24,568 results match your criteria opposite roles

The lncRNA RP3-439F8.1 promotes GBM cell proliferation and progression by sponging miR-139-5p to upregulate NR5A2.

Pathol Res Pract 2021 Jan 2;223:153319. Epub 2021 Jan 2.

Department of Neurosurgery, Yunnan Cancer Hospital, Kunming, China. Electronic address:

Background: Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2, LRH-1) is an oncogene in a wide range of cancer types. Bioinformatics analysis on glioblastoma multiforme (GBM) tumors has revealed that the miR-139-5p-NR5A2 axis may be putatively regulated by the long non-coding RNA (lncRNA) RP3-439F8.1. Read More

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January 2021

Secretory Galectin-3 promotes hepatic steatosis via regulation of the PPARγ/CD36 signaling pathway.

Cell Signal 2021 May 12:110043. Epub 2021 May 12.

Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Department of Gerontology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China. Electronic address:

Galectin-3 (Gal3) is an essential regulator of a number of metabolic disorders. Previous studies have established that Gal3 is a positive regulator of inflammation, fibrosis, and insulin resistance. However, its function in the early pathogenesis of hepatic lipid accumulation in non-alcoholic fatty liver disease (NAFLD) remains unresolved. Read More

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Long noncoding RNA AC092155 facilitates osteogenic differentiation of adipose-derived stem cells through the miR-143-3p/STMN1 axis.

J Gene Med 2021 May 15:e3363. Epub 2021 May 15.

Department of Orthopedic Surgery, Jinling Hospital, Nanjing University, Nanjing, China.

Background: Numerous studies have demonstrated that long noncoding RNAs (lncRNAs) induce osteogenesis in adipose-derived stem cells (ADSCs). This study aimed to explore the role of lncRNAs AC092155 in promoting osteogenic differentiation of ADSCs.

Methods: MicroRNA (miRNA) and lncRNA sequencing were performed in ADSCs that underwent normal or osteogenic induction. Read More

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STAT3/miR-135b/NF-κB axis confers aggressiveness and unfavorable prognosis in non-small-cell lung cancer.

Cell Death Dis 2021 May 14;12(5):493. Epub 2021 May 14.

Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, 300060, Tianjin, China.

Non-small-cell lung cancer (NSCLC) is one of the most commonly diagnosed cancers worldwide but has limited effective therapies. Uncovering the underlying pathological and molecular changes, as well as mechanisms, will improve the treatment. Dysregulated microRNAs (miRNAs) have been proven to play important roles in the initiation and progression of various cancers, including NSCLC. Read More

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microRNA-210/ Long non-coding RNA MEG3 axis inhibits trophoblast cell migration and invasion by suppressing EMT process.

Placenta 2021 May 5;109:64-71. Epub 2021 May 5.

Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

Introduction: Pre-eclampsia is characterized by insufficient spiral artery remodeling, and trophoblast dysfunction plays an important role in this process. Noncoding RNAs (microRNAs (miRNAs) and long noncoding RNAs (LncRNAs) are included) can regulate trophoblasts. MicroRNA-210 (miR-210) can decrease trophoblast cell migration and invasion and may act as a biomarker for preeclampsia. Read More

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The moderating role of attention control in the relationship between pain catastrophizing and negatively-biased pain memories in youth with chronic pain.

J Pain 2021 May 11. Epub 2021 May 11.

Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium.

The present study examined the role of attention control in understanding the development of negatively-biased pain memories as well as its moderating role in the relationship between pain catastrophizing and negatively-biased pain memories. Youth with chronic pain (N = 105) performed a cold pressor task (CPT) and completed self-report measures of state/trait pain catastrophizing and attention control, with the latter comprising both attention focusing and attention shifting. Two weeks after the CPT, youth's pain-related memories were elicited via telephone allowing to compute pain and anxiety memory bias indices (i. Read More

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Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide.

