37,723 results match your criteria oral squamous


The effect of reconstruction on positive margin rates in oral cancer: Using length of stay as a proxy measure for flap reconstruction in a national database.

Am J Otolaryngol 2021 Mar 29;42(5):103012. Epub 2021 Mar 29.

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address:

Purpose: Planned flap reconstruction, allowing aggressive resections of oral cavity squamous cell carcinoma (OCSCC), may decrease positive surgical margins. The purpose of this study was to determine if length of stay (LOS), as a proxy measure for flap reconstruction, is associated with positive margin rates in OCSCC.

Materials And Methods: Data from the National Cancer Database was retrospectively collected for patients undergoing surgery for previously untreated clinical T1-3 OCSCC. Read More

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Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors.

Biosens Bioelectron 2021 Apr 3;183:113213. Epub 2021 Apr 3.

Department of Biological Science and Technology, College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, 30068, Taiwan; Center for Intelligent Drug Systems and Smart Bio-devices (IDS(2)B), National Yang Ming Chiao Tung University, Hsinchu, 30068, Taiwan; Department of Electrophysics, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan; Institute of Physics, Academia Sinica, Nankang, Taipei, 11529, Taiwan. Electronic address:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells through the binding of its spike protein (S-protein) to the cell surface-expressing angiotensin-converting enzyme 2 (ACE2). Thus, inhibition of S-protein-ACE2 binding may impede SARS-CoV-2 cell entry and attenuate the progression of Coronavirus disease 2019 (COVID-19). In this study, an electrochemical impedance spectroscopy-based biosensing platform consisting of a recombinant ACE2-coated palladium nano-thin-film electrode as the core sensing element was fabricated for the screening of potential inhibitors against S-protein-ACE2 binding. Read More

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Novel hybrid endoscopy-assisted larynx-preserving esophagectomy for cervical esophageal cancer (with video).

Jpn J Clin Oncol 2021 Apr 14. Epub 2021 Apr 14.

Division of Esophageal Surgery, National Cancer Center Hospital, Tokyo, Japan.

Hybrid endoscopy-assisted larynx-preserving esophagectomy is developed for cervical esophageal squamous cell carcinoma encroaching or extending above the upper esophageal sphincter. First, a cervical incision was surgically performed followed by cervical lymph node dissection. Second, the margin of cervical esophageal squamous cell carcinoma was endoscopically identified with iodine staining and marked endoscopically followed by semi-circumferential or circumferential endoscopic full-thickness excision around the lumen of the esophagus. Read More

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Mining TCGA database for prognostic genes in head and neck squamous cell carcinoma microenvironment.

J Dent Sci 2021 Mar 16;16(2):661-667. Epub 2020 Oct 16.

School of Dentistry, Hainan Medical University, Hainan, China.

Background/purpose: Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors. The aim of this study was to elucidate the effect of tumor microenvironment-related genes on the prognosis of HNSCC and to obtain tumor microenvironment-related genes that can predict poor prognosis in HNSCC patients.

Materials And Methods: The ESTIMATE algorithm was applied to the HNSCC transcriptomic data downloaded from the TCGA (The cancer genome atlas), and then the samples were divided into two groups: high and low immune scoring groups, and high and low basal scoring groups to screen for differentially expressed genes (DEGs) associated with poor patient outcomes. Read More

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Increased tumor-infiltrating plasmacytoid dendritic cells promote cancer cell proliferation and invasion via TNF-α/NF-κB/CXCR-4 pathway in oral squamous cell carcinoma.

J Cancer 2021 19;12(10):3045-3056. Epub 2021 Mar 19.

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Tumor-infiltrating immune cells are closely associated with tumor occurrence and progression. The present study explored the potential mechanism of tumor-infiltrating plasmacytoid dendritic cells (pDC) mediating the proliferation and metastasis of cancer cells in oral squamous cell carcinoma (OSCC). pDC distribution was detected by immunofluorescence and flow cytometry. Read More

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Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer.

J Oncol 2021 13;2021:6663720. Epub 2021 Feb 13.

