426,337 results match your criteria oral cavity

Overloading stress-induced progressive degeneration and self-repair in condylar cartilage.

Ann N Y Acad Sci 2021 May 7. Epub 2021 May 7.

Department of Orthodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, China.

Overloading stress-induced condylar cartilage degeneration acts as the main pathologic change in temporomandibular joint osteoarthritis (TMJ-OA). However, the progression of degeneration and the ability for self-repair remain poorly understood. Here, we explored the progression of cartilage degeneration by dividing pathological stages using a steady mouth-opening mouse model. Read More

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The relevance of vitamin D in the oral health of HIV infected patients.

J Steroid Biochem Mol Biol 2021 May 4:105905. Epub 2021 May 4.

Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.

HIV infection affects 36.9 million people globally, and vitamin D deficiency is a global public health concern for HIV patients. Approximately 70% to 80% of HIV-infected patients have vitamin D deficiency. Read More

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Lipid nanocapsules loaded with prilocaine and lidocaine and incorporated in gel for topical application.

Int J Pharm 2021 May 4:120675. Epub 2021 May 4.

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas - São Paulo, Brazil. Electronic address:

Lipid nanocapsules (LNC) are special drug delivery system (DDS) carriers obtained by the phase-inversion temperature method (PIT). This study describes the encapsulation of the local anesthetics (LA) prilocaine (PLC) and lidocaine (LDC) in lipid nanocapsules (LNC) optimized by 2 factorial design, characterized through DLS, NTA, CRYO-EM and release kinetics and incorporated in carbopol gel (Gel) prior to in vivo anesthetic effect (in mice) evaluation. A very homogeneous population of small (50 nm; polydispersity index = 0. Read More

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Impact of wearing a surgical and cloth mask during cycle exercise.

Appl Physiol Nutr Metab 2021 May 7. Epub 2021 May 7.

University of Waterloo, 8430, Department of Kinesiology, BMH 1110, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1;

We sought to determine the impact of wearing cloth or surgical masks on the cardiopulmonary responses to moderate-intensity exercise. Twelve subjects (n=5 females) completed three, 8-min cycling trials while breathing through a: non-rebreathing valve (laboratory control), cloth, or surgical mask. Heart rate (HR), oxyhemoglobin saturation (SpO2), breathing frequency (Fb), mouth pressure, partial pressure of end-tidal carbon dioxide (PetCO2) and oxygen (PetO2), dyspnea, were measured throughout exercise. Read More

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Prelaminated flaps in head and neck cancer reconstructive surgery: A systematic review.

Microsurgery 2021 May 7. Epub 2021 May 7.

Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Modena, Italy.

Background: Prelamination is a reconstructive technique providing fasciomucosal or composite flaps with low donor-site morbidity. We conducted a systematic review of retrospective studies to assess the application of prelaminated flaps in reconstructive surgery of head and neck cancer patients, and to evaluate the advantages and disadvantages of this technique.

Methods: This systematic review adhered to the recommendations of the PRISMA (Preferred Reporting Items of Systematic Reviews and Meta-analysis) 2009 guidelines. Read More

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An activated-zinc oral rinse reduces pro-inflammatory cytokine secretion and promotes proliferation in Porphyromonas gingivalis LPS-challenged gingival tissues - A pilot study.

Clin Exp Dent Res 2021 May 6. Epub 2021 May 6.

Southern Illinois University School of Dental Medicine, Alton, Illinois, USA.

Objectives: The use of adjunct post-treatment mouth rinses containing chlorhexidine (CHX) for periodontitis patients is associated with side effects that reduce patient compliance. Our aim was to evaluate the proinflammatory and cell proliferation effects of an activated-zinc mouth rinse (SM) that has been suggested as an alternative post-treatment therapeutic.

Materials And Methods: Tissue models of gingival epithelium were used to simulate periodontal disease and compare inflammatory reactions after treatment with CHX or SM. Read More

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Uncommon Pigmented Carcinoma In Situ: Case Report and Brief Review.

Clin Pathol 2021 Jan-Dec;14:2632010X211009819. Epub 2021 Apr 20.

Department of Pathology, School of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil.

Pigmented lesions of the oral mucosa encompass several benign and malignant conditions that may be a matter of concern under both clinical and histopathological views. We reported a case of a 62-year-old woman, presenting with an asymptomatic, deeply pigmented lesion on the soft palate. On examination, it appeared asymmetrical, with irregular borders and an area of ulceration. Read More

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Large Rhinolith Mimicking Atypical Odontogenic Pain: Case Report and Brief Review of the Literature.

Case Rep Dent 2021 17;2021:5550187. Epub 2021 Apr 17.

Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Rhinoliths are rare calcified entities in the nasal fossa, frequently originating around a nidus near the midway point in the inferior meatus, where the passage is the narrowest. They can be clinically asymptomatic and undetected for years. In this study, we present a rare case of large rhinolith mimicking atypical odontogenic pain in a 40-year-old Caucasian female in the left nasal cavity. Read More

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Vinyl bag cover method to avoid droplet-containing aerosol escape from endoscopic forceps channel caps during COVID-19 pandemic (with Video 1 and Video 2).

World J Gastrointest Endosc 2021 Apr;13(4):111-114

Endoscopy Center, Aso Iizuka Hospital, Iizuka 820-8505, Japan.

Endoscopists are at high risk of allowing transmission of coronavirus disease 2019 (COVID-19) during gastrointestinal endoscopy (GIE) procedures under pandemic conditions. The main avenues of droplet-containing aerosol generated during GIE are the mouth, anus, and endoscopic forceps channel. Although the usefulness of personal protective equipment for preventing COVID-19 dissemination has been well reported, measures to address infected aerosol escaping during endoscopic forceps use have been neglected. Read More

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Phylogeny and diversity of (Polyporales, Basidiomycota), including four new species from South America and Asia.

MycoKeys 2021 26;79:149-172. Epub 2021 Apr 26.

School of Ecology and Nature Conservation, Beijing Forestry University, Beijing 100083, China Beijing Forestry University Beijing China.

Four new species of , viz. , , , and , are described from tropical America and Asia. is characterised by dark grey to black pore surface, a monomitic hyphal system, hyaline to yellowish-brown generative hyphae, and ellipsoid basidiospores measuring 3. Read More

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Covid-19 Community Mitigation Status at Selected Districts of Southwest Ethiopia: A Mixed Design Survey.

Risk Manag Healthc Policy 2021 28;14:1763-1775. Epub 2021 Apr 28.

Health Education in School of Public Health, College of Medicine and Health Sciences, Nech Sar Campus, Arba Minch University, Arba Minch, Southwest Ethiopia, Ethiopia.

Background: The spread of covid-19 was alarmingly continued in Ethiopia. This survey assessed the status of community mitigations to fight the pandemic. The ongoing forward effort by local task forces can be assessed to note the achievements. Read More

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Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition.

Sci Rep 2021 May 6;11(1):9719. Epub 2021 May 6.

Collaborative and Translation Unit for HFMD, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

The Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults. It has however emerged as a significant public health threat in recent years as outbreaks have been occurring regularly, especially in the Asia-Pacific. The disease can result from infections by a wide variety of human enteroviruses, particularly, Enterovirus A71 (EV-A71) has garnered more attention due to its association with severe disease in infected patients. Read More

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Glenohumeral Arthrodesis Using Pelvic Reconstruction Plates: a Series of 15 Patients.

Ortop Traumatol Rehabil 2021 Apr;23(2):59-64

Artemis Hospital, Gurgaon, Haryana, India.

Background: Glenohumeral joint arthrodesis has become a rare entity due to the introduction of shoulder arthroplasty. It is an excellent salvage procedure for patients with severe shoulder dysfunction, with limited treatment options, indicated for brachial plexus injury, tumour resection, chronic infection, failed prosthetic arthroplasty, or pseudoparalysis of the shoulder due to combined rotator cuff and deltoid deficiency. Shoulder arthrodesis relieves the patient of pain and gives a decent amount of function. Read More

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Oral myofibroma presenting as an aggressive gingival lesion.

BMJ Case Rep 2021 May 6;14(5). Epub 2021 May 6.

Department of Oral & Maxillofacial Pathology and Microbiology, Amrita Vishwa Vidyapeetham, Amrita School of Dentistry, Kochi, Kerala, India.

Myofibromas are benign neoplasms of myofibroblastic origin and rarely encountered in the oral cavity. Myofibroma may frequently grow rapidly leading to suspicion of malignancy. This may lead to a tendency for aggressive management. Read More

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Can perioperative hemodilution be monitored with non-invasive measurement of blood hemoglobin?

BMC Anesthesiol 2021 May 6;21(1):138. Epub 2021 May 6.

Department of Anesthesiology and Intensive Care, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Background: Trends in non-invasive measurements of blood hemoglobin (Hb) may be useful for identifying the need for transfusion in the perioperative period.

Methods: Crystalloid fluid (5-20 mL/kg) was administered intravenously or by mouth to 30 volunteers and 33 surgical patients in five non-randomized clinical studies where Hb was measured on 915 occasions by non-invasive (Radical-7™) and invasive methodology. The hemodilution curves were compared by volume kinetic analysis and linear regression, with the slope and scattering of the data as key outcome measures. Read More

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Surgery alone for transorally resected human papillomavirus-driven head and neck cancer-Can we de-intensify adjuvant therapy to 0 Gy and 0 mg/m ?

