12,024 results match your criteria oral targeted

Fertility-sparing approach for endometrial cancer: the role of office hysteroscopy.

Minim Invasive Ther Allied Technol 2021 Jul 22:1-8. Epub 2021 Jul 22.

Department of Obstetrics and Gynecology, University of California Davis Medical Center, Sacramento, CA, USA.

Endometrial cancer is the most common gynecologic malignancy in developed countries, with increasing incidence among younger, nulliparous patients. These epidemiological shifts are attributed to increasing rates of obesity, in combination with delayed childbearing. This highlights a need for fertility-sparing options for individuals who wish to delay standard surgical management with hysterectomy, bilateral salpingoophorectomy, and assessment of pelvic/para-aortic lymph nodes. Read More

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Colon-Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora.

Adv Sci (Weinh) 2021 Jul 22:e2101619. Epub 2021 Jul 22.

Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China.

Intestinal immune homeostasis and microbiome structure play a critical role in the pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment remains a challenge as the first-line drugs show limited therapeutic efficiency and great side effect. In this study, a colon-targeted adhesive core-shell hydrogel microsphere is designed and fabricated by the ingenious combination of advanced gas-shearing technology and ionic diffusion method, which can congregate on colon tissue regulating the gut immune-microbiota microenvironment in IBD treatment. The degradation experiment indicates the anti-acid and colon-targeted property of the alginate hydrogel shell, and the in vivo imaging shows the mucoadhesive ability of the thiolated-hyaluronic acid hydrogel core of the microsphere, which reduces the systematic exposure and prolongs the local drug dwell time. Read More

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Sorafenib for hepatocellular carcinoma: potential molecular targets and resistance mechanisms.

J Chemother 2021 Jul 22:1-16. Epub 2021 Jul 22.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.

Hepatocellular carcinoma (HCC) is the most widespread typical therapy-resistant, unresectable type of malignant solid tumour with a high death rate constituting huge medical concern. Sorafenib is a small molecule oral multi-target kinase potent inhibitor that acts by suppressing/blocking the multiplication of the tumour cells, angiogenesis, and encouraging apoptosis of the tumour cells. Though, the precise mechanism of tumour cell death induction by sorafenib is yet under exploration. Read More

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Impact of Tenascin-C on Radiotherapy in a Novel Syngeneic Oral Squamous Cell Carcinoma Model With Spontaneous Dissemination to the Lymph Nodes.

Front Immunol 2021 5;12:636108. Epub 2021 Jul 5.

INSERM U1109-MN3T, The Microenvironmental Niche in Tumorigenesis and Targeted Therapy, Strasbourg, France.

Radiotherapy, the most frequent treatment of oral squamous cell carcinomas (OSCC) besides surgery is employed to kill tumor cells but, radiotherapy may also promote tumor relapse where the immune-suppressive tumor microenvironment (TME) could be instrumental. We established a novel syngeneic grafting model from a carcinogen-induced tongue tumor, OSCC13, to address the impact of radiotherapy on OSCC. This model revealed similarities with human OSCC, recapitulating carcinogen-induced mutations found in smoking associated human tongue tumors, abundant tumor infiltrating leukocytes (TIL) and, spontaneous tumor cell dissemination to the local lymph nodes. Read More

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Complete Pathologic Response of Multiple Liver Metastases and Clinical Complete Response of Rectal Cancer in a Patient with Ataxia-Telangiectasia Mutated Gene Mutations After XELOXIRI Plus Bevacizumab: A Case Report.

Onco Targets Ther 2021 15;14:4201-4209. Epub 2021 Jul 15.

Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, People's Republic of China.

Background: Doublet or triplet chemotherapy plus or minus targeted drugs can achieve a high objective response rate (ORR) and are currently considered to be the backbone of conventional therapy for liver metastatic colorectal cancer (mCRC). However, current biomarkers (such as UGT1A1 and DPYD) are limited to the prediction of toxicity and there are no effective biomarkers to predict chemotherapy response. Therefore, personalized cancer chemotherapy underpinned by genomic alterations in mCRC has received increasing attention. Read More

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BRCA mutations in pancreatic cancer and progress in their targeting.