Department of Surgery, Stomatology, Pathology and Radiology (Area of Pathology), Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

Background: The present study aimed to investigate the clinical significance and prognostic value of the immunoexpression of cancer stem cell markers, ALDH1 and Notch1, in subtypes of oral squamous cell carcinoma.

Materials And Methods: The expression of ALDH1 and Notch1 in 63 patients with well and poorly differentiated oral squamous cell carcinomas and their subtypes, verrucous carcinoma and basaloid squamous cell carcinoma, was evaluated by immunohistochemistry. The semi-quantitative analysis of the ALDH1 and Notch immunoexpression levels, based on the capture of 10 microscopic fields, at 400X magnification, at the invasive tumor front was performed and associated with clinicopathological variables using the chi-square test or Fisher's exact test. Read More

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February 2021

Sweet syndrome with bitter outcomes in cervical cancer: A case report.

Gynecol Oncol Rep 2021 May 16;36:100749. Epub 2021 Mar 16.

University of Texas Medical Branch, Department of Obstetrics & Gynecology, United States.

Background: Sweet Syndrome, or acute febrile neutrophilic dermatosis, is a non-infectious, painful rash accompanied by fever, leukocytosis and skin biopsy showing neutrophilic dermal inflammation. It is either idiopathic, drug-induced or malignancy associated (MASS). MASS is uncommon in cervical cancer, and usually signals diagnosis, progression or recurrence. Read More

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Comparison of CECT and CT perfusion in differentiating benign from malignant neck nodes in oral cavity cancers.

Eur J Radiol Open 2021 26;8:100339. Epub 2021 Mar 26.

Department of Pathology, Maulana Azad Medical College & Associated Hospitals, New Delhi, Delhi, India.

Aim: The objective of the study was to assess the performance of CT Perfusion in comparison to CECT for preoperative detection of metastases to lymph nodes in squamous cell cancers of oral cavity.

Methods: Twenty-five patients with squamous cell cancers of oral cavity underwent CECT and CTP. Two radiologists evaluated CECT and CTP parameters independently. Read More

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Comparative study on the diagnostic value of intravenous/peritumoral injection of indocyanine green for metastatic lymph node location in patients with head and neck squamous cell carcinoma (HNSCC).

Ann Transl Med 2021 Mar;9(6):507

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Background: Accurate assessment of regional lymph node (LN) status is essential for the treatment of head and neck squamous cell carcinoma (HNSCC) patients. In this study, we aimed to compare the difference between intravenous injection of indocyanine green (ICG) and peritumoral injection of ICG in the location of metastatic LNs.

Methods: Twenty-nine patients were enrolled in this study with 13 patients receiving intravenous injection of ICG and 16 patients receiving peritumoral injection of ICG. Read More

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MicroRNA-363-3p inhibits tumor cell proliferation and invasion in oral squamous cell carcinoma cell lines by targeting SSFA2.

Exp Ther Med 2021 Jun 24;21(6):549. Epub 2021 Mar 24.

Department of Stomatology, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China.

The aim of the present study was to evaluate the expression levels of microRNA (miR)-363-3p and its underlying physiological function in oral squamous cell carcinoma (OSCC). miR-363-3p expression levels were measured in OSCC cell lines using reverse transcription-quantitative PCR. The role of miR-363-3p in OSCC cells was examined using gain-of-function assays . Read More

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Novel TGF-β inhibitors ameliorate oral squamous cell carcinoma progression and improve the anti-tumor immune response of anti-PD-L1 immunotherapy.

Mol Cancer Ther 2021 Apr 13. Epub 2021 Apr 13.

Departments of Pathology, Immunology and Otolaryngology, University of Pittsburgh.

TGF-β is a key regulator of oral squamous cell carcinoma (OSCC) progression and its potential role as a therapeutic target has been investigated with a limited success. This study evaluates two novel TGF-β inhibitors as mono or combinatorial therapy with anti-PD-L1 antibodies (α-PD-L1 Abs) in a murine OSCC model. Immunocompetent C57BL/6 mice bearing malignant oral lesions induced by 4-nitroquinoline 1-oxide (4-NQO) were treated for 4 weeks with TGF-β inhibitors mRER (i. Read More

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ENTPD1(CD39) expression inhibits ultraviolet radiation-induced DNA damage repair via purinergic signaling and is associated with metastasis in human cutaneous squamous cell carcinoma.

