56,647 results match your criteria optic nerve


Optic nerve mobilization as an alternative to anterior clinoidectomy in superior carotid-ophthalmic aneurysms: Operative technique.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Neurosurgery, Padilla Hospital, Tucumán, Argentina.

Background: Carotid-ophthalmic aneurysms arise from the internal carotid artery between the distal dural ring and the origin of the posterior communicating artery. The surgical treatment of these aneurysms usually requires an anterior clinoidectomy. However, this procedure is not without complications. Read More

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Neuro-ophthalmic manifestations of tuberculosis.

Eye (Lond) 2021 Jun 14. Epub 2021 Jun 14.

Neuro-Ophthalmology Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Neuro-ophthalmic features are a known association in tuberculosis, especially common in central nervous system tuberculosis (CNS-TB). They are mostly the result of the visual pathway and/or ocular motor and other cranial nerve involvement. Furthermore, toxic optic neuropathy and paradoxical response to anti-tubercular drugs (ATT) are also not uncommon. Read More

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Clinical Evaluation of Unilateral Open-Angle Glaucoma: A Two-Year Follow-Up Study.

Chonnam Med J 2021 May 24;57(2):144-151. Epub 2021 May 24.

Department of Ophthalmology, Chonnam National University Hospital, Gwangju, Korea.

To evaluate the clinical characteristics of unilateral open-angle glaucoma, patients diagnosed with unilateral open-angle glaucoma from January 2017 to October 2018 were divided into primary open-angle glaucoma and normal-tension glaucoma groups according to the type of glaucoma diagnosed. The glaucoma and the contralateral eyes were compared, and the contralateral eye was analyzed for conversion to glaucoma and its risk factors were assessed during the 2-year follow-up period. Among 99 patients, 36 were diagnosed with primary open-angle glaucoma and 63 with normal-tension glaucoma. Read More

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Visual Snow-Like Symptoms and Posterior Uveitis following COVID-19 Infection.

Case Rep Ophthalmol Med 2021 29;2021:6668552. Epub 2021 May 29.

Retina Macula Institute, Torrance, California, USA.

Visual snow (VS) is a neurologic condition consisting of a constant positive visual disturbance described as "static" with diagnosis requiring exclusion of competing neurologic and ophthalmologic disorders. The authors describe the first case of visual snow-like symptoms in a patient following coronavirus disease 2019 (COVID-19) infection. He was found to have a transient subtle mild inflammatory reaction in the vitreous and optic nerve edema which resolved, but the VS persisted. Read More

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The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome.

Front Neurosci 2021 26;15:618098. Epub 2021 May 26.

Genetics Laboratory, UDIAT-Centre Diagnòstic, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.

KIF1A is a microtubule-dependent motor protein responsible for fast anterograde transport of synaptic vesicle precursors in neurons. Pathogenic variants in have been associated with a wide spectrum of neurological disorders. Here, we report a patient presenting a severe neurodevelopmental disorder carrying a novel missense variant p. Read More

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Optic disc drusen mimicking Idiopathic Intracranial Hypertension (IIH): rely on ultrasound.

Neurol Res Pract 2021 Jun 14;3(1):33. Epub 2021 Jun 14.

Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Rimini 1, Chaidari, 12462, Athens, Greece.

Optic nerve ultrasound is an established routine supplementary diagnostic tool for idiopathic intracranial pressure but it can also be helpful in avoiding misdiagnoses. We describe a case of an obese 15- year-old girl with persistent headaches, fundoscopic findings suggesting papilledema, normal brain imaging who underwent two lumbar punctures with unremarkable cerebrospinal fluid findings before ultrasound revealed optic disc drusen as the cause of the optic disc elevation. Read More

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Evaluation of Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Parameters in Obstructive Sleep Apnoea Patients.

Korean J Ophthalmol 2021 Jun 4;35(3):223-230. Epub 2021 Jun 4.

Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Purpose: To study the retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters in obstructive sleep apnoea (OSA) patients and their relationship with severity of the disease.

Methods: A cross-sectional, hospital-based study. Fifty-four OSA subjects and 54 controls were recruited. Read More

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Unilateral Optic Neuritis Associated with SARS-CoV-2 Infection: A Rare Complication.

Am J Case Rep 2021 Jun 13;22:e931665. Epub 2021 Jun 13.

Department of Medicine, St. George's University School of Medicine, St. Georges, Grenada.

BACKGROUND Since the outbreak of the SARS-CoV-2 infection, extensive research has been conducted on the pulmonary implications of this novel disease. However, there has been limited data on the extrapulmonary manifestations. There have been few documented causes of optic involvement and little is understood about the pathophysiology around its presentation and the possible treatments to prevent long-term complications. Read More

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Rare Appearance of Optic Nerve after Transient Central Retinal Artery Occlusion.