Expert Opin Ther Targets 2021 Jul 22. Epub 2021 Jul 22.

Division of Hematology/ Oncology, Karmanos Cancer Institute, Detroit, MI, USA.

Introduction: Genomic instability resulting from DNA damage repair (DDR) deficiencies is hallmark of cancer and offers treatment opportunities. Homologous recombination DDR defect is result of multiple critical gene mutations including . Targeting DNA DDR defects in pancreatic cancer (PC) is emerging as potential treatment strategy with current focus on BRCA mutations. Read More

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Acceptability, utility, and cost of an mHealth cancer screening education application for training primary care physicians in India.

Oncologist 2021 Jul 19. Epub 2021 Jul 19.

Senior Visiting Scientist, IARC, Lyon, France.

Purpose: Mobile health (mHealth)-based oncology education can be a powerful tool for providing cancer screening knowledge to physicians, as mobile technology is widely available and inexpensive. We developed a mobile application (M-OncoED) to educate physicians on cancer screening and tested the acceptability, utility, and cost of two different approaches to recruit physicians.

Methods: M-OncoED was designed to perform pre- and post-learning assessments through the in-built quizzes; present case studies and educational materials for cervical, breast, and oral cancer screening; collect responses to interactive queries; document module completion; send reminders and alerts; and track user metrics, including number of sessions to complete each module and time spent per session. Read More

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Impact of pharmacist consultation at clinical trial inclusion: an effective way to reduce drug-drug interactions with oral targeted therapy.

Cancer Chemother Pharmacol 2021 Jul 20. Epub 2021 Jul 20.

Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Montpellier, France.

Purpose: Pharmacist consultation is unfrequently performed in oncology clinical trials that include patients who often have many co-treatments increasing the risk of drug-drug interactions (DDI). The aim of this study was to determine whether best possible medication history (BPMH) by hospital pharmacist at inclusion and therapeutic drug monitoring could be used for DDI risk evaluation and for current oral targeted therapy management.

Methods: A prospective clinical trial (ALCINA 2, NCT04025541) was carried out in metastatic breast cancer cohort treated by palbociclib to conduct pharmacokinetics-toxicity correlation study. Read More

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High-throughput compound screening identifies navitoclax combined with irradiation as a candidate therapy for HPV-negative head and neck squamous cell carcinoma.

Sci Rep 2021 Jul 20;11(1):14755. Epub 2021 Jul 20.

Department of Oral and Maxillofacial Diseases, University of Helsinki, 00014, Helsinki, Finland.

Conventional chemotherapeutic agents are nonselective, often resulting in severe side effects and the development of resistance. Therefore, new molecular-targeted therapies are urgently needed to be integrated into existing treatment regimens. Here, we performed a high-throughput compound screen to identify a synergistic interaction between ionizing radiation and 396 anticancer compounds. Read More

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Nanomaterials for the Diagnosis and Treatment of Head and Neck Cancers: A Review.

Materials (Basel) 2021 Jul 2;14(13). Epub 2021 Jul 2.

Department of Chemistry, College of Natural Science, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Korea.

Head and neck cancer (HNC) is a category of cancers that typically arise from the nose-, mouth-, and throat-lining squamous cells. The later stage of HNC diagnosis significantly affects the patient's survival rate. This makes it mandatory to diagnose this cancer with a suitable biomarker and imaging techniques at the earlier stages of growth. Read More

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Chloride intracellular channels as novel biomarkers for digestive system tumors (Review).

Mol Med Rep 2021 Sep 19;24(3). Epub 2021 Jul 19.

Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China.

