59,732 results match your criteria oral doses

Sericin Protects Against Acute Sleep Deprivation-Induced Memory Impairment via Enhancement of Hippocampal Synaptic Protein Levels and Inhibition of Oxidative Stress and Neuroinflammation in Mice.

Brain Res Bull 2021 Jun 18. Epub 2021 Jun 18.

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Sleep deprivation (SD) induces learning and memory deficits via inflammatory responses and oxidative stress. On the other hand, sericin (Ser) possesses potent antioxidant and neuroprotective effects. We investigated the effect of different doses of Ser on the SD-induced cognitive impairment. Read More

View Article and Full-Text PDF

Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure.

Food Chem Toxicol 2021 Jun 18:112352. Epub 2021 Jun 18.

Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Louvain centre for Toxicology and Applied Pharmacology, Avenue Hippocrate 57, 1200, Brussels, Belgium.

Background: Nanotechnologies provide new opportunities for improving the safety, quality, shelf life, flavor and appearance of foods. The most common nanoparticles (NPs) in human diet are silver metal, mainly present in food packaging and appliances, and silicon and titanium dioxides used as additives. The rapid development and commercialization of consumer products containing these engineered NPs is, however, not well supported by appropriate toxicological studies and risk assessment. Read More

View Article and Full-Text PDF

[Prescription of phosphorus, calcium and magnesium: choice of the millimole unit to establish the equivalence of doses between oral and injectable forms].

Ann Pharm Fr 2021 Jun 18. Epub 2021 Jun 18.

Service pharmaceutique, hospices civils de Lyon, hôpital de la Croix-Rousse, groupement hospitalier Nord, 103 grande rue de la Croix Rousse, 69317 Lyon Cedex 04, France.

Objectives: Information available on the packaging of drugs indicated for patients electrolytes replenishment differs from one manufacturer to another. They relate, for example, the unit chosen to express elemental electrolyte concentration. These differences constitute a risk factor for medication errors. Read More

View Article and Full-Text PDF

Efficacy and safety of adalimumab in paediatric patients with moderate-to-severe ulcerative colitis (ENVISION I): a randomised, controlled, phase 3 study.

Lancet Gastroenterol Hepatol 2021 Jun 18. Epub 2021 Jun 18.

Shaare Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.

Background: Biologic treatment options are limited for children with ulcerative colitis. The aim of this study was to assess the safety and efficacy of adalimumab in children with moderate-to-severe ulcerative colitis.

Methods: The double-blind ENVISION I study was done at 24 hospitals in ten countries. Read More

View Article and Full-Text PDF

Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice.

Front Cell Dev Biol 2021 4;9:669732. Epub 2021 Jun 4.

Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, China.

The association between the accumulation of synthetic chemicals with estrogenic activity and risks to oogenesis has become a growing concern. This study indicates that estrogen exposure can affect homologous recombination in early oogenesis and influence the reproductive potential and lifespan of female offspring. We conducted this study in developing mouse ovaries using two different models: oral doses administered to the mother, and fetal ovary cultures. Read More

View Article and Full-Text PDF

Demystifying particle-based oral vaccines.

Expert Opin Drug Deliv 2021 Jun 19. Epub 2021 Jun 19.

Department of Chemical Engineering, Texas Tech University, Lubbock, Texas, USA.

Introduction: The oral route of vaccination is pain- and needle-free and can induce systemic and mucosal immunity. However, gastrointestinal barriers and antigen degradation impose significant hurdles in the development of oral vaccines. Live attenuated viruses and bacteria can overcome these barriers but at the risk of introducing safety concerns. Read More

View Article and Full-Text PDF

Clinical Features and Dosimetric Evaluation of Carbon Ion Radiation-Induced Osteoradionecrosis of Mandible in Head and Neck Tumors.

Radiother Oncol 2021 Jun 17. Epub 2021 Jun 17.

Gunma University Heavy Ion Medical Center, Maebashi, Gunma, 371-8511, Japan.

Background And Purpose: Osteoradionecrosis (ORN) affects the patient's quality of life by making eating and maintaining oral hygiene painful. This study aimed to analyze carbon ion radiotherapy (C-ion RT)-induced ORN of the mandible.

Materials And Methods: A retrospective study of 199 patients with head and neck tumors treated with C-ion RT was performed from 2010-2019. Read More

View Article and Full-Text PDF

A Toxicological Evaluation of Lithium Orotate.

