50,181 results match your criteria oral glucose


WJCPR11 reverses the TNF-α-induced inhibition of adipocyte differentiation and glucose uptake.

Biochem Biophys Res Commun 2021 Sep 20;578:150-156. Epub 2021 Sep 20.

College of Pharmacy & Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea. Electronic address:

Berberine is a natural isoquinoline alkaloid present in various herbs and is effective against metabolic syndrome in the pre-diabetic stage and high insulin resistance. The present study aimed to determine the effectiveness of WJCPR11, a berberine derivative that is commonly used for diabetes treatment, in ameliorating insulin resistance and diabetes treatment. WJCPR11 promoted adipocyte differentiation to a higher extent than other berberine derivatives and showed no noticeable toxicity in its effective concentration range. Read More

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September 2021

Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during AsO-induced endoplasmic reticulum stress in BEAS-2B cells.

Toxicology 2021 Sep 21;462:152962. Epub 2021 Sep 21.

Department of Occupational Medicine and Environmental Toxicology, College of Public Health, Nantong University, Nantong, Jiangsu, 226019, China. Electronic address:

Inorganic arsenic is widely present in the environment. Exposure to moderate to high concentrations of arsenic from drinking water or air can cause various cancers and multisystem dysfunction. Glucose-regulated protein 78 (GRP78) is an endoplasmic reticulum (ER) stress sensor of unfolded protein response (UPR) under stress conditions and it enhances cell survival. Read More

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September 2021

Evaluation of venous plasma glucose measured by point-of-care testing (Accu-Chek Inform II) and a hospital laboratory hexokinase method (Cobas c701) in oral glucose tolerance testing during pregnancy - a challenge in diagnostic accuracy.

Scand J Clin Lab Invest 2021 Sep 24:1-8. Epub 2021 Sep 24.

Department of Obstetrics and Gynecology, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

To diagnose gestational diabetes mellitus (GDM), plasma glucose measurements during oral glucose tolerance test (OGTT) put high demands on the methods in terms of accuracy. The aim was to evaluate and compare diagnostic performance of a point-of-care test and a glucose hexokinase laboratory method. Using risk-based screening, 175 pregnant women were included. Read More

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September 2021

The characteristics of intestinal flora in overweight pregnant women and the correlation with gestational diabetes mellitus.

Endocr Connect 2021 Sep 1. Epub 2021 Sep 1.

H Wang, Shanghai General Hospital, Shanghai Jiao Tong University school of Medicine,, Shanghai, 201600, China.

Objective: To investigate the characteristics of intestinal flora in overweight pregnant women and the correlation with gestational diabetes mellitus (GDM).

Methods: A total of 122 women were enrolled and divided into four groups according to their pre-pregnancy body mass index (BMI) and the presence of GDM: group 1 (n = 71) with a BMI < 24 kg/m2, without GDM; group 2 (n = 27) with a BMI < 24 kg/m2, with GDM; group 3 (n = 17) with a BMI ≥ 24 kg/m2, without GDM; and group 4 (n = 7) with a BMI ≥ 24 kg/m2 with GDM. Feces were collected on the day that the oral glucose tolerance test was conducted. Read More

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September 2021

Association of Sugar-sweetened Beverage Consumption with Prediabetes and Glucose Metabolism Markers in Hispanic/Latino Adults in the United States: Results from HCHS/SOL.

J Nutr 2021 Sep 24. Epub 2021 Sep 24.

Department of Medicine, Division of Endocrinology, Metabolims and Nutrition, Duke University School of Medicine, Durham NC.

Background: Diabetes mellitus and consumption of sugar-sweetened beverages is high in the Hispanic/Latino population in the United States. The associations between consumption of sugar-sweetened beverages, artificially sweetened beverages, and 100% fruit juice with prediabetes and glucose metabolism markers in the diverse Hispanic/Latino population in the US are unknown.

Objective: To examine the cross-sectional associations between consumption of sugar-sweetened beverages, artificially sweetened beverages, and 100% fruit juice with prediabetes and glucose metabolism markers such as fasting glucose and insulin, 2-hour oral glucose tolerance test (OGTT) glucose, HOMA index for insulin resistance (HOMA-IR), HOMA index for β-cell function (HOMA-B), and hemoglobin A1C (HbA1c) among US Hispanic/Latino adults. Read More

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September 2021

Effectiveness of a nurse-led online educational programme based on basic insulin therapy in patients with diabetes mellitus: A quasi-experimental trial.