Photodiagnosis Photodyn Ther 2021 Jun 10:102389. Epub 2021 Jun 10.

Kartal Dr Lutfi Kırdar State Hospital, Ophthalmology Department, 34865, Kartal, Istanbul, Turkey. Electronic address:

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Endoscopic ultrasound imaging with high flow mode for endonasal transsphenoidal pituitary surgery.

J Clin Neurosci 2021 Jul 21;89:329-335. Epub 2021 May 21.

Department of Orthpedics, Edogawa Hospital, Tokyo, Japan.

Intraoperative ultrasound during transsphenoidal surgery (TSS) for pituitary tumors has been reported. In reports of endonasal ultrasound (US), Doppler US vessel images were informative and effective in endoscopic TSS. We performed endoscopic US imaging with high flow mode, which is a novel technology, to visualize small vessels during endonasal endoscopic TSS. Read More

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Physiological and pathological functions of βB2-crystallins in multiple organs: a systematic review.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Changhai Hospital, Naval Military Medical University, Yangpu, Shanghai 200433, China.

Crystallins, the major constituent proteins of mammalian lenses, are significant not only for the maintenance of eye lens stability, transparency, and refraction, but also fulfill various physiopathological functions in extraocular tissues. βB2-crystallin, for example, is a multifunctional protein expressed in the human retina, brain, testis, ovary, and multiple tumors. Mutations in the βB2 crystallin gene or denaturation of βB2-crystallin protein are associated with cataracts, ocular pathologies, and psychiatric disorders. Read More

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Clinical electrophysiology of the optic nerve and retinal ganglion cells.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

College of Optometry, State University of New York, New York, NY, USA.

Clinical electrophysiological assessment of optic nerve and retinal ganglion cell function can be performed using the Pattern Electroretinogram (PERG), Visual Evoked Potential (VEP) and the Photopic Negative Response (PhNR) amongst other more specialised techniques. In this review, we describe these electrophysiological techniques and their application in diseases affecting the optic nerve and retinal ganglion cells with the exception of glaucoma. The disease groups discussed include hereditary, compressive, toxic/nutritional, traumatic, vascular, inflammatory and intracranial causes for optic nerve or retinal ganglion cell dysfunction. Read More

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Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy.

Sci Rep 2021 Jun 11;11(1):12382. Epub 2021 Jun 11.

Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan.

The fatty acid-binding protein4 (FABP4) and vascular endothelial growth factor A (VEGFA) play key roles in the metabolic and cardiovascular diseases, and proliferative diabetic retinopathy (PDR), respectively. To identify FABP4 in vitreous fluid in PDR, vitreous concentrations of FABP4 (V-FABP4) and VEGFA (V-VEGFA) from PDR (n = 20) and non-PDR (n = 20) patients were determined by Enzyme-Linked ImmunoSorbent Assays. The data, which included height and weight, systemic blood pressures, several blood biochemical parameters and blood flow at the optic nerve head (ONH) by laser speckle flowgraphy (LSFG) were collected. Read More

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Exploring the systemic delivery of a poorly water-soluble model drug to the retina using PLGA nanoparticles.

Eur J Pharm Sci 2021 Jun 8:105905. Epub 2021 Jun 8.

Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany; Clinic of Neurology with Institute of Translational Neurology, University Clinic Muenster, Mendel Str. 7, 48149 Muenster, Germany.

During the drug development process, many pharmacologically active compounds are discarded because of poor water solubility, but nanoparticle-based formulations are increasingly proposed as a solution for this problem. We therefore studied the distribution of nanoparticulate carriers and the delivery of their poorly water-soluble cargo to a structure of the central nervous system, the retina, under naive and pathological conditions. The lipophilic fluorescent dye coumarin 6 (Cou6) was encapsulated into poly(lactic-co-glycolic acid) PLGA nanoparticles (NPs). Read More

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Protection against experimental cisplatin-induced optic nerve toxicity using resveratrol: A mouse model study.

Cutan Ocul Toxicol 2021 Jun 11:1-17. Epub 2021 Jun 11.

Erzincan Binali Yildirim University Faculty of Medicine, Department of Pharmacology, 24100, Erzincan, Turkey.

To investigate the effects of resveratrol on oxidative stress and inflammation parameters and histological alterations in cisplatin-induced optic nerve damage in a mouse model. At the end of the experimental period, the rats were sacrificed with high-dose (50 mg/kg) thiopental sodium, and their optic nerves were dissected. Malondialdehyde (MDA), total glutathione (tGSH), total oxidant status (TOS), total antioxidant status (TAS), tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-KB) levels, and histopathological findings were assessed using the optic nerve tissues. Read More

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Long term observation of hydrogel buckle intrusion without vision loss.

