1,165,983 results match your criteria oral manifestations

Can text messages encourage flossing among orthodontic patients?

Angle Orthod 2021 May 4. Epub 2021 May 4.

Objectives: To assess the extent to which text messages on WhatsApp play a role in patient awareness of the importance of proper oral hygiene and flossing on a daily basis and to test the null hypothesis that daily text messages do not influence the flossing habits of orthodontics patients.

Materials And Methods: Forty-four patients wearing fixed orthodontic appliances with a mean age of 14.3 years participated in the study. Read More

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Oculomotor Paresis with Cyclic Spasms in Chinese Populations: A Review of the Chinese Literature and a Case Report.

Pediatr Neurosurg 2021 May 4:1-8. Epub 2021 May 4.

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Introduction: Oculomotor paresis with cyclic spasms (OPCS) is a rare disorder in which the muscles innervated by the third cranial nerve undergo alternating rhythmic spasm and paralysis. This disease is usually noticeable at birth or developing during the first year of life. To date, most of the OPCS cases reported in the English-language literature were Caucasians. Read More

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Associations of Stylet Use during Neonatal Intubation with Intubation Success, Adverse Events, and Severe Desaturation: A Report from NEAR4NEOS.

Neonatology 2021 May 4:1-9. Epub 2021 May 4.

Department of Anesthesiology, Critical Care, and Pediatrics, University of Pennsylvania School of Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Introduction: Intubations are frequently performed procedures in neonatal intensive care units (NICU) and delivery rooms (DR). Unsuccessful first attempts are common as are tracheal intubation-associated events (TIAEs) and severe desaturations. Stylets are often used during intubation, but their association with intubation outcomes is unclear. Read More

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Polymer-coated microparticle scaffolds engineered for potential use in musculoskeletal tissue regeneration.

Biomed Mater 2021 May 4. Epub 2021 May 4.

Department of Oral and Craniofacial Sciences, University of Missouri Kansas City School of Dentistry, 650 E 25th St, Kansas City, Missouri, 64108-2716, UNITED STATES.

Biomaterials constructed exclusively of sintered microspheres have great potential in tissue engineering scaffold applications, offering the ability to create shape-specific scaffolds with precise controlled release yet to be matched by traditional additive manufacturing methods. The problem is that these microsphere-based scaffolds are limited in their stiffness for applications such as bone regeneration. Our vision to solve this problem was borne from a hierarchical structure perspective, focusing on the individual unit of the structure: the microsphere itself. Read More

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Tetrazoles as PPARγ ligands: A structural and computational investigation.

J Mol Graph Model 2021 Apr 26;106:107932. Epub 2021 Apr 26.

Grupo de Biotecnologia Molecular, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil. Electronic address:

Diabetes is an important chronic disease affecting about 10% of the adult population in the US and over 420 million people worldwide, resulting in 1.6 million deaths every year, according to the World Health Organization. The most common type of the disease, type 2 diabetes, can be pharmacologically managed using oral hypoglycemic agents or thiazolidinediones (TZDs), such as pioglitazone, which act by activating the Peroxisome Proliferated-Activated Receptor γ. Read More

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Inhomogeneity of stiffness and density of the extracellular matrix within the leukoplakia of human oral mucosa as potential physicochemical factors leading to carcinogenesis.

Transl Oncol 2021 May 1;14(7):101105. Epub 2021 May 1.

Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland; Department of Microbiology and Immunology, Institute of Medical Science, Collegium Medicum, Jan Kochanowski University in Kielce, PL-25317 Kielce, Poland. Electronic address:

Oral leukoplakia is a clinical term relating to various morphological lesions, including squamous cell hyperplasia, dysplasia and carcinoma. Leukoplakia morphologically manifested as hyperplasia with epithelial dysplasia is clinically treated as precancerous condition. Nevertheless, there is a lack of good markers indicating the transformation of premalignancies towards cancer. Read More

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Role of progesterone, cerclage and pessary in preventing preterm birth in twin pregnancies: A systematic review and network meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 24;261:166-177. Epub 2021 Apr 24.

