100 results match your criteria opium pregnancy


Opium Effect in Pregnancy on the Dynamics of Maternal Behavior: Testing a Neurochemical Model.

Neuropsychobiology 2021 19;80(2):147-157. Epub 2021 Feb 19.

Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Background: Investigations into neurochemical mechanisms of opioid addiction are difficult due to the complexity of behavior and multiplicity of involved neurotransmitter and hormonal systems. The aim of this study was to examine the benefits of structured analysis of these mechanisms using the framework of the neurochemical model Functional Ensemble of Temperament (FET) and the example of maternal behavior under the condition of opium consumption in pregnancy. The FET differentiates between (a) endurance, (b) speed of integration, and (c) emotionality aspects of behavior suggesting that these systems are differentially regulated by (a) serotonin-neuropeptides-brain-derived neurotrophic factor (BDNF), (b) dopamine-GABA, and (c) opioid receptor systems, correspondingly. Read More

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February 2021

Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.

Cochrane Database Syst Rev 2020 09 24;9:CD012871. Epub 2020 Sep 24.

Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

Background: Preterm birth (PTB) remains the foremost global cause of perinatal morbidity and mortality. Thus, the prevention of spontaneous PTB still remains of critical importance. In an attempt to prevent PTB in singleton pregnancies, cervical cerclage, in combination with other treatments, has been advocated. Read More

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September 2020

Brain-derived neurotrophic factor and nerve growth factor concentrations in maternal and umbilical cord blood of opium-addicted mothers.

Int J Dev Neurosci 2020 Nov 24;80(7):594-600. Epub 2020 Aug 24.

Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Background: It is reported that opium consumption during pregnancy is associated with adverse pregnancy outcomes and neurodevelopmental defects in infants. BDNF and NGF alterations during pregnancy cause neurobehavioral deficits in the offspring. The aim of this study was to investigate the effect of opium addiction of pregnant women on BDNF and NGF levels in maternal and umbilical cord blood as well as pregnancy outcome. Read More

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November 2020

Emerging therapies for the treatment of neonatal abstinence syndrome.

J Matern Fetal Neonatal Med 2020 Mar 9:1-9. Epub 2020 Mar 9.

School of Pharmacy, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.

To examine the evidence for emerging treatment options, buprenorphine or clonidine, as monotherapy for the treatment of neonatal abstinence syndrome (NAS) against standards of care, morphine or methadone. A PubMed literature search from 1946 to 2019 was performed using the terms NAS, neonatal withdrawal, buprenorphine and NAS, clonidine and NAS, morphine and NAS, methadone and NAS, opioids and pregnancy, opioids and NAS, prenatal exposure and opioids. Study evaluation was limited to English-language studies conducted in humans. Read More

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Risk Factors and Outcome of Acute Kidney Injury after Isolated CABG Surgery: a Prospective Cohort Study.

Braz J Cardiovasc Surg 2019 Jan-Feb;34(1):70-75

Department of Anesthesiology and Critical Care, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Acute kidney injury (AKI) is a frequent event after cardiac surgery with increased mortality and morbidity. We explored frequency, risk factors, and associated morbidity and mortality of AKI after isolated coronary artery bypass grafting (CABG) surgery at a single institution.

Methods: All consecutive adults undergoing CABG surgery from March 2013 to October 2016 were assessed for development and severity of AKI based on Acute Kidney Injury Network (AKIN) criteria. Read More

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Comparing opium tincture and methadone for medication-assisted treatment of patients with opioid use disorder: Protocol for a multicenter parallel group noninferiority double-blind randomized controlled trial.

Int J Methods Psychiatr Res 2019 03 4;28(1):e1768. Epub 2019 Feb 4.

Addiction and Concurrent Disorders Group, Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry, University of British Columbia, Vancouver, Canada.

Objectives: This is the first study to compare the safety and efficacy of opium tincture (OT) with methadone for treatment of opioid use disorder.

Methods: In this multicenter, double-blind, noninferiority controlled trial, a stratified sample of 204 participants with opioid use disorder were recruited from community outreach, drop-in centers, and triangular clinics. Participants were excluded in case of active participation in another treatment program for opioid use disorder, hypersensitivity to trial medications, pregnancy, and certain serious medical conditions. Read More

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Opium use during pregnancy and infant size at birth: a cohort study.

BMC Pregnancy Childbirth 2018 Oct 1;18(1):358. Epub 2018 Oct 1.

Clinical Epidemiology Unit & Centre for Pharmacoepidemiology, Department of Medicine, Karolinska Institute, Solna, Sweden.