Digestive system malignant tumors are common tumors, and the traditional treatment methods for these tumors include surgical resection, radiotherapy, chemotherapy, and molecularly targeted drugs. However, diagnosis remains challenging, and the early detection of postoperative recurrence is complicated. Therefore, it is necessary to explore novel biomarkers to facilitate clinical diagnosis and treatment. Read More

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September 2021

The PERSonalized Glucose Optimization Through Nutritional Intervention (PERSON) Study: Rationale, Design and Preliminary Screening Results.

Front Nutr 2021 30;8:694568. Epub 2021 Jun 30.

Top Institute Food and Nutrition, Wageningen, Netherlands.

It is well-established that the etiology of type 2 diabetes differs between individuals. Insulin resistance (IR) may develop in different tissues, but the severity of IR may differ in key metabolic organs such as the liver and skeletal muscle. Recent evidence suggests that these distinct tissue-specific IR phenotypes may also respond differentially to dietary macronutrient composition with respect to improvements in glucose metabolism. Read More

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Murine Salivary Amylase Protects Against -Induced Caries.

Front Physiol 2021 2;12:699104. Epub 2021 Jul 2.

Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, United States.

Saliva protects dental surfaces against cavities (i. e., dental caries), a highly prevalent infectious disease frequently associated with acidogenic . Read More

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The cost and intermediary cost-effectiveness of oral HIV self-test kit distribution across 11 distribution models in South Africa.

BMJ Glob Health 2021 Jul;6(Suppl 4)

Health Economics and Epidemiology Research Office (HERO), Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Background: Countries around the world seek innovative ways of closing their remaining gaps towards the target of 95% of people living with HIV (PLHIV) knowing their status by 2030. Offering kits allowing HIV self-testing (HIVST) in private might help close these gaps.

Methods: We analysed the cost, use and linkage to onward care of 11 HIVST kit distribution models alongside the Self-Testing AfRica Initiative's distribution of 2. Read More

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Safety of PSMA-targeted molecular radioligand therapy with Lu-PSMA-617: results from the prospective multicenter phase 2 trial RESIST-PC NCT03042312.

J Nucl Med 2021 Jul 16. Epub 2021 Jul 16.

Excel Diagnostics and Nuclear Oncology Center, United States.

To report the safety evaluation of Lu-PSMA-617 derived from the cohort of 64 patients exposed to Lu-PSMA-617 in the RESIST-PC trial NCT03042312 RESIST-PC was a prospective multicenter phase 2 trial. Patients with progressive mCRPC after ≥1 novel androgen-axis drug, either chemotherapy naïve or post-chemotherapy, with sufficient bone marrow reserve, normal kidney function, sufficient PSMA expression by PSMA PET and no visceral PSMA-negative lesions were eligible. Patients were randomized (1:1) into two activity groups (6. Read More

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Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity.

J Immunother Cancer 2021 Jul;9(7)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China

Background: Mesenteric lymph nodes (MLNs) are critical draining lymph nodes of the immune system that accommodate more than half of the body's lymphocytes, suggesting their potential value as a cancer immunotherapy target. Therefore, efficient delivery of immunomodulators to the MLNs holds great potential for activating immune responses and enhancing the efficacy of antitumor immunotherapy. Self-microemulsifying drug delivery systems (SMEDDS) have attracted increasing attention to improving oral bioavailability by taking advantage of the intestinal lymphatic transport pathway. Read More

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A Noninvasive Gut-to-Brain Oral Drug Delivery System for Treating Brain Tumors.

Adv Mater 2021 Jul 16:e2100701. Epub 2021 Jul 16.

Department of Chemical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, 30013, Taiwan.

Most orally administered drugs fail to reach the intracerebral regions because of the intestinal epithelial barrier (IEB) and the blood-brain barrier (BBB), which are located between the gut and the brain. Herein, an oral prodrug delivery system that can overcome both the IEB and the BBB noninvasively is developed for treating gliomas. The prodrug is prepared by conjugating an anticancer drug on β-glucans using a disulfide-containing linker. Read More

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Adopting the COM-B model and TDF framework in oral and dental research: A narrative review.