Jared M Weiss

Cancer 2021 May 6. Epub 2021 May 6.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Lay Summary: Although smoking has traditionally been the dominant causative factor of head and neck cancer, cancers of the tonsils and base of tongue increasingly are being driven by human papillomavirus, and these cancers are easier to cure. When radiation is used as the primary curative treatment, a number of studies have shown good outcomes with reduced doses of both radiation and chemotherapy. New techniques that access the tumor through the mouth instead of the jaw have made surgery dramatically less toxic. Read More

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Role of Microbes in the Pathogenesis of Neuropsychiatric Disorders.

Front Neuroendocrinol 2021 May 3:100917. Epub 2021 May 3.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA. Electronic address:

Microbes inhabit different anatomical sites of the human body including oral cavity, gut, and skin. A growing literature highlights how microbiome variation is associated with human health and disease. There is strong evidence of bidirectional communication between gut and brain mediated by neurotransmitters and microbial metabolites. Read More

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Neonatal suppurative parotitis: Case reports and literature review.

Pediatr Int 2021 May 6. Epub 2021 May 6.

Department of Pediatrics, NTT East Sapporo Hospital, Sapporo, Hokkaido, Japan.

Background: Neonatal suppurative parotitis is a rare disease, characterized mainly by unilateral parotid swelling with erythema and tenderness, and often purulent discharge from the Stensen's duct into the oral cavity. Only 44 cases were reported in the English literature between 1970 and 2013.

Methods: A MEDLINE search was conducted using the terms acute, neonatal, newborn, suppurative, bacterial, purulent, parotitis, parotid swelling, and parotid abscess, limited to the English-language literature starting from 2011. Read More

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Does knowing about the long-term health effects of alcohol matter? Evidence from a university sample in Lebanon.

East Mediterr Health J 2021 Apr 27;27(4):336-343. Epub 2021 Apr 27.

Department of Epidemiology, Columbia University Mailman School of Public Health, New York, United States of America.

Background: Research linking awareness of health effects of alcohol and harmful alcohol drinking status is limited.

Aims: To investigate the association between awareness of long-term alcohol effects and alcohol use disorders.

Methods: University students aged 18-25 years (n = 1155) completed a self-filled survey. Read More

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The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.

FEMS Microbiol Rev 2021 May;45(3)

NEXBIOME Therapeutics, 22 allée Alan Turing, 63000 Clermont-Ferrand, France.

Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial barriers and immune defences. Their perturbation can lead to fungal outgrowth and the development of mucosal infections such as oropharyngeal or vulvovaginal candidiasis, and patients with compromised immunity are susceptible to life-threatening systemic infections. Read More

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Not all yawns tell the same story: The case of Tonkean macaques.

Am J Primatol 2021 May 6:e23263. Epub 2021 May 6.

Natural History Museum, University of Pisa, Pisa, Italy.

Here we show for the first time that the plasticity in morphology and duration of yawning in Macaca tonkeana can be associated with different functional contexts. Macaca tonkeana is classified as a tolerant macaque species characterized by social interactions minimally constrained by dominance rank or kinship. Tonkean macaques, as other egalitarian species, rely on a complex facial communicative system. Read More

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Nonsurgical periodontal therapy decreases the severity of rheumatoid arthritis and the plasmatic and salivary levels of RANKL and Survivin: a short-term clinical study.

Clin Oral Investig 2021 May 5. Epub 2021 May 5.

Department of Dental Clinics, Oral Pathology, and Oral Surgery, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Aim: To investigate the influence of nonsurgical periodontal treatment (NSPT) on clinical periodontal status, rheumatoid arthritis (RA) activity, and plasmatic and salivary levels of biomarkers through a controlled clinical trial on individuals with RA and periodontitis (PE).

Methods: Sixty-six individuals from a convenience sample were considered eligible and consecutively allocated in 3 groups: (1) individuals without PE and RA (-PE-RA, n = 19); (2) individuals without PE and with RA (-PE+RA, n = 23), and (3) individuals with PE and RA (+PE+RA, n = 24). Full-mouth periodontal clinical examinations, Disease Activity Score (DAS-28) evaluations, and analysis in plasma and saliva of RANKL, OPG, RANKL/OPG, and Survivin were performed at baseline (T1) and 45 days after NSPT (T2). Read More

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A phase I study of a PARP1-targeted topical fluorophore for the detection of oral cancer.