Fetal Medicine Unit, Saint George's University of London, London, United Kingdom; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, United Kingdom.

Objective: To determine the role of progesterone, pessary and cervical cerclage in reducing the risk of (preterm birth) PTB in twin pregnancies and compare these interventions using pairwise and network meta-analysis.

Study Design: Medline, Embase, CINAHL and Cochrane databases were explored. The inclusion criteria were studies in which twin pregnancies were randomized to an intervention for the prevention of PTB (any type of progesterone, cervical cerclage, cervical pessary, or any combination of these) or to a control group (e. Read More

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Electrophilic nitro-fatty acids suppress psoriasiform dermatitis: STAT3 inhibition as a contributory mechanism.

Redox Biol 2021 Apr 24;43:101987. Epub 2021 Apr 24.

Departments of Dermatology, University of Pittsburgh School of Medicine. Pittsburgh, PA 15261, USA; Immunology, University of Pittsburgh School of Medicine. Pittsburgh, PA 15261, USA. Electronic address:

Psoriasis is a chronic inflammatory skin disease with no cure. Although the origin of psoriasis and its underlying pathophysiology remain incompletely understood, inflammation is a central mediator of disease progression. In this regard, electrophilic nitro-fatty acids (NO-FAs) exert potent anti-inflammatory effects in several in vivo murine models of inflammatory diseases, such as chronic kidney disease and cardiovascular disease. Read More

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FKBP11 promotes cell proliferation and tumorigenesis via p53-related pathways in oral squamous cell carcinoma.

Biochem Biophys Res Commun 2021 May 1;559:183-190. Epub 2021 May 1.

Department of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, 300041, China. Electronic address:

Oral squamous cell carcinoma (OSCC) is one of the causes of cancer-related death worldwide. The abnormal proliferation ability of OSCC has become one of the major reasons for its poor prognosis. FK-506 binding protein 11 (FKBP11) is abnormally expressed in malignant tumors and affects many biological processes. Read More

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Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer's disease.

Bioorg Chem 2021 Apr 17;111:104922. Epub 2021 Apr 17.

Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India. Electronic address:

Novel N-Benzylpyrrolidine hybrids were designed, synthesized, and tested against multiple in-vitro and in-vivo parameters. Among all the synthesized molecules, 8f and 12f showed extensive inhibition against beta-secretase-1 (hBACE-1), human acetylcholinesterase (hAChE) & human butyrylcholinesterase (hBuChE). These molecules are also endowed with significant AChE-peripheral anionic site (PAS) binding capability, blood-brain barrier permeability, potential disassembly of Aβ aggregates along with neuroprotection ability on SHSY-5Y cell lines. Read More

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Change in sense of food safety associated with social connectedness and information sources-A 10-year longitudinal survey before and after the Fukushima nuclear power plant accident.

Public Health 2021 May 1;194:156-162. Epub 2021 May 1.

Ken-poku Development Bureau, Fukushima Prefectural Goverment, Japan.

Objectives: This study analyzes the change in the sense of food safety over time, from 2 years before to 8 years after the Fukushima accident in 2011, and its association with social connectedness using cohort data, taking into account regional differences in Fukushima Prefecture.

Study Design: Repeated cross-sectional data from Fukushima Prefectural Government from 2009 to 2018 were used.

Methods: We randomly selected 1300 people every fiscal year (FY). Read More

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Higenamine alleviates allergic rhinitis by activating AKT1 and suppressing the EGFR/JAK2/c-JUN signaling.

Phytomedicine 2021 Apr 20;86:153565. Epub 2021 Apr 20.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Guangzhou Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou 510515, China; Guangdong Provincial Engineering Laboratory of Chinese Medicine Preparation Technology, Guangzhou 510515, China. Electronic address:

Background: Allergic rhinitis (AR) is an inflammatory, immunoglobulin E (IgE)-mediated disease characterized by the typical symptoms of sneezing, rhinorrhea, nasal itching, and congestion. Higenamine (HG) is a plant-based alkaloid, possesses a wide range of activities, including vascular and tracheal relaxation, antioxidative, antiapoptotic, anti-inflammatory, and immunomodulatory activities. So far, the effect and the underlying mechanism of HG on AR have not been studied. Read More

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Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARα pathway.