J Cell Biol 2021 Jul 14;220(7). Epub 2021 May 14.

Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH.

LC3s are canonical proteins necessary for the formation of autophagosomes. We have previously established that two paralogs, LC3B and LC3C, have opposite activities in renal cancer, with LC3B playing an oncogenic role and LC3C a tumor-suppressing role. LC3C is an evolutionary late gene present only in higher primates and humans. Read More

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Circulating Exosomal MiR-107 Restrains Tumorigenesis in Diffuse Large B-Cell Lymphoma by Targeting 14-3-3η.

Front Cell Dev Biol 2021 27;9:667800. Epub 2021 Apr 27.

Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Exosomes, nanometer-sized membranous vesicles in body fluids, have emerged as promising non-invasive biomarkers for cancer diagnosis. However, the function of exosomes in diffuse large B-cell lymphoma (DLBCL) remains elusive. This study aimed to investigate the role of exosomal miR-107 in lymphomagenesis and explore its clinical significance. Read More

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The Role of Humidity in the Management of Premature Neonates in a Rural Incubator.

Cureus 2021 Apr 10;13(4):e14411. Epub 2021 Apr 10.

Obstetrics and Gynaecology, Divya Hospital, Thirpur, IND.

Background While growing inside the uterus, the human fetus floats in amniotic fluid, and the mother maintains a stable temperature of 37 °C and a humidity of 100%. In most neonatal incubators, a stable temperature is maintained but not the humidity. We hypothesised that maintaining a humidity of 70% and a temperature of 32 °C in incubator rooms might improve the outcomes related to low birth weight (LBW) neonates. Read More

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Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting complement activation and upregulation of miR-499.

Exp Ther Med 2021 Jul 26;22(1):684. Epub 2021 Apr 26.

Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

The complement system plays a vital role in myocardial ischemia/reperfusion (I/R) injury. microRNA (miR)-499 is involved in the cardioprotection of ischemic postconditioning (IPostC). The present study aimed to study the role of the complement system and miR-499 in IPostC. Read More

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RNA polymerase I subunit 12 plays opposite roles in cell proliferation and migration.

Biochem Biophys Res Commun 2021 May 10;560:112-118. Epub 2021 May 10.

College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, 430065, China. Electronic address:

RNA polymerase I (Pol I) is responsible for the synthesis of the majority of ribosomal RNA molecules in eukaryotes. Pol I subunit 12 (RPA12) is involved in the transcriptional termination and lipid metabolism in yeast. However, its role in human cells hasn't been investigated so far. Read More

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Fit to be good: Physical fitness is negatively associated with deviance.

J Appl Psychol 2021 May 13. Epub 2021 May 13.

Department of Management and Organisation, NUS Business School, National University of Singapore.

While modern organizations generate economic value, they also produce negative externalities in terms of human physical fitness, such that workers globally are becoming physically unfit. In the current research, we focus on a significant but overlooked indirect cost that lack of physical fitness entails-deviance. In contrast to early (and methodologically limited) research in criminology, which suggests that physically fit people are more likely to behave in a deviant manner, we draw on self-control theory to suggest the opposite: That physically fit people are less likely to engage in deviance. Read More

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TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways.

Aging (Albany NY) 2021 May 11;13. Epub 2021 May 11.

Department of Oncology, Jiangjin Central Hospital of Chongqing, Chongqing, China.

Melanoma is one of the most aggressive cancers with poor overall survival. To date, there are still few effective methods for the treatment of melanoma. TRIM14 was previously reported to be an important oncogene in many tumors. Read More

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Blocking circ_UBR4 suppressed proliferation, migration, and cell cycle progression of human vascular smooth muscle cells in atherosclerosis.

Open Life Sci 2021 27;16(1):419-430. Epub 2021 Apr 27.

Department of Cardiology, Zhongshan Affiliated Hospital, Dalian University, No. 6, Zhonshan Road, Dalian, 116001, Liaoning, China.