Am J Ophthalmol Case Rep 2021 Sep 26;23:101127. Epub 2021 May 26.

University of Hawaii John A. Burns School of Medicine, 651 Ilalo St., Honolulu, HI, 96813, USA.

Hydrogel buckle intrusion due to progressive swelling is a known complication, which usually requires surgical intervention due to vitreous hemorrhage, retinal detachment, or progressive encroachment into the optic nerve or macula. Hydrogel buckle surgery with successful retinal detachment repair was performed in this one-eyed physician in 1990, and there was slow progressive intrusion towards the macula and optic nerve without surgical intervention for 30 years and with visual acuity maintained at 20/40. Read More

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September 2021

miR-340 Promotes Retinoblastoma Cell Proliferation, Migration and Invasion Through Targeting WIF1.

Onco Targets Ther 2021 4;14:3635-3648. Epub 2021 Jun 4.

Department of Pediatric Ophthalmology, Cangzhou Central Hospital, Cangzhou, 061001, People's Republic of China.

Background: MicroRNAs (miRNAs) function as important regulators of gene expression involved in tumor pathogenesis, including retinoblastoma. However, the expression profiles and potential roles in retinoblastoma are still largely unclear.

Material And Methods: Differentially expressed miRNAs (DEmiRs) and genes (DEGs) in retinoblastoma were extracted from Gene Expression Omnibus (GEO) repository. Read More

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Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes.

Clin Ophthalmol 2021 3;15:2335-2344. Epub 2021 Jun 3.

Ludwig-Maximilians University, Eye Clinic, Campus Innenstadt, Munich, D-80336, Germany.

Purpose: Lowering the intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG) with filtration surgery can induce morphological changes to the bulbus and structures of the retina. In this study, we have evaluated changes of Bruch's membrane-based parameters and retinal nerve fiber layer (RNFL) derived by spectral-domain optical coherence tomography (SD-OCT) in eyes that have undergone glaucoma filtration surgery.

Patients And Methods: SD-OCT imaging of the optic nerve head (ONH) and of the RNFL was performed in 54 eyes of 54 patients with medically uncontrolled POAG before and after IOP-lowering surgery (trabeculectomy or deep sclerectomy). Read More

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Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy.

Clin Ophthalmol 2021 3;15:2327-2333. Epub 2021 Jun 3.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.

Purpose: Peripapillary halos (PPH) are peripapillary changes observed surrounding the optic nerve head in normal eyes and eyes with different disorders. Recognizing the microstructure and mechanism of development of these halos will help clinicians understand the different associated retinal and optic nerve head pathologies. We describe the in vivo histological characteristics of PPH in birdshot chorioretinopathy (BSCR). Read More

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Effect of changes in optic nerve elasticity on central retinal artery blood flow in patients with idiopathic intracranial hypertension.

J Neuroradiol 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, Faculty of Medicine, Mansoura University, Egypt.

Purpose: To assess changes in central retinal artery (CRA) blood flow by orbital color-coded Doppler ultrasonography in patients with idiopathic intracranial hypertension (IIH) and their relation with optic nerve (ON) elasticity assessed by shear wave elastography (SWE).

Methods: This study was carried out on 68 eyes of patients diagnosed with IIH and 32 eyes of healthy controls. The severity of papilledema in IIH patients was sub-classified into mild and moderate/severe groups. Read More

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A Rare Fungal Orbital Infection in an Immunocompetent Young Male Caused by (.

Ocul Immunol Inflamm 2021 Jun 10:1-4. Epub 2021 Jun 10.

Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

: To present a case of orbital fungal infection caused by a rare fungus, Lichtheimia corymbifera (Absidia corymbifera) in an immunocompetent individual.: A retrospective case study.: A 23-year-old male presented with painful proptosis of the right eye for 3 months. Read More

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Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma.

Transl Vis Sci Technol 2021 Jun;10(7):13

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Purpose: To assess microvascular beds in the optic nerve head (ONH), peripapillary tissue, and the nailfold in patients with primary open-angle glaucoma (POAG) versus controls.

Methods: Patients with POAG (n = 22) and controls (n = 12) underwent swept-source optical coherence tomography angiography of ophthalmic microvasculature and nailfold video capillaroscopy of the hand. The main outcomes were vessel density (VD) and blood flow of the ONH, the peripapillary and the nailfold microvasculatures. Read More

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Estimated Utility of the Short-term Assessment of Glaucoma Progression Model in Clinical Practice.

JAMA Ophthalmol 2021 Jun 10. Epub 2021 Jun 10.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla.