Background: The reported positive association between opiatic drug use during pregnancy and adverse pregnancy outcomes might be confounded by other factors related to high-risk behaviors, including the use of other harmful substances. In rural areas of Iran, opium use during pregnancy is relatively common among women who otherwise do not have a hazardous lifestyle, which reduces the risk of residual confounding and increasing the possibility to identify its effects. We aimed to examine the association of antenatal exposure to opium with risks of small for gestational age, short birth length, and small head circumference at birth. Read More

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October 2018

Opioid dependence and pregnancy in early twentieth-century America.

Authors:
Nathan Tauger

Addiction 2018 05 15;113(5):952-957. Epub 2018 Jan 15.

Independent scholar, 1437 Dogwood Avenue, Morgantown, WV 26505, USA.

Background And Aims: Research on Neonatal Abstinence Syndrome has prompted discussion over how to ensure best outcomes for pregnant women who use drugs and for drug-dependent newborns. Before Neonatal Abstinence Syndrome and the 1980s panic of "crack babies," turn-of-the-century American medical journals discussed infants born to drug-using mothers. This paper aimed to determine whether women who used drugs while pregnant in early twentieth-century America were subject to the stigma many face today. Read More

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Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.

PLoS One 2017 27;12(4):e0176588. Epub 2017 Apr 27.

Clinical Epidemiology Unit & Centre for Pharmacoepidemiology, Department of Medicine, Karolinska Institute, Solna, Sweden.

Background: Use of narcotic or "recreational" drugs has been associated with adverse pregnancy outcomes such as preterm delivery. However, the associations might be confounded by other factors related to high-risk behaviours. This is the first study to investigate the association between traditional opium use during pregnancy and risk of preterm delivery. Read More

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September 2017

Morphine Inhibited the Rat Neural Stem Cell Proliferation Rate by Increasing Neuro Steroid Genesis.

Neurochem Res 2016 Jun 30;41(6):1410-9. Epub 2016 Jan 30.

Department of Medical Education, Medical Education Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Up to present, a large number of reports unveiled exacerbating effects of both long- and short-term administration of morphine, as a potent analgesic agent, on opium-addicted individuals and a plethora of cell kinetics, although contradictory effect of morphine on different cells have been introduced until yet. To address the potent modulatory effect of morphine on neural multipotent precursors with emphasis on endogenous sex-related neurosteroids biosynthesis, we primed the rat neural stem cells isolated from embryonic rat telencephalon to various concentrations of morphine including 10, 20, 50 and 100 µM alone or in combination with naloxone (100 µM) over period of 72 h. Flow cytometric Ki-67 expression and Annexin-V/PI based necrosis and apoptosis of exposed cells were evaluated. Read More

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Pain relief in childbirth: changing historical and feminist perspectives.

Authors:
G A Skowronski

Anaesth Intensive Care 2015 Jul;43 Suppl:25-8

Department of Intensive Care, St George Hospital, Kogarah, New South Wales.

Pain during human childbirth is ubiquitous and severe. Opium and its derivatives constitute the oldest effective method of pain relief and have been used in childbirth for several thousand years, along with numerous folk medicines and remedies. Interference with childbirth pain has always been criticised by doctors and clergy. Read More

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[Methods in neonatal abstinence syndrome (NAS): results of a nationwide survey in Austria].

Z Geburtshilfe Neonatol 2015 Aug 3;219(4):185-9. Epub 2015 Jun 3.

Klinische Abteilung für Neonatologie, Universitätsklinik für Kinder- und Jugendheilkunde, Medizinische Universität Graz, Österreich.

Background: Neonatal abstinence syndrome (NAS) occurs in neonates whose mothers have taken addictive drugs or were under substitution therapy during pregnancy. Incidence numbers of NAS are on the rise globally, even in Austria NAS is not rare anymore. The aim of our survey was to reveal the status quo of dealing with NAS in Austria. Read More

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The effects of co-administration of opium and morphine with nicotine during pregnancy on spatial learning and memory of adult male offspring rats.

Iran J Basic Med Sci 2014 Sep;17(9):694-701

NPRC and Physiology Dept., School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences Kerman, Iran.

Objectives: Smoking opium/cigarette is a global health concern. The aim of this study was to examine learning and memory of rat male offsprings whose mothers had been exposed to either opium or morphine with nicotine during pregnancy.

Materials And Methods: Wistar rats were used for the experiments. Read More

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September 2014

Validity and reliability of a questionnaire designed to assess risk factors of pancreatic cancer in Iran.

Arch Iran Med 2014 Feb;17(2):102-5

Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: The objective of this study is to develop a questionnaire to study risk factors of pancreatic cancer in Iran and to assess its reliability and validity.

