35,813 results match your criteria oral delivery


Tiered Guidelines in a Pediatric Orthopaedic Practice Reduce Opioids Prescribed at Discharge.

J Pediatr Orthop 2021 Sep 27. Epub 2021 Sep 27.

Department of Orthopedic Surgery, Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.

Background: Data regarding opioid prescribing patterns following pediatric orthopaedic procedures is limited. The aim of this work was to evaluate the effects of tiered guidelines for discharge opioid prescriptions following common pediatric orthopaedic procedures.

Methods: Quality improvement project conducted at a single academic institution. Read More

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September 2021

Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification technique for transdermal delivery.

Biomed Pharmacother 2021 Sep 21;143:112130. Epub 2021 Sep 21.

Department of Pharmaceutics, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt. Electronic address:

Hydroxyzine HCL (HHCL) is an antihistamine, used for the treatment of allergic skin conditions. The purpose of this study was to achieve a dual phase drug delivery rate across the intact skin, to enhance HHCL permeation through the stratum corneum, to assess the peripheral H-antihistaminic activity and the extent to which HHCL was systemically absorbed from transdermal gel loaded with solid lipid nanoparticles (SLNs), as well as to avoid its extreme bitterness. According to 2 factorial design, eight formulations of HHCL-SLNs were prepared by the double emulsification method. Read More

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September 2021

Protocol for a feasibility randomized trial of self-management support for people with chronic obstructive pulmonary disease using lay health coaches.

Contemp Clin Trials 2021 Sep 21:106570. Epub 2021 Sep 21.

Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

Challenges with self-management are a major contributor to poor outcomes among adults with chronic obstructive pulmonary disease (COPD). The causes of poor self-management in COPD are manifold, and they arise from physical, cognitive, socioeconomic, environmental and societal sources. To address this complexity, we developed the Supporting self-Management Behaviors in Adults with COPD (SaMBA-COPD) model, which uses lay health coaches to identify a patient's barriers to effective COPD self-management and provide tailored support to help them overcome those barriers, reduce their symptoms and need for urgent care and improve their quality of life. Read More

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September 2021

A ROS-responsive fluorescent probe detecting experimental colitis by functional polymeric nanoparticles.

Int J Pharm 2021 Sep 21:121125. Epub 2021 Sep 21.

Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China; Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China; Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Current evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of inflammatory bowel disease (IBD). TotalROX (λabs/λem = 425/525 nm) is a ratiometric probe with high detection sensitivity and a superior capacity to monitor total cellular oxidative capacity. Herein, we investigated the potential of combining totalROX with an oral nanoparticle delivery system to detect the degree of colitis. Read More

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September 2021

Cholera pulse vaccination: A possible elimination strategy for cholera in endemic countries.

Indian J Public Health 2021 Jul-Sep;65(3):311-314

Senior Resident, Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Cholera is a diarrheal disease causing major health issue in developing countries where it is endemic and causes outbreaks. India ranks first with an estimated 675,188 number of cases and 20,256 number of deaths annually with one-third of its population at risk. The two broad approaches for cholera control are improving sanitation and vaccination. Read More

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September 2021

Enhanced oral bioavailability and anti-hyperuricemic activity of liquiritin via self-nanoemulsifying drug delivery system.

J Sci Food Agric 2021 Sep 24. Epub 2021 Sep 24.

Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Zhenjiang, 212001, China.

Background: This study focused on the development of a self-nanoemulsifying drug delivery system (SNEDDS) to potentially improve the solubility and oral bioavailability of liquiritin (LQ).

Methods: The solubilities of the LQ in different types of excipients namely oils (OLs), emulsifiers (EMs) and co-emulsifiers (CO-EMs) were evaluated, meanwhile the pseudo-ternary phase diagram (PTPD) and the formulation optimization were established. The characterizations of the prepared self-nanoemulsifying drug delivery system of liquiritin (LQ-SNEDDS) were assessed using droplet size (DS), zeta potential (ZP), polydispersity index (PDI), droplet morphology, drug release in vitro and oral bioavailability. Read More

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September 2021

Predictors of periodontal and caries related perinatal oral healthcare, investigation of dentists' practices: a cross-sectional study.

PeerJ 2021 1;9:e12080. Epub 2021 Sep 1.

School of Dentistry, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan.

Background: The objectives of the study were to assess the knowledge, attitude, and practice of dentists towards providing oral health care to pregnant women and to identify barriers and predictors of periodontal and caries related perinatal oral healthcare practices.

Methods: A cross-sectional analytical survey was conducted on dentists by using a random sampling technique, and a pre-validated questionnaire was delivered to 350 dentists from May 2018 to October 2018. Data were analyzed by utilizing SPSS software. Read More

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September 2021

pH-Responsive Nanocomposite Based Hydrogels for the Controlled Delivery of Ticagrelor; In Vitro and In Vivo Approaches.