Community Dent Oral Epidemiol 2021 Jul 16. Epub 2021 Jul 16.

Faculty of Dentistry, Oral and Craniofacial Sciences, King' College London, Guy's Hospital, London, UK.

Background: Recent advances in the psychological understanding of health-related behaviour have focused on producing a comprehensive framework to model such behaviour. The Capability-Opportunity-Motivation-Behaviour (COM-B) and its associated Theoretical Domains Framework (TDF) allow researchers to classify psychological and behavioural constructs in a consistent and transferable manner across studies.

Aim: To identify oral and dental health-related studies that have used the TDF and/or COM-B as frameworks to guide research and examine the ways in which these concepts have been practically used in such research. Read More

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Oral mucosal lesions and oral symptoms of the SARS-CoV-2 infection.

Minerva Dent Oral Sci 2021 Aug;70(4):161-168

Research Center, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia.

Introduction: SARS-CoV-2 develops well in the oral mucosa because, it is the first contact area with the virus. The oral mucosa is highly expressed with angiotensin-converting enzyme 2 (ACE2) and makes the virus replicated in the epithelial cells and produce both oral lesions and oral symptoms. This review aimed to describe the oral mucosal symptoms and lesions related to SARS-CoV-2-infected patients that have been reported around the world. Read More

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Heterogeneity response to afatinib in gastric cancer patient with uncommon epidermal growth factor receptor (EGFR) mutations: a case report.

Ann Transl Med 2021 May;9(9):814

The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China.

Despite concerted efforts that have been made to characterize and understand the genomic landscape of gastric cancer (GC), only HER2 has been validated as a molecular target for GC treatment. Identifying new valid therapeutic targets is important for the treatment of this disease. The present report describes a Chinese male with a history of smoking two packs per day, who did not have a family history of cancer or other hereditary diseases, we discovered a small painless lump in the right groin in February 2018. Read More

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Expression and Prognosis Analysis of SUMOylation Regulators in Oral Squamous Cell Carcinoma Based on High-Throughput Sequencing.

Front Genet 2021 29;12:671392. Epub 2021 Jun 29.

Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.

Introduction: Oral squamous cell carcinoma (OSCC) originates from oral mucosal epithelial cells, accounting for more than 90% of oral cancers. The relationship between the expression and prognostic role of SUMOylation regulators in OSCC is rarely studied.

Materials And Methods: The expression and survival data of OSCC were derived from TCGA and GEO databases. Read More

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: A Review of an Unexpected Scourge.

Int J Gen Med 2021 9;14:3259-3270. Epub 2021 Jul 9.

Department of Internal Medicine, Faculty of Medicine, Krida Wacana Christian University, Jakarta, Indonesia.

is a common environmental bacterium that rarely causes disease in humans but has a high fatality rate if it does. Due to the rarity of the cases, clinicians are often unaware of the rapid progression of infection and its unexpected antibiotic resistance pattern, which contribute to the failure of patient management. Our review provides the clinical characteristics, possible sources of exposure, and comorbidities and determines factors associated with survival. Read More

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Plasmablastic Lymphoma Involving Kidney in an HIV Positive Patient: A Case Report with Review of the Literature.

Indian J Nephrol 2021 Mar-Apr;31(2):176-178. Epub 2021 Feb 8.

Department of Hematology and Medical Oncology, HCG Hospital, Bengaluru, Karnataka, India.

Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with HIV infection. It most commonly presents in the oral cavity and rarely involves the kidney. Herein, we report a case of HIV positive male with renal involvement of PBL. Read More

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February 2021

Malignant melanoma without primary, presenting as solitary pulmonary nodule: a case report.

J Med Case Rep 2021 Jul 16;15(1):347. Epub 2021 Jul 16.