J Clin Nurs 2021 Sep 23. Epub 2021 Sep 23.

Department of Endocrinology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, No.7 Weiwu Street, Zhengzhou, 450000, China.

Aims And Objectives: To evaluate the effectiveness of a nurse-led online educational programme based on patients with diabetes mellitus treated with initial basal insulin therapy.

Background: Patients with type 2 diabetes mellitus (T2DM) need to be treated with insulin to control hyperglycaemia and reduce the risk of diabetic complications when oral hypoglycaemic drugs are not effective or contraindicated. Current practices emphasise the leading role of nurses in patients treated with initial basal insulin therapy after discharge. Read More

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September 2021

The 1-Hour Plasma Glucose: Common Link Across the Glycemic Spectrum.

Authors:
Michael Bergman

Front Endocrinol (Lausanne) 2021 7;12:752329. Epub 2021 Sep 7.

Division of Endocrinology, Diabetes and Metabolism, VA New York Harbor Healthcare System, NYU Grossman School of Medicine, New York, NY, United States.

Evidence from populations at risk for type 1 diabetes, type 2 diabetes or gestational diabetes substantiates the 1-hour plasma glucose as a sensitive alternative marker for identifying high-risk individuals when ß-cell function is relatively more functional. An elevated 1-hour plasma glucose could therefore diagnose dysglycemia and risk for complications across the glycemic spectrum. Reducing the 2-hour oral glucose tolerance test to 1-hour would reduce the burden on patients, likely reduce costs, and enhance its accessibility in practice. Read More

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September 2021

Plasma Ceramides containing Saturated Fatty Acids are Associated with Risk of Type 2 Diabetes.

J Lipid Res 2021 Sep 20:100119. Epub 2021 Sep 20.

University of Washington Cardiovascular Health Research Unit, 1730 Minor Ave #1360 Seattle, WA 98101 USA; Medicine, 1410 NE Campus Parkway, Seattle WA, 98105 USA.

Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bound lipid species. Here we investigated associations of 15 ceramide and sphingomyelin species (i. Read More

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September 2021

Maternotoxicity and fetotoxicity in Rattus norvegicus albinus exposed to tramadol during the late phase of pregnancy.

Birth Defects Res 2021 Sep 22. Epub 2021 Sep 22.

Department of Pharmacology, Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan.

Objectives: Tramadol, an atypical opioid, is clinically efficacious in treating moderate to severe pain. The aim of current study was to find out the toxicological effects of tramadol exposure to pregnant rats and fetuses during the late phase of pregnancy.

Methods: Wistar pregnant rats were exposed to 1. Read More

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September 2021

Qingre Yiqi Method along with Oral Hypoglycemic Drugs in Treating Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2021 11;2021:4395228. Epub 2021 Sep 11.

Graduate School, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Objective: To evaluate the efficacy of the Qingre Yiqi method in the treatment of type 2 diabetes mellitus (T2DM) with meta-analysis.

Method: The randomized controlled trials (RCTs) of the Qingre Yiqi method in the treatment of T2DM in the PubMed, Medline, EMBase, Cochrane Library, Web of Science, Weipu Journal, China Knowledge Network (CNKI), and Wanfang database were conducted. Three reviewers independently conducted the screening, extracted the data, and assessed methodological quality. Read More

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September 2021

The Deterrence of Rapid Metabolic Decline within 3 Months after Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes.

Diabetes 2021 Sep 22. Epub 2021 Sep 22.

Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.

Endpoints that provide an early identification of treatment effects are needed to implement type 1 diabetes prevention trials more efficiently. To this end, we assessed whether metabolic endpoints can be used to detect a teplizumab effect on rapid β-cell decline within 3 months after treatment in high-risk individuals in the TrialNet teplizumab trial. Glucose and C-peptide response curves (GCRCs) were constructed by plotting mean glucose and C-peptide values from 2-hour oral glucose tolerance tests on a 2-dimensional grid. Read More

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September 2021

Type 2 diabetes mellitus promotes the proliferation, metastasis and suppresses the apoptosis in oral squamous cell carcinoma.