Biomed Pharmacother 2021 May 1;139:111630. Epub 2021 May 1.

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, PR China. Electronic address:

Background: Cardiac fibrosis occurs in ischemic and non-ischemic heart failure, hereditary cardiomyopathy, diabetes and aging. Energy metabolism, which serves a crucial function in the course and treatment of cardiovascular diseases, might have therapeutic benefits for myocardial fibrosis. Ginsenoside Rb3 (G-Rb3) is one of the main components of Ginseng and exhibits poor oral bioavailability but still exerts regulate energy metabolism effects in some diseases. Read More

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CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance.

Cell Stem Cell 2021 Apr 28. Epub 2021 Apr 28.

Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

Immunosurveillance is a critical mechanism guarding against tumor development and progression. Checkpoint inhibitors have shown significant success in cancer treatment, but expression of key factors such as PD-L1 in putative cancer stem cell (CSC) populations in squamous cell carcinoma has been inconclusive, suggesting that CSCs may have developed other mechanisms to escape immune surveillance. Here we show that CSCs upregulate the immune checkpoint molecule CD276 (B7-H3) to evade host immune responses. Read More

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The experience of transplantation as reflected in dream life: A case study illustrating the mental processing of a lung transplant.

Int J Psychoanal 2019 Jun;100(3):517-539

International Psychoanalytic University, Berlin, Germany.

Although it is well known that a lung transplant enhances the recipient's quality of life, our knowledge of how it is processed mentally is limited. In this study, interviews were conducted with a lung-transplant patient two weeks, three months, and six months after surgery so as to investigate the relevant unconscious processing mechanisms. A dream reported in the first interview was analysed in accordance withapplying the Zurich Dream Process Coding System. Read More

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In conversation: Freud, Abraham and Ferenczi on "Mourning and Melancholia" (1915-1918).

Ulrike May

Int J Psychoanal 2019 Feb;100(1):77-98

Berliner Psychoanalytisches Institut, Karl-Abraham-Institut, Berlin.

This article concentrates on Freud's draft of "Mourning and Melancholia," written in 1915 and published in 1996. After presenting a summary of the main theses of Freud's draft, Abraham's and Ferenczi's reactions to the text are discussed as well as Freud's response to their comments. In addition to reviewing Freud's partial adoption of Ferenczi's introjection and his reluctance towards Abraham's "mouth eroticism and sadism," the article considers the question of whether and to what extent his disciples' interjections-particularly Abraham's approach-made their way into the final version of "Mourning and Melancholia. Read More

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February 2019

Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M.

J Med Chem 2021 May 4. Epub 2021 May 4.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40508, United States.

The cullin-RING ubiquitin ligases (CRLs) are ubiquitin E3 enzymes that play a key role in controlling proteasomal degradation and are activated by neddylation. We previously reported inhibitors that target CRL activation by disrupting the interaction of defective in cullin neddylation 1 (DCN1), a CRL neddylation co-E3, and UBE2M, a neddylation E2. Our first-generation inhibitors possessed poor oral bioavailability and fairly rapid clearance that hindered the study of acute inhibition of DCN-controlled CRL activity in vivo. Read More

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Effect of interleukin-1β on bone morphogenetic protein-9-induced osteoblastic differentiation of human periodontal ligament fibroblasts.

Eur J Oral Sci 2021 May 4:e12792. Epub 2021 May 4.

Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Bone morphogenetic protein-9 (BMP-9) has been shown to potently induce osteoblastic differentiation of periodontal ligament fibroblasts (PDLFs) and may be a candidate therapeutic agent for periodontal tissue healing/regeneration, but the effect of the inflammatory environment of periodontitis on such approaches is unclear. We investigated whether interleukin-1β (IL-1β) affected BMP-9-mediated osteoblastic differentiation of human (h) PDLFs. IL-1β suppressed BMP-9-induced osteogenic differentiation of hPDLFs, as evidenced by reduced alkaline phosphatase (ALP) activity and mineralization, and the downregulated expression of BMP-9-mediated bone-related genes, RUNX2, SP7, IBSP, and SPP1. Read More

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Effect of dental malocclusion on cerebellar neuron activation via the dorsomedial part of the principal sensory trigeminal nucleus.

