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SOME FEATURES OF THE CLINICAL COURSE OF LICHEN PLANUS IN THE ORAL MUCOSA. A CLINICAL CASE OF GRINSHPAN-POTEKAEV SYNDROME.

Georgian Med News 2021 Mar(312):71-74

Tbilisi State Medical University, department of dermatology and venerology, Georgia.

The clinical picture and course of lichen planus (LP) on the mucous membrane of the oral cavity have significant differences from its manifestations on the skin. In particular, greater resistance to treatment, which is due to the structural features of the mucous membrane, as well as the specificity of biological and physicochemical processes in the oral cavity. There are 6 clinical forms of LP of the red border of the lips and oral mucosa - typical, hyperkeratotic, exudative-hyperemic, erosive - ulcerative, bullous and atypical. Read More

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New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies.

Biomed Pharmacother 2021 May 5;139:111678. Epub 2021 May 5.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iași, 16 University Street, Iasi, Romania. Electronic address:

In this study we present design and synthesis of nineteen new nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold (NO-IND-TZDs) (6a-s), as a new safer and efficient multi-targets strategy for inflammatory diseases. The chemical structure of all synthesized derivatives (intermediaries and finals) was proved by NMR and mass spectroscopic analysis. In order to study the selectivity of NO-IND-TZDs for COX isoenzymes (COX-1 and COX-2) a molecular docking study was performed using AutoDock 4. Read More

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Sino-orbital mucormycosis in a COVID-19 patient: A case report.

Int J Surg Case Rep 2021 May 4;82:105957. Epub 2021 May 4.

Department Of Oral and Maxillofacial Surgery, D. Y. Patil University, Sector 7 Nerul, Navi Mumbai 400706, India.

Introduction: We report a case of post COVID-19 Sino-orbital Mucormycosis infection caused by Rhizopus oryzae and its management.

Presentation Of Case: The patient was diagnosed with COVID-19 and treated according to the persisting protocols. Following recovery, on the 18th day, the patient developed chemosis and pain in the left eye. Read More

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Are they too perfect to eat healthy? Association between eating disorder symptoms and perfectionism in adolescent rhythmic gymnasts.

Eat Behav 2021 May 1;41:101514. Epub 2021 May 1.

School of Physical Education & Sport Science, National & Kapodistrian University of Athens, Greece.

Objective: Eating disorders are associated with perfectionism in adults, but evidence is lacking in adolescent competitive athletes. This study examined eating disorder symptoms and perfectionism in a sample of 13-15 years old, adolescent rhythmic gymnasts.

Methods: Eighty-nine female rhythmic gymnasts (41 international and 48 recreational level gymnasts), completed the Eating Attitudes Tests 26 (EAT-26), the Sport Perfectionism Questionnaire (SPQ), the Social Desirability Scale (SDS) and provided information on their training. Read More

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Evaluation of the chemopreventive effects of Hypericum perforatum L on DMBA-applied rat oral mucosa.

Arch Oral Biol 2021 Apr 30;127:105139. Epub 2021 Apr 30.

Ankara University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.

Objective: Hypericum perforatum L also known as St. John's wort is known to have many beneficial properties for the organism including its antioxidant and anticancer activities. It is also known to have shown antiproliferative and cytotoxic effects against various cancer cell lines. Read More

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Dental age estimation: Development and validation of a reference data set for Kuwaiti children, adolescents, and young adults.

Arch Oral Biol 2021 Apr 25;127:105130. Epub 2021 Apr 25.

Dept of Orthodontics, Guy's and St Thomas 'Hospital, King's College London, Floor 22, Guy's Tower Wing, Great Maze Pond, London Bridge, SE1 9RT, UK. Electronic address:

Objectives: This study was designed to establish a Reference Data Set for Dental Age Estimation of young Kuwaiti subjects.

Design: Dental Panoramic Tomographs of 1393 Kuwaiti children, adolescents, and young adults aged between 3 and 26 years were re-used to establish a Reference Data Set. The Tooth Development Stages described by Demirjian et al. Read More

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Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation.

Redox Biol 2021 Apr 30;43:101994. Epub 2021 Apr 30.