Regul Toxicol Pharmacol 2021 Jun 16:104973. Epub 2021 Jun 16.

Toxi-Coop Zrt., Berlini utca 47-49, H-1045 Budapest, Hungary. Electronic address:

Lithium orotate, the salt of lithium and orotic acid, has been marketed for decades as a supplemental source of lithium with few recorded adverse events. Nonetheless, there have been some concerns in the scientific literature regarding orotic acid, and pharmaceutical lithium salts are known to have a narrow therapeutic window, albeit, at lithium equivalent therapeutic doses 5.5-67 times greater than typically recommended for supplemental lithium orotate. Read More

View Article and Full-Text PDF

Tildacerfont in Adults with Classic Congenital Adrenal Hyperplasia: Results from Two Phase 2 Studies.

J Clin Endocrinol Metab 2021 Jun 19. Epub 2021 Jun 19.

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI and Department of Pharmacology, University of Michigan, Ann Arbor, MI.

Context: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD) is typically treated with lifelong supraphysiologic doses of glucocorticoids (GCs). Tildacerfont, a corticotropin-releasing factor type-1 receptor antagonist, may reduce excess androgen production, allowing for GC dose reduction.

Objective: Assess tildacerfont safety and efficacy. Read More

View Article and Full-Text PDF

Effects of Itraconazole and Rifampin on the Pharmacokinetics of Mobocertinib (TAK-788), an Oral Epidermal Growth Factor Receptor Inhibitor, in Healthy Volunteers.

Clin Pharmacol Drug Dev 2021 Jun 19. Epub 2021 Jun 19.

Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.

Mobocertinib (TAK-788) is an investigational oral tyrosine kinase inhibitor targeting epidermal growth factor receptor and human epidermal growth factor 2. A phase 1 open-label, 2-period, fixed-sequence, 2-part study (NCT03928327) characterized effects of a strong CYP3A4 inhibitor (itraconazole) and inducer (rifampin) on the pharmacokinetics (PK) of mobocertinib and its active metabolites, AP32960 and AP32914. Healthy volunteers (n = 12 per part) received a single dose of mobocertinib alone (20 mg, part 1; 160 mg, part 2) and with multiple doses of itraconazole 200 mg once daily (part 1) or rifampin 600 mg once daily (part 2). Read More

View Article and Full-Text PDF

Developmental stages influence in vivo antimalarial activity of aerial part extracts of Schkuhria pinnata.

J Ethnopharmacol 2021 Jun 15:114341. Epub 2021 Jun 15.

Department of Biology, Faculty of Science, Mbarara University of Science and Technology, Mbarara, Uganda; Pharm-Biotechnology and Traditional Medicine Center, Mbarara University of Science and Technology, Mbarara, Uganda. Electronic address:

Ethnopharmacological Relevance: Malaria remains a dire health challenge, particularly in sub-Saharan Africa. In Uganda, it is a most ordinary condition in hospital admission and outpatient care. The country's meager health services compel malaria patients to use herbal remedies such as Schkuhria pinnata (Lam. Read More

View Article and Full-Text PDF

A Toxicological Evaluation of Geranylgeraniol.

Regul Toxicol Pharmacol 2021 Jun 15:104975. Epub 2021 Jun 15.

TOXI-COOP Zrt., Berlini utca 47-49, H-1045, Budapest, Hungary. Electronic address:

Geranylgeraniol (GGOH) is an isoprenoid compound found in annatto seeds and an intermediate of the mevalonate pathway found within organisms serving various functions. Toxicological studies on its safety profile are not readily available. To assess the safety of GGOH, a molecularly distilled, food grade annatto oil, consisting of approximately 80% trans-GGOH, was subjected to a bacterial reverse mutation test, an in vitro mammalian chromosomal aberration test, and an in vivo mammalian micronucleus test in order to investigate its genotoxic potential and a 90-day repeated-dose oral toxicity study in rats in order to investigate its potential subchronic toxicity and identify any target organs. Read More

View Article and Full-Text PDF

Clinical validation of AggreGuide A-100 ADP, a novel assay for assessing the antiplatelet effect of oral P2Y antagonists.

J Thromb Thrombolysis 2021 Jun 18. Epub 2021 Jun 18.

PCS Houston LLC, Houston, TX, USA.

