common compensatory strategy to manage dysphagia is diet modification. However, this technique is often associated with poor patient quality of life and adverse long-term effects. Read More

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Pioneer plant species and fungal root endophytes in metal-polluted tailings deposited near human populations and agricultural areas in Northern Mexico.

Environ Sci Pollut Res Int 2021 Jun 14. Epub 2021 Jun 14.

Departamento El Hombre y su Ambiente, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico.

As a consequence of industrial mining activity, high volumes of tailings are scattered around Mexico. Frequently, tailings contain heavy metals (HM) which entail threats against all organisms. The aim of this research was to identify plants and root fungal endophytes in polymetallic polluted tailings with the potential to be used in strategies of bioremediation. Read More

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Magnetic order-dependent phonon properties in 2D magnet CrI.

Nanoscale 2021 Jun 14. Epub 2021 Jun 14.

Institute of High Performance Computing, A*STAR, 138632, Singapore.

We carried out a systematic theoretical study on how spin affects the phononic properties of CrI3 monolayers. We find that the frequencies of two infrared-active (IR) modes are significantly influenced by the magnetic configuration. Thus an IR spectrum may be applied to identify the magnetic order by utilizing the spin-lattice correlation. Read More

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Help Us Help You: Engaging Emergency Physicians to Identify Organizational Strategies to Reduce Burnout.

West J Emerg Med 2021 Apr 8;22(3):696-701. Epub 2021 Apr 8.

Harvard Medical School, Massachusetts General Hospital, Department of Emergency Medicine, Boston, Massachusetts.

Introduction: Burnout is a major threat to patient care quality and physician career longevity in emergency medicine. We sought to develop and implement a quality improvement process to engage emergency department (ED) faculty in identifying sources of burnout and generating interventions targeted at improving the work environment.

Methods: In this prospective interventional study conducted at a large, urban, academic medical center, we surveyed a 60-person faculty group using the Professional Fulfilment Index (PFI), as well as burnout-relevant questions from the American Medical Association's Mini-Z survey and the Maslach-Leiter framework for organizational burnout, in order to identify organizational sources of burnout. Read More

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Emergency Department Access During COVID-19: Disparities in Utilization by Race/Ethnicity, Insurance, and Income.

West J Emerg Med 2021 Apr 28;22(3):552-560. Epub 2021 Apr 28.

Stanford University School of Medicine, Department of Emergency Medicine, Palo Alto, California.

Introduction: In March 2020, shelter-in-place orders were enacted to attenuate the spread of coronavirus 2019 (COVID-19). Emergency departments (EDs) experienced unexpected and dramatic decreases in patient volume, raising concerns about exacerbating health disparities.

Methods: We queried our electronic health record to describe the overall change in visits to a two-ED healthcare system in Northern California from March-June 2020 compared to 2019. Read More

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US Guided Si.La.D. A new technique for minimally invasive pilonidal disease treatment, using ultrasound guided laser ablation.

Expert Rev Med Devices 2021 Jun 14. Epub 2021 Jun 14.

3rd Department of Surgery, ``AHEPA`` University Hospital, Aristotle University of Thessaloniki, Medical School of Health Sciences, Thessaloniki,Greece.

Background: The destruction of the pilonidal sinus with a radial laser probe has been suggested as a safe procedure with good results and low morbidity. Nevertheless the drawbacks of this technique are: a blind technique, if the sinus has some ramifications, or e non-linear development we cannot be sure for their destruction.

Methods: 17: patients (12 men, 5 women) were operated with US guided laser destruction- US guided Si. Read More

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Policy Challenges Facing the Scale Up of Integrated Community Case Management (iCCM) in Uganda.

Int J Health Policy Manag 2021 May 24. Epub 2021 May 24.

School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda.

Background: Integrated Community Case Management (iCCM) of malaria, pneumonia and diarrhoea is an equity focused strategy, to increase access to care for febrile illness in children under-5 years of age, in rural communities. Lay community members are trained to diagnose and treat malaria, pneumonia and diarrhoea in children, and to identify and refer very ill children. Today, many low-income countries including Uganda, have a policy for iCCM which is being rolled out through public sector community health workers (CHWs). Read More

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