J Invest Dermatol 2021 Apr 10. Epub 2021 Apr 10.

Department of Dermatology, Duke University School of Medicine, Durham, NC, USA; Pinnell Center for Investigative Dermatology and Skin Disease Research Center, Duke University School of Medicine, Durham, NC; Duke Cancer Institute, Duke University Medical Center, Durham, NC; Department of Immunology, Duke University School of Medicine, Durham, NC; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC. Electronic address:

Ultraviolet radiation (UVR) and immunosuppression are major risk factors for cutaneous squamous cell carcinoma (cSCC). Regulatory T cells (Tregs) promote cSCC carcinogenesis and in other solid tumors, infiltrating Tregs and CD8 T cells express ENTPD1 (also known as CD39), an ecto-enzyme that catalyzes the rate-limiting step in converting extracellular ATP to extracellular adenosine. We previously demonstrated that extracellular purine nucleotides influence DNA Damage Repair (DDR). Read More

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The predictive role of neutrophil-to-lymphocyte ratio in the outcomes of patients with sarcomatoid carcinoma of oral cavity.

Eur Arch Otorhinolaryngol 2021 Apr 13. Epub 2021 Apr 13.

Department of Surgical Oncology, HCG Manavata Cancer Centre, Nashik, 422002, Maharashtra, India.

Introduction: The aim of the present study was to evaluate the prognostic value of the inflammatory response biomarkers and their impact on survival outcomes in the patients with sarcomatoid carcinoma (SC) of oral cavity, a rare variant of squamous cell carcinoma (SqC).

Materials And Methods: Seventeen patients diagnosed with SC of oral cavity without metastases treated between Jan 2017 to June 2020 were identified and included in the present study. Pre- and post-operative inflammatory biomarkers and other prognostic markers were evaluated and their impact on disease-free survival (DFS) and overall survival (OS) was studied. Read More

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Contribution of Genomics to the Surgical Management and Study of Oral Cancer.

Ann Surg Oncol 2021 Apr 12. Epub 2021 Apr 12.

UR7516 "CHIMERE, Université de Picardie Jules Verne", Amiens, France.

Background: Oral squamous cell carcinoma (OSCC) is the most frequent type of tumor arising from the oral cavity. Surgery is the cornerstone of the treatment of these cancers. Tumor biology has long been overlooked as an important contributor to the outcome of surgical procedures, but recent studies are challenging this concept. Read More

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Prognostic value of intratumoral Fusobacterium nucleatum and association with immune-related gene expression in oral squamous cell carcinoma patients.

Sci Rep 2021 Apr 12;11(1):7870. Epub 2021 Apr 12.

Department of Genetics, Institut Curie, PSL Research University, Paris, France.

Changes in the oral microbiome, particularly Fusobacterium nucleatum, are associated with oral squamous cell carcinoma (OSCC). F. nucleatum has been reported to modulate local immunity in cancers. Read More

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Is it time to look beyond just the depth of invasion to decide the management of neck in early oral squamous cell carcinoma?

Oral Oncol 2021 Apr 9:105291. Epub 2021 Apr 9.

Dept. of Head & Neck Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai 400012, India. Electronic address:

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TNM 8 staging is a better prognosticator than TNM 7 for patients with locally advanced oral cavity squamous cell carcinoma treated with surgery and post-operative radiotherapy.

Radiother Oncol 2021 Apr 9. Epub 2021 Apr 9.

Department of Clinical Oncology, Guy's and St Thomas, NHS Trust London, UK; King's College London, UK.

Purpose: To assess TNM 8 staging in discriminating overall survival (OS) amongst patients with locally advanced oral cavity squamous cell carcinoma (OCSCC) treated with surgery and post-operative radiotherapy (PORT), compared to TNM 7.

Material And Methods: Data from OCSCC patients treated with surgery and PORT between January 2010 and December 2018 were reviewed. Demographics, tumour characteristics and treatment response data were collected, and patients staged according to both TNM 7 and TNM 8. Read More

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Treatment of Recurrent Respiratory Papillomatosis: Case Series and Review of Technique.