Methods: Following a comprehensive literature search and consulting with six expert gastroenterologists,these domains were included in the questionnaire: demographic variables; anthropometric indices; socioeconomic status indicators; signs and symptoms of the current disease; occupational history and exposure to certain physical and chemical agents; medical and drug history; family history of cancer; history of alcohol, tobacco, or opium use; history of tea and coffee consumption; pregnancy and menstrual data (only for women); and dietary habits and cooking methods. A total of 113 questions were developed and included in the questionnaire. Read More

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February 2014

The Effect of Opium Dependency of Parent (s) on Offspring's Spatial Learning & Memory in Adult Male Rats.

Iran J Basic Med Sci 2013 May;16(5):694-9

Kerman Neuroscience Research Center, Kerman University of Medical Sciences Kerman, Iran.

Objective(s): As far as we know, there has been no report regarding the effects of opium addiction or dependency of both parents on the learning and memory process in offspring. The aim of this study was to examine the learning and memory changes of adult male offspring whose mothers, fathers and/or both parents had dependency to opium before and during pregnancy. Materials and Methods : All experiments were carried out on Wistar rats. Read More

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The cause and consequence of domestic violence on pregnant women in India.

Authors:
N N Sarkar

J Obstet Gynaecol 2013 Apr;33(3):250-3

Department of Reproductive Biology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

The objective of this study is to evaluate and elucidate the impact of domestic violence on the health and pregnancy outcomes of women. Data were extracted from literature through the MEDLINE database for years 2000-2011. Domestic violence occurs in every society, irrespective of class, creed, religion and country. Read More

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[The first labor analgesia with drug was already performed in late Meiji-Period (1868-1912): trace of opioid-scopolamine which was used in Akiko Yosano, back to its origins].

Masui 2013 Feb;62(2):239-43

Division of Obstetric Anesthesia, Center for Perinatal Medicine, Kitasato University Hospital, Sagamihara 252-0375.

There have been some records of labor analgesia with intravenous or rectal anesthetics in early Showa-period (1926-1989). However, the author found that labor analgesia had been already attempted for some women in late Meiji-period (1868-1912). One of agents used was pantopon, a water-soluble opioid without serious respiratory depression as morphine. Read More

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February 2013

The rate of addiction in parents of toddlers with congenital heart disease.

Int J High Risk Behav Addict 2013 12;1(4):154-8. Epub 2013 Mar 12.

Department of Ophtalmology, Zahedan University of Medical Sciences, Zahedan, IR Iran.

Background: Opium abuse is one of the widespread social problems, and one of the most worrying aspects of it is the effect of parents' drug abuse on the fetus.

Objectives: The present study has investigated the correlation between opium abuse during pregnancy in mothers with congenital heart defects in their children.

Materials And Methods: From early 2009 to late 2011, for two consecutive years in specialized pediatric center of Zahedan Medical University, 225 of children suffering from congenital heart defects were examined and compared with 480 healthy ones for mother opium dependency. Read More

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Effect of methadone maintenance therapy on anthropometric indices in opioid dependent patients.

Int J High Risk Behav Addict 2012 26;1(3):100-3. Epub 2012 Nov 26.

Department of Psychiatry ,Baharan Psychiatric Hospital, Zahedan University of Medical Sciences, Zahedan, IR Iran.

Background: Opium abuse significantly affects the nutritional status of users and frequently leads to undernourishment. Methadone maintenance therapy has been used as one of the possible ways to prevent of infection diseases such as HIV and hepatitis B and C and improve the quality of life in opioid-dependent patients.

Objectives: The aim of this study was to assess the anthropometric and socio-demographic characteristics of opium addicted persons before and after 8 weeks of methadone maintenance therapy (MMT). Read More

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Maternal and neonatal complications of substance abuse in Iranian pregnant women.

Acta Med Iran 2012 ;50(6):411-6

Infertility & Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

There is an increased prevalence of maternal substance abuse during pregnancy in younger women in all socioeconomic classes and races. Our aim was to determine the prevalence and correlates of self-reported substance abuse among pregnant women and obstetric complications or neonatal outcomes in Iran. This retrospective cohort study is covering a five year period on medical records of pregnant women attending the maternity unit of four major hospitals (Mahdieh, Taleghani, Imam Hossein and Akbarabadi Hospitals). Read More

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November 2012

The occasional management of narcotic exposure in neonates.

Can J Rural Med 2011 ;16(3):98-101

Division of Clinical Sciences, Northern Ontario School of Medicine, Sioux Lookout, Ont.

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September 2011

Domestic abuse before, during and after pregnancy in Jahrom, Islamic Republic of Iran.

East Mediterr Health J 2010 Jul;16(7):752-8

Department of Psychiatry, Medical College, Jahrom University of Medical Sciences, Jahrom, Islamic Republic of Iran.

We conducted a cross-sectional study among 300 women with a child aged 6 to 18 months, to determine the prevalence and determinants of domestic abuse against women in Jahrom; before, during and after pregnancy. The prevalence of abuse during pregnancy (42%) was lower than during the 1 year before pregnancy (51.7%) and after delivery (53. Read More

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Treatment of neonatal withdrawal with clonidine after long-term, high-dose maternal use of tramadol.