Laboratory of Mitochondria and Metabolism, Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China; Laboratory of Anesthesia and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Ischemia-reperfusion (I/R) injury is detrimental to cardiovascular system. Alteration in glucose metabolism has been recognized as an important adaptive response under hypoxic conditions. However, the biological benefits underlying this metabolic phenotype remain to be elucidated. Read More

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Differential risks of changes in seizure frequency with transitions between hormonal and non-hormonal contraception in women with epilepsy: A prospective cohort study.

Epilepsy Behav 2021 May 5;120:108011. Epub 2021 May 5.

Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA, United States.

This prospective, observational, cohort study of 101 women with epilepsy (WWE) assesses the seizure safety of systemic hormonal contraception (HC) versus non-HC (NHC). It reports risks of changes in seizure frequency associated with transition from NHC to HC relative to HC to NHC for (1) proportions of WWE with ≥50% increase and decrease in seizure frequency, (2) changes in seizure frequency, (3) changes in seizure severity, and 4) changes in AED regimen during the study. In comparing NHC to HC versus HC to NHC, NHC to HC had greater risk of ≥50% increase in seizure frequency: RR = 1. Read More

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Early versus late fluconazole prophylaxis in autologous hematopoietic cell transplantation.

Transplant Cell Ther 2021 May 5. Epub 2021 May 5.

University Hospital, Universidade Federal do Rio de Janeiro.

Candidemia is a major complication in hematopoietic cell transplantation (HCT), and antifungal prophylaxis with fluconazole decreases the incidence of this complication. We compared two strategies of fluconazole prophylaxis in hematologic patients receiving autologous HCT between 1997 and 2017. From 1997 to 2003, fluconazole prophylaxis (400 mg/d) was given to all HCTs, started with the conditioning regimen (early prophylaxis), and given until neutrophil engraftment or the need of non-prophylactic antifungal therapy. Read More

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Clinical practice patterns in the management of dry eye disease: A TFOS international survey.

Ocul Surf 2021 May 5. Epub 2021 May 5.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand.

Purpose: To examine clinical management and prescribing patterns for dry eye disease (DED), in relation to severity and subtype, by eyecare practitioners across the globe.

Methods: An online-anonymous cross-sectional survey (on Qualtrix) translated into 14 languages was distributed to eyecare practitioners across the globe. The survey included six questions around the management of DED, in relation to severity and subtype. Read More

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Delivering therapeutic cannabinoids via skin: Current state and future perspectives.

J Control Release 2021 May 5. Epub 2021 May 5.

Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, USA. Electronic address:

Adequate evidence exists in the literature indicating a relatively positive shift with regards to the legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries. Concomitantly, scientists are showing renewed interest in cannabis-related research work. Over the years, clinical and preclinical studies have demonstrated the therapeutic significance of cannabinoids for diverse indications. Read More

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Resurgence of Alcohol Seeking Following Abstinence Induced by Punishment in Male and Female Rats.

Behav Brain Res 2021 May 5:113345. Epub 2021 May 5.

Utah State University, United States. Electronic address:

To better approximate the human condition, animal models of relapse to drug and alcohol seeking have increasingly employed negative consequences to generate abstinence. Here we report the first demonstration of relapse to punishment-suppressed alcohol seeking induced by loss of non-drug reward (i.e. Read More

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Three-dimensional printing of gastro-floating tablets using polyethylene glycol diacrylate-based photocurable printing material.

Int J Pharm 2021 May 5:120674. Epub 2021 May 5.

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.

Extruded three-dimensional (3D) printing based on photocurable materials has shown good application prospects in the medical field. This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product. However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time. Read More

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Mortality after In-Hospital Cardiac Arrest in Patients with COVID-19: A Systematic Review and Meta-Analysis.

Resuscitation 2021 May 5. Epub 2021 May 5.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Italy; Department of Anaesthesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, Palermo, Italy. Electronic address:

Aim: To estimate the mortality rate, the rate of return of spontaneous circulation (ROSC) and survival with favorable neurological outcome in patients with COVID-19 after in-hospital cardiac arrest (IHCA) and attempted cardiopulmonary resuscitation (CPR).

Methods: PubMed, EMBASE, Web of Science, bioRxiv and medRxiv were surveyed up to 8th February 2021 for studies reporting data on mortality of patients with COVID-19 after IHCA. The primary outcome sought was mortality (in-hospital or at 30 days) after IHCA with attempted CPR. Read More

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Is Outpatient Management of Mandibular Fractures Associated With Inflammatory Complications? An ACS-NSQIP Study.