Eur J Nucl Med Mol Imaging 2021 May 5. Epub 2021 May 5.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Background: Visual inspection and biopsy is the current standard of care for oral cancer diagnosis, but is subject to misinterpretation and consequently to misdiagnosis. Topically applied PARPi-FL is a molecularly specific, fluorescent contrast-based approach that may fulfill the unmet need for a simple, in vivo, non-invasive, cost-effective, point-of-care method for the early diagnosis of oral cancer. Here, we present results from a phase I safety and feasibility study on fluorescent, topically applied PARPi-FL. Read More

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Molecular Epidemiology and Phylogeny of Crimean-Congo Haemorrhagic Fever (CCHF) Virus of Ixodid Ticks in Khorasan Razavi Province of Iran.

J Arthropod Borne Dis 2020 Dec 31;14(4):400-407. Epub 2020 Dec 31.

Department of Foot and Mouth Disease Vaccine Production, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran.

Background: Crimean-Congo hemorrhagic fever (CCHF) is a fatal disease caused by Nairovirus classified within the Bunyaviridae family. The virus is transmitted to humans through the bites of infected ticks or direct contact with viremic animals or humans. The current study aimed to detect the virus genome in ticks from Khorasan Razavi Province. Read More

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December 2020

Association between Periodontal Disease and Comorbidities in Saudi's Eastern Province.

Biomed Res Int 2021 16;2021:5518195. Epub 2021 Apr 16.

Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31411, P.O. Box 1982, Saudi Arabia.

The incidence of periodontal diseases is associated with multiple comorbidities that influence a patient's treatment planning. This study evaluates the relation between periodontal disease and multiple comorbidities reported in the Saudi population from the Eastern province. This study was conducted on 190 patients, who visited the periodontology clinics at Imam Abdulrahman Bin Faisal University, Saudi Arabia. Read More

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Occurrence of Recurrent Aphthous Stomatitis (RAS) as a Rare Oral Manifestation in a Patient with Gilbert's Syndrome.

Case Rep Dent 2021 16;2021:6648729. Epub 2021 Apr 16.

Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University, Str. Koryun 2, Yerevan 0025, Armenia.

Recurrent aphthous stomatitis is an ulcerative disease of the oral cavity and can occur in isolation or as a manifestation of many systemic diseases. It is a quite common entity and may hence often be overlooked as an isolated lesion. Gilbert's syndrome is a genetic disorder where a deficiency of an enzyme associated with the conjugation of bilirubin results in unconjugated hyperbilirubinemia. Read More

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Addition of Nimotuzumab to Standard TPF Regimen in Locally Advanced Head and Neck Cancer: A Single Institutional Study.

J Oncol 2021 16;2021:6641963. Epub 2021 Apr 16.

Department of Medical Oncology, Healthcare Global Enterprises Limited, Bengaluru, Karnataka, India.

Background: Induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by definitive concurrent chemoradiation remains the standard of care in locally advanced squamous cell carcinoma of head and neck cancers despite which the survival remains low. So, we analyzed the efficacy and adverse effect profile of the addition of nimotuzumab to standard TPF induction chemotherapy. Methods. Read More

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A Case of Major Depression with Burning Mouth Syndrome and Tinnitus Successfully Treated with Vortioxetine.

Int Med Case Rep J 2021 28;14:271-273. Epub 2021 Apr 28.

Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, 8078555, Japan.

We reported a case involving a patient diagnosed with major depression with associated burning mouth syndrome (BMS) and tinnitus who was successfully treated with vortioxetine. The case was 57-year-old Japanese woman diagnosed with major depression according to DSM-5. She experienced increased levels of stress when performing daily duties. Read More

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Evaluating flow-field and expelled droplets in the mockup dental clinic during the COVID-19 pandemic.

Phys Fluids (1994) 2021 Apr 21;33(4):047111. Epub 2021 Apr 21.

Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong Island, Hong Kong, China.

In the setting of widespread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) community transmission, reducing the exposure risk on dental professionals and the next patients is the key to reopening dental services in this pandemic environment. The study is motivated by the lack of understanding of the flow-field characteristics and droplet distribution during aerosol-generating procedures. The particle image velocimetry measurements with high temporal and spatial resolutions were performed under ultrasonic scaling in the mockup experimental dental clinic. Read More

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Airway gas temperature within endotracheal tube can be monitored using rapid response thermometer.

Sci Rep 2021 May 5;11(1):9537. Epub 2021 May 5.

Department of Paediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Japan.

Inappropriate preparation of respiratory gases is associated with serious complications during mechanical ventilation. To develop a temperature monitoring system of respiratory gases within the endotracheal tube, four newborn piglets were studied using an ultra-rapid-response thermometer attached to the closed endotracheal tube suction system. Respiratory gas temperatures were monitored at the mouth-corner level of the endotracheal tube using three thermocouples (T, inserted into the endotracheal tube via the closed suction system; T and T, embedded within the endotracheal tube 0. Read More

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