The circ_UBR4 (hsa_circ_0010283) is a novel abnormally overexpressed circRNA in oxidized low-density lipoprotein (ox-LDL)-induced model of atherosclerosis (AS) in human vascular smooth muscle cells (VSMCs). However, its role in the dysfunction of VSMCs remains to be further investigated. Here, we attempted to explore its role in ox-LDL-induced excessive proliferation and migration in VSMCs by regulating Rho/Rho-associated coiled-coil containing kinase 1 (ROCK1), a therapeutic target of AS. Read More

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Diversification in Functions and Expressions of Soybean Genes Fine-Tunes Seasonal Flowering.

Front Plant Sci 2021 26;12:613675. Epub 2021 Apr 26.

Division of Applied Life Science (BK21 Four), Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju, South Korea.

The proper timing of flowering in response to environmental changes is critical for ensuring crop yields. () homologs of the phosphatidylethanolamine-binding protein family play important roles as floral integrators in many crops. In soybean, we identified 17 genes of this family, and characterized biological functions in flowering for ten homologs. Read More

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Molecular dynamics shows complex interplay and long-range effects of post-translational modifications in yeast protein interactions.

PLoS Comput Biol 2021 May 12;17(5):e1008988. Epub 2021 May 12.

KU Leuven, Centre of Microbial and Plant Genetics, Leuven, Belgium.

Post-translational modifications (PTMs) play a vital, yet often overlooked role in the living cells through modulation of protein properties, such as localization and affinity towards their interactors, thereby enabling quick adaptation to changing environmental conditions. We have previously benchmarked a computational framework for the prediction of PTMs' effects on the stability of protein-protein interactions, which has molecular dynamics simulations followed by free energy calculations at its core. In the present work, we apply this framework to publicly available data on Saccharomyces cerevisiae protein structures and PTM sites, identified in both normal and stress conditions. Read More

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IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis.

Ophthalmic Genet 2021 May 12:1-11. Epub 2021 May 12.

Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.

: Several single-nucleotide polymorphisms (SNPs) in genes have been associated with KTCN. However, the results of these studies were not conclusive. This meta-analysis association study is aimed to quantitatively estimate the association of ( and (), and () polymorphisms with KTCN susceptibility. Read More

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Stoichiometric traits (N:P) of understory plants contribute to reductions in plant diversity following long-term nitrogen addition in subtropical forest.

Ecol Evol 2021 May 9;11(9):4243-4251. Epub 2021 Mar 9.

Department of Earth and Environmental Sciences The University of Manchester Manchester UK.

Nitrogen enrichment is pervasive in forest ecosystems, but its influence on understory plant communities and their stoichiometric characteristics is poorly understood. We hypothesize that when forest is enriched with nitrogen (N), the stoichiometric characteristics of plant species explain changes in understory plant diversity. A 13-year field experiment was conducted to explore the effects of N addition on foliar carbon (C): N: phosphorus (P) stoichiometry, understory plant species richness, and intrinsic water use efficiency (iWUE) in a subtropical Chinese fir forest. Read More

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Dextran Sulfate Effects EMT of Human Gastric Cancer Cells by Reducing HIF-1α/ TGF-β.

J Cancer 2021 12;12(11):3367-3377. Epub 2021 Apr 12.

Department of Pathology, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.

The peritoneal implant metastasis is one of the main pathway and main cause for high mortality for gastric cancer metastasis. Researchs show that epithelial-mesenchymal transition (EMT) playing essential role in modulating gastric cancer metastasis, and the expression of hypoxia inducible factor-1α (HIF-1α) can promote EMT in tumor cells. This research aims to explore the influence and mechanism of Dextran Sulfate (DS) affecting EMT of human gastric cancer. Read More

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Understanding the Effect of Water on CO Adsorption.

Chem Rev 2021 May 11. Epub 2021 May 11.

Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.