Eur J Oral Sci 2021 May 4:e12788. Epub 2021 May 4.

School of Stomatology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.

Occlusion has been proposed to play a role for body posture and balance, both of which are mediated mainly by the cerebellum. The dorsomedial part of the principal sensory trigeminal nucleus (Vpdm) has direct projection to the cerebellum. The experimental unilateral anterior crossbite (UAC) has an impact on the motor nuclei in the brain stem via trigeminal mesencephalic nucleus (Vme). Read More

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The role of cognitive and non-cognitive factors in dental anxiety: A mediation model.

Eur J Oral Sci 2021 May 4:e12793. Epub 2021 May 4.

Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Napoli, Italy.

Dental anxiety is a crucial problem for dentistry because it may represent a significant risk to oral health. Different factors, whether non-cognitive (e.g. Read More

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The lingual foramen as a potential anatomical complication for dental implant placement in the anterior mandible.

J Oral Implantol 2021 May 4. Epub 2021 May 4.

Saveetha Dental College and Hospitals Prosthodontics 162 Poonamallee High Road INDIA Chennai Tamil nadu 600077 +91-98401-42716.

The purpose of this article is to assess the incidence of lingual foramina and associated vasculature in the anterior mandible to improve the understanding of their locations for dental implant placement. Intra-operative bleeding can be a significant complication. Pre-surgical assessment of the surgical site should be performed to identify anatomical landmarks. Read More

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Implant-based oral rehabilitation in systemic sclerosis patients: a systematic review.

J Oral Implantol 2021 May 4. Epub 2021 May 4.

Universite de Strasbourg 1: Universite de Strasbourg Faculté de Chirurgie Dentaire 8 rue Sainte Elisabeth FRANCE STRASBOURG Alsace 67000 Université de Strasbourg, Faculté de Chirurgie Dentaire - Hôpitaux Universitaires de Strasbourg, Centre de Référence Maladies Rares Orales et Dentaires - INSERM UMR_S 1109 - Strasbourg, France.

Systemic sclerosis is a rare multisystem autoimmune disorder that significantly impacts the orofacial region. Several oral features including microstomia and increased tooth loss contribute to the mouth-related disability. Prosthetic rehabilitation is very challenging in these patients. Read More

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Digital workflow for CAD-CAM custom abutments of immediate implants based on natural emergence profile of the tooth to be extracted.

J Oral Implantol 2021 May 4. Epub 2021 May 4.

University of Malta Associate Professort Dental Surgery Mater dei Hospital, MSD, Block 1, Level 2 MALTA Msida Msida 2090 551132662049 +35699729634 School of Dentistry, University of São Paulo.

The aim of this report is to present a digital workflow technique to design a customized abutment for provisionalization of an immediate-placed implant based on the natural emergence profile of the tooth to be extracted. The workflow involves the combination of intraoral and CBCT scans, from which three-dimensional (3D) reconstructions of soft tissue and alveolar bone, as well as of the tooth to be extracted are obtained and exported as STL files. The files are imported to a computer-aided design (CAD) software, in which a virtual wax-up and custom abutment design are performed considering the natural emergence profile of the patient's tooth prior to extraction. Read More

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Second-stage surgery in the posterior maxilla to enhance and thicken the keratinized gingiva - a case report.

J Oral Implantol 2021 May 4. Epub 2021 May 4.

Ludwig-Maximilians-Universitat Munchen Prosthodontics Goethestr. 70 GERMANY Munich Bavaria 93413 Ludwig-Maximilians-Universitat Munchen.

Purpose: Bone augmentation and implant placement often lead to a coronal shift of the soft tissue. Therefore replacement of the mucogingival border during second-stage surgery is required. Different techniques have been described in the literature. Read More

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Fungal asthma among Ugandan adult asthmatics.

