Int J Methods Psychiatr Res 2019 03 4;28(1):e1768. Epub 2019 Feb 4.
Addiction and Concurrent Disorders Group, Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Objectives: This is the first study to compare the safety and efficacy of opium tincture (OT) with methadone for treatment of opioid use disorder.
Methods: In this multicenter, double-blind, noninferiority controlled trial, a stratified sample of 204 participants with opioid use disorder were recruited from community outreach, drop-in centers, and triangular clinics. Participants were excluded in case of active participation in another treatment program for opioid use disorder, hypersensitivity to trial medications, pregnancy, and certain serious medical conditions. Read More