Carbon capture from large sources and ambient air is one of the most promising strategies to curb the deleterious effect of greenhouse gases. Among different technologies, CO adsorption has drawn widespread attention mostly because of its low energy requirements. Considering that water vapor is a ubiquitous component in air and almost all CO-rich industrial gas streams, understanding its impact on CO adsorption is of critical importance. Read More

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Bone marrow adiposity in premenopausal women with type 2 diabetes with observations on peri-trabecular adipocytes.

J Clin Endocrinol Metab 2021 May 11. Epub 2021 May 11.

Endocrine Division (SEMPR), Department of Internal Medicine, Federal University of Parana, Curitiba, Brazil.

Context: No study has evaluated the relationships among of bone marrow adiposity(BMA), bone histomorphometry(BH) and glycemic control in premenopausal women with type 2 diabetes(T2DM).

Objectives: Assess the effect of glycemic control on BMA;correlate the parameters of BH with BMA and correlate BMA with the use of hypoglycemic agents and with BMD.

Design, Settings And Patients: This was a cross-sectional study that evaluated 26 premenopausal women with T2DM were divided into groups with HbA1c<7% (GC,n=10) and HbA1c>7% (PC,n=16). Read More

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Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks.

Mol Psychiatry 2021 May 10. Epub 2021 May 10.

Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, The Netherlands.

Activity in the healthy brain relies on a concerted interplay of excitation (E) and inhibition (I) via balanced synaptic communication between glutamatergic and GABAergic neurons. A growing number of studies imply that disruption of this E/I balance is a commonality in many brain disorders; however, obtaining mechanistic insight into these disruptions, with translational value for the patient, has typically been hampered by methodological limitations. Cadherin-13 (CDH13) has been associated with autism and attention-deficit/hyperactivity disorder. Read More

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Hydrogen Bonds between Ions of Opposite and Like Charge in Hydroxyl-Functionalized Ionic Liquids: an Exhaustive Examination of the Interplay between Global and Local Motions and Intermolecular Hydrogen Bond Lifetimes and Kinetics.

J Phys Chem B 2021 May 11. Epub 2021 May 11.

Institut für Chemie, Abteilung Physikalische und Theoretische Chemie, Universität Rostock, Albert-Einstein-Str. 21, D-18059 Rostock, Germany.

Hydroxyl-functionalized ionic liquids (ILs) represent a new interesting class of ILs where hydrogen bonds (HBs) play an important role: here, "typical" HBs between cations and anions (ca) are competing with "atypical" HBs connecting pairs of cations (cc). We study the equilibrium and kinetics of (cc) and (ca) HBs in 1-(-hydroxyalkyl)-pyridinium bis(trifluoromethlysulfonyl)imide [HOCPy][NTf] ILs by means of molecular dynamics simulations. (cc) HBs are found to be between 0. Read More

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How people experience and respond to their distress predicts problem drinking more than does the amount of distress.

Addict Behav 2021 Apr 23;120:106959. Epub 2021 Apr 23.

University of Kentucky, United States.

Although broad dispositional negative affect predicts problematic alcohol use, emerging evidence suggests that individual differences in how people experience and respond to negative affect may play an important role in risk. In a sample of 358 college students assessed twice across their first year of college, the current study investigated the predictive roles of trait negative affect, affective lability (the tendency to experience rapid and intense shifts in mood), negative urgency (the tendency to act rashly when highly emotional), and problem drinking via self-report measures completed online. Data were analyzed using structural equation modeling (SEM). Read More

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Beta-lactam resistance development during the treatment processes of municipal wastewater treatment plants.

Chemosphere 2021 May 3;280:130749. Epub 2021 May 3.

Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, CZ-710 00, Ostrava, Czech Republic.