In this prospective, 3-arm, repeated-measure multicenter investigation in 280 patients with cardiovascular risk factors, platelet aggregation was measured with the novel AggreGuide A-100 ADP (A-100 ADP) and VerifyNow (VN)-PRU assays at baseline, and after United States Food and Drug Administration approved loading and 7 days maintenance doses of clopidogrel (n = 94), prasugrel (n = 43) or ticagrelor, (n = 143). Based on the predetermined cutoff values of < 4.7 platelet activity index with A-100 ADP assay to indicate antiplatelet response, more than 91% of patients met the criteria following loading and maintenance doses of prasugrel and more than 84% patients met the criteria following loading and maintenance doses of ticagrelor whereas only 32% and 51% of patients met the criteria following loading and maintenance doses of clopidogrel, respectively. Read More

View Article and Full-Text PDF

An Ayurveda Gargle Regimen in Management of Radiotherapy-induced Oral Mucositis.

South Asian J Cancer 2020 Oct 15;9(4):250-252. Epub 2021 Jun 15.

Department of Medical Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India.

 Radiotherapy-induced oral mucositis (RIOM) in patients with head and neck cancer may lead to significant morbidity. OM may result in erythema, ulceration, and pseudomembrane formation. The usual time of onset is second or third week of radiotherapy (RT), after the doses of 16 to 18 Gy. Read More

View Article and Full-Text PDF
October 2020

Safety assessment of Bong. Steud leaves extract: acute, sub-acute toxicity, antioxidant, and antihemolytic evaluations.

Toxicol Res (Camb) 2021 May 29;10(3):613-626. Epub 2021 May 29.

Laboratório de Neuroendocrinologia e Metabolismo, Departamento de Fisiologia e Farmacologia, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Prof. Moraes Rego, 1235, 50670-901, Recife, Pernambuco, Brasil.

(Fabaceae), known popularly as pata-de-vaca and mororó has been largely recommended treating several diseases in folk medicine. However, information on safe doses and use is still scarce. The goal was to evaluate antioxidant and antihemolytic and also acute and sub-acute toxicity effects of hydroalcoholic extract from leaves (HaEBcl). Read More

View Article and Full-Text PDF

Modulatory effects of catechin hydrate on benzo[a]pyrene-induced nephrotoxicity in adult male albino rats.

Toxicol Res (Camb) 2021 May 17;10(3):542-550. Epub 2021 May 17.

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.

Benzo [a] pyrene (B[a]P) is a potent mutagen and carcinogen, considered one of the commonest concomitants in the environment. The study aimed to evaluate the effect of catechin hydrate on benzo pyrene-induced kidney toxicity. Thirty-six adult male albino rats were divided into six groups: group I untreated control, group II received 10 mL/kg of corn oil (solvent of benzo [a] pyrene) twice a week, group III received 1 mL/kg 0. Read More

View Article and Full-Text PDF

Discovery of Arylsulfonamide Na1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile.

ACS Med Chem Lett 2021 Jun 1;12(6):1038-1049. Epub 2021 Jun 1.

Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

The voltage-gated sodium channel Na1.7 continues to be a high-profile target for the treatment of various pain afflictions due to its strong human genetic validation. While isoform selective molecules have been discovered and advanced into the clinic, to date, this target has yet to bear fruit in the form of marketed therapeutics for the treatment of pain. Read More

View Article and Full-Text PDF

Electronic monitoring of adherence to once-daily and twice-daily direct oral anticoagulants in patients with atrial fibrillation: Baseline data from the SMAAP-AF trial.

J Arrhythm 2021 Jun 30;37(3):616-625. Epub 2021 Mar 30.

Department of Cardiology Tokyo Women's Medical University Tokyo Japan.

Background: Nonadherence diminishes the efficacy of direct oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation (NVAF). This report presents the baseline survey results regarding medication adherence among NVAF patients who were treated with once-daily edoxaban or twice-daily apixaban from a randomized control trial of the effect of an educational intervention on DOAC adherence.

Methods: We prospectively studied 301 NVAF patients who were treated with edoxaban (n = 175) or apixaban (n = 126) during the 12-week observation period. Read More

View Article and Full-Text PDF

Safety evaluation of long-chain glycolipids from .

EFSA J 2021 Jun 14;19(6):e06609. Epub 2021 Jun 14.