Int J Nanomedicine 2021 16;16:6345-6366. Epub 2021 Sep 16.

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.

Background: Ticagrelor (TG), an antiplatelet drug is employed to treat patients with acute coronary syndrome, but its inadequate oral bioavailability due to poor solubility and low permeability restricts its effectiveness.

Purpose: This contemporary work was aimed to design a novel pH-sensitive nanocomposite hydrogel (NCH) formulation incorporating thiolated chitosan (TCH) based nanoparticles (NPs) of Ticagrelor (TG), to enhance its oral bioavailability for effectively inhibiting platelet aggregation.

Methods: NCHs were prepared by free radical polymerization technique, using variable concentrations of chitosan (CH) as biodegradable polymer, acrylic acid (AA) as a monomer, N,N-methylene bisacrylamide (MBAA) as cross-linker, and potassium persulphate (KPS) as initiator. Read More

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September 2021

Patient preferences in retinal drug delivery.

Sci Rep 2021 Sep 23;11(1):18996. Epub 2021 Sep 23.

Eugene and Marilyn Glick Eye Institute and Department of Ophthalmology, Indiana University School of Medicine, 1160 West Michigan Street, Indianapolis, IN, 46202, USA.

Retinal vascular diseases (RVDs) are often treated with intravitreally (IVT) injected drugs, with relatively low patient compliance and potential risks. Ongoing research explores alternative RVD treatments, including eye drops and oral tablets. This study surveyed RVD patients treated with IVT injections to establish factors influencing low compliance rates while gauging treatment delivery method preferences. Read More

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September 2021

Intranasal iloprost prevents tumors in a murine lung carcinogenesis model.

Cancer Prev Res (Phila) 2021 Sep 23. Epub 2021 Sep 23.

Medicine/Division of Pulmonary Sciences, Eastern Colorado Veterans Affairs Medical Center

Lung cancer chemoprevention with the prostacyclin analogue iloprost is the most promising approach to date for intercepting progression of premalignant lung lesions in former smokers. Previous pre-clinical studies of iloprost used oral delivery, but a study modeling delivery directly to the target organ was needed. In vivo and in vitro studies have identified gene expression changes following iloprost treatment, including increased E-cadherin and PPAR𝛄 and decreased COX2 and Vimentin. Read More

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September 2021

Management of sinus graft infection-a systematic review.

Int J Oral Maxillofac Surg 2021 Sep 20. Epub 2021 Sep 20.

Université de Lille, CHU Lille, INSERM, Service de Chirurgie Maxillo-Faciale et Stomatologie, U1008 - Controlled Drug Delivery Systems and Biomaterial, Lille, France.

Sinus graft infections are rare but serious complications, as they are associated with significant morbidity and sinus graft loss. The aim of this study was to systematically review the management of sinus graft infection in order to define which protocols should be implemented. The terms searched in each database were "sinus graft infection management", "maxillary sinus lift infection", "maxillary sinus graft infection", "maxillary sinus elevation infection", and "maxillary sinus augmentation infection". Read More

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September 2021

Morphometry and displacement analysis of the upper lips following maxillary full-arch implant-supported fixed prostheses: a 3D morphometric study.

BMC Oral Health 2021 Sep 23;21(1):461. Epub 2021 Sep 23.

Department of Implantology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, People's Republic of China.

Background: With the emergence of three-dimensional (3D) integration technology, analysis of soft tissue displacement and morphological changes after maxillary full-arch implant-supported fixed prostheses can be performed. The aim of this study was to verify the feasibility of the 3D integration method for constructing the relative position of the prostheses and facial soft tissue, evaluate the displacement and morphological variation of the upper lips after maxillary full-arch implant-supported fixed prostheses.

Methods: Twenty-five maxillary edentulous patients were recruited in this study. Read More

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September 2021

Combination therapy of vanillic acid and oxaliplatin co-loaded in polysaccharide based functionalized polymeric micelles could offer effective treatment for colon cancer: A hypothesis.

Med Hypotheses 2021 Sep 14;156:110679. Epub 2021 Sep 14.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India. Electronic address:

Colon cancer is characterised by the persistent change in bowel habits due to the formation of polyps (cancerous) in the inner lining of the colon. Clinically, there are several anticancer drugs available to treat colon cancer. Oxaliplatin (third generation platinum drug) is widely prescribed anticancer drug due to its broad range anticancer properties and low toxicities over cisplatin and carboplatin. Read More

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September 2021

Transition from Compounded to Monotherapy Intrathecal Pain Medication Reduces Drug Costs: Retrospective Analysis of Patient Billing Data.

Pain Physician 2021 Sep;24(6):489-494

Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, RI.