Ann Pharmacother 2010 Jul-Aug;44(7-8):1342-4. Epub 2010 Jun 29.

Women's Hospital of Greensboro, Greensboro, NC 27401, USA.

Objective: To describe a case of tramadol withdrawal in a neonate and treatment with clonidine after exposure to long-term maternal use of high-dose tramadol.

Case Summary: A 34-week gestational age neonate displayed symptoms of tramadol withdrawal within 48 hours of delivery. Due to a confusing initial clinical picture, including presumed congenital Chlamydia, questionable seizures, and an original report of maternal use of ketorolac (Toradol), diagnosis was delayed until day of life 5. Read More

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October 2010

Perinatal isolated atrial flutter associated with maternal cocaine and opiate use in a late preterm infant.

J Matern Fetal Neonatal Med 2010 Sep;23(9):1062-5

Department of Pediatrics, Division of Neonatology, NY Methodist Hospital, Brooklyn, New York, USA.

Atrial flutter is a serious form of neonatal tachyarrhythmia. Maternal drug use of cocaine and/or opiate is associated with central and autonomic nervous signs in fetuses and newborn infants. The fetal cardiovascular effects of cocaine and opiate exposure are not well characterized. Read More

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September 2010

[Nursing management of neonatal opiate abstinence syndrome].

Hu Li Za Zhi 2008 Dec;55(6):68-72

Department of Nursing, Taipei Medical University Shuang Ho Hospital, ROC.

Caring for infants with neonatal opiate abstinence syndrome is a challenge for nursing staff. These infants are at high risk for many complications. Nurses should be aware of the influences on neonates of maternal opium addiction during pregnancy. Read More

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December 2008

HIV sero-prevalence and knowledge, behaviour and practices regarding HIV/AIDS in specific population groups in Ludhiana, Punjab.

Indian J Public Health 2007 Jan-Mar;51(1):33-8

Department of Community Medicine, Christian Medical College, Ludhiana - 141008, Punjab.

Objectives: To assess HIV serostatus, knowledge, behaviour and practices regarding HIV/AIDS among blood donors, pregnant women and the general population in Ludhiana and to find out any association between these factors.

Methods: The descriptive cross sectional study was conducted among blood donors attending the blood bank, pregnant women attending the antenatal clinics of the peripheral health centres of the department of Community Medicine, Christian Medical College Ludhiana, and the general population of the field practice areas of the Department, aged 15 years or more and willing to join the investigation. The study subjects were interviewed through a self-administered questionnaire and screened for HIV using ELISA technique. Read More

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February 2008

Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions.

Rev Gastroenterol Disord 2007 ;7 Suppl 3:S3-10

Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, USA.

Diarrhea continues to be a prevalent symptom in patients with inflammatory bowel disease (IBD), requiring a wide differential diagnosis to define the pathophysiologic mechanisms in individual patients. It is essential that physicians properly evaluate complaints of diarrhea by assessing both patient symptoms and potential physiologic impacts on fluid and electrolyte status. Underlying mechanisms of diarrhea with IBD are the location, extent, and severity of inflammation; malabsorption; altered motility; and iatrogenic causes such as medications, diet, and antibiotic-associated colitis (eg, Clostridium difficile). Read More

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February 2008

[Attacks of apnea in a newborn aged 18 days].

Authors:
Jan Bauer

Forsch Komplementmed 2006 Aug 5;13(4):241-3. Epub 2006 Sep 5.

Kinder- und Jugendklinik des Städtischen Klinikum Offenbach, Landgrafenring 20, 63071 Offenbach, Germany.

Clinical case of an 18-day-old newborn of the 40th + 1 pregnancy week with postpartum respiratory adjustment disorder including periodical decreases in blood oxygen saturation. On day 8 postpartum the newborn developed myoclonic cramps of unknown origin combatted with phenobarbital. 6 days later Cheyne-Stokes breathing began under normal phenobarbital level being the cause for an additional homeopathic therapy trial. Read More

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A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal.

Authors:
Martha J Wunsch

J Addict Dis 2006 ;25(3):27-33

Department of Pediatrics, Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA 24060, USA.

Neonatal opioid withdrawal often requires treatment but there have been few recent studies of current pharmacological interventions to guide treatment. This retrospective chart review provides an exploratory examination of newborns treated with either methadone or paregoric for opioid withdrawal and outlines dosage ranges and intervals, side effects, and clinical outcomes of the two regimens. The outcome variables examined were time to resolution of withdrawal symptoms, rate of decrease in symptom severity, and length of hospital stay. Read More

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February 2007