The EFSA Panel on Food Additives and Flavourings (FAF) provides a scientific opinion on the safety of long-chain glycolipids from (also called AM-1) as a food additive. AM-1 is a purified mixture of long-chain glycolipid congeners obtained by fermentation of the edible non-genetically modified fungus . AM-1 glycolipids have very low oral bioavailability and overall available toxicology data do not demonstrate any adverse effects of the proposed food additive. Read More

View Article and Full-Text PDF

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study.

Clin Pharmacol 2021 10;13:123-134. Epub 2021 Jun 10.

Research and Development, Aclaris Therapeutics, Inc., and Confluence Discovery Technologies, Inc., St. Louis, MO, USA.

Purpose: ATI-450 is an oral, small-molecule inhibitor of the p38α mitogen-activated protein kinase (MAPK)/MAPK-activated protein kinase 2 (MK2) inflammatory signaling pathway. This phase 1, single and multiple ascending dose (SAD, MAD) study evaluated ATI-450 safety, tolerability, pharmacokinetics, and pharmacodynamics.

Patients And Methods: Healthy adults were randomly assigned to SAD (10, 30, 50, 100 mg; n=24) and MAD (10, 30, 50 mg twice daily [BID] for 7 days; n=24) cohorts of ATI-450 or placebo (n=14). Read More

View Article and Full-Text PDF

Risk of upper gastrointestinal bleeding in patients on oral anticoagulant and proton pump inhibitor co-therapy.

PLoS One 2021 17;16(6):e0253310. Epub 2021 Jun 17.

Division of Cardiology, Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, Korea.

Background: Proton pump inhibitors (PPIs) are known to reduce the risk of upper gastrointestinal bleeding in patients on oral anticoagulants, and patients are increasingly on oral anticoagulants and PPI co-therapy. However, evidence is lacking on the safety and effectiveness of oral anticoagulants when co-administered with PPIs.

Methods: Among patients initiating oral anticoagulants (warfarin and non-vitamin K antagonist oral anticoagulants [NOACs], i. Read More

View Article and Full-Text PDF

Acute drug effects differentially predict desire to take dextroamphetamine again for work and recreation.

Psychopharmacology (Berl) 2021 Jun 17. Epub 2021 Jun 17.

Department of Psychology, University of Illinois At Chicago, 1007 W. Harrison St, MC 285, Chicago, IL, 60607, USA.

Rationale: Misuse of dextroamphetamine occurs in work and recreational contexts. While acute drug effects broadly predict abuse liability, few studies have considered the relationship between acute effects and context.

Objectives: This study examined how individual differences in acute effects of dextroamphetamine relate to desire to take dextroamphetamine again in different contexts. Read More

View Article and Full-Text PDF

Pharmacokinetics of Meloxicam Tablets in Healthy Chinese Adults in the Fasting and Fed States: A Single-Site, Single-Dose, Randomized, Open, 2-Period, 2-Sequence, Crossover Bioequivalence Study.

Clin Pharmacol Drug Dev 2021 Jun 17. Epub 2021 Jun 17.

Phase I Clinical Research Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Meloxicam is an enolate nonsteroidal anti-inflammatory agent. This trial investigated the pharmacokinetics, safety, and bioequivalence of single oral doses of Aomei meloxicam (15 mg) and Mobic meloxicam (15 mg) in healthy volunteers under fasting and fed conditions. A single-site, single-dose, randomized, open, 2-period, 2-sequence, crossover bioequivalence study was performed: 24 healthy volunteers were enrolled in each of the fasting and fed arms. Read More

View Article and Full-Text PDF

Antibody Responses to SARS-CoV-2 mRNA Vaccines Are Detectable in Saliva.

Pathog Immun 2021 7;6(1):116-134. Epub 2021 Jun 7.

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.

The approved Pfizer and Moderna mRNA vaccines are well known to induce serum antibody responses to the SARS-CoV-2 Spike (S)-protein. However, their abilities to elicit mucosal immune responses have not been reported. Saliva antibodies represent mucosal responses that may be relevant to how mRNA vaccines prevent oral and nasal SARS-CoV-2 transmission. Read More

View Article and Full-Text PDF

The Immunomodulating Effect of Baicalin on Inflammation and Insulin Resistance in High-Fat-Diet-Induced Obese Mice.

Evid Based Complement Alternat Med 2021 27;2021:5531367. Epub 2021 May 27.

Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.

Background: Obesity is a chronic low-grade systemic inflammation state, which causes insulin resistance, diabetes, and other metabolic diseases. Baicalin is known to have anti-inflammatory and antiobesity effects. In this study, we investigated the cellular and molecular immunological effects of baicalin on obesity-induced inflammation. Read More

View Article and Full-Text PDF

Protective Effects of Hydroalcoholic Extract of Fruit on Vancomycin-Induced Nephrotoxicity in Rats.

J Toxicol 2021 28;2021:5525714. Epub 2021 May 28.

Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

Vancomycin-induced nephrotoxicity (VIN) has been reported to occur in 5-35% of recipient patients. The aims of the study were to evaluate protective effects of (RC) on VIN in rats. Rats were randomly divided into five groups as follows: control group I, group II (received VAN 400 mg/kg/day, every 12 h at doses of 200 mg/kg/day, for 7 consecutive days), group III (VAN + RC 250 mg/kg/day, for 7 consecutive days), group IV (VAN + RC 500 mg/kg/day, for consecutive days), and group V (received RC 500 mg/kg/day, for consecutive 7 days). Read More

View Article and Full-Text PDF

Rupatadine Oral Solution Titration by Body Weight in Paediatric Patients Suffering from Allergic Rhinitis: A Population Pharmacokinetic Study.

Clin Pharmacol 2021 8;13:115-122. Epub 2021 Jun 8.

Departament de Farmacologia, de Terapèutica i de Toxicologia, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Allergic rhinitis (AR) and chronic urticaria, both are treated in children with doses of second generation of antihistamines that have been mostly based on extrapolation of data obtained in adults. The objectives of this work were to develop a model to explain the pharmacokinetics (PK) of rupatadine, a second generation antihistamine, administered to children 2-11 years old and to calculate the non-compartmental PK parameters for two groups of age (2-5 and 6-11 years old) based on the individual Bayesian estimates from the selected model.

Methods: Data from two PK studies with rupatadine oral solution (1 mg/mL) were pooled: Study A, an extensive blood sampling study performed in 11 children (6-11 years old) who received a single oral dose of rupatadine; and Study B, a sparse blood sampling study in 40 children (2-5 years old) receiving multiple oral doses. Read More

View Article and Full-Text PDF

Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system.

Part Fibre Toxicol 2021 Jun 16;18(1):23. Epub 2021 Jun 16.

Dipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milano, 26900, Lodi, Italy.

Background: Widespread use of silver in its different forms raises concerns about potential adverse effects after ingestion, the main exposure route for humans. The aim of this study was to investigate in CD-1 (ICR) male mice the tissue distribution and in vivo effects of 4-week oral exposure to 0.25 and 1 mg Ag/kg bw 10 nm citrate coated silver nanoparticles (AgNPs) and 1 mg Ag/kg bw silver acetate (AgAc) at the end of treatment (EoT) and after 4 weeks of recovery. Read More

View Article and Full-Text PDF

Reductions in endometriosis-associated pain among women treated with elagolix are consistent across a range of baseline characteristics reflective of real-world patients.

BMC Womens Health 2021 Jun 16;21(1):246. Epub 2021 Jun 16.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.

Background: Elagolix is an oral, gonadotropin-releasing hormone (GnRH) receptor antagonist, that significantly reduces dysmenorrhea and non-menstrual pelvic pain (NMPP) in women with moderate to severe endometriosis-associated pain.

Methods: Data were pooled from two 6-month, placebo-controlled, phase 3 studies (Elaris Endometriosis [EM]-I and II) in which 2 doses of elagolix were evaluated (150 mg once daily and 200 mg twice daily). Pooled data from > 1600 women, aged 18-49, were used to evaluate the efficacy of elagolix and health-related quality of life (HRQoL) in prespecified subgroups of women with various baseline characteristics. Read More

View Article and Full-Text PDF

Language impairment in the moderate stage of dementia due to Alzheimer's disease.

Arq Neuropsiquiatr 2021 Apr;79(4):283-289

Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brazil.

Background: During the moderate stage of dementia due to Alzheimer's disease (AD), language disorder is more evident and it impacts on communication. An overview of language impairment could be helpful to find compensatory communication strategies for these patients.

Objective: To identify all language impairments among patients with moderate-stage of AD. Read More

View Article and Full-Text PDF