Surg Technol Int 2021 Apr 9;38. Epub 2021 Apr 9.

Fox Chase Cancer Center, Philadelphia, PA.

Adult Recurrent Respiratory Papillomatosis (RRP) is a rare disease caused by the human papilloma virus in which papilloma grows from the respiratory epithelium. Patients can suffer from significant respiratory distress secondary to tracheal or bronchial obstruction by papilloma and the mainstay of treatment is bronchoscopic debridement. There are a variety of techniques to resect the endoluminal tumor, including CO2 or YAG laser, argon plasma coagulation, microdebrider and cold forceps. Read More

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Knockdown of LncRNA PANDAR by CRISPR-dCas9 Decreases Proliferation and Increases Apoptosis in Oral Squamous Cell Carcinoma.

Front Mol Biosci 2021 26;8:653787. Epub 2021 Mar 26.

Department of Stomatology,The First Medical Center of Chinese PLA General Hospital, Beijing, China.

Oral squamous cell carcinoma (OSCC) is the most common malignant epithelial tumor in the oral cavity. Emerging evidence has demonstrated the important function roles of long noncoding RNAs (lncRNAs) in human cancers. LncRNA promoter of CDKN1A antisense DNA damage activated RNA (PANDAR) functions as an oncogene in multiple carcinomas, whereas its function in OSCC has not been investigated yet. Read More

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Deep Learning for Automatic Segmentation of Oral and Oropharyngeal Cancer Using Narrow Band Imaging: Preliminary Experience in a Clinical Perspective.

Front Oncol 2021 24;11:626602. Epub 2021 Mar 24.

Department of Advanced Robotics, Istituto Italiano di Tecnologia, Genoa, Italy.

Introduction: Fully convoluted neural networks (FCNN) applied to video-analysis are of particular interest in the field of head and neck oncology, given that endoscopic examination is a crucial step in diagnosis, staging, and follow-up of patients affected by upper aero-digestive tract cancers. The aim of this study was to test FCNN-based methods for semantic segmentation of squamous cell carcinoma (SCC) of the oral cavity (OC) and oropharynx (OP).

Materials And Methods: Two datasets were retrieved from the institutional registry of a tertiary academic hospital analyzing 34 and 45 NBI endoscopic videos of OC and OP lesions, respectively. Read More

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Cholesteatoma of Maxillary Sinus Simulating Neoplasia: A Rare Case Report.

Int J Appl Basic Med Res 2021 Jan-Mar;11(1):56-59. Epub 2021 Jan 26.

Department of Oral Pathology and Microbiology, Gitam Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India.

The term cholesteatoma refers to "chole": cholesterol, "steat": fat and "oma,": "tumor". This tumor has been reported to be the most common in the middle ear. The occurrence of such a tumor in the maxillary sinus is deemed to be very rare and hardly 4 cases were reported in India and 26 cases described worldwide. Read More

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January 2021

Ponderous Pleomorphic Adenoma of Parotid Obscuring a Grievous Tumor of the Head and Neck: A Rare Case Report.

Int J Appl Basic Med Res 2021 Jan-Mar;11(1):47-49. Epub 2021 Jan 26.

Department of Head and Neck Oncology, Karnataka Cancer Therapy and Research Institute, Hubli, Karnataka, India.

We present a rare case of simultaneous occurrence of pleomorphic adenoma of the left parotid gland and squamous cell carcinoma (SCC) of left buccal mucosa in a 59-year-old patient. The synchronous occurrence of these two entities has not been reported in the literature. A PubMed database search did not yield any results for search words involving "Oral Cancer," "Synchronous Oral Cancer and Pleomorphic Adenoma of Parotid gland" and "Oral SCC and Pleomorphic Adenoma of Parotid gland. Read More

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January 2021

Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer.

Am J Transl Res 2021 15;13(3):1594-1606. Epub 2021 Mar 15.

Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich Germany.

Triple-negative breast cancer (TNBC) patients have the worst outcome among all breast cancer subtypes. In oral squamous carcinoma cells, miR-378 was reported to target the mRNA of kallikrein-related peptidase 4 (KLK4), resulting in inhibition of cell proliferation, migration and invasion, induction of apoptosis, and reduction of tumor growth . Similarly, a miR-378/KLK4 axis has been proposed in prostate cancer. Read More

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Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression.