J Oral Pathol Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya hospital of Central South University, Changsha, Hunan, 410008, China.

Background: Our previous study revealed that patients with oral squamous cell carcinoma and concomitant type 2 diabetes mellitus presented a lower 5-year survival rate. Hyperglycemia has been increasingly recognized as a risk factor for more advanced disease and poorer prognosis in patients with oral squamous cell carcinoma. However, its role remains unclear. Read More

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September 2021

Effects of methylphenidate on height, weight and blood biochemistry parameters in prepubertal boys with attention deficit hyperactivity disorder: an open label prospective study.

Scand J Child Adolesc Psychiatr Psychol 2021 9;9:163-173. Epub 2021 Sep 9.

Clinical Biochemistry Division, Health Sciences University, Antalya Training and Research Hospital, Antalya, Turkey.

Adverse effects of stimulants on growth in children have long been studied, but the results remain to be clarified, because metabolic changes or predictors accompanying the growth deviations were not sufficiently studied. This open label-prospective study investigated the effects of methylphenidate (MPH) on weight, height, blood biochemistry in children with attention deficit hyperactivity disorder (ADHD). Prepubertal boys treated with MPH in Child and Adolescent Psychiatry Clinic at Antalya Training and Research Hospital in Health Sciences University, Turkey were recruited. Read More

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September 2021

Buccal Bone Remodeling Around Immediate Implants in STZ-Induced Diabetic Dogs: A Histologic and Microcomputed Tomographic Analysis.

Int J Periodontics Restorative Dent 2021 Sep-Oct;41(5):683-690

Buccal bone remodeling around immediate implants placed in animals with streptozotocin (STZ)-induced diabetes has not been investigated. The present histologic and microcomputed tomography (μCT) in vivo experiment assessed the buccal bone remodeling around immediate implants, extraction socket healing, and bone-to-implant contact (BIC) in dogs with and without STZ-induced diabetes. Three male beagle dogs with STZ-induced diabetes and three healthy dogs (controls) were included. Read More

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September 2021

Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes.

Pharmacogenet Genomics 2021 Sep 20. Epub 2021 Sep 20.

Department of Endocrinology Department of Infection Control Department of Neurology, Meizhou People's Hospital, Meizhou, Guangdong Province Department of Endocrinology, Central Hospital of Shenzhen Guangming New District, Shenzhen Department of Endocrinology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, People's Republic of China.

Metformin is the first-choice oral anti-hyperglycemic drug for type 2 diabetes mellitus (T2DM) patients. There are controversies about the association of SLC22A1 rs622342, which was not reported in the Chinese population, and ataxia-telangiectasia mutated (ATM) rs11212617 polymorphisms with metformin efficacy in T2DM. Our study was to investigate the effects of the two single nucleotide polymorphisms on the efficacy of metformin in T2DM of Han nationality in Chaoshan China. Read More

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September 2021

The effect of N-acetylcysteine and ascorbic acid-2-phosphate supplementation on Mesenchymal Stem Cell function in B6.C-Lepob/J type 2 diabetic mice.

Stem Cells Dev 2021 Sep 21. Epub 2021 Sep 21.

Stellenbosch University Faculty of Medicine and Health Sciences, 121470, Medicine, Fransie van Zijl drive, Tygerberg Campus, Clinical building, Cape Town, South Africa, 7500;

Diabetes is a complex multifactorial disorder associated with hyperglycaemia, oxidative stress and inflammation. The pathological microenvironment impairs MSC viability and dysregulates their pro-regenerative and immune-modulatory function causing maladaptive tissue damage. Targeting stem cells to protect them against impairment could thus delay the onset of complications and enhance the quality of life in DM patients. Read More

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September 2021

Efficacy and safety of empagliflozin at different doses in patients with type 2 diabetes mellitus: A network meta-analysis based on randomized controlled trials.

J Clin Pharm Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardio-Thoracic Surgery, The second affiliated hospital of Nanchang University, Nanchang, China.

What Is Known And Objective: As an oral hypoglycaemic drug that significantly reduces cardiovascular risk, empagliflozin is often used in patients with type 2 diabetes mellitus (T2DM). However, the dosage and administration of empagliflozin are still controversial clinically. To determine the most appropriate dose, we performed this network meta-analysis. Read More

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September 2021

The effects of glucose-free and glucose-containing dialysate during dialysis in MHD patients: a prospective cross-over study.