Department of Radiology, Kettering General Hospital NHS Foundation Trust, Kettering, UK.

Background: Solitary pulmonary nodules are the most common incidental finding on chest imaging. Their management is very well defined by several guidelines, with risk calculators for lung cancer being the gold standard. Solitary intramuscular metastasis combined with a solitary pulmonary nodule from malignant melanoma without a primary site is rare. Read More

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Dihydromyricetin suppresses cell metastasis in human osteosarcoma through SP-1- and NF-κB-modulated urokinase plasminogen activator inhibition.

Phytomedicine 2021 Jun 26;90:153642. Epub 2021 Jun 26.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:

Background: Metastasis caused a decline in the 5-years survival rate of osteosarcoma. Therefore, developing new targeted therapeutics for osteosarcoma treatment is imperative. Dihydromyricetin (DHM) has several physiological functions: it counteracts inflammation, oxidation, and antitumor properties. Read More

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Case Report: Low-Dose Apatinib in the Treatment of Intrahepatic Biliary Cystadenoma With Recurrence and Malignant Transformation.

Front Oncol 2021 28;11:676092. Epub 2021 Jun 28.

Department of Ultrasound Diagnostics, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Apatinib is a new oral tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor-2. It has been proven effective in treating multiple solid tumors. Herein, we report the case of a 67-year-old Chinese patient who was diagnosed with recurrent and malignant transformation of intrahepatic biliary cystadenoma. Read More

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Norcantharidin counteracts acquired everolimus resistance in renal cell carcinoma by dual inhibition of mammalian target of rapamycin complex 1 and complex 2 pathways in Vitro.

Anticancer Drugs 2021 Jul 12. Epub 2021 Jul 12.

Department of Urology Clinical Laboratory, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou Center for Medical Experiments, University of Chinese Academy of Science-Shenzhen Hospital, Shenzhen, Guangdong Institute of Genetic, Zhejiang University School of Medicine, Hangzhou, Zhejiang Institute of Biotherapy, School of Biotechnology, Southern Medical University, Guangzhou, Guangdong, China.

Everolimus, an oral mammalian target of rapamycin complex 1 (mTORC1) inhibitor, presents a therapeutic option in metastatic renal cell carcinoma (RCC) patients who were intolerant to, or previously failed, immune- and vascular endothelial growth factor-targeted therapies. However, the onset of drug resistance limits its clinical use. One possible mechanism underpinning the resistance is that inhibiting mTORC1 by everolimus results in mTORC2-dependent activation of v-Akt murine thymoma viral oncogene (AKT) and upregulation of hypoxia-inducible transcription factors (HIF). Read More

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Oral Hygiene Instructions and Methods: A Comparative Survey of European General Dentists, Periodontists and Dental Hygienists.

Oral Health Prev Dent 2021 Jan;19(1):327-337

Purpose: To study the practices of general dentists, periodontists and dental hygienists who are members of the European Federation of Periodontology, regarding oral hygiene education, plaque control assessment, recommended dental and interdental hygiene tools, and antimicrobial agents.

Materials And Methods: A web-based survey was sent to 13,622 members of the European Federation of Periodontology (EFP) through its 29 national member societies. It targeted general dentists (GD), specialists in periodontology (DSP) and dental hygienists (DH). Read More

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January 2021

Durable complete remission of leptomeningeal melanoma by intrathecal methotrexate maintained with systemic ipilimumab.

Immunotherapy 2021 Jul 14. Epub 2021 Jul 14.

Department of Dermatology & National Center for Tumor Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 460, Heidelberg, 69120, Germany.

Leptomeningeal disease (LMD) is a complication of metastasized melanoma, with poor prognosis even in the era of immunotherapy. We present the case of a 37-year-old man who was diagnosed with stage IV melanoma with lymphonodular, splenic and pulmonary metastases. Treatment with dabrafenib and trametinib led to a complete remission, but subsequent symptomatic LMD. Read More

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