Med Mycol 2021 May 4. Epub 2021 May 4.

Makerere University Lung Institute, College of Health Sciences, Makerere University, P.O. Box 7749, Kampala, Uganda.

Fungal sensitization is associated with poor asthma control. We aimed to determine the prevalence and factors associated with fungal asthma among Ugandan adults. Individuals aged ≥18 years with a new diagnosis of asthma in the last 12 months participating in the African Severe Asthma Program constituted the study population. Read More

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Evaluation of fracture resistance of zirconia modification/polishing around implant abutments.

J Oral Implantol 2021 May 4. Epub 2021 May 4.

Associate Professor, Phillip Maurer Tennis Professor of Clinical Dentistry, Assistant Director of Advanced Prosthodontics, Director of Predoctoral Implant Dentistry, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, Califor.

Subcrestal placement of implants may have interproximal bone proximity issues that interfere with submucosal contour of the implant-supported Zirconia restorations during delivery of these restorations.  Modification of the mesial distal submucosal areas may be necessary to fully seat the restoration without impingement of the interproximal bone. Our aim was to determine if modification of submucosal cervical contour of implant supported zirconia titanium base (Zi-Ti base) restorations result in a significant change in fracture strength compared to Zi-Ti base restorations without any modification near the cervical submucosal area. Read More

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Implant therapy in the rehabilitation of mandibular arteriovenous malformations.

J Oral Implantol 2021 May 4. Epub 2021 May 4.

Aix-Marseille Universite Faculte de Medecine Oral surgery 264 Rue Saint-Pierre FRANCE Marseille 13385 Aix-Marseille Universite Faculte de Medecine.

Purpose: Mandibular arteriovenous malformations are rare congenital malformations which require multidisciplinary care. Implant-supported rehabilitation of significant bone defect after embolization and resection is poorly described in the literature.

Clinical Report: We present the case of a 24 year-old patient with a right sided mandibular arteriovenous malformations diagnosed after massive hemorrhage and treated by embolization and resection surgery. Read More

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Implant-Prosthetic Rehabilitation of a Patient with Squamous Cell Carcinoma: A Case Report.

J Oral Implantol 2021 May 4. Epub 2021 May 4.

Atatürk University Faculty of Dentistry Prosthodontics Atatürk University Faculty of Dentistry Department of Prosthodontics TURKEY Erzurum Yakutiye 25240 Atatürk University Faculty of Dentistry.

Patients who have undergone maxillary resection procedures are rehabilitated with dental obturators or microvascular reconstruction. This case report describes implant-supported prosthetic rehabilitation of a patient who underwent maxillary resection due to squamous cell carcinoma. After maxillectomy surgery, the patient was rehabilitated using a surgical obturator for one week followed by an interim obturator until the surgical field was completely healed. Read More

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Small molecule natural products in human nasal/oral microbiota.

J Ind Microbiol Biotechnol 2021 Feb 6. Epub 2021 Feb 6.

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley 94720, USA.

Small molecule natural products are a chemically diverse class of biomolecules that fulfill myriad biological functions, including autoregulation, communication with microbial neighbors and the host, interference competition, nutrient acquisition, and resistance to oxidative stress. Human commensal bacteria are increasingly recognized as a potential source of new natural products, which may provide insight into the molecular ecology of many different human body sites as well as novel scaffolds for therapeutic development. Here, we review the scientific literature on natural products derived from residents of the human nasal/oral cavity, discuss their discovery, biosynthesis, and ecological roles, and identify key questions in the study of these compounds. Read More

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February 2021

Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage.

PLoS One 2021 4;16(5):e0250862. Epub 2021 May 4.

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Resolvin D1, a specialized pro-resolving lipid mediator produced from docosahexaenoic acid by 15- and 5-lipoxygenase, exerts anti-inflammatory effects driving to the resolution of inflammation. The present study aimed to elucidate its role in small intestinal damage induced by nonsteroidal anti-inflammatory drug (NSAID). Indomethacin was administered orally to C57BL/6J male mice, which were sacrificed 24 h later to collect small intestine specimens. Read More

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