This work monitored the effect of a municipal and a village wastewater treatment plant (WWTP) technology on the fate of beta-lactam resistance genes in bacterial populations in different phases of the wastewater treatment process. In case of the municipal WWTP1, the bacteria possessing a high ampicillin resistance (minimal inhibitory concentration (MIC) values of 20 mg/mL) accumulated in the sedimentation tank, which was accompanied with a higher concentration of ampicillin in the wastewater samples (28.09 ng/L) and an increase in the relative abundance of the blaTEM gene in the bacterial population. Read More

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Fisetin Alleviates Neointimal Hyperplasia via PPAR/PON2 Antioxidative Pathway in SHR Rat Artery Injury Model.

Oxid Med Cell Longev 2021 21;2021:6625517. Epub 2021 Apr 21.

Medical and Healthcare Center, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China.

The phenotypic transformation of proliferation and migration in vascular smooth muscle cells (VSMCs) from media to intima is the basic pathology of neointimal hyperplasia after angioplasty in hypertensive patients. Angiotensin II (AngII) stimulates oxidative stress in VSMC, inducing VSMC proliferation and migration, which is a critical factor in both developments of hypertension and angioplasty-induced arterial restenosis. Fisetin, a plant flavonoid polyphenol, has been reported to be antioxidative and potent senolytic. Read More

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Technicization of "Birth" and "Mothering": Bioethical Debates from Feminist Perspectives.

Zairu Nisha

Asian Bioeth Rev 2021 Jun 8;13(2):133-148. Epub 2021 Mar 8.

Philosophy Department, Ramanujan College, University of Delhi, Delhi, India.

Birthing is a natural phenomenon. However, in the era of modernisation, it has dramatically changed and transformed into a technological affair. Some feminists claim that advances in medicine and assisted reproductive technologies (ARTs) have opened up numerous opportunities and choices for women to free themselves from their destined role of maternity by separating sex from reproduction. Read More

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Hypoxia-inducible factor-1α regulates PI3K/AKT signaling through microRNA-32-5p/PTEN and affects nucleus pulposus cell proliferation and apoptosis.

Exp Ther Med 2021 Jun 18;21(6):646. Epub 2021 Apr 18.

Department of Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan 570311, P.R. China.

Intervertebral disc degeneration and resulting low back pain arises from the programmed apoptosis of nucleus pulposus cells (NPCs). Recent studies show that hypoxia-inducible factor-1α plays a vital role in the etiology and pathogenesis of disc degeneration. However, the underlying mechanism of HIF-1α in NPCs is unclear. Read More

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Geographical Latitude Remains as an Important Factor for the Prevalence of Some Myositis Autoantibodies: A Systematic Review.

Front Immunol 2021 22;12:672008. Epub 2021 Apr 22.

Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Reumatología y del Sistema Músculo-Esquelético (IIRSME), Universidad de Guadalajara, Guadalajara, Mexico.

The idiopathic inflammatory myopathies (IIM) are characterized by muscular weakness, cutaneous manifestations, muscle damage revealed by increase of muscular enzymes, muscle biopsy, electromyography and changes on magnetic resonance imaging. However, the hallmark of these IIM, is the development of myositis specific antibodies (MSA) or myositis associated antibodies (MAA). The theories about their presence in the serum of IIM is not known. Read More

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Pathological Hyperinsulinemia and Hyperglycemia in the Impaired Glucose Tolerance Stage Mediate Endothelial Dysfunction Through miR-21, PTEN/AKT/eNOS, and MARK/ET-1 Pathways.

Front Endocrinol (Lausanne) 2021 23;12:644159. Epub 2021 Apr 23.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Disease, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Background: Impaired glucose tolerance (IGT) is an important prediabetic stage characterized by elevated concentrations of glucose and insulin in the blood. The pathological hyperglycemia and hyperinsulinemia in IGT may regulate the expression of microRNA-21 (miR-21) and affect the downstream insulin signaling pathways, leading to endothelial cell dysfunction and early renal damage.

Methods: The individual and combined effects of insulin and glucose were investigated using human glomerular endothelial cells (HGECs). Read More

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