J Oral Maxillofac Surg 2021 Mar 26. Epub 2021 Mar 26.

Assistant Professor, Oral & Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA. Electronic address:

Purpose: Timing of mandibular fracture repair has long been debated. The purpose of the present study was to assess the incidence of postoperative inflammatory complications (POICs) following open repair of mandibular fractures managed non-urgently in the outpatient setting versus urgently in the inpatient setting.

Methods: The authors utilized the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database to enroll a sample of patients with mandibular fractures who underwent open repair. Read More

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Pre-incision Adjunctive Prophylaxis for Cesarean Sections: A Systematic Review and Meta-analysis.

Am J Obstet Gynecol 2021 May 5. Epub 2021 May 5.

ObGyn & Women's Health Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195. Electronic address:

Objective: To systematically review the relative effectiveness of pre-incision cefazolin with or without adjunctive prophylaxis (macrolides or metronidazole), versus cefazolin alone, in decreasing the incidence of post-Cesarean surgical site infections.

Data Sources: We performed a systematic search of PubMed, Ovid EMBASE, Google Scholar, ClinicalTrials.gov and Cochrane Central Register of Controlled Trials from October 25 to November 25, 2020, to identify studies comparing cefazolin with adjunctive macrolides or metronidazole to cefazolin alone. Read More

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Simulation-based ventilatory training for the caregivers at primary and rural health care workers in Central India for dealing with COVID-19 pandemic: recommendations.

J Complement Integr Med 2021 May 8. Epub 2021 May 8.

Anatomy, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India.

In 2020 COVID-19 made a major burden on health care system. The capacity of the healthcare system particularly emergency departments, ICU, hospital beds are insufficient to manage the increasing number of patients in cities and rural areas too. The primary health care centers and rural hospitals need preparedness for such disasters conditions. Read More

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Efficacy and Safety of Daprodustat in Japanese Peritoneal Dialysis Patients.

Ther Apher Dial 2021 May 8. Epub 2021 May 8.

Clinical Sciences, GlaxoSmithKline, King of Prussia, PA, USA.

Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor for the treatment of anemia of chronic kidney disease. This phase 3 study evaluated the efficacy and safety of daprodustat in an uncontrolled cohort of 56 Japanese peritoneal dialysis patients with anemia over 52 weeks. Subjects received daprodustat 4 mg orally once daily for 4 weeks and the dose was subsequently adjusted every 4 weeks. Read More

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Lymph node characteristics and their prognostic significance in oral squamous cell carcinoma.

Head Neck 2021 May 8. Epub 2021 May 8.

Department of Maxillofacial and Oral Surgery, Dubrava University Hospital, University of Zagreb School of Medicine, Zagreb, Croatia.

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Single implant overdenture reinforced with a metallic framework: A 2-year clinical follow-up.

Spec Care Dentist 2021 May 8. Epub 2021 May 8.

Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Introduction: To prevent single-implant overdenture (SIO) fracture, the inclusion of a framework in the overdenture has been suggested. However, no investigations verified their benefits.

Objective: To evaluate prosthetic maintenance events, patient satisfaction, and mastication of SIO reinforced by metallic framework users. Read More

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Assessment of the tongue frenulum in Beckwith-Wiedemann syndrome: Pre- and post-frenectomy findings.

Spec Care Dentist 2021 May 8. Epub 2021 May 8.

Department of Medicine, Federal University of Sergipe, Avenida Gov. Marcelo Déda, no number, Bairro São José, Lagarto, Sergipe, 49400-000, Brazil.

Aim: To report the pre- and post-frenectomy findings of a patient with Beckwith-Wiedemann syndrome.

Methods And Results: Clinical case report of a patient with a confirmed genetic-molecular diagnosis of the referred syndrome. The minor was evaluated and reassessed by the protocol for the evaluation of the tongue's frenulum for babies in two moments: pre-surgical and 2 months after the frenectomy. Read More

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A comparative study on fabrication techniques of gelable bone matrix derived from porcine tibia.

J Biomed Mater Res B Appl Biomater 2021 May 8. Epub 2021 May 8.