Background: Chronic pain accounts for several hundred billion dollars in total treatment costs, and lost productivity annually. Selecting cost-effective pain treatments can reduce the financial burden on both individuals and society. Targeted drug delivery (TDD), whereby medications used to treat pain are delivered directly to the intrathecal space, remains an important treatment modality for chronic pain refractory to oral medication management. Read More

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September 2021

Oral delivery of solid lipid nanoparticles: underlining the physicochemical characteristics and physiological condition affecting the lipolysis rate.

Expert Opin Drug Deliv 2021 Sep 23. Epub 2021 Sep 23.

Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Lipid-based nano-drug delivery systems (LBNDDSs) have gained widespread attention in oral drug delivery due to their tunable and versatile properties such as biocompatibility and biodegradability, which makes them promising delivery systems for a variety of therapeutics. Currently, different types of LBNDDSs including liposomes, micelles, nanoemulsions, and solid lipid nanoparticles (SLNs) are developed for drug delivery applications. SLNs can be used as a controlled drug delivery system for oral delivery applications. Read More

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September 2021

Natural Nano-Drug Delivery System in Extract with Modified Berberine Hydrochloride Pharmacokinetics.

Int J Nanomedicine 2021 14;16:6297-6311. Epub 2021 Sep 14.

Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.

Purpose: This study aimed to evaluate the pharmaceutical and pharmacokinetic effects of the natural nanoparticles (Nnps) isolated from extract on berberine hydrochloride (BBR) and systematically explore the related mechanisms.

Methods: Firstly, Nnps were isolated from extract and then an Nnps-BBR complex was prepared. After qualitative and quantitative analysis in terms of size, Zeta potential, morphology, and composition of the Nnps and the Nnps-BBR complex, the effects of the Nnps on the crystallization of BBR were characterized. Read More

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September 2021

Formulation and fluoride content of dentifrices: a review of current patterns.

Br Dent J 2021 Sep 21. Epub 2021 Sep 21.

National Lead for Oral Health Improvement, Public Health England, UK.

Introduction Consumer oral hygiene products play a key role in improving and maintaining population oral health. The oral personal care market is rapidly diversifying; a growing number of dentifrices marketed a 'natural' and fluoride-free are entering mainstream retailers, which may have implications for the oral health of the population 'with regards to caries risk.Aims To investigate the range of fluoride concentrations, flavour formulations and delivery mechanisms of dentifrices available on the UK market. Read More

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September 2021

3D-Printed Pacifier-Shaped Mouthpiece for fMRI-Compatible Gustometers.

eNeuro 2021 Sep 22. Epub 2021 Sep 22.

Swiss Center for Affective Science, University of Geneva, Switzerland.

Gustometers have made it possible to deliver liquids in functional magnetic resonance imaging (fMRI) settings for decades, and mouthpieces are a critical part of these taste delivery systems. Here, we propose an innovative 3D-printed fMRI mouthpiece inspired by children's pacifiers, allowing human participants to swallow while lying down in an MRI scanner. We used a large sample to validate the effectiveness of our method. Read More

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September 2021

Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial.

BMJ 2021 Sep 22;374:n2103. Epub 2021 Sep 22.

Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia.

Objective: To evaluate whether extended release metformin could be used to prolong gestation in women being expectantly managed for preterm pre-eclampsia.

Design: Randomised, double blind, placebo controlled trial.

Setting: Referral hospital in Cape Town, South Africa. Read More

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September 2021

Oral colon-targeting core-shell microparticles loading curcumin for enhanced ulcerative colitis alleviating efficacy.

Chin Med 2021 Sep 22;16(1):92. Epub 2021 Sep 22.

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China.

Background: The oral colon-targeting drug delivery vehicle is vital for the efficient application of curcumin (Cur) in ulcerative colitis (UC) treatment because of its lipophilicity and instability in the gastrointestinal tract.

Methods: The core-shell microparticle (MP) system composed of eco-friendly materials, zein and shellac, was fabricated using a coaxial electrospray technique. In this manner, Cur was loaded in the zein core, with shellac shell coating on it. Read More

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September 2021

Platelet lysate functionalized GelMA microspheres for improving angiogenesis in endodontic regeneration.

Acta Biomater 2021 Sep 19. Epub 2021 Sep 19.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Chengdu Shiliankangjian Biotechnology Co., Ltd.. Electronic address:

Rapid angiogenesis is one of the challenges in endodontic regeneration. Recently, tailored polymeric microsphere system that loaded pro-angiogenic growth factors (GFs) is promising in facilitating vascularization in dental pulp regeneration. In addition, the synergistic effect of multiple GFs is considered more beneficial, but combination usage of them is rather complex and costly. Read More

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September 2021

Nano Spray-Dried Drugs for Oral Administration: A Review.

Assay Drug Dev Technol 2021 Sep 21. Epub 2021 Sep 21.

Institute for Energy Systems, Eastern Switzerland University of Applied Sciences of Technology, Buchs, Switzerland.

Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. Read More

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September 2021

A comprehensive review on possibilities of treating psoriasis using dermal cyclosporine.

Drug Deliv Transl Res 2021 Sep 22. Epub 2021 Sep 22.

Department of Pharmacy, Institute of Technology and Management, Gorakhpur, UP, 273209, India.

Psoriasis is an autoimmune, chronic proliferative, inflammatory skin disease with high comorbidity. Psoriasis is not a curable disease; it can only be managed. Cyclosporine A (CyA) is one of the FDA-approved immunosuppressant drug used in severe Psoriasis. Read More

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September 2021

Decision aids for shared decision-making and appropriate anticoagulation therapy in patients with atrial fibrillation: a systematic review and meta-analysis.

Eur J Cardiovasc Nurs 2021 Sep 22. Epub 2021 Sep 22.

Shenzhen Qianhai and Shekou Free Trade Zone Hospital, No. 36, 7th Industrial Road, Nanshan District, Shenzhen City, Guangdong Province 518067, P.R. China.

Aims: Underuse of oral anticoagulants (OACs) is commonly observed among patients with atrial fibrillation (AF), which hinders stroke prevention in AF. Shared decision-making (SDM) can help enhance adherence by minimizing patients' misunderstanding of treatment and aligning care with their preferences. Decision aids (DAs) have been developed to facilitate the SDM process. Read More

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September 2021

The status of fertility control for rodents - recent achievements and future directions.

Integr Zool 2021 Sep 22. Epub 2021 Sep 22.

CSIRO Health and Biosecurity, Canberra, ACT, Australia.

Management of overabundant rodents at a landscape scale is complex but often required to sustainably reduce rodent abundance below damage thresholds. Current conventional techniques such as poisoning are not species specific, with some approaches becoming increasingly unacceptable to the general public. Fertility control, first proposed for vertebrate pest management over 5 decades ago, has gained public acceptance because it is perceived as a potentially more species-specific and humane approach compared with many lethal methods. Read More

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September 2021

The high potency of polymeric nanoparticles in the drug delivery system for hypertension treatment; A systematic review.

Curr Hypertens Rev 2021 Sep 21. Epub 2021 Sep 21.

Cardiovascular Research Center, Lorestan University of Medical Sciences, Khorramabad. Iran.

Background: Polymeric nanomaterials with size ranging from 10 to 1000 nm are one of the most widely used types of nanoparticles with ideal properties in the drug delivery systems. Here, we decided to systematically review the antihypertensive effects of polymeric nanomaterials in vitro, in vivo, and clinical trials.

Methods: The present review was conducted based on the 06- PRISMA guideline; whereas five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar without time limitation were used for searching the publications related to antihypertensive effects of natural and synthetic polymeric nanoparticles. Read More

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September 2021

Application of commercially available mesoporous silica for drug dissolution enhancement in oral drug delivery.

Eur J Pharm Sci 2021 Sep 18:106015. Epub 2021 Sep 18.

Faculty of Pharmacy, University of Ljubljana, 1000, Ljubljana, Slovenia. Electronic address:

Due to the high number of poorly water-soluble active pharmaceutical ingredients, oral drug delivery development has become challenging. One of the strategies to enhance drug solubility and to achieve high oral bioavailability is to formulate such compounds into amorphous solid dispersions. In recent years, porous materials have been investigated as possible carriers into which a drug can be adsorbed, such as mesoporous silica, in particular. Read More

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September 2021

Aberrant neurogenesis and late onset suppression of synaptic plasticity as well as sustained neuroinflammation in the hippocampal dentate gyrus after developmental exposure to ethanol in rats.

Toxicology 2021 Sep 18:152958. Epub 2021 Sep 18.

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address:

Drinking alcohol during pregnancy may cause fetal alcohol spectrum disorder. The present study investigated the effects of maternal oral ethanol (EtOH) exposure (0, 10, or 12.5% in drinking water) from gestational day 6 until day 21 post-delivery (weaning) on postnatal hippocampal neurogenesis at weaning and in adulthood on postnatal day 77 in rat offspring. Read More

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September 2021

Marginal Bone and Keratinized Mucosa Alterations Around Sloped Implants Placed in Healed Sloped Crests: A Long-Term Cohort Study.

Int J Periodontics Restorative Dent 2021 Sep-Oct;41(5):733-741

To improve the adaptation to bone level discrepancies of sloped alveolar crests, an implant with a sloped implant-abutment interface has been developed. In a previously reported international multicenter study, 65 sloped implants replaced single teeth with a buccolingual bone level discrepancy at least 3 months after tooth loss. The present study reports the long-term outcomes of one study center and also evaluates marginal bone and keratinized mucosa alterations around sloped implants in healed, sloped crests in a long-term follow-up. Read More

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September 2021