Importance: Clinical trials of glaucoma therapies focused on protecting the optic nerve have required large sample sizes and lengthy follow-up to detect clinically relevant change due to its slow rate of progression. Whether shorter trials may be possible with more frequent testing and use of rate of change as the end point warrants further investigation.

Objective: To describe the design for the Short-term Assessment of Glaucoma Progression (STAGE) model and provide guidance on sample size and power calculations for shorter clinical trials. Read More

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Optic Nerve Sheath Fenestration With a Multi-Arm Continuum Robot.

IEEE Robot Autom Lett 2020 Jul 25;5(3):4874-4881. Epub 2020 Jun 25.

Robotics and Vision in Medicine (RViM) Lab, School of Biomedical Engineering & Imaging Sciences, King's College London, London E14 3WF, U.K.

This article presents a medical robotic system for deep orbital interventions, with a focus on Optic Nerve Sheath Fenestration (ONSF). ONSF is a currently invasive ophthalmic surgical approach that can reduce potentially blinding elevated hydrostatic intracranial pressure on the optic disc via an incision on the optic nerve. The prototype is a multi-arm system capable of dexterous manipulation and visualization of the optic nerve area, allowing for a minimally invasive approach. Read More

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Central Nervous System Hemangioblastoma in a Pediatric Patient Associated With Von Hippel-Lindau Disease: A Case Report and Literature Review.

Front Oncol 2021 24;11:683021. Epub 2021 May 24.

Department of Neurosurgery, First Hospital of Jilin University, Changchun, China.

Background: Hemangioblastoma is a benign tumor of the central nervous system and may appear as a component of von Hippel-Lindau (VHL) disease. At present, approximately 40 cases of optic nerve HGBs have been reported in the literature. VHL disease is a rare autosomal-dominant inherited cancer syndrome with different phenotypes caused by variants in the VHL gene. Read More

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Loss of Rbfox1 Does Not Affect Survival of Retinal Ganglion Cells Injured by Optic Nerve Crush.

Front Neurosci 2021 24;15:687690. Epub 2021 May 24.

Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, United States.

Rbfox1 is a multifunctional RNA binding protein that regulates alternative splicing, transcription, mRNA stability and translation. Its roles in neurogenesis and neuronal functions are well established. Recent studies also implicate Rbfox1 in the regulation of gene networks that support cell survival during stress. Read More

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Neuro-Ophthalmological Findings as First Manifestation of Occipital Tuberculoma.

Neuroophthalmology 2021 17;45(2):120-125. Epub 2020 Jul 17.

Ophthalmology Residents.

We present a 54-year-old male garbage collector, who came to the ophthalmology department due to one-month history of bilateral blurred vision, palinopsia, headache and visual geometrical hallucinations. The examination showed a normal anterior segment, a homonymous left upper central scotoma and tilted segmental hypoplasia of the optic nerve of the left eye. Contrast-enhanced brain magnetic resonance imaging showed a mass lesion in the right occipital cortex. Read More

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Recurrent and Reversible, Bitemporal Field Defect from Presumed Chiasmitis in a Patient with Systemic Lupus Erythematosus.

Neuroophthalmology 2021 16;45(2):117-119. Epub 2020 Jul 16.

Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Systemic lupus erythematosus (SLE) is a chronic, recurrent and remitting autoimmune disease affecting mostly women and presenting between late adolescence and the fourth decade of life. Ocular manifestations may occur in one-third of patients with SLE, with keratoconjunctivitis sicca as the most common and optic nerve and retina abnormalities as the most severe. Neuro-ophthalmological manifestations occur in approximately 1% of patients with SLE, usually in the form of optic neuropathy. Read More

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Optic Nerve Head Blood Flow Analysis in Patients with Optic Disc Drusen Using Laser Speckle Flowgraphy.

Neuroophthalmology 2021 20;45(2):92-98. Epub 2020 Aug 20.

Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.

Visual field defects are common in patients with optic disc drusen (ODD). Our aim was to examine whether reduced optic nerve head (ONH) microcirculation is related to visual field defects in ODD patients. Vascular and tissue area mean blur rate (MBR and MBR), measured using laser speckle flowgraphy (LSFG), was significantly lower in the 32 included ODD eyes when compared with 40 healthy eyes ( <. Read More

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The Effect of Congenital and Acquired Bilateral Anophthalmia on Brain Structure.

Neuroophthalmology 2021 1;45(2):75-86. Epub 2021 Mar 1.

Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.

The aim of this study was to compare the pattern of changes in brain structure resulting from congenital and acquired bilateral anophthalmia. Brain structure was investigated using 3T magnetic resonance imaging (MRI) in Oxford (congenital) or Manchester (acquired). T1-weighted structural and diffusion-weighted scans were acquired from people with anophthalmia and sighted control participants. Read More

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