Joint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Recently, several types of native tissues have been enzymatically digested to prepare hydrogels that have natural-mimic extracellular matrix (ECM) proteins, architecture, and biologic activities. However, the residual detergents and salts remaining in the hydrogel may cause some undesirable effects on compatibility, functionality, and bioactivity of the material. In this study, we enzymatically digested the demineralized and decellularized bone matrix (DDBM) and adopted two common methods that included dialysis against distilled water and acetone precipitation for sample desalting. Read More

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Epidemiology of Tongue Squamous Cell Carcinoma: A Retrospective Cohort Study.

Oral Dis 2021 May 8. Epub 2021 May 8.

Clinical Research Division, National Cancer Institute, Rio de Janeiro (RJ), Brazil.

Objective: Analyze the epidemiological profile and the specific survival of patients diagnosed with tongue squamous cell carcinoma at the National Cancer Institute (INCA).

Materials And Methods: Hospital Cancer Registry System Data and Mortality Information from 2007 to 2009 were retrieved in a retrospective cohort study of patients diagnosed with tongue squamous cell carcinoma. Specific survival was estimated using the Kaplan-Meier method. Read More

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Effect of the local probiotics in the therapy of periodontitis A randomised prospective study.

Int J Dent Hyg 2021 May 8. Epub 2021 May 8.

Department of Periodontology and Oral medicine, Medical faculty, University of Nis, Serbia.

Objectives: The use of local probiotics in the therapy of periodontitis is reflected in their ability to antagonize periodontopathogens and modulate the immune response of the host to the presence of pathogenic microorganisms. The aim of this study was to investigated the use of local probiotics in the treatment of periodontitis as an adjunctive therapy to scaling and root planning (SRP).

Methods: The study involved 80 patients diagnosed with periodontitis. Read More

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Pattern and localization of perineural invasion predict poor survival in oral tongue carcinoma.

Oral Dis 2021 May 8. Epub 2021 May 8.

Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Ancona, Italy.

Background: Survival rate for oral tongue squamous cell carcinoma (OTSCC) is still poor and, despite Tumor-Node-Metastasis staging system has been recently updated, patients included under the same stage still show difference in prognosis. Perineural invasion (PNI) emerged to be an indicator of tumour aggressive behavior and unfortunate events. In this study we investigate the clinic and prognostic value of PNI in a cohort of OTSCC patients. Read More

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A randomized controlled trial of manual versus powered tooth brushing during haematopoietic stem cell transplantation.

Oral Dis 2021 May 8. Epub 2021 May 8.

Department of Dentistry, Radboudumc, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Aim: To compare manual and powered tooth brushing (MT and PT) with respect to patient compliance to brushing frequency advice, plaque removal and severity of oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT) after high dose chemotherapy.

Materials & Methods: A randomized controlled trial was conducted. Forty six patients scheduled to receive myelo-ablative conditioning regimen before autologous HSCT were included and randomly assigned to control (MT, n=23) or test (PT, n=23) groups. Read More

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Dental practice during the era of COVID-19 pandemic: an Egyptian experience.

Authors:
Shereen Ali

Oral Dis 2021 May 8. Epub 2021 May 8.

Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Egypt.

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The effect of ankyloglossia and tongue-tie division on speech articulation: A systematic review.

Int J Paediatr Dent 2021 May 8. Epub 2021 May 8.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P. R. China.

Aim: Ankyloglossia is a common congenital malformation characterized by a short, thick, or tight tongue frenulum and its effect on speech articulation remains controversial. This study aimed to evaluate 1) the association between ankyloglossia and speech disorders, and 2) the effectiveness of surgical interventions on the articulation of patients with ankyloglossia.

Material And Methods: A comprehensive search of PubMed was conducted. Read More

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Identification and validation of novel biomarkers and therapeutics for pulpitis using connectivity mapping.

Int Endod J 2021 May 8. Epub 2021 May 8.

School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

Aim: To create an irreversible pulpitis gene signature from microarray data of healthy and inflamed dental pulps, followed by a bioinformatics approach using connectivity mapping to identify therapeutic compounds that could potentially treat pulpitis.

Methodology: The Gene Expression Omnibus (GEO) database, an international public repository of genomics datasets, was searched for human microarray datasets assessing pulpitis. An irreversible pulpitis gene expression signature was generated by differential expression analysis. Read More

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