Tohoku J Exp Med 2021 ;253(4):249-259

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University.

Bacterial infection contributes to tumor development and malignant progression. Fusobacterium nucleatum (F. nucleatum) is reported to promote oral squamous cell carcinoma. Read More

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January 2021

What has the National Cancer Database taught us about oral cavity squamous cell carcinoma?

Int J Oral Maxillofac Surg 2021 Apr 8. Epub 2021 Apr 8.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA; Department of Oral and Maxillofacial Surgery, University of Pennsylvania, Philadelphia, PA, USA.

The wealth of data in the National Cancer Database (NCDB) has allowed numerous studies investigating patient, disease, and treatment-related factors in oral cavity squamous cell carcinoma (OCSCC); however, to date, no summation of these studies has been performed. The aim of this study was to provide a concise review of the NCDB studies on OCSCC, with the hopes of providing a framework for future, novel studies aimed at enhancing our understanding of clinical parameters related to OCSCC. Two databases were searched, and 27 studies published between 2002 and 2020 were included. Read More

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Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma.

Genomics Inform 2021 Mar 26;19(1):e5. Epub 2021 Mar 26.

Biomedical Research Unit and Laboratory Animal Centre-Dental Research Cell, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India.

Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity, paranasal sinuses, oral cavity, tongue, pharynx, and larynx. The Wnt signaling pathway is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Read More

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Differential Expression of Potential Biomarkers of Oral Squamous Cell Carcinoma Development.

Head Neck Pathol 2021 Apr 11. Epub 2021 Apr 11.

Departamento de Patologia, Programa de Pós-Graduação Em Biotecnologia, Centro de Ciências da Saúde - Universidade Federal do Espírito santo, Av. Marechal Campos, 1468 Maruípe, Vitoria, Espírito Santo, 29.043-900, Brazil.

To evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2A (CDKN2A), epidermal growth factor receptor (EGFR), polo like kinase 1 (PLK1), p63, p40 (Δnp63 isoform), cyclin D1 (CCND1) and BCL2 apoptosis regulator (BCL2) proteins could predict malignant transformation. Different tissue segments (tumor adjacent epithelium; dysplasia and tumor) from a total of 109 patients were analyzed by immunohistochemistry. An increased expression of survivin (p < 0. Read More

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Meta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients.

Biochim Biophys Acta Proteins Proteom 2021 Apr 8:140659. Epub 2021 Apr 8.

Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, São Paulo, Brazil. Electronic address:

Saliva is a biofluid that maintains the health of oral tissues and the homeostasis of oral microbiota. Studies have demonstrated that Oral squamous cell carcinoma (OSCC) patients have different salivary microbiota than healthy individuals. However, the relationship between these microbial differences and clinicopathological outcomes is still far from conclusive. Read More

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The combination of traditional and auricular acupuncture to prevent xerostomia and anxiety in irradiated patients with HNSCC: a preventive, parallel, single-blind, 2-arm controlled study.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Feb 27. Epub 2021 Feb 27.

Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil; Dilson Godinho Hospital, Montes Claros, Minas Gerais, Brazil. Electronic address:

Objective: The purpose of the present study was to investigate the effect of acupuncture on xerostomia in irradiated patients with head and neck squamous cell carcinoma (HNSCC).

Study Design: A preventive, 2-arm, parallel, single-blind trial was performed. Patients with HNSCC (N = 296) were checked for eligibility, and 107 patients were enrolled in the study. Read More

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February 2021

Do ipsilateral lateralized squamous cell carcinomas of oral tongue with a depth of invasion (DOI) greater than 10 mm warrant a bilateral neck dissection to prevent future regional recurrences on contralateral side? A continuing conundrum.

Oral Oncol 2021 Apr 7:105285. Epub 2021 Apr 7.

Department of Otorhinolaryngology and Head-Neck Surgery, Teaching Block, All India Institute Of Medical Sciences (AIIMS), New Delhi 110029, India. Electronic address:

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