Perfusion 2021 Sep 19:2676591211042726. Epub 2021 Sep 19.

Department of Nephrology, Beijing Tsinghua Changgung Hospital, Medical Center, Tsinghua University, Changping District, Beijing, China.

Objective: To investigate the effects of glucose-free and glucose-containing dialysates during dialysis in maintenance hemodialysis (MHD) patients by the prospective cross-over study, and detect glucose control methods in MHD patients.

Methods: A total of 66 MHD 18-75 years old patients in our hospital from Nov. 2019 to Mar. Read More

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September 2021

Maternal Serum Delta-Like 1 and Nesfatin-1 Levels in Gestational Diabetes Mellitus: A Prospective Case-Control Study.

Cureus 2021 Aug 8;13(8):e17001. Epub 2021 Aug 8.

Biochemistry, Yozgat Bozok University, Faculty of Medicine, Yozgat, TUR.

Objective Delta-like 1 (DLK1) and nesfatin-1 are adipokines that have been shown to affect glucose metabolism. We aimed to search serum DLK1 and nesfatin-1 concentrations at 24-28 weeks of pregnancy in women newly defined with gestational diabetes mellitus (GDM) and investigate the relationship of these adipokines with various metabolic parameters. Methods Serum levels of DLK1 and nesfatin-1 were evaluated in 44 women with GDM, and in 40 healthy pregnant women by enzyme-linked immunosorbent assay (ELISA) kits. Read More

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Full The Relationship between Continuous Glucose Monitoring and OGTT in Youth and Young Adults with Cystic Fibrosis.

J Clin Endocrinol Metab 2021 Sep 19. Epub 2021 Sep 19.

Department of Pediatrics, Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Center, Aurora, CO.

Context: Early glucose abnormalities in people with CF (PwCF) are commonly detected by continuous glucose monitoring (CGM). Relationships between these CGM abnormalities and oral glucose tolerance testing (OGTT) in PwCF have not been fully characterized.

Objective(s): 1) To determine the relationship between CGM and common OGTT-derived estimates of β-cell function, including C-peptide index and oral disposition index (oDI) and 2) to explore whether CGM can be used to screen for OGTT-defined prediabetes and cystic fibrosis related diabetes (CFRD). Read More

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September 2021

Future directions in insulin therapy.

Authors:
Philip Home

Metabolism 2021 Sep 15:154889. Epub 2021 Sep 15.

Translational and Clinical Research Institute, Newcastle University, UK. Electronic address:

Insulin therapy has a long history at the cutting edge of technological development through purification, extended-action, molecular chemistry, and devices, and in support technologies including self-measurement and patient education. But unmet needs remain large. Today's therapy cannot deliver minute-to-minute control of glucose levels, and cannot imitate the reflex/incretin driven physiological insulin delivery at mealtimes. Read More

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September 2021

Effectiveness of a customised mobile phone text messaging intervention supported by data from activity monitors for improving lifestyle factors related to the risk of type 2 diabetes among women after gestational diabetes: protocol for a multicentre randomised controlled trial (SMART MUMS with smart phones 2).

BMJ Open 2021 Sep 17;11(9):e054756. Epub 2021 Sep 17.

Westmead Applied Research Centre, The University of Sydney, Sydney, New South Wales, Australia.

Introduction: Gestational diabetes (GDM) contributes substantially to the population burden of type 2 diabetes (T2DM), with a high long-term risk of developing T2DM. This study will assess whether a structured lifestyle modification programme for women immediately after a GDM pregnancy, delivered via customised text messages and further individualised using data from activity monitors, improves T2DM risk factors, namely weight, physical activity (PA) and diet.

Methods And Analysis: This multicentre randomised controlled trial will recruit 180 women with GDM attending Westmead, Campbelltown or Blacktown hospital services in Western Sydney. Read More

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September 2021

Megakaryocytes mediate hyperglycemia-induced tumor metastasis.

Cancer Res 2021 Sep 17. Epub 2021 Sep 17.

Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University

High blood glucose has long been established as a risk factor for tumor metastasis, yet the molecular mechanisms underlying this association have not been elucidated. Here we describe that hyperglycemia promotes tumor metastasis via increased platelet activity. Administration of glucose, but not fructose, reprogrammed the metabolism of megakaryocytes to indirectly prime platelets into a pro-metastatic phenotype with increased adherence to tumor cells. Read More

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September 2021

Magneto-Responsive Microneedle Robots for Intestinal Macromolecule Delivery.

Adv Mater 2021 Sep 17:e2104932. Epub 2021 Sep 17.

Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210002, China.

Oral administration is the most convenient and commonly used approach for drug delivery, while it is still a challenge to overcome the complicated gastrointestinal barriers and realize efficient macromolecular drug absorption. Here, novel magneto-responsive microneedle robots are presented for efficient oral delivery of versatile macromolecules. These microneedle robots with three components of the magnetic substrate, the separable connection, and tips are generated by a Lego-brick-stacking-inspired multistage 3D fabrication strategy. Read More

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September 2021

The effects of insulin therapy on mortality in diabetic patients undergoing percutaneous coronary intervention.

Ann Transl Med 2021 Aug;9(16):1294

Cardiovascular Department, Tianjin Medical University General Hospital, Tianjin, China.

Background: A growing number of studies have reported insulin therapy to be associated with a higher incidence of major adverse cardiac events in diabetic patients with coronary artery disease. However, the relationship between insulin use and the clinical outcomes of patients with diabetes who undergoing percutaneous coronary intervention (PCI) has not been fully clarified.

Methods: A total of 1,069 consecutive patients with diabetes who underwent PCI were enrolled and divided into 2groups: oral hypoglycemic agents (OHA) group (709 patients) and insulin therapy group (360 patients). Read More

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Factors Associated With Gestational Diabetes Mellitus: A Cross-Sectional Study.

Cureus 2021 Aug 11;13(8):e17113. Epub 2021 Aug 11.

Obstetrics and Gynaecology, Isra University, Hyderabad, PAK.

Introduction The absence of tolerance in the levels of carbohydrates at the onset or at the time of pregnancy amongst females is known as gestational diabetes mellitus (GDM). This study is designed to determine the frequency of GDM and factors responsible for GDM to assess the actual magnitude of the outcome. Furthermore, it allows for developing strategies to minimize morbidities and improve the pregnancy outcome by early diagnosis and timely management, which can help reduce the frequency of GDM. Read More

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Study of TCM Syndrome Identification Modes for Patients with Type 2 Diabetes Mellitus Based on Data Mining.

Evid Based Complement Alternat Med 2021 6;2021:5528550. Epub 2021 Sep 6.

School of Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

Objective: To establish the diagnosis model for syndromes of type 2 diabetes mellitus (T2-DM) and explore symptoms, the pulse and tongue signs, and laboratory indexes related to syndromes of T2-DM.

Methods: A syndromatologic and laboratory investigation was conducted in 554 T2-DM patients with 58 symptoms, 14 tongue signs, 6 pulse signs, and 12 laboratory indexes. The clinical data on the syndrome were collected and analyzed by using logistic regression analysis, decision tree, and -nearest neighbor to establish a diagnostic model for effectively distinguishing the typical syndromes in T2-DM patients. Read More

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September 2021

Beta-cell failure rather than insulin resistance is the major cause of abnormal glucose tolerance in Africans: insight from the Africans in America study.

BMJ Open Diabetes Res Care 2021 Sep;9(1)

NIDDK, National Institutes of Health, Bethesda, Maryland, USA

Introduction: Uncertainties exist on whether the main determinant of abnormal glucose tolerance (Abnl-GT) in Africans is β-cell failure or insulin resistance (IR). Therefore, we determined the prevalence, phenotype and characteristics of Abnl-GT due to β-cell failure versus IR in 486 African-born blacks (male: 64%, age: 38±10 years (mean±SD)) living in America.

Research Design And Methods: Oral glucose tolerance test were performed. Read More

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September 2021

Shape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin.

BMJ Open Diabetes Res Care 2021 Sep;9(1)

Research and Development, VA Puget Sound Health Care System Seattle Division, Seattle, Washington, USA.

Introduction: The shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to determine if phenotypic or metabolic characteristics were associated with glucose response curve shape in adults with type 2 diabetes treated with metformin alone. Read More

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September 2021